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Circulation research, ISSN 1524-4571, 2018, Volume 122, Issue 10, pp. 1369 - 1384
RATIONALE:Macrophages face a substantial amount of cholesterol following the ingestion of apoptotic cells and the lysosomal acid lipase (LIPA) has a major role... 
CLEARANCE | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | oxysterols | STORAGE DISEASE | mitochondria | MACROPHAGE FOAM CELLS | macrophage | NLRP3 INFLAMMASOME | AUTOPHAGY | inflammation | APOPTOTIC CELLS | CALCIUM | cholesterol | PERIPHERAL VASCULAR DISEASE | ACID LIPASE | HEMATOLOGY | CORONARY-ARTERY-DISEASE | Cholesterol Esters - metabolism | Inflammasomes - metabolism | Sterol Esterase - metabolism | Inflammation - metabolism | Lysosomes - metabolism | Biological Transport | Oxysterols - metabolism | Lymphocytes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Mice, Inbred C57BL | Receptors, LDL - metabolism | Neuropeptides - metabolism | Liver X Receptors - metabolism | Mitochondria - metabolism | Splenomegaly - metabolism | Cholesterol - metabolism | Hydrolysis | Macrophages - metabolism | Animals | Erythrocytes - metabolism | Sterol Esterase - antagonists & inhibitors | Mice | Hypercholesterolemia - metabolism | rac1 GTP-Binding Protein - metabolism | Apoptosis | Usage | Lysosomes | Research | Macrophages | Health aspects | Cholesterol | Spleen | Splenomegaly | Oxidative stress | Liver diseases | Liver X receptors | Erythrocytes | Caspase | Esters | Rac1 protein | Inflammation | Botulinum toxin | Caspase-1 | Mitochondria | Pyrin protein | Hypercholesterolemia | Lymphocytes | LipA protein
Journal Article
Nature medicine, ISSN 1546-170X, 2016, Volume 22, Issue 8, pp. 945 - 951
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 06/2005, Volume 25, Issue 12, pp. 5205 - 5214
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 02/2012, Volume 302, Issue 4, pp. C644 - C651
Borst O, Abed M, Alesutan I, Towhid ST, Qadri SM, Foller M, Gawaz M, Lang F. Dynamic adhesion of eryptotic erythrocytes to endothelial cells via... 
Scavenger receptor binding phosphatidylserine and oxidized low-density lipoprotein | Eryptosis | Phosphatidylserine | Endothelium | endothelium | CHEMOKINE LIGAND-16 | PHYSIOLOGY | CATION CONDUCTANCE | SR-PSOX | INFECTED ERYTHROCYTES | CELL BIOLOGY | phosphatidylserine | eryptosis | SCAVENGER RECEPTOR | DISINTEGRIN | scavenger receptor binding phosphatidylserine and oxidized low-density lipoprotein | RED-BLOOD-CELLS | PHOSPHATIDYLSERINE EXPOSURE | SUICIDAL DEATH | EXPRESSION | Endothelium, Vascular - cytology | RNA, Small Interfering - genetics | Antibodies - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Calcium - metabolism | Humans | Receptors, Scavenger - antagonists & inhibitors | Human Umbilical Vein Endothelial Cells - cytology | Erythrocytes - cytology | Cell Membrane - metabolism | Receptors, Scavenger - metabolism | Chemokines, CXC - antagonists & inhibitors | Chemokine CXCL16 | Rheology | Phosphatidylserines - metabolism | Gene Silencing | Cell Size | Chemokines, CXC - genetics | Cell Adhesion | Glucose - deficiency | Annexin A5 - metabolism | Cell Death - physiology | Receptors, Scavenger - genetics | Endothelium, Vascular - metabolism | Chemokines, CXC - metabolism | Erythrocytes - metabolism | Ionomycin - metabolism | Calcium Ionophores - metabolism | Cytosol - metabolism | Erythrocyte Count | RNA, Small Interfering - metabolism | Research | Properties | Cell adhesion | Erythrocytes
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2017, Volume 114, Issue 46, pp. E9989 - E9998
Prior RNA sequencing (RNA-seq) studies have identified complete transcriptomes for most renal epithelial cell types. The exceptions are the cell types that... 
Principal cell | Intercalated cell | Systems biology | Kidney | systems biology | principal cell | PROTEIN | SODIUM-TRANSPORT | RAT-KIDNEY | ATPASE | MULTIDISCIPLINARY SCIENCES | intercalated cell | RECEPTOR | kidney | EPITHELIUM | GENE-EXPRESSION | VASOPRESSIN | INTERCALATED CELLS | MICE | Identification and classification | Transcription factors | Research | Biological Sciences | PNAS Plus
Journal Article
Nature communications, ISSN 2041-1723, 2018, Volume 9, Issue 1, pp. 825 - 12
STIM1 and Orai1 are key components of the Ca2+-release activated Ca2+ (CRAC) current. Orai1, which represents the subunit forming the CRAC channel complex, is... 
CHANNEL FUNCTION | OPERATED CALCIUM-ENTRY | ORAI CHANNELS | MULTIDISCIPLINARY SCIENCES | MUTATION | CA2+ SENSOR | STORE | INTERACTION MOLECULE-1 STIM1 | PLASMA-MEMBRANE | SAM DOMAIN | CRAC CHANNEL | Calcium - metabolism | Dyslexia - metabolism | Humans | Dyslexia - pathology | Green Fluorescent Proteins - genetics | Calcium - chemistry | ORAI1 Protein - chemistry | Migraine Disorders - pathology | Stromal Interaction Molecule 1 - chemistry | Neoplasm Proteins - genetics | Binding Sites | Blood Platelet Disorders - genetics | ORAI1 Protein - metabolism | Amino Acid Sequence | Gene Expression | Models, Molecular | Recombinant Proteins - chemistry | Neoplasm Proteins - chemistry | Patch-Clamp Techniques | Migraine Disorders - genetics | Miosis - pathology | Luminescent Proteins - genetics | Muscle Fatigue - genetics | Miosis - metabolism | Blood Platelet Disorders - pathology | Ichthyosis - metabolism | Protein Multimerization | Erythrocytes, Abnormal - metabolism | Neoplasm Proteins - metabolism | Stromal Interaction Molecule 1 - genetics | Migraine Disorders - metabolism | Ichthyosis - pathology | Miosis - genetics | HEK293 Cells | Ichthyosis - genetics | Ion Transport | Protein Interaction Domains and Motifs | Spleen - pathology | Genes, Reporter | Recombinant Proteins - metabolism | Green Fluorescent Proteins - metabolism | Protein Conformation, alpha-Helical | ORAI1 Protein - genetics | Bacterial Proteins - genetics | Gene Expression Regulation | Recombinant Proteins - genetics | Spleen - abnormalities | Dyslexia - genetics | Point Mutation | Stromal Interaction Molecule 1 - metabolism | Erythrocytes, Abnormal - pathology | Spleen - metabolism | Protein Binding | Bacterial Proteins - metabolism | Blood Platelet Disorders - metabolism | Amino Acid Substitution | Luminescent Proteins - metabolism | Calcium channels | STIM1 protein | Activation | Exposure | Orai1 protein | Elongation | Calcium ions
Journal Article
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 2017, Volume 18, Issue 9, p. 1932
Sepsis induces a wide range of effects on the red blood cell (RBC). Some of the effects including altered metabolism and decreased 2,3-bisphosphoglycerate... 
Erythrocyte | Morphology and microcirculation | Sepsis | Rheology | RAT SKELETAL-MUSCLE | morphology and microcirculation | OXIDATIVE STRESS | rheology | INTRACELLULAR CALCIUM HOMEOSTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO P50 | DEPENDENT HYPOXIC VASODILATION | CHEMISTRY, MULTIDISCIPLINARY | erythrocyte | RESPIRATORY-DISTRESS-SYNDROME | SEPTIC SHOCK | RED-BLOOD-CELL | HYDROGEN-PEROXIDE | CRITICALLY-ILL PATIENTS | sepsis | Oxidative Stress | Calcium - metabolism | Antioxidants - metabolism | Humans | Critical Illness | Erythrocyte Indices | Oxygen - metabolism | Microcirculation | Sepsis - pathology | Sepsis - metabolism | Adenosine Triphosphate - metabolism | Cell Shape | Erythrocytes - pathology | Membrane Proteins - metabolism | 2,3-Diphosphoglycerate - metabolism | Neutrophils - metabolism | Disease Models, Animal | Oxidation-Reduction | Cell Survival | Endothelial Cells - metabolism | Erythrocyte Membrane - metabolism | Hemoglobins - metabolism | Cell Size | Animals | Erythrocytes - metabolism | Protein Binding | Virulence Factors - metabolism | Erythrocyte Deformability | Sepsis - blood | Sepsis - microbiology | Efflux | Deformability | Calcium (intracellular) | Deformation mechanisms | Virulence | Blood cells | Erythrocytes | Homeostasis | Formability | Phospholipids | Metabolism | Membrane proteins | Antioxidants | Proteins | Autoxidation | Virulence factors | Hemoglobin | Hypoxia | Bacteria | Microvasculature | ATP | Adenosine triphosphate | Calcium homeostasis
Journal Article