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Molecular Systems Biology, ISSN 1744-4292, 05/2005, Volume 1, Issue 1, pp. 2005.0008 - n/a
Interactions between short modified peptide motifs and modular protein domains are central events in cell signal‐transduction. We determined interaction... 
QUANTITATIVE PROTEOMICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | post-translational modification | SILAC | receptor tyrosine kinase signaling | SACCHAROMYCES-CEREVISIAE | SH2 DOMAINS | SIGNAL-TRANSDUCTION | INSULIN-RECEPTOR | EPIDERMAL-GROWTH-FACTOR | PROTEIN-PROTEIN INTERACTIONS | protein-protein interaction | BINDING-SITES | phosphorylation | PHOSPHOLIPASE C-GAMMA | EGF RECEPTOR | Adaptor Proteins, Signal Transducing - chemistry | Phosphorylation | Phosphotyrosine - immunology | Immunoprecipitation | Humans | Receptor, ErbB-2 - chemistry | Molecular Sequence Data | STAT5 Transcription Factor - chemistry | Receptor, ErbB-3 - chemistry | Systems Biology | Phosphotyrosine - physiology | Binding Sites | Shc Signaling Adaptor Proteins | Protein Structure, Tertiary | Amino Acid Sequence | Phosphatidylinositol 3-Kinases - chemistry | GRB2 Adaptor Protein - chemistry | Phosphotyrosine - chemistry | Receptor, Epidermal Growth Factor - chemistry | Amino Acid Motifs | Protein Interaction Mapping | Peptide Fragments - chemical synthesis | Peptide Fragments - chemistry | Sequence Alignment | Src Homology 2 Domain-Containing, Transforming Protein 1 | Protein Binding | Signal Transduction - physiology | Protein Processing, Post-Translational | HeLa Cells | Receptor, ErbB-4 | Tumor Suppressor Proteins | Peptides | Phosphotyrosine | Mapping | Kinases | Experiments | Proteins | Signal transduction | Ratios | Synthetic peptides | Tyrosine | Epidermal growth factor receptors | ErbB protein | Mass spectroscopy | Stat5 protein | ErbB-3 protein | ErbB-2 protein | Peptide mapping | 1-Phosphatidylinositol 3-kinase | Grb2 protein | Domains | Signaling | Correlation analysis | Proteomics | Ligands | Transduction | Scientific imaging | Protein interaction | Mass spectrometry | Binding sites | Methods
Journal Article
Cancer Research, ISSN 0008-5472, 04/2017, Volume 77, Issue 8, pp. 1983 - 1996
The ErbB3 receptor-binding protein EBP1 encodes two alternatively spliced isoforms P48 and P42. While there is evidence of differential roles for these... 
EPITHELIAL-MESENCHYMAL TRANSITION | CYCLIN-E | ONCOLOGY | PHOSPHORYLATION | POOR-PROGNOSIS | TUMOR-SUPPRESSOR GENE | DEGRADATION | CELL-PROLIFERATION | EXPRESSION | F-BOX PROTEIN | FBW7 UBIQUITIN LIGASE | Immunohistochemistry | Neoplasms - metabolism | F-Box-WD Repeat-Containing Protein 7 | RNA-Binding Proteins - genetics | Humans | Cytoplasm - metabolism | Protein Interaction Maps | Heterografts | Neoplasms - genetics | HEK293 Cells | Cell Cycle Proteins - genetics | Binding Sites | F-Box Proteins - metabolism | HCT116 Cells | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Cell Cycle Proteins - deficiency | Glycogen Synthase Kinase 3 beta - metabolism | Phenotype | Animals | Mice, Nude | Protein Isoforms | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Ubiquitin-Protein Ligases - deficiency | Mice | Proteasome Endopeptidase Complex - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Neoplasms - pathology | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | RNA-Binding Proteins - metabolism | Binding | Ubiquitin | Alternative splicing | Adapters | ErbB-3 protein | Cytosol | Substrates | Cdc4 protein | Degradation | Proteins | Isoforms | Tumor suppressor genes | Tumorigenesis | Ubiquitin-protein ligase | Cancer | EBP1 protein | Index Medicus | EBP1 P48 | colorectal cancer | BASIC BIOLOGICAL SCIENCES | FBXW7 | protein isoform | 60 APPLIED LIFE SCIENCES | EBP1 P42 | Protein isoform | Colorectal cancer
Journal Article
Journal Article
Breast Cancer Research and Treatment, ISSN 0167-6806, 4/2012, Volume 132, Issue 2, pp. 463 - 470
Journal Article
Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 1, pp. 58 - 71
Activation of the PI3K-AKT pathway in tumors is modulated by negative feedback, including mTORC1-mediated inhibition of upstream signaling. We now show that... 
RAPAMYCIN | TARGET | FORKHEAD TRANSCRIPTION FACTOR | CELLS | INSULIN-RECEPTOR | ACTIVATION | ONCOLOGY | SIGNALING PATHWAY | PHOSPHORYLATION | UPSTREAM | HUMAN CANCER | CELL BIOLOGY | RNA, Small Interfering - genetics | Receptor, IGF Type 1 - metabolism | Protein Binding - genetics | Receptor, ErbB-3 - metabolism | Humans | Forkhead Transcription Factors - metabolism | Protein Binding - drug effects | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Receptor, ErbB-2 - antagonists & inhibitors | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Quinoxalines - therapeutic use | Carcinoma, Non-Small-Cell Lung - metabolism | Receptor, ErbB-3 - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Breast Neoplasms - drug therapy | Receptor, IGF Type 1 - genetics | Signal Transduction - drug effects | Mice, Nude | Models, Biological | Cell Line, Tumor | Mice | TOR Serine-Threonine Kinases | Feedback, Physiological - physiology | Quinazolines - pharmacology | Proteins - antagonists & inhibitors | Neoplasms - metabolism | Gene Expression - drug effects | Multiprotein Complexes | Receptor, ErbB-2 - metabolism | Promoter Regions, Genetic - genetics | Proto-Oncogene Proteins c-akt - genetics | Breast Neoplasms - metabolism | Mechanistic Target of Rapamycin Complex 1 | Quinoxalines - pharmacology | Receptor, Insulin - genetics | Female | Forkhead Transcription Factors - antagonists & inhibitors | Gene Expression Regulation, Neoplastic - drug effects | Drug Therapy, Combination | Gene Expression Regulation, Neoplastic - physiology | Carcinoma, Non-Small-Cell Lung - pathology | Up-Regulation - genetics | Forkhead Transcription Factors - genetics | Xenograft Model Antitumor Assays | Animals | Receptor Protein-Tyrosine Kinases - genetics | Breast Neoplasms - pathology | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Feedback, Physiological - drug effects | Receptor, Insulin - metabolism | Signal Transduction - physiology | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Benzylamines - pharmacology | Benzylamines - therapeutic use | Proto-Oncogene Proteins c-akt - antagonists & inhibitors
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, pp. e53510 - e53510
Background: There is increasing evidence that opioid analgesics may interfere with tumour growth. It is currently thought that these effects are mediated by... 
ACTIVATED PROTEIN-KINASE | INHIBITION | CARCINOMA CELLS | TYROSINE KINASE | DESENSITIZATION | MULTIDISCIPLINARY SCIENCES | DOWN-REGULATION | RESISTANCE | OPIOID RECEPTORS | MECHANISMS | EGF RECEPTOR | Receptor, ErbB-3 - metabolism | Receptor, ErbB-2 - genetics | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Receptor, ErbB-2 - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Neuregulin-1 - genetics | Proto-Oncogene Proteins c-akt - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Receptors, Opioid, kappa - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Morphine - pharmacology | Receptors, Opioid, mu - metabolism | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Receptors, Opioid, kappa - metabolism | Receptor, ErbB-3 - genetics | Adenocarcinoma - drug therapy | Breast Neoplasms - drug therapy | Phosphatidylinositol 3-Kinases - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Neuregulin-1 - metabolism | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Receptors, Opioid, mu - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Tyrosine | Morphine | Breast cancer | Growth | Protein kinases | Cancer cells | Adenocarcinoma | Phosphorylation | Immunoprecipitation | Laboratories | Switching theory | AKT protein | Feedback loops | Heregulin | Kinases | Receptors | Cell growth | Epidermal growth factor | Analgesics | Protein-tyrosine kinase receptors | Metalloproteinase | Protein-tyrosine kinase | ErbB-1 protein | Opioid receptors | ErbB protein | Extracellular signal-regulated kinase | ErbB-3 protein | Protein kinase inhibitors | ErbB-2 protein | 1-Phosphatidylinositol 3-kinase | Signaling | Breast | Sensitivity enhancement | Control theory | Cancer | Tumors | Apoptosis | Index Medicus
Journal Article
Journal of Peptide Science, ISSN 1075-2617, 02/2018, Volume 24, Issue 2, p. e3066
HER2 receptors are surface proteins belonging to the epidermal growth factor family of receptors. Their numbers are elevated in breast, lung, and ovarian... 
lung cancer | protein-protein interaction | peptidomimetic | HER2 | structural activity relationships | CHEMISTRY, ANALYTICAL | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL LUNG-CANCER | BREAST-CANCER | GROWTH-FACTOR RECEPTOR | PEPTIDES | HERCEPTIN | RESISTANCE | ERBB SIGNALING NETWORK | HOT-SPOTS | MONOCLONAL-ANTIBODIES | Receptor, ErbB-3 - metabolism | Peptidomimetics - chemical synthesis | Receptor, ErbB-2 - genetics | Stereoisomerism | Antineoplastic Agents - chemical synthesis | Humans | Receptor, ErbB-2 - metabolism | Amino Acids, Cyclic - chemical synthesis | Structure-Activity Relationship | MCF-7 Cells | Biomarkers, Tumor - metabolism | Inhibitory Concentration 50 | Female | Antineoplastic Agents - pharmacology | Receptor, ErbB-2 - antagonists & inhibitors | Protein Stability | Biomarkers, Tumor - antagonists & inhibitors | Binding Sites | Binding, Competitive | Amino Acid Sequence | Gene Expression | Peptidomimetics - pharmacology | Amino Acids, Cyclic - pharmacology | Receptor, ErbB-3 - antagonists & inhibitors | Receptor, ErbB-3 - genetics | Cell Line, Tumor | Protein Binding | Biomarkers, Tumor - genetics | Cell Proliferation - drug effects | Amino acids | Epidermal growth factor | Lung cancer | Analysis | Protein-protein interactions | Ovarian cancer | Cell culture | Biotechnology | Phosphorylation | Tumor cell lines | ErbB-2 protein | D-Amino acids | Analogs | Proteins | Receptors | Peptidomimetics | Cell lines | Surface plasmon resonance | In vivo methods and tests | Inhibition | Protein interaction | Surface stability | Dimerization | Three dimensional models | Cancer | Protein-protein interaction
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 07/2008, Volume 118, Issue 7, pp. 2609 - 2619
Although some cancers are initially sensitive to EGFR tyrosine kinase inhibitors (TKIs), resistance invariably develops. We investigated mechanisms of acquired... 
BREAST-CANCER | GENE-MUTATIONS | MEDICINE, RESEARCH & EXPERIMENTAL | LUNG-CANCER | GROWTH-FACTOR-RECEPTOR | T790M MUTATIONS | IN-VIVO | TUMOR-CELLS | ANTITUMOR-ACTIVITY | GEFITINIB SENSITIVITY | ERLOTINIB | Insulin-Like Growth Factor Binding Protein 3 - genetics | Receptor, IGF Type 1 - metabolism | Insulin-Like Growth Factor I - pharmacology | Receptor, ErbB-3 - metabolism | Receptor, IGF Type 1 - antagonists & inhibitors | Gene Expression - drug effects | Carcinoma, Squamous Cell - pathology | Humans | Drug Resistance, Neoplasm | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Insulin-Like Growth Factor Binding Protein 3 - metabolism | Insulin Receptor Substrate Proteins | Insulin-Like Growth Factor Binding Protein 4 - metabolism | Female | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Cell Survival - drug effects | Insulin-Like Growth Factor Binding Proteins - genetics | Insulin-Like Growth Factor Binding Protein 4 - genetics | Insulin-Like Growth Factor II - metabolism | Insulin-Like Growth Factor Binding Proteins - metabolism | Xenograft Model Antitumor Assays | Animals | Carcinoma, Squamous Cell - drug therapy | Mice, Nude | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Protein Kinase Inhibitors - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Quinazolines - pharmacology | Insulin-Like Growth Factor I - metabolism | Tyrosine | Phenols | Binding proteins | Analysis | Cancer cells
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2010, Volume 107, Issue 12, pp. 5622 - 5627
Journal Article
Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7413, pp. 660 - 664
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e64672
Journal Article