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1. Full Text Intrathecal dihydroergotamine inhibits capsaicin-induced vasodilatation in the canine external carotid circulation via GR127935- and rauwolscine-sensitive receptors
by Marichal-Cancino, Bruno A and González-Hernández, Abimael and Manrique-Maldonado, Guadalupe and Ruiz-Salinas, Inna I and Altamirano-Espinoza, Alain H and MaassenVanDenBrink, Antoinette and Villalón, Carlos M
European Journal of Pharmacology, ISSN 0014-2999, 10/2012, Volume 692, Issue 1-3, pp. 69 - 77
It has been suggested that during a migraine attack trigeminal nerves release calcitonin gene-related peptide (CGRP), producing central nociception and... 
Dihydroergotamine | External carotid artery | Capsaicin | CGRP | Migraine | RAT | SUMATRIPTAN | ERGOTAMINE | 5-HT1D RECEPTORS | DURA-MATER | PHARMACOLOGY & PHARMACY | BINDING | VASOCONSTRICTION | AGONIST | Carotid Arteries - drug effects | Carotid Arteries - metabolism | Capsaicin - pharmacology | Serotonin 5-HT1 Receptor Antagonists - pharmacology | Male | Yohimbine - pharmacology | Dose-Response Relationship, Drug | Dihydroergotamine - pharmacology | Propylene Glycol - administration & dosage | Oxadiazoles - pharmacology | Receptor, Serotonin, 5-HT1B - metabolism | Serotonin 5-HT1 Receptor Antagonists - administration & dosage | Dihydroergotamine - administration & dosage | Injections, Spinal | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Calcitonin Gene-Related Peptide - pharmacology | Piperazines - pharmacology | Propylene Glycol - pharmacology | Animals | Carotid Arteries - physiology | Dogs | Blood Circulation - drug effects | Hemodynamics - drug effects | Vasodilation - drug effects | Blood vessels | Acetylcholine | Peptides | Dilatation
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2. Full Text GR-127935-sensitive Mechanism Mediating Hypotension in Anesthetized Rats: Are 5-HT5B Receptors Involved?
by Sánchez-Maldonado, Carolina and López-Sánchez, Pedro and Anguiano-Robledo, Liliana and Leopoldo, Marcello and Lacivita, Enza and Terrón, José A
Journal of Cardiovascular Pharmacology, ISSN 0160-2446, 04/2015, Volume 65, Issue 4, pp. 335 - 341
The 5-HT1B/1D receptor antagonist, GR-127935, inhibits hypotensive responses produced by the 5-HT1A, 5-HT1B/1D and 5-HT7 receptor agonist, and 5-HT5A/5B... 
Anesthetized rats | Systemic blood vessels | receptors | 5-HT | Hypotension | hypotension | CARDIAC & CARDIOVASCULAR SYSTEMS | ANTAGONIST | OUTFLOW | 5-HYDROXYTRYPTAMINE | 5-CARBOXAMIDOTRYPTAMINE | 5-HT1B/1D receptors | systemic blood vessels | FAMILY | PITHED RATS | POTENT | PHARMACOLOGY & PHARMACY | SEROTONIN | 5-HT5A/5B receptors | anesthetized rats | BRAIN | Rats | Piperidones - pharmacology | Receptors, Serotonin - genetics | Serotonin - pharmacology | Serotonin Antagonists - pharmacology | Piperazines - pharmacology | Receptors, Serotonin - metabolism | Serotonin Receptor Agonists - pharmacology | Dose-Response Relationship, Drug | Hypotension - drug therapy | Animals | Hypotension - metabolism | Biphenyl Compounds - pharmacology | Oxadiazoles - pharmacology | Serotonin - analogs & derivatives | Hypotension - etiology | Blood Pressure - drug effects | Ergotamine - pharmacology | Drug Therapy, Combination | Spiro Compounds - pharmacology | Disease Models, Animal
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3. Full Text Understanding the pharmacology of headache
by Rolan, Paul Edward
Current Opinion in Pharmacology, ISSN 1471-4892, 2013, Volume 14, Issue 1, pp. 30 - 33
Highlights • Current migraine prophylaxis targets neuronal excitability and/or vascular mechanisms. • New migraine prophylactic targets include CGRP and... 
Internal Medicine | Medical Education | ERGOTAMINE | ANTIDEPRESSANTS | ACTIVATION | MECHANISM | TRIGGERS | PHARMACOLOGY & PHARMACY | RECEPTORS | MIGRAINE | Antihypertensive Agents - pharmacology | Headache - drug therapy | Humans | Anticonvulsants - therapeutic use | Headache - physiopathology | Antihypertensive Agents - therapeutic use | Molecular Targeted Therapy | Anticonvulsants - pharmacology | Migraine Disorders - drug therapy | Antidepressive Agents - therapeutic use | Animals | Drug Design | Migraine Disorders - physiopathology | Antidepressive Agents - pharmacology | Calcitonin Gene-Related Peptide - metabolism | Drug therapy | Migraine | Pharmacology
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4. Full Text Ergotamine and Dihydroergotamine: History, Pharmacology, and Efficacy
by Silberstein, Stephen D and McCrory, Douglas C
Headache: The Journal of Head and Face Pain, ISSN 0017-8748, 02/2003, Volume 43, Issue 2, pp. 144 - 166
Ergotamine and dihydroergotamine share structural similarities with the adrenergic, dopaminergic, and serotonergic neurotransmitters. As a result, they have... 
DHE | ergotamine | guidelines | serotonin | dihydroergotamine | Ergotamine | Dihydroergotamine | Serotonin | Guidelines | NASAL SPRAY | TARTRATE | SUBCUTANEOUS SUMATRIPTAN | CLINICAL NEUROLOGY | COMPARATIVE TRIAL | MIGRAINE ATTACKS | EMERGENCY TREATMENT | NAPROXEN SODIUM | HEADACHE | INTRAVENOUS DIHYDROERGOTAMINE | CEREBRAL-BLOOD-FLOW | Vasoconstrictor Agents - pharmacology | Vasoconstrictor Agents - therapeutic use | Dihydroergotamine - therapeutic use | United States | History, 20th Century | Humans | Receptors, Serotonin - drug effects | Ergotamine - therapeutic use | Treatment Outcome | Dihydroergotamine - history | Migraine Disorders - drug therapy | Dihydroergotamine - pharmacology | Animals | History, 19th Century | Ergotamine - pharmacology | Ergotamine - history | Vasoconstrictor Agents - history
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5. Full Text Potential vascular alpha1-adrenoceptor blocking properties of an array of 5-HT receptor ligands in the rat
by Centurión, David and Mehotra, Suneet and Sánchez-López, Araceli and Gupta, Saurabh and MaassenVanDenBrink, Antoinette and Villalón, Carlos M
European journal of pharmacology, ISSN 0014-2999, 03/2006, Volume 535, Issue 1-3, p. 234
This study set out to analyse the potential ability of some 5-hydroxytryptamine (5-HT) receptor ligands widely used in cardiovascular experimental models to... 
Methiothepin - pharmacology | Rats, Wistar | Adrenergic alpha-1 Receptor Agonists | Male | Lisuride - pharmacology | Methysergide - pharmacology | Buspirone - pharmacology | Serotonin Receptor Agonists - pharmacology | Yohimbine - pharmacology | Dose-Response Relationship, Drug | Heart Rate - drug effects | Clozapine - pharmacology | Drug Interactions | Phenylephrine - pharmacology | Prazosin - pharmacology | Pizotyline - pharmacology | Heart Rate - physiology | Blood Pressure - drug effects | Blood Pressure - physiology | Adrenergic alpha-1 Receptor Antagonists | Receptors, Adrenergic, alpha-1 - physiology | Ketanserin - pharmacology | Adrenergic alpha-Antagonists | Metergoline - pharmacology | Rats | 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology | Serotonin Antagonists - pharmacology | Piperazines - pharmacology | Animals | Adrenergic alpha-Agonists - pharmacology | Decerebrate State | Pyridines - pharmacology | Ergotamine - pharmacology
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6. Full Text Structure and function of serotonin G protein-coupled receptors
by McCorvy, John D and Roth, Bryan L
Pharmacology and Therapeutics, ISSN 0163-7258, 06/2015, Volume 150, pp. 129 - 142
Serotonin receptors are prevalent throughout the nervous system and the periphery, and remain one of the most lucrative and promising drug discovery targets... 
5-HT2B | GPCR | 5-HT1B | β-Arrestin | Serotonin | Functional selectivity | 5-HT | BETA ADRENERGIC-RECEPTOR | RESOLUTION CRYSTAL-STRUCTURE | PHARMACOLOGICAL CHARACTERIZATION | VALVULAR HEART-DISEASE | LIGAND-BINDING SITES | MUSCARINIC ACETYLCHOLINE-RECEPTOR | RAT STOMACH FUNDUS | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | MOLECULAR-CLONING | beta-Arrestin | ADENYLATE-CYCLASE | Vasoconstrictor Agents - pharmacology | Vasoconstrictor Agents - therapeutic use | GTP-Binding Proteins - physiology | Signal Transduction | Receptor, Serotonin, 5-HT2B - metabolism | Humans | Models, Molecular | Ergotamine - therapeutic use | Receptors, Serotonin - chemistry | Migraine Disorders - drug therapy | Receptors, Serotonin - metabolism | Migraine Disorders - metabolism | Serotonin Receptor Agonists - pharmacology | Receptor, Serotonin, 5-HT2B - chemistry | Serotonin Receptor Agonists - therapeutic use | Animals | Heart Valve Diseases - metabolism | Allosteric Site | Receptor, Serotonin, 5-HT1B - chemistry | Protein Conformation | Receptor, Serotonin, 5-HT1B - metabolism | Heart Valve Diseases - drug therapy | Ergotamine - pharmacology | Phenols | G proteins | Index Medicus | 7TM | serotonin | β-arrestin | ligand bias | functional selectivity
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7. Full Text Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications
by Rothman, R.B and Baumann, M.H and Savage, J.E and Rauser, L and McBride, A and Hufeisen, S.J and Roth, B.L
Circulation, ISSN 0009-7322, 12/2000, Volume 102, Issue 23, pp. 2836 - 2841
Serotonergic medications with various mechanisms of action are used to treat psychiatric disorders and are being investigated as treatments for drug... 
Fenfluramine | Valves | Receptors | Norfenfluramine | Norfenfluramine - pharmacokinetics | Fenfluramine - pharmacokinetics | Serotonin Antagonists - pharmacokinetics | Ergotamine - pharmacokinetics | Norfenfluramine - pharmacology | Humans | Methylergonovine - pharmacology | Receptors, Serotonin - drug effects | Fenfluramine - adverse effects | Serotonin Antagonists - pharmacology | Fenfluramine - pharmacology | Receptors, Serotonin - metabolism | Dose-Response Relationship, Drug | Methylergonovine - pharmacokinetics | Serotonin Antagonists - adverse effects | Heart Valve Diseases - epidemiology | Heart Valve Diseases - chemically induced | Norfenfluramine - adverse effects | Ergotamine - pharmacology
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8. Full Text Modulatory effect of the 5-HT1A agonist buspirone and the mixed non-hallucinogenic 5-HT1A/2A agonist ergotamine on psilocybin-induced psychedelic experience
by Pokorny, Thomas and Preller, Katrin H and Kraehenmann, Rainer and Vollenweider, Franz X
European Neuropsychopharmacology, ISSN 0924-977X, 2016, Volume 26, Issue 4, pp. 756 - 766
Abstract The mixed serotonin (5-HT) 1A/2A/2B/2C/6/7 receptor agonist psilocybin dose-dependently induces an altered state of consciousness (ASC) that is... 
Internal Medicine | Psychiatry | Ergotamine | 5-HT2A receptor | Buspirone | Psilocybin | Visual hallucinations | 5-HT1A receptor | PREPULSE INHIBITION | PSYCHIATRY | HUMANS | SCHIZOPHRENIA | HEALTHY-HUMAN VOLUNTEERS | RAT PREFRONTAL CORTEX | NEUROSCIENCES | CLINICAL NEUROLOGY | SEROTONIN(2A) RECEPTORS | PHARMACOLOGY & PHARMACY | 2A RECEPTORS | IN-VIVO ACTIONS | RECEPTOR AGONIST | INDUCED PSYCHOSES | Behavior Rating Scale | Hallucinogens - pharmacology | Double-Blind Method | Humans | Male | Buspirone - pharmacology | Psilocybin - pharmacology | Serotonin Receptor Agonists - pharmacology | Consciousness Disorders - chemically induced | Young Adult | Healthy Volunteers - psychology | Psilocybin - antagonists & inhibitors | Female | Consciousness Disorders - psychology | Ergotamine - pharmacology | Psychotherapy | Buspirone hydrochloride | Hallucinogenic drugs | Nervous system diseases | Psychiatric hospital care | Psychiatric hospitals
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9. Full Text Role of 5-HT5A and 5-HT1B/1D receptors in the antinociception produced by ergotamine and valerenic acid in the rat formalin test
by Vidal-Cantú, Guadalupe C and Jiménez-Hernández, Mildred and Rocha-González, Héctor I and Villalón, Carlos M and Granados-Soto, Vinicio and Muñoz-Islas, Enriqueta
European Journal of Pharmacology, ISSN 0014-2999, 06/2016, Volume 781, pp. 109 - 116
Sumatriptan, dihydroergotamine and methysergide inhibit 1% formalin-induced nociception by activation of peripheral 5-HT receptors. This study set out to... 
Ergotamine | 5-HT5A receptors | Valerenic acid | Inflammatory pain | 5-HT1B/1D receptors | receptors | 5-HT | Analgesics - pharmacology | Indenes - pharmacology | Rats, Wistar | Receptor, Serotonin, 5-HT1D - metabolism | Formaldehyde - adverse effects | Rats | Serotonin Antagonists - pharmacology | Animals | Nociception - drug effects | Behavior, Animal - drug effects | Female | Receptor, Serotonin, 5-HT1B - metabolism | Ergotamine - pharmacology | Sesquiterpenes - pharmacology | Receptor, Serotonin, 5-HT1A - metabolism
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10. Full Text Involvement of Signaling Pathways in Bovine Sperm Motility, and Effect of Ergot Alkaloids
by Hehai Wang and Michael L. Looper and Zelpha B. Johnson and Rick W. Rorie and Charles F. Rosenkrans
In Vitro Cellular & Developmental Biology. Animal, ISSN 1071-2690, 9/2009, Volume 45, Issue 8, pp. 483 - 489
There is evidence that ergot alkaloids can directly interact with mammalian spermatozoa affecting sperm functions. Ergot alkaloids exert their toxic or... 
Alkaloids | Spermatozoa | Receptors | Ungulates | Calcium | Signal Transduction | Sperm motility | Toxins | Adrenergic receptors | Ergot alkaloids | Arithmetic mean | Signaling pathways | Bovine | Relative sperm motility | HUMAN SPERMATOZOA | RAT | INTRACELLULAR CALCIUM | ADENOSINE | DEVELOPMENTAL BIOLOGY | ANTAGONIST ACTIVITY | YEARLING BEEF BULLS | CELL BIOLOGY | IN-VITRO | DIHYDROERGOTAMINE | A2 RECEPTORS | CAPACITATION | Receptors, Adrenergic, alpha - metabolism | Ergot Alkaloids - pharmacology | Male | Chelating Agents - pharmacology | Spermatozoa - drug effects | Yohimbine - pharmacology | Cyclic AMP - pharmacology | Dihydroergotamine - pharmacology | Sperm Motility - drug effects | Animals | Egtazic Acid - pharmacology | Receptors, Adrenergic, alpha - drug effects | Cyclic AMP - analogs & derivatives | Signal Transduction - drug effects | Sperm Motility - physiology | Cattle | Prazosin - pharmacology | Egtazic Acid - analogs & derivatives | Cholera Toxin - pharmacology | Ergotamine - pharmacology | Pertussis Toxin - pharmacology | Index Medicus
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11. Full Text Pharmacology of Dihydroergotamine and Evidence for Efficacy and Safety in Migraine
by Saper, Joel R and Silberstein, Stephen
Headache: The Journal of Head and Face Pain, ISSN 0017-8748, 11/2006, Volume 46, Issue 4, pp. S171 - S181
Dihydroergotamine mesylate (DHE), an ergot alkaloid, has been extensively utilized and studied in the treatment of episodic and chronic migraine. This article... 
safety | tolerability | pharmacology | ergotamine tartrate | efficacy | dihydroergotamine mesylate | migraine headache | Ergotamine tartrate | Migraine headache | Dihydroergotamine mesylate | Efficacy | Pharmacology | Tolerability | Safety | DHE | NASAL SPRAY | BIOAVAILABILITY | CLINICAL NEUROLOGY | REPETITIVE INTRAVENOUS DIHYDROERGOTAMINE | INTRAMUSCULAR DIHYDROERGOTAMINE | PHARMACOKINETICS | HEADACHE | SUBCUTANEOUS DIHYDROERGOTAMINE | HEALTHY-VOLUNTEERS | Analgesics, Non-Narcotic - pharmacokinetics | Dihydroergotamine - chemistry | Analgesics, Non-Narcotic - adverse effects | Dihydroergotamine - adverse effects | Humans | Dihydroergotamine - pharmacokinetics | Chronic Disease | Migraine Disorders - drug therapy | Analgesics, Non-Narcotic - chemistry | Migraine | Analysis
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12. Full Text Effect of ergot alkaloids on contractility of bovine right ruminal artery and vein
by Foote, A.P and Harmon, D.L and Strickland, J.R and Bush, L.P and Klotz, J.L
Journal of Animal Science, ISSN 0021-8812, 09/2011, Volume 89, Issue 9, pp. 2944 - 2949
Ergot alkaloids produced by the endophyte (Neotyphodium coenophialum) associated with tall fescue (Lolium arundinaceum) are implicated in the clinical signs of... 
Fescue toxicosis | Ergot alkaloid | Bovine | Ruminal artery and vein | Vasoconstriction | ruminal artery and vein | AGRICULTURE, DAIRY & ANIMAL SCIENCE | ergot alkaloid | INVITRO | CATTLE | BEEF HEIFERS | BIOASSAY | RESPONSES | GRASS | bovine | vasoconstriction | ERGOVALINE | INFECTED TALL FESCUE | CAUDAL ARTERY | fescue toxicosis | Ergot Alkaloids - pharmacology | Arteries - drug effects | Ergotamines - pharmacology | Vasoconstriction - drug effects | Dose-Response Relationship, Drug | Veins - drug effects | Lolium - microbiology | Animals | Cattle | Lysergic Acid - pharmacology | Muscle Contraction - drug effects | Endophytes | Ergonovine - pharmacology | Female | Rumen - blood supply | Ergotamine - pharmacology | Ergolines - pharmacology | Muscle, Smooth, Vascular - drug effects | Physiological aspects | Alkaloids | Rumen | Research | Index Medicus
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13. Full Text Pharmacological evidence that 5-HT1A/1B/1D, α2-adrenoceptors and D2-like receptors mediate ergotamine-induced inhibition of the vasopressor sympathetic outflow in pithed rats
by Villamil-Hernández, Ma. Trinidad and Alcántara-Vázquez, Oscar and Sánchez-López, Araceli and Gutiérrez-Lara, Erika J and Centurión, David
European Journal of Pharmacology, ISSN 0014-2999, 10/2014, Volume 740, pp. 512 - 521
The sympathetic nervous system that innervates the peripheral circulation is regulated by several mechanisms/receptors. It has been reported that prejunctional... 
GR 127935 | D2-like | Ergotamine | α2-adrenoceptors | Sympatho-inhibition | WAY 100635 | α | D | like | adrenoceptors | Vasoconstrictor Agents - pharmacology | Norepinephrine - pharmacology | Gallamine Triethiodide - pharmacology | Rats, Wistar | Receptors, Adrenergic, alpha-2 - metabolism | Male | Receptors, Dopamine D2 - metabolism | Receptors, Serotonin, 5-HT1 - metabolism | Heart Rate - drug effects | Desipramine - pharmacology | Animals | Blood Pressure - drug effects | Ergotamine - pharmacology | adrenoceptors No items selected
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