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Nature, ISSN 0028-0836, 05/2016, Volume 534, Issue 7605, pp. 55 - 62
Somatic mutations have been extensively characterized in breast cancer, but the effects of these genetic alterations on the proteomic landscape remain poorly... 
PATHWAYS | HETEROGENEITY | PIK3CA MUTATIONS | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | GENES | BIOLOGY | RECEPTOR | EXPRESSION | SIGNATURE | REVEALS | Protein Kinases - metabolism | Focal Adhesion Kinase 1 - genetics | Receptor, Epidermal Growth Factor - genetics | Protein Kinases - genetics | Cyclin-Dependent Kinases - metabolism | Receptor, ErbB-2 - genetics | Receptors, G-Protein-Coupled - metabolism | Genomics | Humans | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | Phosphoproteins - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Tumor Suppressor Protein p53 - genetics | Breast Neoplasms - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Breast Neoplasms - enzymology | Receptor, Epidermal Growth Factor - metabolism | Phosphoproteins - analysis | Mass Spectrometry | src-Family Kinases - metabolism | Female | Cyclin-Dependent Kinases - genetics | Focal Adhesion Kinase 1 - metabolism | Chromosomes, Human, Pair 5 - genetics | Breast Neoplasms - classification | Chromosome Deletion | p21-Activated Kinases - genetics | Signal Transduction | Molecular Sequence Annotation | Calcium-Binding Proteins - deficiency | Phosphoproteins - genetics | Mutation - genetics | S-Phase Kinase-Associated Proteins - metabolism | p21-Activated Kinases - metabolism | Phosphatidylinositol 3-Kinases - genetics | Breast Neoplasms - genetics | Class I Phosphatidylinositol 3-Kinases | Proteomics | S-Phase Kinase-Associated Proteins - genetics | Receptors, G-Protein-Coupled - genetics | src-Family Kinases - genetics | Calcium-Binding Proteins - genetics | Breast cancer | Genetic aspects | Research | Oncology, Experimental | Cancer | Physiological aspects | Methods | Mutation (Biology) | Proteins | Gene amplification | Peptides | Protein expression | Genomes | Mutation | Kinases | Deoxyribonucleic acid--DNA | Tumors | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2014, Volume 9, Issue 8, pp. e103094 - e103094
The epidermal growth factor receptor 2, ERBB2, is a well-validated target for cancer diagnostics and therapy. Recent studies suggest that the over-expression... 
COMPLEX | MODULE | STRUCTURAL BASIS | MULTIDISCIPLINARY SCIENCES | SURFACE DISPLAY | PICOMOLAR AFFINITY | HER2 | SELECTION | DOMAINS | Binding, Competitive | Amino Acid Sequence | Albumins - metabolism | Humans | Receptor, ErbB-2 - chemistry | Receptor, ErbB-2 - metabolism | Antibodies, Monoclonal, Humanized - metabolism | Molecular Sequence Data | Antibody Affinity - immunology | Antibodies, Bispecific - immunology | Flow Cytometry | Cell Surface Display Techniques | Protein Engineering | Cell Line, Tumor | Protein Binding | Transition Temperature | Trastuzumab | Albumin | Biological products | Chemical properties | Binding proteins | Health aspects | Protein binding | Biotechnology | Drug delivery systems | Peptides | Phages | Amino acids | Genomes | Cell surface | Proteins | Engineering | Phage display | Epidermal growth factor | Format | Deoxyribonucleic acid--DNA | Binding | Human serum albumin | Excretion | Immunoglobulins | Kidneys | Pharmacology | Serum albumin | ErbB-2 protein | Overexpression | Mutagenesis | Monoclonal antibodies | Affinity | Pharmacokinetics | Binding sites | Cancer | Index Medicus | binding affinity | unclassified drug | DNA sequence | albumin binding domain derived affinity protein | antigen binding | protein domain | amino acid sequence | protein targeting | Natural Sciences | protein expression | fluorescence activated cell sorting | epidermal growth factor receptor 2 | binding site | Biological Sciences | protein protein interaction | protein purification | peptides and proteins | protein binding | article | trastuzumab | protein engineering | Naturvetenskap | controlled study | Biologiska vetenskaper | albumin | nonhuman | amino acid substitution | epitope | Deoxyribonucleic acid | DNA
Journal Article
Molecular Cell, ISSN 1097-2765, 03/2012, Volume 45, Issue 6, pp. 764 - 776
Aberrant ErbB2 receptor tyrosine kinase activation in breast cancer is strongly linked to an invasive disease. The molecular basis of ErbB2-driven invasion is... 
PATHWAYS | ONCOGENE | METASTASIS | EPITHELIAL-CELLS | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | CYSTEINE CATHEPSINS | FIBROBLASTS | MULTISTAGE TUMORIGENESIS | ERBB RECEPTORS | CELL BIOLOGY | Cathepsin L - genetics | Protein Kinase C-alpha - metabolism | Proto-Oncogene Protein c-ets-1 - metabolism | Receptor, ErbB-2 - genetics | Protein-Tyrosine Kinases - metabolism | Cathepsin B - genetics | Humans | Protein Kinase C-alpha - genetics | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | Cathepsin L - metabolism | Breast Neoplasms - metabolism | Protein-Tyrosine Kinases - genetics | Kruppel-Like Transcription Factors - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Female | Promoter Regions, Genetic | p21-Activated Kinases - genetics | Myotonin-Protein Kinase | Response Elements | Signal Transduction | Neoplasm Invasiveness | Cathepsin B - metabolism | p21-Activated Kinases - metabolism | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cell Line, Tumor | Proto-Oncogene Protein c-ets-1 - genetics | Kruppel-Like Transcription Factors - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Tyrosine | Cysteine | Oncology, Experimental | Genes | Cathepsins | Breast cancer | DNA binding proteins | Genetic transcription | Research | Cystine | Analysis | Universities and colleges | Protein kinases | Phosphotransferases | Protein binding | Cancer | Protein kinase C | Transcription factors | Introns | Invasiveness | cathepsins | AKT protein | ErbB-2 protein | Zinc | Enhancers | Cathepsin B | Protein-tyrosine kinase receptors | Protein-serine/threonine kinase | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2015, Volume 10, Issue 10, pp. e0141786 - e0141786
The two cytosolic/nuclear isoforms of the molecular chaperone HSP90, stress-inducible HSP90 alpha and constitutively expressed HSP90 beta, fold, assemble and... 
ACTIVATION | COMPLEX | MECHANISM | GELDANAMYCIN | MULTIDISCIPLINARY SCIENCES | KINASE | HSF1 | ATP BINDING | HEAT-SHOCK | CHAPERONE | REVEALS | Humans | Receptor, ErbB-2 - metabolism | Molecular Sequence Data | Intracellular Signaling Peptides and Proteins - metabolism | Heat Shock Transcription Factors | DNA-Binding Proteins - metabolism | Protein Isoforms - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Protein Isoforms - chemistry | Adenosine Triphosphate - metabolism | HEK293 Cells | HSP90 Heat-Shock Proteins - chemistry | HSP90 Heat-Shock Proteins - genetics | Binding Sites | Kelch-Like ECH-Associated Protein 1 | Amino Acid Sequence | Tumor Suppressor Proteins - metabolism | Lactams, Macrocyclic - pharmacology | Benzoquinones - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | HSP90 Heat-Shock Proteins - antagonists & inhibitors | HSP90 Heat-Shock Proteins - metabolism | Protein Binding | Protein Conformation | Protein Kinase Inhibitors - pharmacology | Mutation | Protein Isoforms - antagonists & inhibitors | GTP-Binding Proteins - metabolism | Protein Isoforms - genetics | Ubiquitin | Heat shock proteins | DNA binding proteins | Ligases | Protein binding | Medical research | Hsp90 protein | Transcription factors | Life assessment | Oncology | Genomes | Geldanamycin | Kinases | Clients | ErbB-2 protein | Mutants | Proteins | Inhibitors | Isoforms | Hypoxia | HSF1 protein | ATP | Binding sites | Cancer | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2015, Volume 10, Issue 8, pp. e0135851 - e0135851
Overexpression of Twist, a highly conserved basic helix-loop-helix transcription factor, is associated with epithelial-mesenchymal transition (EMT) and... 
TRANSCRIPTION FACTORS | METASTASIS | PROTEIN | LOCAL RECURRENCE | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | GLYCOGEN-SYNTHASE KINASE-3 | RESISTANCE | BETA-CATENIN | CONSERVING THERAPY | CARCINOMA | Carcinoma, Ductal, Breast - genetics | Prognosis | Cadherins - metabolism | Receptor, ErbB-2 - genetics | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | Ki-67 Antigen - metabolism | Receptors, Progesterone - genetics | Epithelial-Mesenchymal Transition - genetics | Carcinoma, Ductal, Breast - mortality | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | Receptors, Progesterone - metabolism | Neoplasm Grading | Biomarkers, Tumor - metabolism | Adult | Carcinoma, Ductal, Breast - pathology | Estrogen Receptor alpha - metabolism | Female | Cadherins - genetics | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Lymphatic Metastasis | Carcinoma, Ductal, Breast - diagnosis | Vascular Endothelial Growth Factor C - genetics | Breast Neoplasms - genetics | Estrogen Receptor alpha - genetics | Ki-67 Antigen - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Breast Neoplasms - pathology | Vascular Endothelial Growth Factor C - metabolism | Survival Analysis | Twist-Related Protein 1 - genetics | Cell Line, Tumor | Breast Neoplasms - mortality | Biomarkers, Tumor - genetics | Breast Neoplasms - diagnosis | Neoplasm Staging | Twist-Related Protein 1 - metabolism | Transcription factors | Physiological aspects | Breast cancer | Genetic aspects | Research | Gene expression | Immunohistochemistry | Mesenchyme | Laboratories | Estrogens | Estrogen receptors | AKT protein | Activation | Metastasis | Kinases | Cancer therapies | E-cadherin | Proteins | Signal transduction | Tumorigenesis | Bioindicators | Helix-loop-helix proteins | Vascular endothelial growth factor | Medical research | Immunoglobulins | Invasiveness | Extracellular signal-regulated kinase | Mammography | Patients | ErbB-2 protein | Hospitals | Protein kinase | Biomarkers | Breast | Progesterone | Prostate | Cell migration | Cancer | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2010, Volume 107, Issue 34, pp. 15039 - 15044
The human epidermal growth factor receptor 2 (HER2) is specifically overexpressed in tumors of several cancers, including an aggressive form of breast cancer.... 
Molecules | Protein engineering | Receptors | Hydrogen bonds | Medical treatment | Antibodies | Libraries | Epitopes | Cancer | Crystal structure | Molecular recognition | Protein conformational dynamics | Protein - protein interactions | Cancer therapy | COMPLEX | DOMAIN | TRASTUZUMAB | protein conformational dynamics | NMR-SPECTROSCOPY | STABILIZATION | MULTIDISCIPLINARY SCIENCES | AFFIBODY MOLECULES | BETA PEPTIDE | protein-protein interactions | BREAST-CANCER | cancer therapy | protein engineering | THERMODYNAMICS | HERCEPTIN | molecular recognition | Protein Structure, Tertiary | Recombinant Fusion Proteins - immunology | Amino Acid Sequence | Biophysical Phenomena | Epitopes - metabolism | Protein Structure, Secondary | Humans | Receptor, ErbB-2 - chemistry | Receptor, ErbB-2 - metabolism | Models, Molecular | Molecular Sequence Data | Crystallography, X-Ray | Recombinant Fusion Proteins - chemistry | Recombinant Fusion Proteins - metabolism | Thermodynamics | Protein Engineering | Nuclear Magnetic Resonance, Biomolecular | Recombinant Fusion Proteins - genetics | Epitopes - chemistry | Receptor, ErbB-2 - immunology | Protein Stability | In Vitro Techniques | Binding Sites | Development and progression | Tumors | Bioengineering | Amino acids | Biophysics | Gene expression | Comparative analysis | Cancer therapies | Binding sites | Index Medicus | protein–protein interactions | Biological Sciences | Livsmedelsvetenskap | Food Science
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 2018, Volume 36, Issue 9, pp. 911 - 919
Journal Article
Breast Cancer Research and Treatment, ISSN 0167-6806, 4/2012, Volume 132, Issue 2, pp. 463 - 470
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2007, Volume 117, Issue 12, pp. 3765 - 3773
S-phase kinase-associated protein 2 (SKP2) is a component of the E3 ubiquitin ligase SKP1-Cul1-Fbox complex. Overexpression of SKP2 results in cell cycle... 
MEDICINE, RESEARCH & EXPERIMENTAL | UBIQUITIN-MEDIATED DEGRADATION | BOX PROTEIN SKP2 | ENTEROPATHY | DISRUPTION | P27 | MOUSE | SCURFY | EXPRESSION | CELL-CYCLE INHIBITION | P27(KIP1) | Oncogene Proteins - genetics | RNA, Small Interfering - genetics | Receptor, ErbB-2 - genetics | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | Receptor, ErbB-2 - metabolism | Repressor Proteins - antagonists & inhibitors | Breast Neoplasms - metabolism | Genes, X-Linked | S-Phase Kinase-Associated Proteins - antagonists & inhibitors | Cell Transformation, Neoplastic - genetics | Forkhead Transcription Factors - metabolism | Mice, Mutant Strains | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Cullin Proteins - metabolism | Female | Forkhead Transcription Factors - antagonists & inhibitors | Gene Expression Regulation, Neoplastic - drug effects | Gene Expression Regulation, Neoplastic - genetics | Repressor Proteins - metabolism | Tumor Suppressor Proteins - metabolism | RNA, Small Interfering - pharmacology | Cell Cycle Proteins - metabolism | Gene Silencing | Oncogene Proteins - metabolism | Repressor Proteins - genetics | Forkhead Transcription Factors - genetics | S-Phase Kinase-Associated Proteins - metabolism | Cell Transformation, Neoplastic - metabolism | Oncogene Proteins - antagonists & inhibitors | Cullin Proteins - genetics | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Ploidies | Cell Line, Tumor | Heterozygote | S-Phase Kinase-Associated Proteins - genetics | Mice | Mice, Inbred BALB C | Cell Transformation, Neoplastic - pathology | Tumor suppressor genes | Breast cancer | Genetic aspects | Research | DNA binding proteins | Identification and classification | Health aspects | Risk factors | Index Medicus | Abridged Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, pp. e68394 - e68394
Journal Article
Cancer Discovery, ISSN 2159-8274, 09/2011, Volume 1, Issue 4, pp. 352 - 365
Cancers with specific genetic mutations are susceptible to selective kinase inhibitors. However, there is a wide spectrum of benefit among cancers harboring... 
CELL LUNG-CANCER | BREAST-CANCER | GEFITINIB | ACTIVATION | GROWTH-FACTOR-RECEPTOR | MET AMPLIFICATION | ONCOLOGY | INDUCED APOPTOSIS | PHASE-II | MUTATIONS | EGFR | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Receptor, ErbB-2 - genetics | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Receptor, ErbB-2 - metabolism | Apoptosis - genetics | BH3 Interacting Domain Death Agonist Protein - genetics | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proto-Oncogene Proteins - biosynthesis | Receptor, Epidermal Growth Factor - metabolism | Bcl-2-Like Protein 11 | Apoptosis Regulatory Proteins - genetics | Female | Membrane Proteins - metabolism | Receptor, ErbB-2 - antagonists & inhibitors | Retrospective Studies | BH3 Interacting Domain Death Agonist Protein - metabolism | Oncogenes | Apoptosis Regulatory Proteins - biosynthesis | Lung Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Membrane Proteins - genetics | Proto-Oncogene Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | Phosphatidylinositol 3-Kinases - genetics | Membrane Proteins - biosynthesis | Animals | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Protein Kinase Inhibitors - pharmacology | Cohort Studies | Index Medicus | oncogene addiction | apoptosis | HER2 | BIM
Journal Article