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Journal Article
Journal Article
International Archives of Allergy and Immunology, ISSN 1018-2438, 06/2012, Volume 158, Issue 4, pp. 418 - 422
IL-2-inducible T-cell kinase (ITK) deficiency is a rare inherited immunodeficiency disease characterized by homozygous mutations in the ITK gene and the... 
Novel Insights from Clinical Practice | Epstein-Barr virus-positive lymphoproliferative disorder | Rituximab | Lung involvement | IL-2-inducible T-cell kinase deficiency | LINKED LYMPHOPROLIFERATIVE SYNDROME | ITK | CYTOKINE PRODUCTION | ALLERGY | IMMUNOLOGY | MATURATION | Cough - drug therapy | Humans | Pneumonia, Viral - drug therapy | Cough - diagnosis | DNA, Viral - analysis | Tomography, X-Ray Computed | Lung - diagnostic imaging | Cough - enzymology | Lymphoproliferative Disorders - diagnostic imaging | Lung - enzymology | Lung - virology | Lymphocyte Activation - genetics | Protein-Tyrosine Kinases - genetics | Lymphoproliferative Disorders - enzymology | B-Lymphocytes - virology | Female | B-Lymphocytes - pathology | Fever - pathology | Lung - pathology | Cough - virology | Bronchoalveolar Lavage Fluid - virology | Epstein-Barr Virus Infections - enzymology | Lymphoproliferative Disorders - virology | Pneumonia, Viral - pathology | Fever - diagnosis | Epstein-Barr Virus Infections - drug therapy | Fever - virology | Lymphoproliferative Disorders - pathology | Epstein-Barr Virus Infections - pathology | B-Lymphocytes - drug effects | Point Mutation | Fever - enzymology | Cough - pathology | Lymphocyte Activation - drug effects | Lung - drug effects | Adolescent | Pneumonia, Viral - enzymology | Lymphoproliferative Disorders - drug therapy | Fever - drug therapy | Antibodies, Monoclonal, Murine-Derived - therapeutic use | Immunologic Factors - therapeutic use | Monoclonal antibodies | Viruses | Mutation | Drug therapy | Genes
Journal Article
Virology, ISSN 0042-6822, 2016, Volume 500, pp. 96 - 102
Journal Article
Journal of Virology, ISSN 0022-538X, 03/2018, Volume 92, Issue 6
Epstein-Barr virus (EBV) is linked to the development of both lymphoid and epithelial malignancies worldwide. The M81 strain of EBV, isolated from a Chinese... 
DNA replication | SM protein | DNA polymerase | EBV | Epstein-Barr virus | Posttranscriptional control mechanisms | Posttranscriptional RNA-binding proteins | Transcriptional regulation | Translational control | Herpesvirus | transcriptional regulation | EXPORT FACTOR EB2 | translational control | VIRION PRODUCTION | BINDING PROTEIN | IDENTIFICATION | INVITRO TRANSFORMING ACTIVITY | NASOPHARYNGEAL CARCINOMA | VIROLOGY | PHYSIOLOGICAL GENE TARGETS | MESSENGER-RNA | herpesvirus | posttranscriptional RNA-binding proteins | EXPRESSION | posttranscriptional control mechanisms | Nasopharyngeal Neoplasms - genetics | Protein Biosynthesis | DNA, Viral - biosynthesis | Humans | Carcinoma - virology | Nasopharyngeal Neoplasms - virology | DNA-Directed DNA Polymerase - genetics | Nasopharyngeal Neoplasms - pathology | Carcinoma - enzymology | HEK293 Cells | Epstein-Barr Virus Infections - genetics | 3' Untranslated Regions | Carcinoma - pathology | Neoplasm Proteins - genetics | Viral Proteins - biosynthesis | DNA-Directed DNA Polymerase - biosynthesis | Genome, Viral | Nasopharyngeal Carcinoma | Epstein-Barr Virus Infections - enzymology | Neoplasm Proteins - biosynthesis | Herpesvirus 4, Human - physiology | Nasopharyngeal Neoplasms - enzymology | Viral Proteins - genetics | DNA-Binding Proteins - genetics | Epstein-Barr Virus Infections - pathology | DNA Replication - physiology | Carcinoma - genetics | DNA, Viral - genetics | DNA-Binding Proteins - biosynthesis | Virus Replication - physiology
Journal Article
Journal of Virology, ISSN 0022-538X, 06/2012, Volume 86, Issue 12, pp. 6656 - 6667
Journal Article
PLoS ONE, ISSN 1932-6203, 2015, Volume 10, Issue 4, p. e0123645
The Epstein-Barr virus (EBV) is transmitted from host-to-host via saliva and is associated with epithelial malignancies including nasopharyngeal carcinoma... 
B-CELLS | EBV INFECTION | MEMBRANE-PROTEIN 1 | MULTIDISCIPLINARY SCIENCES | STABLE REPLICATION | VIRAL GENOME | ORAL HAIRY LEUKOPLAKIA | NUCLEAR ANTIGEN-2 | TERMINAL DIFFERENTIATION | NORMAL EPITHELIAL-CELLS | LINES HNE-1 | Nasopharyngeal Neoplasms - genetics | Nasopharyngeal Carcinoma | Carcinoma | Herpesvirus 4, Human - genetics | Epstein-Barr Virus Infections - virology | Epstein-Barr Virus Infections - enzymology | Humans | Nasopharyngeal Neoplasms - enzymology | Epithelial Cells - pathology | Nasopharynx - enzymology | Nasopharyngeal Neoplasms - pathology | Gene Expression Regulation, Enzymologic | Telomerase - biosynthesis | Telomerase - genetics | Epithelial Cells - virology | Epithelial Cells - enzymology | HEK293 Cells | DNA Replication - genetics | Epstein-Barr Virus Infections - genetics | Herpesvirus 4, Human - pathogenicity | Nasopharynx - pathology | Care and treatment | Epstein-Barr virus diseases | Development and progression | Genetic aspects | Research | Gene expression | Stomach cancer | Risk factors | Tropism | Telomerase reverse transcriptase | Epithelial cells | Viruses | Infections | BZLF1 protein | Epidemiology | Nasopharyngeal carcinoma | Inoculation | Lymphocytes | Cell cycle | Telomerase | Gastric cancer | Recombinant | Medical research | Tumor cells | Infectious diseases | Hospitals | Disease transmission | Plasmids | Cell lines | Stem cells | Saliva | Cancer
Journal Article
Scandinavian Journal of Immunology, ISSN 0300-9475, 08/2013, Volume 78, Issue 2, pp. 130 - 139
BTK and ITK are cytoplasmic tyrosine kinases of crucial importance for B and T cell development, with loss‐of‐function mutations causing X‐linked... 
POTENT INHIBITOR | BONE-MARROW | X-LINKED AGAMMAGLOBULINEMIA | CHRONIC LYMPHOCYTIC-LEUKEMIA | IMMUNOLOGY | BRUTONS-TYROSINE-KINASE | MICE LACKING | IBRUTINIB PCI-32765 | CELL-ACTIVATION | TEC FAMILY KINASES | ANTILEUKEMIC AGENT | Pyrazoles - therapeutic use | Agammaglobulinemia - genetics | Genetic Diseases, X-Linked - enzymology | Protein-Tyrosine Kinases - metabolism | Humans | Antineoplastic Agents - therapeutic use | Agammaglobulinemia - pathology | Lymphoma - drug therapy | Protein-Tyrosine Kinases - genetics | Agammaglobulinemia - drug therapy | Agammaglobulinemia - enzymology | Genetic Diseases, X-Linked - drug therapy | T-Lymphocytes - drug effects | Epstein-Barr Virus Infections - genetics | Lymphoma - enzymology | Genetic Diseases, X-Linked - genetics | Lymphoma - pathology | Gene Expression Regulation, Neoplastic - drug effects | Epstein-Barr Virus Infections - enzymology | Small Molecule Libraries - therapeutic use | Lymphoma - genetics | Epstein-Barr Virus Infections - drug therapy | Epstein-Barr Virus Infections - pathology | B-Lymphocytes - drug effects | B-Lymphocytes - immunology | Signal Transduction - drug effects | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Genetic Diseases, X-Linked - pathology | T-Lymphocytes - immunology | Inflammation - prevention & control | Autoimmunity - drug effects | Protein-Tyrosine Kinases - antagonists & inhibitors | Drugs | Autoimmunity | Care and treatment | Multiple myeloma | Lymphomas | Drug therapy | Health aspects | Phosphotransferases | Cancer
Journal Article
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 4, pp. 6461 - 6474
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2014, Volume 9, Issue 8, p. e105163
Nasopharyngeal carcinoma (NPC) is a common viral-associated neoplasm in which multiple signaling cascades are interfered with by Epstein-Bar virus (EBV) latent... 
TRANSFORMATION | PROTEIN | GENE | CONSTITUTIVE ACTIVATION | MULTIDISCIPLINARY SCIENCES | PTEN TUMOR-SUPPRESSOR | IDENTIFICATION | ESTABLISHMENT | CANCER | EXPRESSION | EPSTEIN-BARR-VIRUS | Nasopharyngeal Neoplasms - genetics | Neoplasm Transplantation | Carcinoma | Cell Proliferation | Epigenesis, Genetic | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Nasopharyngeal Neoplasms - virology | Male | Phosphatidylinositol 3-Kinases - metabolism | Carcinogenesis - metabolism | DNA Methylation | Epstein-Barr Virus Infections - genetics | Female | Proto-Oncogene Proteins c-akt - metabolism | Promoter Regions, Genetic | Gene Expression | Nasopharyngeal Carcinoma | Phosphoric Monoester Hydrolases - genetics | Signal Transduction | Epstein-Barr Virus Infections - enzymology | Nasopharyngeal Neoplasms - enzymology | Carcinogenesis - genetics | Animals | Mice, Nude | Cell Line, Tumor | Phosphoric Monoester Hydrolases - metabolism | Immunohistochemistry | Laboratories | Epithelial cells | Genes | Inositol polyphosphate | Viruses | Oncology | AKT protein | Kinases | Inactivation | Phosphatase | Western blotting | Proteins | Nasopharyngeal carcinoma | Ethics | Demethylation | Signal transduction | Cell growth | Restoration | Cascades | Tumorigenesis | CpG islands | Deactivation | Tumor cells | 1-Phosphatidylinositol 3-kinase | Polymerase chain reaction | Pathology | Gene silencing | Signaling | Epigenetics | Mutation | Cancer | Tumors | Apoptosis
Journal Article