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Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 01/2015, Volume 112, Issue 2, pp. 536 - 541
Soluble epoxide hydrolase (sEH) is an emerging therapeutic target in a number of diseases that have inflammation as a common underlying cause. sEH limits... 
Omega-3-derived epoxides | Obesity | Inflammation | Autophagy | Soluble epoxide hydrolase | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Epoxy Compounds - metabolism | Inflammation - pathology | Liver - pathology | Cadherins - metabolism | Cytochrome P-450 Enzyme System - metabolism | Male | Autophagy - physiology | Cytochrome P-450 CYP2E1 - metabolism | Adipose Tissue - metabolism | Inflammation - metabolism | Liver - drug effects | Mice, Mutant Strains | Female | Cadherins - genetics | Fatty Acid Desaturases - genetics | Fatty Acids, Omega-3 - metabolism | Fatty Acid Desaturases - metabolism | Liver - metabolism | Mice, Inbred C57BL | Adipose Tissue - pathology | Enzyme Inhibitors - pharmacology | Mice, Transgenic | 3T3-L1 Cells | Cytochrome P-450 CYP1A1 - metabolism | Obesity - metabolism | Obesity - pathology | Animals | Benzoates - pharmacology | Mice | Phenylurea Compounds - pharmacology | Adipose Tissue - drug effects | Epoxide Hydrolases - antagonists & inhibitors | Adipose tissues | Autophagy (Cytology) | Medical research | Liver | Epoxy compounds | Medicine, Experimental | Research | Health aspects | Tissue | Index Medicus | Obesitat | Liver diseases | Àcids grassos insaturats | Inflamació | Unsaturated fatty acids | Àcids grassos omega-3 | Teixit adipós | Malalties del fetge | Autofàgia | Omega-3 fatty acids | Biological Sciences | autophagy | omega-3–derived epoxides | soluble epoxide hydrolase | inflammation | obesity
Journal Article
Applied and Environmental Microbiology, ISSN 0099-2240, 08/2012, Volume 78, Issue 15, pp. 5043 - 5051
Journal Article
Archives of toxicology, ISSN 0340-5761, 11/2016, Volume 90, Issue 11, pp. 2809 - 2823
Methyleugenol is a substituted alkenylbenzene found in several herbs and spices. It is classified by the European Union’s Scientific Committee on Food as a... 
Biomedicine, general | Biomedicine | Environmental Health | Occupational Medicine/Industrial Medicine | Oxidative metabolites | DNA damage | Topoisomerase inhibition | Methyleugenol | Pharmacology/Toxicology | DNA double-strand breaks | Micronucleus induction | Life Sciences & Biomedicine | Toxicology | Science & Technology | Carcinogens, Environmental - metabolism | Epoxy Compounds - metabolism | Topoisomerase I Inhibitors - metabolism | Mutagens - metabolism | Mutagens - toxicity | Eugenol - metabolism | Food Contamination | Humans | DNA Topoisomerases, Type I - chemistry | Carcinogens, Environmental - analysis | Colonic Neoplasms - chemically induced | Spices - analysis | Neoplasm Proteins - metabolism | Carcinogens, Environmental - toxicity | Colonic Neoplasms - metabolism | Micronucleus Tests | Eugenol - analysis | Protein Processing, Post-Translational - drug effects | Biotransformation | Carcinoma - enzymology | Biomarkers, Tumor - metabolism | Biomarkers, Tumor - agonists | Phosphorylation - drug effects | Neoplasm Proteins - genetics | Topoisomerase I Inhibitors - toxicity | Spices - adverse effects | Recombinant Proteins - metabolism | DNA Topoisomerases, Type I - metabolism | Oxidation-Reduction | Eugenol - toxicity | DNA Topoisomerases, Type I - genetics | Eugenol - analogs & derivatives | Recombinant Proteins - chemistry | Carcinoma - chemically induced | Comet Assay | Epoxy Compounds - analysis | Epoxy Compounds - toxicity | HT29 Cells | Histones - agonists | Neoplasm Proteins - agonists | Topoisomerase I Inhibitors - analysis | Colonic Neoplasms - enzymology | DNA Damage | Histones - metabolism | Mutagens - analysis | Poisoning | Colon cancer | Metabolites | DNA | Protein binding | Oxidative stress | Deoxyribonucleic acid--DNA | Cancer | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, pp. e95004 - e95004
.... Herein, a systematic study was designed to elucidate the multi-compound, multi-target and multi-pathway MOA of a Chinese medicine, QiShenYiQi (QSYQ... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Myocardial Infarction - genetics | Heme Oxygenase-1 - metabolism | Oligonucleotide Array Sequence Analysis | Cell Survival - genetics | Drugs, Chinese Herbal - pharmacology | Male | Gene Regulatory Networks - drug effects | PPAR gamma - metabolism | Heme Oxygenase-1 - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Membrane Proteins - metabolism | Phytotherapy - methods | PPAR gamma - genetics | Cell Line | Cell Survival - drug effects | Gene Regulatory Networks - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Membrane Proteins - genetics | Cells, Cultured | Signal Transduction - genetics | Transcriptome - drug effects | Transcriptome - genetics | Macrophages - cytology | Reverse Transcriptase Polymerase Chain Reaction | Rats, Sprague-Dawley | Blotting, Western | Macrophages - metabolism | Animals | Myocardial Infarction - drug therapy | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Mice | Sesquiterpenes - pharmacology | Drug Combinations | Mitogen-Activated Protein Kinase 1 - metabolism | Epoxy resins | Heart attack | Myocardial infarction | Phosphorylation | Heart attacks | Target recognition | Biology | Kinases | Proteins | Chinese medicine | Immunology | Nerolidol | Rodents | Informatics | Pharmaceutical sciences | Food | Traditional Chinese medicine | Extracellular signal-regulated kinase | Heme oxygenase (decyclizing) | Pharmacology | Inflammation | Gene expression | Mode of action | Medicine | Multilevel | Nitric oxide | Infarction | Cardiovascular diseases | Index Medicus
Journal Article
Toxicological sciences, ISSN 1096-6080, 2/2009, Volume 107, Issue 2, pp. 461 - 472
This study addressed the hypothesis that the vestibular or lethal toxicities of allylnitrile depend on CYP2E1-mediated bioactivation. Wild-type (129S1) and... 
Cyanide | CYP2A5 | Nitrile | Xenobiotic metabolism | CYP2E1 | Vestibular toxicity | Ototoxicity | Cyanides - blood | Epoxy Compounds - metabolism | Nitriles - toxicity | Allyl Compounds - toxicity | Cytochrome P-450 CYP2A6 | Cytochrome P-450 Enzyme Inhibitors | Cytochrome P-450 Enzyme System - metabolism | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | Dose-Response Relationship, Drug | Cytochrome P450 Family 2 | Behavior, Animal - drug effects | Aryl Hydrocarbon Hydroxylases - chemistry | Nitriles - metabolism | Solvents | Cytochrome P-450 CYP2E1 Inhibitors | Cyanides - toxicity | Enzyme Inhibitors - pharmacology | Vestibule, Labyrinth - pathology | Vestibular Diseases - chemically induced | Aryl Hydrocarbon Hydroxylases - metabolism | Mice, Knockout | Vestibular Diseases - pathology | Cyanides - metabolism | Acetone - toxicity | Animals | Allyl Compounds - metabolism | Cytochrome P-450 Enzyme System - genetics | Nitriles - blood | Indicators and Reagents | Mice | Vestibular Function Tests | Index Medicus | Malalties de l'orella | Ear diseases | Equilibrium (Physiology) | Equilibri (Fisiologia) | Toxicologia | Vertigen | Vertigo | Toxicology | Chemical products | Nitriles | Productes químics | Nitrils | Epoxy Compounds | Enzyme Inhibitors | Neurons and Cognition | Vestibular Diseases | Cyanides | Allyl Compounds | Cytochrome P-450 Enzyme System | Behavior, Animal | Life Sciences | Cytochrome P-450 CYP2E1 | Aryl Hydrocarbon Hydroxylases | Acetone | Vestibule, Labyrinth
Journal Article
Planta, ISSN 0032-0935, 1/2018, Volume 247, Issue 1, pp. 155 - 169
Monoterpenoid indole alkaloids (MIAs) have remarkable biological properties that have led to their medical uses for a variety of human diseases. Mutagenesis... 
Life Sciences | Tabersonine-2,3-epoxide | Forestry | Mutant | Monoterpenoid indole alkaloids | Pathway suppression | Agriculture | Ecology | Biosynthesis | Epoxides | Plant Sciences | 16-Methoxytabersonine-2,3-epoxide | Life Sciences & Biomedicine | Science & Technology | Epoxy Compounds - metabolism | Vinblastine - metabolism | Catharanthus - chemistry | Humans | Vinca Alkaloids - chemistry | Vinca Alkaloids - metabolism | Antineoplastic Agents - metabolism | Vinblastine - analogs & derivatives | Indole Alkaloids - chemistry | Plant Leaves - enzymology | Plant Leaves - chemistry | Secologanin Tryptamine Alkaloids - chemistry | Vinblastine - chemistry | Catharanthus - enzymology | Oxidoreductases - metabolism | Oxidoreductases - genetics | Quinolines - chemistry | Secologanin Tryptamine Alkaloids - metabolism | Antineoplastic Agents - chemistry | Quinolines - metabolism | Phenotype | Plant Leaves - genetics | Epoxy Compounds - chemistry | Catharanthus - genetics | Mutation | Indole Alkaloids - metabolism | Alkaloids | Pyrimidines | Analysis | Biological properties | Vindoline | Indole | Amino acid substitution | Substitutes | Coupling (molecular) | Leaves | Genotype & phenotype | Metabolites | Cytosine | Plants (botany) | Cloning | Heredity | Mutants | Intermediates | Thin layer chromatography | Plant diseases | Mutagenesis | Acids | Dimers | Ethyl methanesulfonate | Reductase | Index Medicus
Journal Article