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Nature Chemical Biology, ISSN 1552-4450, 03/2011, Volume 7, Issue 3, pp. 182 - 188
Triptolide (1) is a structurally unique diterpene triepoxide isolated from a traditional Chinese medicinal plant with anti-inflammatory, immunosuppressive,... 
RNA-POLYMERASE-II | TRIPTERYGIUM-WILFORDII | INHIBITION | PROTEIN | INITIATION | COMMON TARGET | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION FACTOR IIH | TRANSLATION | CYTOTOXICITY | CHEMOTHERAPY | Humans | Drugs, Chinese Herbal - pharmacology | Biological Products - pharmacology | Transcription Factor TFIIH - chemistry | RNA Polymerase II - metabolism | Phenanthrenes - isolation & purification | Protein Subunits - metabolism | DNA-Binding Proteins - metabolism | Dose-Response Relationship, Drug | Phenanthrenes - chemistry | Epoxy Compounds - pharmacology | Antineoplastic Agents - isolation & purification | Antineoplastic Agents - pharmacology | Drugs, Chinese Herbal - isolation & purification | Diterpenes - chemistry | Epoxy Compounds - isolation & purification | Diterpenes - pharmacology | Cell Survival - drug effects | DNA Helicases - chemistry | Diterpenes - isolation & purification | Adenosine Triphosphatases - metabolism | Antineoplastic Agents - chemistry | DNA-Binding Proteins - chemistry | Biological Products - isolation & purification | DNA Helicases - metabolism | Phenanthrenes - pharmacology | Biological Products - chemistry | Drugs, Chinese Herbal - chemistry | Epoxy Compounds - chemistry | Transcription Factor TFIIH - metabolism | Protein Binding | Adenosine Triphosphatases - chemistry | RNA Polymerase II - genetics | Protein Subunits - chemistry | HeLa Cells | Chinese medicine | Eukaryotes | Biochemistry | Flowers & plants | Adenosine triphosphatase
Journal Article
The American Journal of Chinese Medicine, ISSN 0192-415X, 2014, Volume 42, Issue 3, pp. 543 - 559
To discover and develop novel natural compounds, active ingredients, single herbs and combination formulas or prescriptions in traditional Chinese medicine... 
Combination Formula | Review | Natural Compound | Antitumor | Herb | Traditional Chinese Medicine | FORBESII BOISS EXTRACT | SOPHORA-FLAVESCENS | PANCREATIC-CANCER | CELL-CYCLE PROGRESSION | GANODERMA-LUCIDUM | ANTITUMOR-ACTIVITY | BREAST-CANCER CELLS | MEDICINE, GENERAL & INTERNAL | IN-VITRO | HEPATOCELLULAR-CARCINOMA | INTEGRATIVE & COMPLEMENTARY MEDICINE | NF-KAPPA-B | Quinolizines - therapeutic use | Antineoplastic Agents, Phytogenic | Podophyllotoxin - pharmacology | Quinolizines - isolation & purification | Humans | Molecular Conformation | Alkaloids - isolation & purification | Podophyllotoxin - therapeutic use | Drugs, Chinese Herbal - pharmacology | Molecular Targeted Therapy | Phenanthrenes - isolation & purification | Flavonoids - therapeutic use | Epoxy Compounds - pharmacology | Neoplasms - genetics | Flavonoids - pharmacology | Drugs, Chinese Herbal - therapeutic use | Epoxy Compounds - isolation & purification | Podophyllotoxin - isolation & purification | Diterpenes - pharmacology | Epoxy Compounds - therapeutic use | Amphibian Venoms - chemistry | Diterpenes - therapeutic use | Phenanthrenes - therapeutic use | Plants, Medicinal - chemistry | Alkaloids - pharmacology | Medicine, Chinese Traditional | Diterpenes - isolation & purification | Quinolizines - pharmacology | Amphibian Venoms - pharmacology | Berberine - isolation & purification | Drug Discovery | Neoplasms - drug therapy | Amphibian Venoms - therapeutic use | Berberine - pharmacology | Phenanthrenes - pharmacology | Animals | Drugs, Chinese Herbal - chemistry | Alkaloids - therapeutic use | Flavonoids - isolation & purification | Berberine - therapeutic use | Neoplasms - pathology | Amphibian Venoms - isolation & purification | Drug Combinations | Podophyllotoxin - analogs & derivatives | Antimitotic agents | Medicine, Chinese | Product development | Research | Antineoplastic agents | Health aspects
Journal Article
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 32, pp. 32790 - 32804
Triptolide and celastrol are two main active compounds isolated from Thunder God Vine with the potent anticancer activity. However, the anticancer effect of... 
Combination therapy | Celastrol | Triptolide | Cancer | INDUCED APOPTOSIS | celastrol | triptolide | DRUG-RESISTANCE | P-GLYCOPROTEIN | CELL BIOLOGY | IN-VITRO | HEPATOCELLULAR-CARCINOMA | combination therapy | cancer | ENDOPLASMIC-RETICULUM | MULTIDRUG-RESISTANCE | INHIBITOR | K562/A02 CELLS | PANCREATIC-CANCER CELLS
Journal Article
Journal Article
Food and Chemical Toxicology, ISSN 0278-6915, 03/2019, Volume 125, pp. 10 - 20
Bioassay-guided isolation of the 80% methanol extract of the aerial parts of (DC.) Boiss. (Asteraceae) led to the isolation of four known guaianolide-type... 
Cytotoxicity | Sesquiterpene lactones | Steroidal glycosides | Chrysophthalmum montanum | HT-29 colon cancer cell line | Asteraceae | FOOD SCIENCE & TECHNOLOGY | GUAIANOLIDES | PLANTS | TOXICOLOGY | EXTRACTS | CONSTITUENTS | INULEAE | Colon cancer | Analysis | Epoxy resins | Lactones
Journal Article
Journal Article