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Journal of Organic Chemistry, ISSN 0022-3263, 09/2018, Volume 83, Issue 17, pp. 9580 - 9591
Targeting essential bacterial processes beyond cell wall, protein, nucleotide, and folate syntheses holds promise to reveal new antimicrobial agents and expand... 
MYCOBACTERIUM-TUBERCULOSIS | 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE | ISOPRENOID BIOSYNTHESIS | PATHWAY | PLASMODIUM-FALCIPARUM | FOSMIDOMYCIN ANALOGS | ENZYMES | DIPHOSPHATE | CHEMISTRY, ORGANIC | CYTIDYLTRANSFERASE | ANTIMALARIAL TARGET | Index Medicus
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Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 03/2013, Volume 23, Issue 6, pp. 1643 - 1647
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MedChemComm, ISSN 2040-2503, 2013, Volume 4, Issue 1, pp. 130 - 134
Stable IspF substrate analogs were synthesized. In the presence of substrate analogs, the E. coli IspF-MEP complex shows activities distinct from IspF, and... 
TARGET | CHEMISTRY, MEDICINAL | ENZYME | PHOSPHONATE | ISOPRENOID BIOSYNTHESIS | PHOSPHORAMIDATE PRODRUG | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | NON-MEVALONATE PATHWAY | INHIBITORS | DERIVATIVES | 2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE
Journal Article
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Plant, Cell & Environment, ISSN 0140-7791, 02/2013, Volume 36, Issue 2, pp. 429 - 437
The methylerythritol phosphate (MEP) pathway in plants produces the prenyl precursors for all plastidic isoprenoids, including carotenoids and quinones. The... 
MEP pathway | isoprenoids | methylerythritol cyclodiphosphate (MEcDP) | hydroxymethylbutenyl diphosphate synthase (HDS) | dimethylallyl diphosphate (DMADP) | Hydroxymethylbutenyl diphosphate synthase (HDS) | Dimethylallyl diphosphate (DMADP) | Methylerythritol cyclodiphosphate (MEcDP) | Isoprenoids | DIFFERENT ENVIRONMENTAL-CONDITIONS | CHLOROPLASTS | NON-MEVALONATE PATHWAY | 4FE-4S PROTEIN | PLANT SCIENCES | ASPEN LEAVES | BIOSYNTHESIS | DIPHOSPHATE SYNTHASE GCPE | EMISSION | 2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE | Darkness | Erythritol - analogs & derivatives | Erythritol - chemistry | Populus - radiation effects | Chromatography, High Pressure Liquid | Acclimatization - radiation effects | Hemiterpenes - metabolism | Reference Standards | Time Factors | Light | Mass Spectrometry | Populus - metabolism | Nitrogen - pharmacology | Erythritol - metabolism | Plant Leaves - drug effects | Fosfomycin - analogs & derivatives | Pentanes - metabolism | Metabolome - radiation effects | Fosfomycin - pharmacology | Plant Extracts | Plant Leaves - radiation effects | Metabolome - drug effects | Plant Leaves - metabolism | Butadienes - metabolism | Metabolic Networks and Pathways - drug effects | Acclimatization - drug effects | Metabolic Networks and Pathways - radiation effects | Phosphates | Hydrogen sulfide | Carotenoids | Metabolites | Phytochemistry | Quinone | Nitriles | Mass spectrometry | Index Medicus
Journal Article
Science, ISSN 0036-8075, 10/2010, Volume 330, Issue 6000, pp. 70 - 74
Taxol (paclitaxel) is a potent anticancer drug first isolated from the Taxus brevifolia Pacific yew tree. Currently, cost-efficient production of Taxol and its... 
Enzymes | Cellular metabolism | Terpenoids | Chemical engineering | Bioreactors | Plasmids | REPORTS | Operons | Biosynthesis | Indoles | Streams | YEAST | CYTOCHROME-P450 | TAXADIENE | CELLS | MULTIDISCIPLINARY SCIENCES | CONSTRUCTION | BIOSYNTHETIC GENES | STEP | OXYGENASES | LYCOPENE PRODUCTION | TERPENOIDS | Metabolomics | NADPH-Ferrihemoprotein Reductase - genetics | Erythritol - analogs & derivatives | Cytochrome P-450 Enzyme System - metabolism | Taxoids - metabolism | Organophosphorus Compounds - metabolism | Recombinant Fusion Proteins - metabolism | Farnesyltranstransferase - metabolism | Escherichia coli K12 - metabolism | Hemiterpenes - metabolism | Indoles - metabolism | Terpenes - metabolism | Erythritol - metabolism | Isomerases - genetics | Diterpenes - metabolism | NADPH-Ferrihemoprotein Reductase - metabolism | Paclitaxel - biosynthesis | Oxidation-Reduction | Fermentation | Taxus - enzymology | Metabolic Networks and Pathways - genetics | Genetic Engineering | Sugar Phosphates - metabolism | Farnesyltranstransferase - genetics | Cytochrome P-450 Enzyme System - genetics | Isomerases - metabolism | Escherichia coli K12 - genetics | Alkenes - metabolism | Escherichia coli K12 - enzymology | Physiological aspects | Research | Health aspects | Escherichia coli | Biological transport | Biochemistry | Pharmacology | E coli | Drugs | Pathways | Searching | Taxol | Modules | Modular | Pacific yew | Optimization | Index Medicus
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