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Science, ISSN 0036-8075, 09/2016, Volume 353, Issue 6304, pp. aaf4238 - aaf4238
Journal Article
Nature, ISSN 0028-0836, 09/2017, Volume 549, Issue 7672, pp. 389 - 393
The pathophysiology of neurodegenerative diseases is poorly understood and there are few therapeutic options. Neurodegenerative diseases are characterized by... 
DENDRITIC CELLS | PATTERN | LANGERHANS CELL HISTIOCYTOSIS | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | KINASE | MICE | MODEL | ERDHEIM-CHESTER-DISEASE | EXPRESSION | Microglia - metabolism | Clone Cells - enzymology | Humans | Male | Myeloid Progenitor Cells - enzymology | Extracellular Signal-Regulated MAP Kinases - metabolism | MAP Kinase Signaling System | Erythroid Precursor Cells - enzymology | Histiocytosis - pathology | Microglia - pathology | Female | Proto-Oncogene Proteins B-raf - metabolism | Disease Models, Animal | Histiocytosis - enzymology | Myeloid Progenitor Cells - metabolism | Neurodegenerative Diseases - pathology | Macrophages - pathology | Microglia - enzymology | Neurodegenerative Diseases - genetics | Myeloid Progenitor Cells - pathology | Histiocytosis - metabolism | Neurodegenerative Diseases - metabolism | Clone Cells - metabolism | Macrophages - enzymology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Erythroid Precursor Cells - pathology | Macrophages - metabolism | Animals | Clone Cells - pathology | Proto-Oncogene Proteins B-raf - genetics | Histiocytosis - genetics | Erythroid Precursor Cells - metabolism | Mosaicism | Mice | Mutation | Neurodegenerative Diseases - enzymology | Physiological aspects | Nervous system | Development and progression | Degeneration | Genetic aspects | Research | Histiocytosis | Mitogen-activated protein kinases | Intervention | Disease | Stem cell transplantation | Activation | Genomes | Kinases | Macrophages | Neuronal-glial interactions | Genotype & phenotype | Allografts | Neurodegeneration | Rodents | Bone marrow | Ataxia | Alzheimer's disease | Myeloid cells | Cytokines | Neurodegenerative diseases | Fetuses | Extracellular signal-regulated kinase | MAP kinase | Cell lineage | Gene expression | Patients | Amyloid precursor protein | Microglia | Organogenesis | Diseases | Neurological diseases | Gliosis | Stem cells | Neural stem cells
Journal Article
Journal Article
Blood, ISSN 0006-4971, 03/2011, Volume 117, Issue 9, pp. 2567 - 2576
Journal Article
Science, ISSN 0036-8075, 12/2008, Volume 322, Issue 5909, pp. 1839 - 1842
Differences in the amount of fetal hemoglobin (HbF) that persists into adulthood affect the severity of sickle cell disease and the ?-thalassemia syndromes.... 
Protein isoforms | K562 cells | Erythroblasts | Genes | Cell lines | Small interfering RNA | Genetic loci | Reports | Erythroid cells | Gene expression | Hemoglobins | LOCUS-CONTROL REGION | COMPLEX | VARIANTS | MULTIDISCIPLINARY SCIENCES | DISEASE | ZINC-FINGER PROTEIN | DIFFERENTIATION | RECRUITS | BETA-THALASSEMIA | LINEAGE | GENOME-WIDE ASSOCIATION | Erythropoiesis | Fetal Hemoglobin - biosynthesis | Multigene Family | Mi-2 Nucleosome Remodeling and Deacetylase Complex | Humans | Erythroblasts - metabolism | gamma-Globins - metabolism | Protein Isoforms - metabolism | RNA Interference | Transcription, Genetic | gamma-Globins - genetics | Nuclear Proteins - genetics | Down-Regulation | Cells, Cultured | Erythroid Cells - metabolism | Gene Expression Regulation | Histone Deacetylases - metabolism | Nuclear Proteins - metabolism | GATA1 Transcription Factor - metabolism | beta-Globins - genetics | Hemoglobinopathies - therapy | Transcription Factors - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | beta-Globins - metabolism | Fetal Hemoglobin - genetics | K562 Cells | Cell Line, Tumor | Erythroid Precursor Cells - metabolism | Mice | Polymorphism, Single Nucleotide | Protein Isoforms - genetics | Sickle cell anemia | Physiological aspects | Thalassemia | Genetic aspects | Risk factors | Fetal hemoglobin | Medical research | Genotype & phenotype | Hematology | Sickle cell disease
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 584 - 596
We report a knockin mouse myeloproliferative neoplasm (MPN) model resembling human polycythemia vera (PV). The MPN is serially transplantable and we... 
CELLCYCLE | POLYCYTHEMIA-VERA | ACTIVATING MUTATION | ONCOLOGY | IN-VIVO | TYROSINE KINASE JAK2 | CONDITIONAL EXPRESSION | MYELODYSPLASTIC-SYNDROMES | ESSENTIAL THROMBOCYTHEMIA | VERA-LIKE DISEASE | CHRONIC MYELOMONOCYTIC LEUKEMIA | CHRONIC MYELOID-LEUKEMIA | Erythropoietin - pharmacology | Gene Expression - genetics | Cell Count | Humans | Hematocrit | Hematopoietic Stem Cells - pathology | Polycythemia Vera - genetics | Gene Expression Profiling | Myeloproliferative Disorders - pathology | Spleen - drug effects | Antigens, CD - metabolism | Bone Marrow Transplantation | Megakaryocyte-Erythroid Progenitor Cells - transplantation | Polycythemia Vera - pathology | Janus Kinase 2 - antagonists & inhibitors | Disease Models, Animal | Megakaryocyte-Erythroid Progenitor Cells - metabolism | Hematopoietic Stem Cell Transplantation | Mice, Transgenic | Myeloid Progenitor Cells - pathology | Megakaryocyte-Erythroid Progenitor Cells - drug effects | Sulfonamides - pharmacology | Megakaryocyte Progenitor Cells - metabolism | Erythroid Precursor Cells - pathology | Survival Analysis | Erythroid Precursor Cells - metabolism | Mice | Megakaryocyte Progenitor Cells - pathology | Myeloproliferative Disorders - genetics | Pyrrolidines - pharmacology | Pyrrolidines - therapeutic use | Cell Differentiation - genetics | Janus Kinase 2 - metabolism | Bone Marrow Cells - drug effects | Spleen - pathology | Hematopoietic Stem Cells - drug effects | Myeloid Progenitor Cells - metabolism | Mice, Inbred C57BL | Janus Kinase 2 - genetics | Hematopoietic Stem Cells - metabolism | Myeloproliferative Disorders - drug therapy | Animals | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Bone Marrow - pathology | Heterozygote | Protein Kinase Inhibitors - pharmacology | Amino Acid Substitution | Megakaryocyte-Erythroid Progenitor Cells - pathology | Physiological aspects | Medical colleges | Analysis | Hematopoietic stem cells | Tumors
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 31, pp. 12764 - 12771
Eukaryotic cells contain hundreds of metalloproteins that are supported by intracellular systems coordinating the uptake and distribution of metal cofactors.... 
metalloprotein | HUMAN BOLA2 | HEME-BIOSYNTHESIS | DEOXYHYPUSINE HYDROXYLASE | BolA2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | glutaredoxin | SACCHAROMYCES-CEREVISIAE | iron metabolism | molecular chaperone | PHP4 FUNCTION | FERRITIN DEGRADATION | poly C-binding protein | IN-VIVO | GENE-EXPRESSION | iron | iron-sulfur protein | SULFUR CLUSTER | MONOTHIOL GLUTAREDOXIN | Molecular Chaperones - metabolism | Humans | Protein Multimerization | Iron-Sulfur Proteins - chemistry | Molecular Chaperones - chemistry | Nuclear Receptor Coactivators - chemistry | Autophagy | Apoferritins - metabolism | Ferritins - metabolism | Cation Transport Proteins - metabolism | Apoenzymes - metabolism | Carrier Proteins - chemistry | Dimerization | Nuclear Receptor Coactivators - metabolism | Erythroid Precursor Cells - cytology | RNA-Binding Proteins - chemistry | Heterogeneous-Nuclear Ribonucleoproteins - metabolism | Models, Molecular | Apoferritins - chemistry | Iron - metabolism | Protein Transport | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Models, Biological | Heterogeneous-Nuclear Ribonucleoproteins - chemistry | Apoenzymes - chemistry | Erythroid Precursor Cells - metabolism | Cytosol - metabolism | Iron-Sulfur Proteins - metabolism | Proteins - chemistry | Cation Transport Proteins - chemistry | Ferritins - chemistry | RNA-Binding Proteins - metabolism | iron–sulfur protein | Minireviews
Journal Article
Journal Article