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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2015, Volume 112, Issue 2, pp. 536 - 541
Soluble epoxide hydrolase (sEH) is an emerging therapeutic target in a number of diseases that have inflammation as a common underlying cause. sEH limits... 
Omega-3-derived epoxides | Obesity | Inflammation | Autophagy | Soluble epoxide hydrolase | PATHWAYS | autophagy | ER STRESS | OMEGA-3-FATTY-ACIDS | MULTIDISCIPLINARY SCIENCES | FATTY-ACIDS | soluble epoxide hydrolase | INDUCED INSULIN-RESISTANCE | EPOXYEICOSANOIDS | inflammation | DOCOSAHEXAENOIC ACID | EICOSAPENTAENOIC ACID | obesity | omega-3-derived epoxides | Epoxy Compounds - metabolism | Inflammation - pathology | Liver - pathology | Cadherins - metabolism | Cytochrome P-450 Enzyme System - metabolism | Male | Autophagy - physiology | Cytochrome P-450 CYP2E1 - metabolism | Adipose Tissue - metabolism | Inflammation - metabolism | Liver - drug effects | Mice, Mutant Strains | Female | Cadherins - genetics | Fatty Acid Desaturases - genetics | Fatty Acids, Omega-3 - metabolism | Fatty Acid Desaturases - metabolism | Liver - metabolism | Mice, Inbred C57BL | Adipose Tissue - pathology | Enzyme Inhibitors - pharmacology | Mice, Transgenic | 3T3-L1 Cells | Cytochrome P-450 CYP1A1 - metabolism | Obesity - metabolism | Obesity - pathology | Animals | Benzoates - pharmacology | Mice | Phenylurea Compounds - pharmacology | Adipose Tissue - drug effects | Epoxide Hydrolases - antagonists & inhibitors | Adipose tissues | Autophagy (Cytology) | Medical research | Liver | Epoxy compounds | Medicine, Experimental | Research | Health aspects | Obesitat | Liver diseases | Àcids grassos insaturats | Inflamació | Unsaturated fatty acids | Àcids grassos omega-3 | Teixit adipós | Malalties del fetge | Autofàgia | Omega-3 fatty acids | Biological Sciences | omega-3–derived epoxides
Journal Article
Annual Review of Pharmacology and Toxicology, ISSN 0362-1642, 01/2013, Volume 53, Issue 1, pp. 37 - 58
Journal Article
Chemical Communications, ISSN 1359-7345, 2008, Issue 10, pp. 1235 - 1237
Hydrolases show good catalytic activity in deep eutectic solvents, despite the presence of urea, which can denature enzymes, or alcohols, which can interfere... 
DYES | POLARITY | EPOXIDE HYDROLASE | CHOLINE CHLORIDE | IMIDAZOLIUM | IONIC LIQUIDS | CHEMISTRY, MULTIDISCIPLINARY | BIOCATALYSIS | Hydrolases - metabolism | Catalysis | Solvents - chemistry | Biotransformation
Journal Article
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 09/2017, Volume 110, pp. 70 - 79
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 09/2017, Volume 25, Issue 17, pp. 4665 - 4676
Journal Article
Nature Genetics, ISSN 1061-4036, 01/2006, Volume 38, Issue 1, pp. 68 - 74
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 12/2013, Volume 305, Issue 11, pp. H1605 - H1613
Soluble epoxide hydrolase (sEH) diminishes vasodilatory and neuroprotective effects of epoxyeicosatrienoic acids by hydrolyzing them to inactive dihydroxy... 
Ischemic stroke | Arachidonic acid | Cerebral blood flow | Middle cerebral artery occlusion | Cytochrome P-450 | arachidonic acid | TARGET | CYTOCHROME-P450 | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | cytochrome P-450 | ARACHIDONIC-ACID | HYPOXIA | FREE FATTY-ACIDS | cerebral blood flow | PERIPHERAL VASCULAR DISEASE | ELECTROCONVULSIVE SHOCK | PERFUSION | CEREBRAL-ISCHEMIA | EPOXYEICOSATRIENOIC ACIDS | ischemic stroke | middle cerebral artery occlusion | BRAIN | Infarction, Middle Cerebral Artery - physiopathology | Neurons - pathology | Brain - enzymology | Motor Activity - drug effects | Male | Recovery of Function | Dose-Response Relationship, Drug | Brain - blood supply | Neuroprotective Agents - pharmacology | Time Factors | Urea - analogs & derivatives | Behavior, Animal - drug effects | Infarction, Middle Cerebral Artery - drug therapy | Cell Death - drug effects | Neurons - drug effects | Disease Models, Animal | Cerebrovascular Circulation - drug effects | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Infarction, Middle Cerebral Artery - pathology | Rats, Sprague-Dawley | Brain - drug effects | Hydroxyeicosatetraenoic Acids - metabolism | Animals | Neurons - enzymology | Benzoates - pharmacology | Brain - pathology | Epoxide Hydrolases - metabolism | Infarction, Middle Cerebral Artery - enzymology | Epoxide Hydrolases - antagonists & inhibitors | Urea - pharmacology | Stroke (Disease) | Benzoic acid | Physiological aspects | Enzymes | Hydrolases | Health aspects | Vascular Biology and Microcirculation
Journal Article