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PloS one, ISSN 1932-6203, 10/2015, Volume 10, Issue 10, p. e0141786
... of numerous client proteins. Because many HSP90 clients are important in cancer, several HSP90 inhibitors have been evaluated in the clinic... 
ACTIVATION | COMPLEX | MECHANISM | GELDANAMYCIN | MULTIDISCIPLINARY SCIENCES | KINASE | HSF1 | ATP BINDING | HEAT-SHOCK | CHAPERONE | REVEALS | Humans | Receptor, ErbB-2 - metabolism | Molecular Sequence Data | Intracellular Signaling Peptides and Proteins - metabolism | Heat Shock Transcription Factors | DNA-Binding Proteins - metabolism | Protein Isoforms - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Protein Isoforms - chemistry | Adenosine Triphosphate - metabolism | HEK293 Cells | HSP90 Heat-Shock Proteins - chemistry | HSP90 Heat-Shock Proteins - genetics | Binding Sites | Kelch-Like ECH-Associated Protein 1 | Amino Acid Sequence | Tumor Suppressor Proteins - metabolism | Lactams, Macrocyclic - pharmacology | Benzoquinones - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | HSP90 Heat-Shock Proteins - antagonists & inhibitors | HSP90 Heat-Shock Proteins - metabolism | Protein Binding | Protein Conformation | Protein Kinase Inhibitors - pharmacology | Mutation | Protein Isoforms - antagonists & inhibitors | GTP-Binding Proteins - metabolism | Protein Isoforms - genetics | Ubiquitin | Heat shock proteins | DNA binding proteins | Ligases | Protein binding | Medical research | Hsp90 protein | Transcription factors | Life assessment | Oncology | Genomes | Geldanamycin | Kinases | Clients | ErbB-2 protein | Mutants | Proteins | Inhibitors | Isoforms | Hypoxia | HSF1 protein | ATP | Binding sites | Cancer
Journal Article
Nature (London), ISSN 1476-4687, 2016, Volume 534, Issue 7605, pp. 55 - 62
Somatic mutations have been extensively characterized in breast cancer, but the effects of these genetic alterations on the proteomic landscape remain poorly... 
PATHWAYS | HETEROGENEITY | PIK3CA MUTATIONS | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | GENES | BIOLOGY | RECEPTOR | EXPRESSION | SIGNATURE | REVEALS | Protein Kinases - metabolism | Focal Adhesion Kinase 1 - genetics | Receptor, Epidermal Growth Factor - genetics | Protein Kinases - genetics | Cyclin-Dependent Kinases - metabolism | Receptor, ErbB-2 - genetics | Receptors, G-Protein-Coupled - metabolism | Genomics | Humans | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | Phosphoproteins - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Tumor Suppressor Protein p53 - genetics | Breast Neoplasms - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Breast Neoplasms - enzymology | Receptor, Epidermal Growth Factor - metabolism | Phosphoproteins - analysis | Mass Spectrometry | src-Family Kinases - metabolism | Female | Cyclin-Dependent Kinases - genetics | Focal Adhesion Kinase 1 - metabolism | Chromosomes, Human, Pair 5 - genetics | Breast Neoplasms - classification | Chromosome Deletion | p21-Activated Kinases - genetics | Signal Transduction | Molecular Sequence Annotation | Calcium-Binding Proteins - deficiency | Phosphoproteins - genetics | Mutation - genetics | S-Phase Kinase-Associated Proteins - metabolism | p21-Activated Kinases - metabolism | Phosphatidylinositol 3-Kinases - genetics | Breast Neoplasms - genetics | Class I Phosphatidylinositol 3-Kinases | Proteomics | S-Phase Kinase-Associated Proteins - genetics | Receptors, G-Protein-Coupled - genetics | src-Family Kinases - genetics | Calcium-Binding Proteins - genetics | Breast cancer | Genetic aspects | Research | Oncology, Experimental | Cancer | Physiological aspects | Methods | Mutation (Biology) | Proteins | Gene amplification | Peptides | Protein expression | Genomes | Mutation | Kinases | Deoxyribonucleic acid--DNA | Tumors
Journal Article
Molecular Systems Biology, ISSN 1744-4292, 2005, Volume 1, Issue 1, pp. 2005.0008 - n/a
Interactions between short modified peptide motifs and modular protein domains are central events in cell signal‐transduction... 
ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | post-translational modification | SILAC | IDENTIFICATION | receptor tyrosine kinase signaling | SH2 DOMAINS | SIGNAL-TRANSDUCTION | INSULIN-RECEPTOR | EPIDERMAL-GROWTH-FACTOR | PROTEIN-PROTEIN INTERACTIONS | protein-protein interaction | phosphorylation | BINDING | EGF RECEPTOR | C-SRC | Adaptor Proteins, Signal Transducing - chemistry | Phosphorylation | Phosphotyrosine - immunology | Immunoprecipitation | Humans | Receptor, ErbB-2 - chemistry | Molecular Sequence Data | STAT5 Transcription Factor - chemistry | Receptor, ErbB-3 - chemistry | Systems Biology | Phosphotyrosine - physiology | Binding Sites | Shc Signaling Adaptor Proteins | Protein Structure, Tertiary | Amino Acid Sequence | Phosphatidylinositol 3-Kinases - chemistry | GRB2 Adaptor Protein - chemistry | Phosphotyrosine - chemistry | Receptor, Epidermal Growth Factor - chemistry | Amino Acid Motifs | Protein Interaction Mapping | Peptide Fragments - chemical synthesis | Peptide Fragments - chemistry | Sequence Alignment | Src Homology 2 Domain-Containing, Transforming Protein 1 | Protein Binding | Signal Transduction - physiology | Protein Processing, Post-Translational | HeLa Cells | Receptor, ErbB-4 | Tumor Suppressor Proteins | Peptides | Phosphotyrosine | Mapping | Kinases | Experiments | Proteins | Signal transduction | Ratios | Synthetic peptides | Tyrosine | Epidermal growth factor receptors | ErbB protein | Mass spectroscopy | Stat5 protein | ErbB-3 protein | ErbB-2 protein | Peptide mapping | 1-Phosphatidylinositol 3-kinase | Grb2 protein | Domains | Signaling | Correlation analysis | Proteomics | Ligands | Scientific imaging | Protein interaction | Mass spectrometry | Binding sites | Methods
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 2018, Volume 19, Issue 10, p. 3282
The protein tyrosine phosphatase interacting protein 51 (PTPIP51) regulates and interconnects signaling pathways, such as the mitogen-activated protein kinase (MAPK... 
Mitogen-activated protein kinase pathway (MAPK pathway) | Protein-protein interaction (PPI) | Protein tyrosine phosphatase interacting protein 51 (PTPIP51) | Cancer signaling | SIGNALING PATHWAYS | cancer signaling | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACUTE MYELOID-LEUKEMIA | mitogen-activated protein kinase pathway (MAPK pathway) | TRASTUZUMAB RESISTANCE | CHEMISTRY, MULTIDISCIPLINARY | BREAST-CANCER | GROWTH-FACTOR RECEPTOR | METASTATIC MELANOMA | MOLECULAR TARGETS | INSULIN-RESISTANCE | protein tyrosine phosphatase interacting protein 51 (PTPIP51) | THERAPEUTIC TARGET | protein-protein interaction (PPI) | GLIOBLASTOMA CELLS | Protein Binding - genetics | Humans | Protein Tyrosine Phosphatases - metabolism | Mitochondrial Proteins - genetics | Signal Transduction - genetics | Protein Tyrosine Phosphatases - genetics | Animals | Mitochondrial Proteins - metabolism | Mitogen-Activated Protein Kinases - genetics | Signal Transduction - physiology | Gene Expression Regulation, Neoplastic - physiology | Gene Expression Regulation, Neoplastic - genetics | Mitogen-Activated Protein Kinases - metabolism | Protein Binding - physiology | Phosphorylation | Leukemia | Serine | Raf protein | AKT protein | Cell interactions | Kinases | Phosphatase | Cell adhesion & migration | Proteins | Signal transduction | Epidermal growth factor | Growth factors | Tyrosine | NF-κB protein | Epidermal growth factor receptors | MAP kinase | Src protein | Organelles | ErbB-2 protein | Signaling | 14-3-3 protein | Protein kinase | Scaffolding | Medical prognosis | Mutation | Scaffolds | Binding sites | Metabolic disorders | Apoptosis | Protein-tyrosine-phosphatase
Journal Article
Nature chemical biology, ISSN 1552-4469, 2014, Volume 10, Issue 7, pp. 558 - 566
PTP1B, a validated therapeutic target for diabetes and obesity, has a critical positive role in HER2 signaling in breast tumorigenesis. Efforts to develop... 
LAPATINIB | OVEREXPRESSION | TYROSINE-PHOSPHATASE 1B | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACQUIRED-RESISTANCE | BINDING-SITE | MECHANISMS | INDUCTION | HUMAN BREAST-CANCER | CONTRIBUTES | TUMORS | Receptor, ErbB-2 - genetics | Humans | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | Molecular Targeted Therapy | Mammary Neoplasms, Experimental - genetics | Breast Neoplasms - enzymology | Protein Binding - drug effects | Mammary Neoplasms, Experimental - pathology | Female | Antineoplastic Agents - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics | Mammary Neoplasms, Experimental - enzymology | Spermine - analogs & derivatives | Mammary Neoplasms, Experimental - drug therapy | Allosteric Regulation - drug effects | Protein Structure, Tertiary | Catalytic Domain | Protein Structure, Secondary | Signal Transduction | Allosteric Site - drug effects | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Spermine - chemistry | Models, Molecular | Antineoplastic Agents - chemistry | Breast Neoplasms - drug therapy | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism | Animals | Breast Neoplasms - genetics | Spermine - pharmacology | Breast Neoplasms - pathology | Cholestanes - chemistry | Cholestanes - pharmacology | Mice | Kinetics | Breast cancer | Tumorigenesis | Diabetes | Drug therapy | Cholestanes | Allosteric Regulation | Breast Neoplasms | Life Sciences | Biomolecules | Biochemistry, Molecular Biology | Antineoplastic Agents | Spermine | Protein Tyrosine Phosphatase, Non-Receptor Type 1 | Mammary Neoplasms, Experimental | Allosteric Site | Protein Binding | Receptor, ErbB-2
Journal Article
PloS one, ISSN 1932-6203, 2015, Volume 10, Issue 8, p. e0135851
Overexpression of Twist, a highly conserved basic helix-loop-helix transcription factor, is associated with epithelial-mesenchymal transition (EMT) and... 
TRANSCRIPTION FACTORS | METASTASIS | PROTEIN | LOCAL RECURRENCE | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | GLYCOGEN-SYNTHASE KINASE-3 | RESISTANCE | BETA-CATENIN | CONSERVING THERAPY | CARCINOMA | Carcinoma, Ductal, Breast - genetics | Prognosis | Cadherins - metabolism | Receptor, ErbB-2 - genetics | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | Ki-67 Antigen - metabolism | Receptors, Progesterone - genetics | Epithelial-Mesenchymal Transition - genetics | Carcinoma, Ductal, Breast - mortality | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | Receptors, Progesterone - metabolism | Neoplasm Grading | Biomarkers, Tumor - metabolism | Adult | Carcinoma, Ductal, Breast - pathology | Estrogen Receptor alpha - metabolism | Female | Cadherins - genetics | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Lymphatic Metastasis | Carcinoma, Ductal, Breast - diagnosis | Vascular Endothelial Growth Factor C - genetics | Breast Neoplasms - genetics | Estrogen Receptor alpha - genetics | Ki-67 Antigen - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Breast Neoplasms - pathology | Vascular Endothelial Growth Factor C - metabolism | Survival Analysis | Twist-Related Protein 1 - genetics | Cell Line, Tumor | Breast Neoplasms - mortality | Biomarkers, Tumor - genetics | Breast Neoplasms - diagnosis | Neoplasm Staging | Twist-Related Protein 1 - metabolism | Transcription factors | Physiological aspects | Breast cancer | Genetic aspects | Research | Gene expression | Immunohistochemistry | Mesenchyme | Laboratories | Estrogens | Estrogen receptors | AKT protein | Activation | Metastasis | Kinases | Cancer therapies | E-cadherin | Proteins | Signal transduction | Tumorigenesis | Helix-loop-helix proteins | Vascular endothelial growth factor | Medical research | Immunoglobulins | Invasiveness | Extracellular signal-regulated kinase | Mammography | Patients | ErbB-2 protein | Hospitals | Protein kinase | Biomarkers | Progesterone | Prostate | Cell migration | Cancer
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 8/2010, Volume 107, Issue 34, pp. 15039 - 15044
Journal Article
PloS one, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, p. e68394
Journal Article
American journal of respiratory and critical care medicine, ISSN 1073-449X, 10/2013, Volume 188, Issue 7, pp. 770 - 775
The remarkable success of epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors in patients with EGFR... 
Molecular targeted therapy | Lung cancer | Cancer genomics | RET | GEFITINIB | EML4-ALK FUSION GENE | KINASE INHIBITOR | ALK INHIBITOR | SOMATIC MUTATIONS | EGFR | CHEMOTHERAPY | lung cancer | PHASE-II TRIAL | RESPIRATORY SYSTEM | CRIZOTINIB | cancer genomics | molecular targeted therapy | CRITICAL CARE MEDICINE | Lung Neoplasms - drug therapy | Oncogene Proteins - genetics | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Adenocarcinoma of Lung | Receptor, ErbB-2 - genetics | Genomics | Humans | ErbB Receptors - genetics | Antineoplastic Agents - therapeutic use | ErbB Receptors - therapeutic use | Anaplastic Lymphoma Kinase | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Adenocarcinoma - genetics | ras Proteins - drug effects | Receptor, ErbB-2 - drug effects | Molecular Targeted Therapy - methods | Lung Neoplasms - genetics | Proto-Oncogene Proteins - drug effects | Carcinoma, Non-Small-Cell Lung - genetics | Proto-Oncogene Proteins c-met - drug effects | Proto-Oncogene Proteins - genetics | Mutation - genetics | Adenocarcinoma - drug therapy | Oncogene Proteins - drug effects | Proto-Oncogene Proteins c-met - genetics | Mutation - drug effects | Receptor Protein-Tyrosine Kinases - genetics | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - drug effects | Proto-Oncogene Proteins B-raf - genetics | Receptor Protein-Tyrosine Kinases - therapeutic use | Proto-Oncogene Proteins c-ret - drug effects | Carcinoma, Non-Small-Cell Lung - drug therapy | Proto-Oncogene Proteins c-ret - genetics | Pulmonary
Journal Article
Breast Cancer Research and Treatment, ISSN 0167-6806, 4/2012, Volume 132, Issue 2, pp. 463 - 470
Journal Article