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Journal of Pharmacological Sciences, ISSN 1347-8613, 07/2019, Volume 140, Issue 3, pp. 242 - 247
xCT, a well-known cystine transporter, is reported to be involved in the proliferation of various cells, such as cancer cells, immune cells, and fibroblasts.... 
xCT | Erastin | System xc | SLC7A11 | Cystathionine
Journal Article
Journal Article
Molecular & Cellular Oncology, ISSN 2372-3556, 10/2015, Volume 2, Issue 4, p. e1054549
Acute myeloid leukemia (AML) is the most common type of leukemia in adults. Development of resistance to chemotherapeutic agents is a major hurdle in the... 
AML | erastin | autophagy | ferroptosis | necroptosis
Journal Article
Journal Article
Cellular Signalling, ISSN 0898-6568, 11/2019, Volume 63, p. 109384
Ferroptosis is a metabolism-related cell death. Stimulating ferroptosis in liver cancer cells is a strategy to treat liver cancer. However, how to eradicate... 
Promoter | Erastin | O-GlcNAcylation | Phosphorylation | Transcription | Glutathione | HEPATOCELLULAR-CARCINOMA CELLS | TRANSLOCATION | DOMAIN-LIKE PROTEIN | YAP | PROLIFERATION | STIMULATES TUMORIGENESIS | CELL BIOLOGY | METABOLISM | EXPRESSION
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 04/2018, Volume 499, Issue 1, pp. 44 - 51
Ferroptosis is an iron- and oxidative-dependent form of regulated cell death and may play important roles in maintaining myocardium homeostasis and pathology... 
ENPP2 | Cardiomyocytes | Ferroptosis | Erastin | CANCER-CELLS | PHYSIOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | ACSL4 | BIOPHYSICS | METABOLISM | NRF2 | LYSOPHOSPHOLIPIDS | EXPRESSION | Index Medicus
Journal Article
eLife, ISSN 2050-084X, 05/2014, Volume 3, Issue 3, p. e02523
Journal Article
Free Radical Research, ISSN 1071-5762, 01/2019, Volume 53, Issue 1, pp. 104 - 114
Thioredoxin reductase 1 (TrxR1) has emerged as a potential target for cancer therapy, because it is overexpressed in several types of cancers and associated... 
erastin | thioredoxin reductase 1 | p38 MAPK | reactive oxygen species | Alantolactone | APOPTOSIS | OXIDATIVE STRESS | CARBOPLATIN | STATISTICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SESQUITERPENE LACTONES | IN-VITRO | GLUTATHIONE | THIOREDOXIN REDUCTASE | EXPRESSION
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 09/2018, Volume 503, Issue 3, pp. 1689 - 1695
Peripheral blood mononuclear cells (PBMCs) contain multipotent progenitor cell populations and possess the potential to differentiate into various types of... 
Lipid peroxidation | Ferroptosis | Erastin | PBMCs | Immunity | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BMP-6 | HUMAN B-CELLS | DEATH | AUTOPHAGY | DISEASES | BIOPHYSICS | EXPRESSION | Bone morphogenetic proteins | Peroxidase | Cell differentiation | Cell death | Lymphocytes | Pancreatic cancer | erastin | ferroptosis | immunity | lipid peroxidation
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2013, Volume 288, Issue 17, pp. 11920 - 11929
Journal Article
Cell Reports, ISSN 2211-1247, 09/2019, Volume 28, Issue 10, pp. 2501 - 2508.e4
Despite recent advances, the poor outcomes in renal cell carcinoma (RCC) suggest novel therapeutics are needed. Ferroptosis is a form of regulated cell death,... 
cell density | erastin | renal cell carcinoma | ferroptosis | Hippo pathway | WW Domain Containing Transcription Regulator 1 | Epithelial Membrane Protein 1 | EMP1 | NOX4 | NADPH Oxidase 4 | TAZ | CANCER-CELLS | INACTIVATION | SENSITIVITY | DEATH | INHIBITORS | EXPRESSION | CELL BIOLOGY
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 09/2018, Volume 503, Issue 3, pp. 1550 - 1556
Ferroptosis is a form of regulated cell death resulting from iron accumulation and lipid peroxidation. While impaired ferroptosis is tightly linked to human... 
Lysosomal cell death | Ferroptosis | Cathepsin | Autophagy | STAT3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | PANCREATIC-CANCER | STAT3 ACTIVATION | HEPATOCELLULAR-CARCINOMA | GEMCITABINE RESISTANCE | INHIBITION | BIOPHYSICS | GROWTH | DEGRADATION | BLOCKING | MOLECULAR-MECHANISMS | Cell death | Pancreatic cancer | Cathepsins | Biochemistry | Genetic engineering | Mitogens | Protein kinases | Adenosine triphosphatase
Journal Article