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Autophagy, ISSN 1554-8627, 11/2014, Volume 10, Issue 11, pp. 2036 - 2052
Earlier studies reported allelic deletion of the essential autophagy regulator BECN1 in breast cancers implicating BECN1 loss, and likely defective autophagy,... 
TNBCs, triple-negative breast cancers | EGF, epidermal growth factor | DAPI, 4′, 6-diamidino-2-phenylindole | MEGM, mammary epithelial growth medium | ATG, autophagy-related | 8-O-dG, 8-oxo-7, 8-dihydroguanine | ITGB1/CD29, Integrin, beta 1 (fibronectin receptor beta polypeptide, antigen CD29 includes MDF2, MSK12) | LY76 | E, 17b-estradiol | EM, electron microscopy | DMEM, Dulbecco's modified Eagle's medium | CD24, cluster of differentiation 24 | KRT, keratin | TNFSF11 | TNBC | TNFRSF11A/TNR11/RANK, tumor necrosis factor receptor superfamily, member 11a, NFKB activator | MAP1LC3B/LC3B, microtubule-associated protein 1 light chain 3 beta | LY76/TER119, lymphocyte antigen 76 | EGFP, enhanced green fluorescent protein | MaPC, mammary progenitor cell | PI, propidium iodide | TNF, tumor necrosis factor | TP53 (TRP53 in mice), tumor protein p53 (transformation related protein 53 in mice) | NFKB | BECN1, Beclin 1, autophagy-related | PECAM1/CD31, platelet/endothelial cell adhesion molecule 1 | RELA/P65, v-rel avian reticuloendotheliosis viral oncogene homolog a | IL, interleukin | lineage negative (CD31 | IF, immunofluorescence | CD45 | SQSTM1/p62, sequestosome1 | GSEA, gene set enrichment analysis | H&E, hematoxylin &, eosin | DFS, disease-free survival | basal-like breast cancer | parity | iMMECs, immortalized mouse mammary epithelial cells | TNFRSF11A | HR, hormone receptor | PGR, progesterone receptor | FACS, fluorescence activated cell sorting | PBS, phosphate-buffered saline | TEBs, terminal end buds | IHC, immunohistochemistry | SD, standard deviation | MGs, mammary glands | ROS, reactive oxygen species | WNT1 | MEC, mammary epithelial cell | ITGB3/CD61, integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | MKI67, marker of proliferation Ki-67 | CASP3, caspase 3 | BSA, bovine serum albumin | MaSC, mammary stem cell | EMT, epithelial-to-mesenchymal transition | Keratin 6 | WNT1, wingless-Type MMTV integration site family, member 1 | TNF11 | NFKB/NFkB, nuclear factor of kappa light polypeptide gene enhancer in B-cells | MMTV, mouse mammary tumor virus | FGF2/bFGF, fibroblast growth factor 2 (basic) | LIN | p-KRT8/p-K8, phosphorylated Keratin 8 | SNPs, single nucleotide polymorphisms | PTPRC/CD45, protein tyrosine phosphatase, receptor type, C | EGFR/ERBB1, epidermal growth factor receptor | Beclin 1 | TNFSF11/TNF11/RANKL, tumor necrosis factor (ligand) superfamily, member 11 | ESR1, estrogen receptor 1 | TNR11 | ERBB2, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | Parity | Basal-like breast cancer | PROGENITOR CELLS | STEM-CELLS | MOUSE | DEFICIENT MICE | CELL BIOLOGY | BREAST-CANCER | EPITHELIAL-CELLS | BECLIN-1 | TUMOR-SUPPRESSOR | LUNG-TUMORS | TRANSGENIC MICE | Beclin-1 | Cell Proliferation | Oligonucleotide Array Sequence Analysis | Signal Transduction | Humans | Gene Expression Regulation, Neoplastic | Stem Cells - cytology | Wnt1 Protein - metabolism | Mammary Neoplasms, Experimental - metabolism | Autophagy | Apoptosis Regulatory Proteins - metabolism | Breast Neoplasms - metabolism | Animals | Mice, Nude | Triple Negative Breast Neoplasms - metabolism | Mammary Neoplasms, Animal - metabolism | Alleles | Female | Heterozygote | Membrane Proteins - metabolism | Mice | Epithelial Cells - cytology | Apoptosis | Index Medicus
Journal Article
FEBS Letters, ISSN 0014-5793, 1999, Volume 447, Issue 2, pp. 227 - 231
ErbB receptor activation is a complex process and is dependent upon the type and number of receptors expressed on a given cell. Previous studies with defined... 
ErbB receptor and ligand | Neuregulin | ErbB2-containing heterodimer | differentiation factor (NDF) or neuregulin (NRG) | HRG, heregulin, also called | EGF, epidermal growth factor | trx, thioredoxin | HB-EGF, heparin-binding egf | EGFR, epidermal growth factor receptor (ErbB1) | BTC, betacellulin | ECD, extracellular domain | ErbB1-IgG, homodimeric fusion protein between the ECD of ErbB1 with the human IgG heavy chain (other homodimeric constructs are ErbB3-IgG and ErbB4-IgG) | ErbB2/3-IgG, heterodimeric fusion protein between the ECD of ErbB2 and ErbB3 with the human IgG heavy chain (other heterodimeric constructs are ErbB2/4-IgG and ErbB1/2-IgG) | BiR, biregulin | EPR, epiregulin | TGFα, transforming growth factor α | neu | RESOLUTION SOLUTION STRUCTURE | BETACELLULIN | EPIREGULIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | neuregulin | HEREGULIN ISOFORMS | SCANNING MUTAGENESIS | EPIDERMAL GROWTH-FACTOR | FACTOR-ALPHA | CELL BIOLOGY | SIGNAL-TRANSDUCTION | BIOPHYSICS | DIFFERENTIATION | NEU | Humans | Glycoproteins - metabolism | Molecular Sequence Data | Nerve Growth Factors - metabolism | Oncogene Proteins v-erbB - metabolism | Neuregulins | Growth Substances - genetics | Growth Substances - chemistry | Epidermal Growth Factor - chemistry | Carrier Proteins - chemistry | Glycoproteins - chemistry | Transforming Growth Factor alpha - metabolism | Binding Sites | Dimerization | Glycoproteins - genetics | Recombinant Proteins - metabolism | Amino Acid Sequence | ErbB Receptors - metabolism | Epidermal Growth Factor - genetics | Transforming Growth Factor alpha - chemistry | Intercellular Signaling Peptides and Proteins | Intracellular Signaling Peptides and Proteins | Recombinant Proteins - chemistry | Epidermal Growth Factor - metabolism | Nerve Growth Factors - chemistry | Transforming Growth Factor alpha - genetics | Macromolecular Substances | Carrier Proteins - genetics | Heparin-binding EGF-like Growth Factor | Carrier Proteins - metabolism | Betacellulin | ErbB Receptors - chemistry | Nerve Growth Factors - genetics | Ligands | Oncogene Proteins v-erbB - chemistry | In Vitro Techniques | Growth Substances - metabolism | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2011, Volume 46, Issue 12, pp. 6002 - 6014
A series of 4- -substituted 6-aryl-7 -pyrrolo[2,3-d]pyrimidine-4-amines have been synthesised, characterised and tested for their EGFR (ErbB1) tyrosine kinase... 
Pyrrolopyrimidine | Tyrosine kinase | ErbB1 | Pyrroles | 4-Chloropyrolopyrimidines | Cancer
Journal Article
Breast Cancer Research and Treatment, ISSN 0167-6806, 6/2012, Volume 133, Issue 3, pp. 1057 - 1065
Journal Article
JOURNAL OF NEUROCHEMISTRY, ISSN 0022-3042, 09/2017, Volume 142, Issue 6, pp. 886 - 900
Phenotypic development of neocortical GABA neurons is highly plastic and promoted by various neurotrophic factors such as neuregulin-1. A subpopulation of GABA... 
GLUTAMIC-ACID DECARBOXYLASE | EEG | BIOCHEMISTRY & MOLECULAR BIOLOGY | CORTICAL GABAERGIC NEURONS | schizophrenia | ERBB1 RECEPTOR | NEUROSCIENCES | EGFR | PREFRONTAL CORTEX | glutamic acid decarboxylase | ADULT-RAT BRAIN | PARVALBUMIN-INTERNEURONS | ALPHA MESSENGER-RNA | parvalbumin | GABA | GENE-EXPRESSION | REACTIVE ASTROCYTES | CENTRAL-NERVOUS-SYSTEM
Journal Article
Oncogene, ISSN 0950-9232, 04/2002, Volume 21, Issue 16, pp. 2584 - 2592
Journal Article
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ISSN 0006-291X, 05/2019, Volume 513, Issue 1, pp. 219 - 225
By year 2025 pancreatic ductal adenocarcinoma (PDAC) is expected to become the second leading cause of cancer related death. However, other than improved... 
TRASTUZUMAB | EGF-RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | HER2/ERBB2 | Monoclonal antibody | PERTUZUMAB | DOCETAXEL | GROWTH-FACTOR RECEPTOR | COMBINATIONS | THERAPY | BIOPHYSICS | Pancreatic cancer | Homo-combination | HER2 | CARCINOMA | EGFR/ERBB1 | Prevention | Chemotherapy | Epidermal growth factor | Analysis | Monoclonal antibodies | DNA synthesis | Tumor proteins | Drug approval | Cancer
Journal Article
IEE Proceedings: Systems Biology, ISSN 1741-2471, 11/2006, Volume 153, Issue 6, pp. 457 - 466
Journal Article
Frontiers in Oncology, ISSN 2234-943X, 06/2016, Volume 6, pp. 142 - 142
We determined whether the approved myelofibrosis drug ruxolitinib (Jakafi(®)), an inhibitor of Janus kinases 1/2 (JAK1 and JAK2), could be repurposed as an... 
Ruxolitinib | Afatinib | Chaperone | ERBB1 | Mitophagy | JAK1/2 | AIF | Care and treatment | Heat shock proteins | Drug therapy, Combination | Health aspects | Drug approval | Tumors | Cancer
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2007, Volume 104, Issue 10, pp. 4071 - 4076
Journal Article
JOURNAL OF CELLULAR BIOCHEMISTRY, ISSN 0730-2312, 04/2008, Volume 103, Issue 6, pp. 1783 - 1797
Exosomes are small membrane vesicles derived from intracellular multivescicular bodies (MVBs) that can undergo constitutive and regulated secretion from cells.... 
CARCINOMA-CELLS | signaling | ectodomain shedding | ErbB1 | EGF | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLEAVAGE | TUMOR-DERIVED EXOSOMES | FACTOR-ALPHA | CELL BIOLOGY | NUCLEAR-LOCALIZATION | BREAST-CANCER CELLS | MULTIVESICULAR ENDOSOMES | SIGNALING NETWORK | metalloprotease | L1 ADHESION MOLECULE | exosome | EGF RECEPTOR
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 11/2009, Volume 15, Issue 21, pp. 6702 - 6708
Purpose: This study determined the range of tolerable doses, clinical safety, pharmacokinetics, and preliminary evidence of clinical activity following once or... 
lapatinib |