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Journal Article
Circulation Research, ISSN 0009-7330, 07/2008, Volume 103, Issue 1, pp. 80 - 88
The role of prostaglandin production in the control of regenerative function of endothelial progenitor cells (EPCs) has not been studied. We hypothesized that... 
Angiogenesis | Cyclooxygenase | Prostaglandins | Adult stem cells | Peroxisome proliferator-activated receptor | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | angiogenesis | PROLIFERATOR-ACTIVATED RECEPTORS | CA2+-ACTIVATED K+ CHANNELS | cyclooxygenase | adult stem cells | TRANSPLANTATION | IN-VIVO | ACUTE MYOCARDIAL-INFARCTION | NITRIC-OXIDE | prostaglandins | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | peroxisome proliferator-activated receptor | GROWTH-FACTOR | HEMATOLOGY | UP-REGULATION | Gene Expression Regulation, Enzymologic - drug effects | Neovascularization, Physiologic - drug effects | RNA, Small Interfering - genetics | Cell Proliferation | Iloprost - pharmacology | Epoprostenol - biosynthesis | Humans | Middle Aged | Culture Media, Conditioned - pharmacology | Male | Stem Cells - cytology | Gene Expression Regulation, Enzymologic - physiology | Stem Cells - enzymology | Adult | Cyclooxygenase 1 - genetics | Cyclooxygenase 1 - biosynthesis | Vasodilator Agents - pharmacology | Cells, Cultured | Enzyme Activation - drug effects | Indomethacin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Neovascularization, Physiologic - physiology | Regeneration | Tumor Necrosis Factor-alpha - pharmacology | Endothelial Cells - cytology | PPAR delta - agonists | Leukocytes, Mononuclear - cytology | Leukocytes, Mononuclear - enzymology | Thiazoles - pharmacology | Endothelial Cells - enzymology | Enzyme Activation - physiology | Index Medicus | peroxisome-proliferator activated receptor
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/1999, Volume 96, Issue 1, pp. 272 - 277
Prostaglandins (PG) are synthesized by two isoforms of the enzyme PG G/H synthase [cyclooxygenase (COX)]. To examine selectivity of tolerated doses of an... 
Volunteerism | Excretion | Prostaglandins | Cyclooxygenase inhibitors | Placebos | Biosynthesis | Biochemistry | Dosage | Platelets | Blood plasma | Monocytes | Celecoxib | Ibuprofen | monocytes | celecoxib | ENDOPEROXIDE-H SYNTHASE-1 | MULTIDISCIPLINARY SCIENCES | ibuprofen | platelets | HUMAN ENDOTHELIAL-CELLS | PRESYSTEMIC ACETYLATION | LOW-DOSE ASPIRIN | MESSENGER-RNA | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | PROSTAGLANDIN-G/H SYNTHASE | prostaglandins | ALVEOLAR MACROPHAGES | BLOOD MONOCYTES | CDNA CLONING | Isoenzymes - blood | 6-Ketoprostaglandin F1 alpha - analogs & derivatives | Epoprostenol - biosynthesis | Cyclooxygenase 2 | Humans | Middle Aged | Cyclooxygenase 1 | Male | Isoenzymes - metabolism | Platelet Aggregation Inhibitors - pharmacology | Adult | Female | Platelet Aggregation - drug effects | Ibuprofen - pharmacology | Pyrazoles | Ibuprofen - pharmacokinetics | Prostaglandin-Endoperoxide Synthases - drug effects | Sulfonamides - pharmacology | Prostaglandin-Endoperoxide Synthases - blood | Thromboxane B2 - analogs & derivatives | Sulfonamides - pharmacokinetics | Cyclooxygenase Inhibitors - pharmacology | Dinoprostone - metabolism | Membrane Proteins | Monocytes - enzymology | Cyclooxygenase 2 Inhibitors | 6-Ketoprostaglandin F1 alpha - urine | Prostaglandin-Endoperoxide Synthases - metabolism | Thromboxane B2 - urine | Isoenzymes - drug effects | Thromboxane B2 - blood | Oxidases | Prostacyclin | Research | Analysis | Enzymes | Pharmacology | Index Medicus | Biological Sciences
Journal Article
Blood, ISSN 0006-4971, 01/2015, Volume 125, Issue 4, pp. 710 - 719
The precise mechanism for reduced thrombosis in prekallikrein null mice (Klkb1(-/-)) is unknown. Klkb1(-/-) mice have delayed carotid artery occlusion times on... 
PLASMA KALLIKREIN | MOLECULAR-WEIGHT KININOGEN | ENDOTHELIAL-CELLS | IN-VIVO | NITRIC-OXIDE | FACTOR EXPRESSION | VASCULAR-PERMEABILITY | DEFICIENT MICE | CONTACT ACTIVATION | HEMATOLOGY | FACTOR-XII | Epoprostenol - genetics | Receptor, Bradykinin B2 - genetics | Receptors, G-Protein-Coupled - metabolism | Epoprostenol - biosynthesis | Peptide Fragments - pharmacology | Carotid Artery Thrombosis - metabolism | Pyrones - pharmacology | Sirtuin 1 - genetics | Thromboplastin - antagonists & inhibitors | Nerve Tissue Proteins - biosynthesis | Synaptotagmins - biosynthesis | Carotid Artery Thrombosis - chemically induced | Prekallikrein | Thromboplastin - biosynthesis | Proto-Oncogene Proteins - metabolism | Kruppel-Like Transcription Factors - biosynthesis | Proto-Oncogene Proteins - antagonists & inhibitors | Angiotensin II - pharmacology | Receptor, Bradykinin B2 - biosynthesis | Sirtuin 1 - biosynthesis | Proto-Oncogene Proteins - genetics | Imidazoles - pharmacology | Angiotensin II - analogs & derivatives | Sulfonamides - pharmacology | Nerve Tissue Proteins - genetics | Sirtuin 1 - antagonists & inhibitors | Mice, Knockout | Naphthalenes - pharmacology | Animals | Partial Thromboplastin Time | Thromboplastin - genetics | Receptors, G-Protein-Coupled - antagonists & inhibitors | Mice | Receptors, G-Protein-Coupled - genetics | Synaptotagmins - genetics | Carotid Artery Thrombosis - genetics | Carotid Artery Thrombosis - pathology | Kruppel-Like Transcription Factors - antagonists & inhibitors | Kruppel-Like Transcription Factors - genetics | RNA, Messenger | Index Medicus | Abridged Index Medicus | Thrombosis and Hemostasis
Journal Article
Circulation Research, ISSN 0009-7330, 02/2009, Volume 104, Issue 4, pp. 506 - 513
Cyclooxygenase (COX)-2 is among the endothelial genes upregulated by uniform laminar shear stress (LSS), characteristically associated with atherosclerotic... 
Shear stress | Cyclooxygenase | Prostaglandins | Tumor necrosis factor-α | Endothelial cells | Prostanoids | endothelial cells | CARDIAC & CARDIOVASCULAR SYSTEMS | HEALTHY-SUBJECTS | NITRIC-OXIDE SYNTHASE | cyclooxygenase | PROSTAGLANDIN ENDOPEROXIDE SYNTHASES | RECEPTOR | THROMBOXANE SYNTHASE | tumor necrosis factor-alpha | FLUID MECHANICAL STIMULI | shear stress | prostanoids | LOW-DOSE ASPIRIN | EPITHELIAL-CELLS | prostaglandins | CYCLOOXYGENASE-2 EXPRESSION | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | HEMATOLOGY | Inflammation - chemically induced | Nitrobenzenes - adverse effects | Propionates - pharmacology | Up-Regulation | Epoprostenol - metabolism | Heme Oxygenase-1 - metabolism | Receptors, Epoprostenol | Humans | Stress, Mechanical | Benzofurans - pharmacology | Dinoprost - metabolism | Nitrobenzenes - pharmacology | Receptors, Prostaglandin - metabolism | Atherosclerosis - enzymology | Aspirin - adverse effects | Prostaglandin D2 - metabolism | Epoprostenol - pharmacology | Aspirin - pharmacology | Receptors, Prostaglandin - drug effects | Atherosclerosis - chemically induced | Down-Regulation | Cells, Cultured | Sulfonamides - pharmacology | Cyclooxygenase Inhibitors - pharmacology | 6-Ketoprostaglandin F1 alpha | Dinoprostone - metabolism | Epoprostenol - analogs & derivatives | Perfusion | Cyclooxygenase 2 - metabolism | Sulfonamides - adverse effects | Cyclooxygenase 1 - metabolism | Cyclooxygenase Inhibitors - adverse effects | Endothelial Cells - enzymology | Inflammation - enzymology | Tumor Necrosis Factor-alpha - biosynthesis | Endothelial Cells - drug effects | Index Medicus
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 04/2012, Volume 341, Issue 1, pp. 242 - 250
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 06/2012, Volume 91, Issue 6, pp. 986 - 993
Nonsteroidal anti‐inflammatory drugs (NSAIDs) elevate cardiovascular risk by disrupting cyclooxygenase‐2 (COX‐2)‐dependent biosynthesis of prostacyclin (PGI 2... 
CYCLOOXYGENASE-2 | METAANALYSIS | COX-2 | ATHEROTHROMBOSIS | HUMANS | RISK | PHARMACOLOGY & PHARMACY | INHIBITORS | ABSORPTION | FOOD | 6-Ketoprostaglandin F1 alpha - analogs & derivatives | Area Under Curve | Furans - pharmacology | Humans | Middle Aged | Male | Furans - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Young Adult | Cyclooxygenase 2 Inhibitors - adverse effects | Furans - pharmacokinetics | Cardiovascular Diseases - epidemiology | Adult | Female | Prostaglandin Antagonists - pharmacology | Pyrazoles - pharmacokinetics | Pyrazoles - adverse effects | Pyrazoles - pharmacology | Prostaglandin Antagonists - pharmacokinetics | Cyclooxygenase 2 Inhibitors - pharmacology | Double-Blind Method | Risk Assessment | Epoprostenol - urine | European Continental Ancestry Group | Prostaglandins - biosynthesis | Carbonic Anhydrase Inhibitors - pharmacology | Celecoxib | Sulfonamides - pharmacology | Cyclooxygenase 2 Inhibitors - pharmacokinetics | Prostaglandin Antagonists - adverse effects | Sulfonamides - pharmacokinetics | Cross-Over Studies | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | 6-Ketoprostaglandin F1 alpha - urine | Adolescent | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Sulfonamides - adverse effects | Cardiovascular Diseases - chemically induced | Thromboxane B2 - blood | Asian Americans | African Continental Ancestry Group | Research | Nonsteroidal anti-inflammatory drugs | Comparative analysis | Analysis | Prostanoids | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
The Journal of Immunology, ISSN 0022-1767, 09/2001, Volume 167, Issue 5, pp. 2831 - 2838
Journal Article