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Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2013, Volume 56, Issue 11, pp. 4277 - 4299
3-(5-Chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6), a known selective cyclooxygenase-1 (COX-1) inhibitor, was used to design a new series of... 
CROSS-TALK | CHEMISTRY, MEDICINAL | LOW-DOSE ASPIRIN | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | HEALTHY-SUBJECTS | STRUCTURAL BASIS | ACTIVE-SITE | VESSEL WALL INTERACTIONS | THROMBOXANE BIOSYNTHESIS | PROSTANOID FORMATION | ARACHIDONIC-ACID | Fibrinolytic Agents - chemistry | Epoprostenol - metabolism | Furans - pharmacology | Humans | Structure-Activity Relationship | Cyclooxygenase 2 Inhibitors - chemistry | Isoxazoles - chemical synthesis | Platelet Aggregation Inhibitors - chemical synthesis | Furans - chemistry | Platelet Aggregation Inhibitors - pharmacology | Thromboxane A2 - antagonists & inhibitors | Female | Fibrinolytic Agents - chemical synthesis | Platelet Aggregation - drug effects | Blood Platelets - drug effects | Thromboxane A2 - biosynthesis | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cell Line | Cyclooxygenase 2 Inhibitors - pharmacology | Mice, Inbred C57BL | Cyclooxygenase Inhibitors - chemistry | Isoxazoles - chemistry | Cyclooxygenase Inhibitors - pharmacology | Isoxazoles - pharmacology | Fibrinolytic Agents - pharmacology | Animals | Blood Platelets - metabolism | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Platelet Aggregation Inhibitors - chemistry | Platelet-Rich Plasma | Mice | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Furans - chemical synthesis | Index Medicus
Journal Article
Organic Letters, ISSN 1523-7060, 01/2012, Volume 14, Issue 1, pp. 299 - 301
Journal Article
Journal Article
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 2014, Volume 307, Issue 3, pp. H319 - H327
This study tested the hypothesis that in diabetic arteries, cyclooxygenase (COX)-1 mediates endothelial prostacyclin (PGI(2)) synthesis, which evokes... 
Diabetes | Arachidonic acid | Metabolism | Thromboxane prostanoid receptors | Contraction | arachidonic acid | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | ARACHIDONIC-ACID | thromboxane prostanoid receptors | VASCULAR SMOOTH-MUSCLE | MOUSE ARTERIES | ENDOTHELIAL-CELLS | HIGH GLUCOSE | contraction | PERIPHERAL VASCULAR DISEASE | metabolism | diabetes | UP-REGULATION | TYROSINE NITRATION | HYPERTENSIVE-RATS | COX-2 CONTRIBUTES | Blood Pressure | Epoprostenol - metabolism | Diabetes Mellitus, Experimental - enzymology | Muscarinic Agonists - pharmacology | Diabetes Mellitus, Type 2 - genetics | Diabetes Mellitus, Experimental - genetics | Nitric Oxide Synthase - antagonists & inhibitors | Acetylcholine - metabolism | Aorta, Abdominal - drug effects | Dose-Response Relationship, Drug | Renal Artery - enzymology | Membrane Proteins - deficiency | Renal Artery - physiopathology | Time Factors | Diet, High-Fat | Hypertension - prevention & control | Membrane Proteins - metabolism | Hypertension - enzymology | Aorta, Abdominal - physiopathology | Diabetes Complications - prevention & control | Diabetes Mellitus, Experimental - physiopathology | Vasoconstrictor Agents - pharmacology | Cyclooxygenase 1 - genetics | Diabetes Complications - physiopathology | Membrane Proteins - genetics | Mice, Inbred C57BL | Diabetes Mellitus, Type 2 - enzymology | Enzyme Inhibitors - pharmacology | Aorta, Abdominal - enzymology | Vasoconstriction - drug effects | Hypertension - physiopathology | Mice, Knockout | Animals | Diabetes Mellitus, Type 2 - physiopathology | Cyclooxygenase 1 - deficiency | Signal Transduction - drug effects | 6-Ketoprostaglandin F1 alpha - metabolism | Diabetes Complications - enzymology | Nitric Oxide Synthase - metabolism | Renal Artery - drug effects | Cyclooxygenase 1 - metabolism | Nitric Oxide - metabolism | Physiological aspects | Complications and side effects | Cyclooxygenases | Prostacyclin | Streptozocin | Ketogenic diet | Diet | Chemical synthesis | Insulin | Rodents | Index Medicus
Journal Article
Journal Article
Journal Article
Organic Letters, ISSN 1523-7060, 07/2006, Volume 8, Issue 14, pp. 3101 - 3104
Journal Article
Organic Letters, ISSN 1523-7060, 11/2005, Volume 7, Issue 23, pp. 5115 - 5118
We describe a convergent and flexible synthesis of 15-deoxy-16-(m-tolyl)-17,18,19,20-tetranorisocarbacyclin (15-deoxy-TIC), a simple isocarbacyclin derivative.... 
CHEMISTRY, ORGANIC | PROSTACYCLIN RECEPTOR | CENTRAL-NERVOUS-SYSTEM | BINDING | BRAIN | Epoprostenol - analogs & derivatives | Stereoisomerism | Epoprostenol - chemical synthesis | Epoprostenol - chemistry | Molecular Structure | Catalysis | Palladium - chemistry | Index Medicus
Journal Article
Journal Article
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 09/2015, Volume 13, Issue 9, pp. 1721 - 1734
Journal Article