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Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2013, Volume 288, Issue 32, pp. 22942 - 22960
TGR5 is a G protein-coupled receptor that mediates bile acid (BA) effects on energy balance, inflammation, digestion, and sensation. The mechanisms and... 
GROWTH-FACTOR RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | GPBAR1 TGR5 | DEPENDENT ENDOCYTOSIS | PROTEIN-COUPLED RECEPTORS | RESONANCE ENERGY-TRANSFER | KINASE ACTIVATION | MU-OPIOID RECEPTOR | BETA-ADRENERGIC RECEPTOR | ACTIVATED RECEPTOR-2 | EGF RECEPTOR | Cholagogues and Choleretics - pharmacology | Phenylalanine - analogs & derivatives | Receptors, G-Protein-Coupled - metabolism | Membrane Microdomains - metabolism | Phenylalanine - pharmacology | Humans | ErbB Receptors - genetics | Oleanolic Acid - pharmacology | Arrestins - genetics | Protein Transport - physiology | Protein Transport - drug effects | G-Protein-Coupled Receptor Kinase 2 - genetics | G-Protein-Coupled Receptor Kinase 2 - metabolism | Arrestins - metabolism | beta-Cyclodextrins - pharmacology | Endosomes - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | HEK293 Cells | Antineoplastic Agents - pharmacology | Cyclic AMP - genetics | Cyclic AMP - metabolism | ErbB Receptors - antagonists & inhibitors | ErbB Receptors - metabolism | Endosomes - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Endocytosis - drug effects | Enzyme Inhibitors - pharmacology | Thiophenes - pharmacology | Tyrphostins - pharmacology | Endocytosis - physiology | Arrestins - antagonists & inhibitors | G-Protein-Coupled Receptor Kinase 5 - metabolism | Deoxycholic Acid - pharmacology | Mitogen-Activated Protein Kinase 3 - metabolism | beta-Arrestin 2 | beta-Arrestin 1 | beta-Arrestins | Receptors, G-Protein-Coupled - genetics | Quinazolines - pharmacology | G-Protein-Coupled Receptor Kinase 5 - genetics | Membrane Microdomains - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Lipid Raft | Bile Acid | Endocytosis | G Protein-coupled Receptors (GPCR) | Arrestin | Signal Transduction
Journal Article
Journal Article
Science Translational Medicine, ISSN 1946-6234, 07/2017, Volume 9, Issue 399, p. eaaa0984
Journal Article
Nature, ISSN 0028-0836, 05/2018, Volume 557, Issue 7707, pp. 724 - 728
Microglia and astrocytes modulate inflammation and neurodegeneration in the central nervous system (CNS)(1-3). Microglia modulate pro-inflammatory and... 
ACTIVATION | ARYL-HYDROCARBON RECEPTOR | MULTIDISCIPLINARY SCIENCES | TGF-ALPHA | CENTRAL-NERVOUS-SYSTEM | SPINAL-CORD-INJURY | DIVERSITY | VEGF-B | EXPRESSION | CNS INFLAMMATION | ENDOTHELIAL GROWTH-FACTOR | Inflammation - pathology | Microglia - metabolism | Central Nervous System - metabolism | Encephalomyelitis, Autoimmune, Experimental - metabolism | Humans | Astrocytes - pathology | Central Nervous System - pathology | Vascular Endothelial Growth Factor B - biosynthesis | Tryptophan - metabolism | Lipopolysaccharide Receptors - metabolism | Inflammation - metabolism | Tryptophan - deficiency | Microglia - pathology | Receptors, Aryl Hydrocarbon - metabolism | Female | Transforming Growth Factor alpha - metabolism | Central Nervous System - microbiology | Disease Models, Animal | Encephalomyelitis, Autoimmune, Experimental - microbiology | Multiple Sclerosis - metabolism | Transforming Growth Factor alpha - biosynthesis | Symbiosis | Inflammation - microbiology | Encephalomyelitis, Autoimmune, Experimental - pathology | ErbB Receptors - metabolism | Mice, Inbred C57BL | Cells, Cultured | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Animals | Vascular Endothelial Growth Factor B - metabolism | Encephalomyelitis, Autoimmune, Experimental - prevention & control | Multiple Sclerosis - pathology | Inflammation - prevention & control | Mice | Astrocytes - metabolism | Physiological aspects | Microbiological research | Metabolites | Transforming growth factors | Astrocytes | Vascular endothelial growth factor | Regulators | Multiple sclerosis | Encephalomyelitis | Transcription | Central nervous system | Hydrocarbons | Nervous system | CD14 antigen | Recruitment | Angiogenesis | Signal transduction | Neurotoxicity | Microorganisms | Neurodegeneration | Aromatic compounds | Bone marrow | ErbB-1 protein | Tryptophan | Inflammation | Gene expression | Experimental allergic encephalomyelitis | Microglia | Neurological diseases | Diet | Lymphocytes B | Flora | Spinal cord injuries | Alzheimers disease | Life Sciences | Immunology
Journal Article
Nature, ISSN 0028-0836, 07/2007, Volume 448, Issue 7151, pp. 362 - 365
Although directed migration is a feature of both individual cells and cell groups, guided migration has been studied most extensively for single cells in... 
MORPHOGENESIS | PROTEIN | PATHWAY | MULTIDISCIPLINARY SCIENCES | DROSOPHILA OOGENESIS | MICROSCOPY | ZEBRAFISH LATERAL-LINE | EGF RECEPTOR | Protein Kinases - metabolism | Protein Kinases - genetics | Adaptor Proteins, Vesicular Transport - genetics | ErbB Receptors - genetics | rac GTP-Binding Proteins - metabolism | Drosophila Proteins - metabolism | raf Kinases - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Drosophila melanogaster - genetics | Drosophila melanogaster - metabolism | Receptors, Invertebrate Peptide - genetics | Receptors, Vascular Endothelial Growth Factor - metabolism | raf Kinases - genetics | Genes, Essential - genetics | Shc Signaling Adaptor Proteins | Phospholipase C gamma - metabolism | ErbB Receptors - metabolism | Signal Transduction | Drosophila melanogaster - cytology | Mutation - genetics | Animals | Receptors, Platelet-Derived Growth Factor - metabolism | Adaptor Proteins, Signal Transducing - genetics | Receptors, Invertebrate Peptide - metabolism | Drosophila Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Cell Movement | Mitogen-Activated Protein Kinases - metabolism | Genetic aspects | Motility | Research | Drosophila | Cell migration | Cells | Proteins | Signal transduction | Cellular biology | Insects | Fish | Genetics | Cell adhesion & migration | Receptors | Pathways | Migration | Clusters | Kinases | Signalling | Borders | Life Sciences
Journal Article
Cancer Cell, ISSN 1535-6108, 08/2014, Volume 26, Issue 2, pp. 207 - 221
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2012, Volume 7, Issue 12, p. e52838
Although evidence has shown the regulating effect of n-3 poly-unsaturated fatty acid (n-3 PUFA) on cell signaling transduction, it remains unknown whether n-3... 
PROTEIN-COUPLED RECEPTOR | INDUCED APOPTOSIS | PATHWAY | ADENYLYL-CYCLASE | MULTIDISCIPLINARY SCIENCES | LIPID RAFTS | GPR30 | PROLIFERATION | PLASMA-MEMBRANE | EXPRESSION | GENE-TRANSCRIPTION | Cyclic AMP-Dependent Protein Kinases - metabolism | Receptors, Estrogen - metabolism | ErbB Receptors - metabolism | Estrogens - pharmacology | Fatty Acids, Omega-3 - metabolism | Receptors, Estrogen - genetics | Receptors, G-Protein-Coupled - metabolism | Apoptosis - drug effects | Humans | Breast Neoplasms - metabolism | Estrogen Receptor beta - metabolism | Breast Neoplasms - genetics | Estrogen Receptor alpha - genetics | Estrogen Receptor beta - genetics | MAP Kinase Signaling System - drug effects | Signal Transduction - drug effects | Fatty Acids, Omega-3 - pharmacology | Cell Line, Tumor | Estrogen Receptor alpha - metabolism | Female | Cell Proliferation - drug effects | Receptors, G-Protein-Coupled - genetics | Estrogens - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Unsaturated fatty acids | Growth | Phenols | Cellular signal transduction | Cyclic adenylic acid | Breast cancer | G proteins | Saturated fatty acids | Estradiol | Omega-3 fatty acids | Apoptosis | Protein kinase A | Polyunsaturated fatty acids | Estrogens | Estrogen | Estrogen receptors | AKT protein | Kinases | Docosahexaenoic acid | Signal transduction | Receptors | Biological effects | Cell growth | Rodents | Stearic acid | Medical research | Epidermal growth factor receptors | Extracellular signal-regulated kinase | Fatty acids | Sex hormones | Signaling | Breast | Eicosapentaenoic acid | Cancer
Journal Article
Journal Article