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Nature, ISSN 0028-0836, 09/2017, Volume 549, Issue 7672, pp. 389 - 393
The pathophysiology of neurodegenerative diseases is poorly understood and there are few therapeutic options. Neurodegenerative diseases are characterized by... 
DENDRITIC CELLS | PATTERN | LANGERHANS CELL HISTIOCYTOSIS | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | KINASE | MICE | MODEL | ERDHEIM-CHESTER-DISEASE | EXPRESSION | Microglia - metabolism | Clone Cells - enzymology | Humans | Male | Myeloid Progenitor Cells - enzymology | Extracellular Signal-Regulated MAP Kinases - metabolism | MAP Kinase Signaling System | Erythroid Precursor Cells - enzymology | Histiocytosis - pathology | Microglia - pathology | Female | Proto-Oncogene Proteins B-raf - metabolism | Disease Models, Animal | Histiocytosis - enzymology | Myeloid Progenitor Cells - metabolism | Neurodegenerative Diseases - pathology | Macrophages - pathology | Microglia - enzymology | Neurodegenerative Diseases - genetics | Myeloid Progenitor Cells - pathology | Histiocytosis - metabolism | Neurodegenerative Diseases - metabolism | Clone Cells - metabolism | Macrophages - enzymology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Erythroid Precursor Cells - pathology | Macrophages - metabolism | Animals | Clone Cells - pathology | Proto-Oncogene Proteins B-raf - genetics | Histiocytosis - genetics | Erythroid Precursor Cells - metabolism | Mosaicism | Mice | Mutation | Neurodegenerative Diseases - enzymology | Physiological aspects | Nervous system | Development and progression | Degeneration | Genetic aspects | Research | Histiocytosis | Mitogen-activated protein kinases | Intervention | Disease | Stem cell transplantation | Activation | Genomes | Kinases | Macrophages | Neuronal-glial interactions | Genotype & phenotype | Allografts | Neurodegeneration | Rodents | Bone marrow | Ataxia | Alzheimer's disease | Myeloid cells | Cytokines | Neurodegenerative diseases | Fetuses | Extracellular signal-regulated kinase | MAP kinase | Cell lineage | Gene expression | Patients | Amyloid precursor protein | Microglia | Organogenesis | Diseases | Neurological diseases | Gliosis | Stem cells | Neural stem cells
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2006, Volume 103, Issue 16, pp. 6224 - 6229
Although a large proportion of patients with polycythemia vera (PV) harbor a valine-to-phenylalanine mutation at amino acid 617 (V617F) in the JAK2 signaling... 
Intermediate uveitis | Receptors | Phenotypes | Stem cells | Bone marrow | Progenitor cells | Genetic mutation | Sequencing | Hematopoietic stem cells | Blood | Mutant allele | Cell fate | JAK | Signaling progenitors | PROGENITOR CELLS | signaling | COLONY-STIMULATING FACTOR | cell fate | MULTIDISCIPLINARY SCIENCES | ACUTE MYELOGENOUS LEUKEMIA | BCR-ABL | ACUTE MYELOID-LEUKEMIA | ESSENTIAL THROMBOCYTHEMIA | CANCER | GRANULOCYTE-MACROPHAGE | progenitors | mutant allele | CHRONIC MYELOPROLIFERATIVE DISORDERS | TYROSINE KINASE JAK2 | ADP-ribosyl Cyclase 1 - analysis | Antigens, CD34 - analysis | Humans | Polycythemia Vera - genetics | Erythroid Precursor Cells - enzymology | Janus Kinase 2 | Valine - chemistry | Protein-Tyrosine Kinases - genetics | Phenylalanine - chemistry | Hematopoietic Stem Cells - chemistry | Proto-Oncogene Proteins - antagonists & inhibitors | Erythroid Precursor Cells - cytology | Polycythemia Vera - enzymology | Hematopoiesis - genetics | Proto-Oncogene Proteins - genetics | Tyrphostins - pharmacology | Point Mutation | Phenylalanine - genetics | Hematopoietic Stem Cells - cytology | Amino Acid Substitution - genetics | Valine - genetics | Protein Kinase Inhibitors - pharmacology | Hematopoietic Stem Cells - enzymology | Thy-1 Antigens - analysis | Protein-Tyrosine Kinases - antagonists & inhibitors | Mutation (Biology) | Research | Biological Sciences
Journal Article
PloS one, ISSN 1932-6203, 2009, Volume 4, Issue 12, pp. e8446 - 12
Journal Article
Journal Article
British Journal of Haematology, ISSN 0007-1048, 01/2013, Volume 160, Issue 2, pp. 177 - 187
Summary Aberrant JAK2 signalling plays an important role in the aetiology of myeloproliferative neoplasms (MPNs). JAK2 inhibitors, however, do not readily... 
myeloproliferative neoplasms | cholesterol | lipid raft | statin | JAK2‐V617F | JAK2-V617F | Lipid raft | Statin | Cholesterol | Myeloproliferative neoplasms | METHYL-BETA-CYCLODEXTRIN | POLYCYTHEMIA-VERA | CONSTITUTIVE ACTIVATION | DISORDERS | ESSENTIAL THROMBOCYTHEMIA | PLASMA-MEMBRANE | CYTOKINE RECEPTOR | MUTATION | TYROSINE KINASE JAK2 | HEMATOLOGY | Myeloproliferative Disorders - enzymology | Apoptosis - drug effects | Erythroid Precursor Cells - drug effects | Cholesterol - physiology | Humans | Cell Line, Tumor - drug effects | Leukemia, Megakaryoblastic, Acute - enzymology | Mutation, Missense | K562 Cells - drug effects | Simvastatin - pharmacology | beta-Cyclodextrins - pharmacology | Erythroid Precursor Cells - enzymology | Myeloproliferative Disorders - blood | STAT5 Transcription Factor - metabolism | Protein Processing, Post-Translational - drug effects | Cholesterol - analysis | Colony-Forming Units Assay | Janus Kinase 2 - physiology | Phosphorylation - drug effects | Drug Evaluation, Preclinical | Leukemia, Erythroblastic, Acute - enzymology | Megakaryocyte Progenitor Cells - drug effects | Cells, Cultured - drug effects | Cell Line, Tumor - enzymology | Janus Kinase 2 - genetics | Membrane Lipids - physiology | Cells, Cultured - enzymology | K562 Cells - enzymology | Point Mutation | Signal Transduction - drug effects | Leukemia, Erythroblastic, Acute - pathology | Membrane Microdomains - drug effects | Megakaryocyte Progenitor Cells - enzymology | Membrane Microdomains - physiology | Leukemia, Megakaryoblastic, Acute - pathology | Development and progression | Statins | Hypercholesterolemia
Journal Article
Developmental Dynamics, ISSN 1058-8388, 12/2017, Volume 246, Issue 12, pp. 1001 - 1014
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e62303
Journal Article
Molecular Systems Biology, ISSN 1744-4292, 12/2009, Volume 5, Issue 1, pp. 334 - n/a
Journal Article
Blood, ISSN 0006-4971, 05/2003, Volume 101, Issue 9, pp. 3436 - 3443
The production of red blood cells is tightly regulated by erythropoietin (Epo). The phosphoinositide 3-kinase (Pi 3-kinase) pathway was previously shown to be... 
HEMATOPOIETIC-CELLS | SIGNAL-TRANSDUCTION | ACTIVATED PROTEIN-KINASE | TYROSINE PHOSPHORYLATION | PHOSPHATIDYLINOSITOL 3-KINASE | RECEPTOR | PHOSPHOINOSITIDE 3-KINASES | T-CELL | HEMATOLOGY | TRANSCRIPTION FACTOR | P27(KIP1) | Erythropoietin - pharmacology | Erythroid Precursor Cells - drug effects | Cells, Cultured - cytology | Humans | Protein-Serine-Threonine Kinases | Multienzyme Complexes - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proteasome Endopeptidase Complex | Chromones - pharmacology | Infant, Newborn | Cells, Cultured - drug effects | Erythroid Precursor Cells - cytology | Tumor Suppressor Proteins - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Cell Cycle Proteins - metabolism | Enzyme Inhibitors - pharmacology | Fetal Blood - cytology | Erythropoietin - physiology | Cells, Cultured - enzymology | Ubiquitin-Protein Ligases | Adaptor Proteins, Signal Transducing | Signal Transduction - drug effects | Forkhead Box Protein O1 | Mice | Protein Processing, Post-Translational | Forkhead Box Protein O3 | Forkhead Transcription Factors | Phosphorylation | Phosphoproteins - metabolism | MAP Kinase Signaling System | DNA-Binding Proteins - metabolism | Erythroid Precursor Cells - enzymology | Cysteine Endopeptidases - metabolism | Cell Division | Insulin Receptor Substrate Proteins | Proto-Oncogene Proteins - metabolism | Cell Survival | Intracellular Signaling Peptides and Proteins | Ligases - metabolism | Morpholines - pharmacology | Enzyme Activation - drug effects | Sirolimus - pharmacology | Cyclin-Dependent Kinase Inhibitor p27 | Proto-Oncogene Proteins c-akt | Transcription Factors - metabolism | Animals | Phosphatidylinositol 3-Kinases - physiology | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases | Phosphoric Monoester Hydrolases - metabolism | Receptors, Erythropoietin - metabolism | Apoptosis
Journal Article
12.