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BioImpacts, ISSN 2228-5660, 12/2018, Volume 8, Issue Suppl 1, pp. S1 - S129
Journal Article
Blood, ISSN 0006-4971, 07/2013, Volume 122, Issue 3, pp. 376 - 385
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2017, Volume 12, Issue 1, p. e0171096
Recently, we developed a small molecule responsive hyperactive Mpl-based Cell Growth Switch (CGS) that drives erythropoiesis associated with macrophages in the... 
CELLS | ERYTHROBLASTIC ISLANDS | PROTEIN EMP | HOMEOSTASIS | DEFINITIVE ERYTHROPOIESIS | MULTIDISCIPLINARY SCIENCES | FUNCTIONAL-CHARACTERIZATION | PERIPHERAL-BLOOD | PROLIFERATION | ENUCLEATION | EXPRESSION | Antigens, CD34 - metabolism | Bone Marrow Cells - cytology | Monocytes - cytology | Coculture Techniques | Humans | Culture Media, Conditioned - pharmacology | Erythroid Cells - cytology | Fetal Blood - cytology | Macrophages - cytology | Cell Division - drug effects | Gene Expression Regulation - drug effects | Monocytes - drug effects | Granulocyte Colony-Stimulating Factor - pharmacology | Erythroid Cells - drug effects | Cell Differentiation - drug effects | Cell Communication - drug effects | Bone Marrow Cells - drug effects | Macrophages - drug effects | Cell Proliferation - drug effects | Erythroblasts - drug effects | Vascular Cell Adhesion Molecule-1 - metabolism | Erythroblasts - cytology | Fetal blood | Physiological aspects | Bone marrow cells | Macrophages | Growth | CD4 lymphocytes | Erythropoiesis | Cell culture | Transplants & implants | Blood | Cell growth | Granulocyte colony-stimulating factor | Cord blood | Cell adhesion | Peripheral blood | Bone marrow | Fibroblasts | Conditioning | Islands | CD34 antigen | Medical research | Cytokines | Cultures | Gene expression | Erythroid cells | Studies | CD163 antigen | Monocytes | Erythroblasts | Cell number | Proteomics | Stem cells | Cancer
Journal Article
Cell Stem Cell, ISSN 1934-5909, 01/2009, Volume 4, Issue 1, pp. 62 - 72
Journal Article
Cancer Cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 584 - 596
We report a Jak2V617F knockin mouse myeloproliferative neoplasm (MPN) model resembling human polycythemia vera (PV). The MPN is serially transplantable and we... 
CELLCYCLE | MYELOFIBROSIS | MURINE MODEL | POLYCYTHEMIA-VERA | ACTIVATING MUTATION | ONCOLOGY | TYROSINE KINASE JAK2 | CONDITIONAL EXPRESSION | MYELOID-LEUKEMIA | DISORDERS | QUIESCENT | ESSENTIAL THROMBOCYTHEMIA | CELL BIOLOGY | Erythropoietin - pharmacology | Gene Expression - genetics | Cell Count | Humans | Hematocrit | Hematopoietic Stem Cells - pathology | Polycythemia Vera - genetics | Gene Expression Profiling | Myeloproliferative Disorders - pathology | Spleen - drug effects | Antigens, CD - metabolism | Bone Marrow Transplantation | Megakaryocyte-Erythroid Progenitor Cells - transplantation | Polycythemia Vera - pathology | Janus Kinase 2 - antagonists & inhibitors | Disease Models, Animal | Megakaryocyte-Erythroid Progenitor Cells - metabolism | Hematopoietic Stem Cell Transplantation | Mice, Transgenic | Myeloid Progenitor Cells - pathology | Megakaryocyte-Erythroid Progenitor Cells - drug effects | Sulfonamides - pharmacology | Megakaryocyte Progenitor Cells - metabolism | Erythroid Precursor Cells - pathology | Survival Analysis | Erythroid Precursor Cells - metabolism | Mice | Megakaryocyte Progenitor Cells - pathology | Myeloproliferative Disorders - genetics | Pyrrolidines - pharmacology | Pyrrolidines - therapeutic use | Cell Differentiation - genetics | Janus Kinase 2 - metabolism | Bone Marrow Cells - drug effects | Spleen - pathology | Hematopoietic Stem Cells - drug effects | Myeloid Progenitor Cells - metabolism | Mice, Inbred C57BL | Janus Kinase 2 - genetics | Hematopoietic Stem Cells - metabolism | Myeloproliferative Disorders - drug therapy | Animals | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Bone Marrow - pathology | Heterozygote | Protein Kinase Inhibitors - pharmacology | Amino Acid Substitution | Megakaryocyte-Erythroid Progenitor Cells - pathology | Physiological aspects | Medical colleges | Analysis | Hematopoietic stem cells | Tumors
Journal Article
Journal Article
Autophagy, ISSN 1554-8627, 06/2016, Volume 12, Issue 6, pp. 936 - 948
Journal Article
Experimental Hematology, ISSN 0301-472X, 2013, Volume 41, Issue 2, pp. 155 - 166.e17
Red cell production is primarily determined by the action of erythropoietin. Additional erythropoiesis-regulatory factors include molecules and cellular... 
Hematology, Oncology and Palliative Medicine | Advanced Basic Science | GLOBIN GENE-EXPRESSION | SYSTEM | MEDICINE, RESEARCH & EXPERIMENTAL | PROTEIN | HEMATOPOIESIS | VEGF | BONE-MARROW | PROLIFERATION | GROWTH-FACTOR | ANEMIA | HEMATOLOGY | ERYTHROID PROGENITORS | Erythroid Precursor Cells - drug effects | Cells, Cultured - cytology | Humans | Culture Media, Conditioned - chemistry | Activin Receptors, Type II - antagonists & inhibitors | Blood Cells - metabolism | Erythropoiesis - drug effects | Gene Expression Profiling | K562 Cells - drug effects | Recombinant Fusion Proteins | RNA, Messenger - biosynthesis | Blood Cells - cytology | Stromal Cells - drug effects | Adult | Bone Marrow Cells - drug effects | Colony-Forming Units Assay | Drug Evaluation, Preclinical | Blood Cells - drug effects | Cytokines - genetics | Cells, Cultured - drug effects | Erythroid Precursor Cells - cytology | Bone Marrow Cells - cytology | Cytokines - secretion | Fetal Blood - cytology | Organ Specificity | Erythropoiesis - physiology | K562 Cells - cytology | K562 Cells - metabolism | Erythroid Precursor Cells - metabolism | Ligands | Cells, Cultured - metabolism | In Vitro Techniques | Stromal Cells - physiology | Bone Marrow Cells - metabolism | Cytokines - biosynthesis | Hemoglobin | Osteoporosis | Medical colleges | Erythropoietin | Transforming growth factors
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 07/2012, Volume 92, Issue 1, pp. 123 - 131
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2015, Volume 112, Issue 31, pp. 9638 - 9643
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 2, p. e14733
Background: Differentiation of pluripotent stem cells in vitro provides a powerful means to investigate early developmental fates, including hematopoiesis. In... 
IMMUNOGENICITY | MULTIDISCIPLINARY SCIENCES | EXPANSION | HUMAN FIBROBLASTS | GROWTH-FACTOR | ANEMIA | FLT3 LIGAND | LINES | Myeloid Cells - cytology | Embryonic Stem Cells - metabolism | Antigens, CD34 - metabolism | Induced Pluripotent Stem Cells - drug effects | Induced Pluripotent Stem Cells - physiology | Humans | Myeloid Cells - physiology | Pluripotent Stem Cells - physiology | Cells, Cultured | Cell Size | Hematopoietic Stem Cells - metabolism | Embryonic Stem Cells - physiology | Cell Lineage - physiology | Animals | Cell Differentiation - drug effects | Hematopoietic Stem Cells - cytology | Pluripotent Stem Cells - drug effects | Culture Media - pharmacology | Hematopoietic Stem Cells - physiology | Myeloid Cells - metabolism | Cell Culture Techniques | Culture Media - chemistry | Culture Media, Serum-Free - pharmacology | Induced Pluripotent Stem Cells - cytology | Cell culture | Flow cytometry | Senescence | Laboratories | Oct-4 protein | Differentiation (biology) | Erythrocytes | Embryo cells | Stem cell transplantation | Leukocytes | Kinases | Assaying | Experiments | Blood | Thrombopoietin | Stem cell factor | Red blood cells | Allografts | Immunology | Cord blood | Hematopoiesis | Rodents | Fibroblasts | Bone marrow | Vascular endothelial growth factor | CD34 antigen | Medical research | Food sources | Colonies | Anemia | Fetuses | Gynecology | Runx1 protein | Cultures | Gene expression | Erythroid cells | Cell differentiation | Embryos | Obstetrics | Hemopoiesis | Endothelium | White blood cells | Pathology | Chemotherapy | Stem cells | Animal protein | Ligands | Pluripotency
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e62303
Journal Article
Developmental Biology, ISSN 0012-1606, 01/2012, Volume 361, Issue 2, pp. 245 - 262
The visceral endoderm (VE) is an epithelial tissue in the early postimplantation mouse embryo that encapsulates the pluripotent epiblast distally and the... 
XEN cell | BMP | Hematopoiesis | LIF | Visceral endoderm | AFP | Live imaging | Extraembryonic endoderm | EMBRYONIC-STEM-CELLS | VEGF | DEFINITIVE ENDODERM | DEVELOPMENTAL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITIONS | MOUSE EMBRYO | GENE-EXPRESSION | BONE MORPHOGENETIC PROTEIN-4 | DIFFERENTIATION | LINEAGE SEGREGATION | ALPHA-FETOPROTEIN | Body Patterning - drug effects | Oligonucleotide Array Sequence Analysis | Viscera - cytology | Erythroid Precursor Cells - drug effects | Endoderm - embryology | Viscera - embryology | Epithelium - embryology | Endoderm - cytology | Cell Polarity - drug effects | Extraembryonic Membranes - embryology | Epithelium - drug effects | Green Fluorescent Proteins - metabolism | Erythroid Precursor Cells - cytology | Epithelium - metabolism | Extraembryonic Membranes - cytology | Gene Expression Regulation, Developmental - drug effects | Signal Transduction - genetics | Viscera - drug effects | Down-Regulation - drug effects | Leukemia Inhibitory Factor - pharmacology | Bone Morphogenetic Protein 4 - pharmacology | Cell Shape - drug effects | Up-Regulation - drug effects | Animals | Signal Transduction - drug effects | Endoderm - drug effects | Erythroid Precursor Cells - metabolism | Mice | Body Patterning - genetics | Extraembryonic Membranes - drug effects | Bone morphogenetic proteins | live imaging | hematopoiesis | extraembryonic endoderm | visceral endoderm
Journal Article