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Journal Article
Cancer Cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 584 - 596
We report a knockin mouse myeloproliferative neoplasm (MPN) model resembling human polycythemia vera (PV). The MPN is serially transplantable and we... 
CELLCYCLE | POLYCYTHEMIA-VERA | ACTIVATING MUTATION | ONCOLOGY | IN-VIVO | TYROSINE KINASE JAK2 | CONDITIONAL EXPRESSION | MYELODYSPLASTIC-SYNDROMES | ESSENTIAL THROMBOCYTHEMIA | VERA-LIKE DISEASE | CHRONIC MYELOMONOCYTIC LEUKEMIA | CHRONIC MYELOID-LEUKEMIA | Erythropoietin - pharmacology | Gene Expression - genetics | Cell Count | Humans | Hematocrit | Hematopoietic Stem Cells - pathology | Polycythemia Vera - genetics | Gene Expression Profiling | Myeloproliferative Disorders - pathology | Spleen - drug effects | Antigens, CD - metabolism | Bone Marrow Transplantation | Megakaryocyte-Erythroid Progenitor Cells - transplantation | Polycythemia Vera - pathology | Janus Kinase 2 - antagonists & inhibitors | Disease Models, Animal | Megakaryocyte-Erythroid Progenitor Cells - metabolism | Hematopoietic Stem Cell Transplantation | Mice, Transgenic | Myeloid Progenitor Cells - pathology | Megakaryocyte-Erythroid Progenitor Cells - drug effects | Sulfonamides - pharmacology | Megakaryocyte Progenitor Cells - metabolism | Erythroid Precursor Cells - pathology | Survival Analysis | Erythroid Precursor Cells - metabolism | Mice | Megakaryocyte Progenitor Cells - pathology | Myeloproliferative Disorders - genetics | Pyrrolidines - pharmacology | Pyrrolidines - therapeutic use | Cell Differentiation - genetics | Janus Kinase 2 - metabolism | Bone Marrow Cells - drug effects | Spleen - pathology | Hematopoietic Stem Cells - drug effects | Myeloid Progenitor Cells - metabolism | Mice, Inbred C57BL | Janus Kinase 2 - genetics | Hematopoietic Stem Cells - metabolism | Myeloproliferative Disorders - drug therapy | Animals | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Bone Marrow - pathology | Heterozygote | Protein Kinase Inhibitors - pharmacology | Amino Acid Substitution | Megakaryocyte-Erythroid Progenitor Cells - pathology | Physiological aspects | Medical colleges | Analysis | Hematopoietic stem cells | Tumors | Index Medicus
Journal Article
Journal Article
Blood, ISSN 0006-4971, 07/2013, Volume 122, Issue 3, pp. 376 - 385
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1828 - 14
NOTCH signaling is required for the arterial specification and formation of hematopoietic stem cells (HSCs) and lympho-myeloid progenitors in the embryonic... 
TRANSITION | PROGENITOR | PATHWAY | DIFFERENTIATION CULTURES | MULTIDISCIPLINARY SCIENCES | EMBRYONIC HEMATOPOIETIC STEM | AORTA-GONAD-MESONEPHROS | HAEMOGENIC ENDOTHELIUM | FATE | EMERGENCE | BLOOD-CELLS | Endothelium, Vascular - cytology | Antigens, CD - immunology | Hemangioblasts - cytology | Receptors, Notch - metabolism | Coculture Techniques | Humans | Hemangioblasts - immunology | Arteries - cytology | Arteries - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Lymphoid Progenitor Cells - immunology | Hematopoiesis | Myeloid Progenitor Cells - immunology | Myeloid Progenitor Cells - cytology | Cell Differentiation | Membrane Proteins - metabolism | Erythroid Precursor Cells - immunology | Cell Line | Erythroid Precursor Cells - cytology | Pluripotent Stem Cells - cytology | Pluripotent Stem Cells - immunology | Signal Transduction | Hematopoietic Stem Cells - metabolism | Lymphoid Progenitor Cells - cytology | Cell Lineage | Animals | Embryo, Mammalian - cytology | Endothelium, Vascular - metabolism | Mice | Cell Tracking - instrumentation | Neovascularization, Physiologic | Myeloid cells | Runx1 protein | Erythroid cells | Embryos | Hematopoietic stem cells | Endothelial cells | Molecular chains | Hemopoiesis | Endothelium | Signaling | Specifications | Stem cells | Aorta | CD73 antigen | Notch protein | CD43 antigen | Pluripotency | Index Medicus
Journal Article
Trends in Immunology, ISSN 1471-4906, 03/2019, Volume 40, Issue 3, pp. 181 - 185
The main role of red blood cells is oxygen-transportation. However, recent studies have unveiled immunomodulatory functions for their immature counterparts,... 
immunosuppression | nucleated erythrocytes | CD71+ erythroid cells | immature red blood cells | erythroid cells | CD71 | IMMUNOLOGY | Medical research | Phosphorylation | Cytokines | Anemia | Immunomodulation | Transportation | Blood cells | Erythrocytes | Infections | Roles | Gene expression | Erythroid cells | Whooping cough | Studies | Pregnancy | Cell growth | Red blood cells | Lymphocytes | Rodents
Journal Article
STEM CELLS, ISSN 1066-5099, 04/2017, Volume 35, Issue 4, pp. 886 - 897
Journal Article
Experimental Hematology, ISSN 0301-472X, 2013, Volume 41, Issue 2, pp. 155 - 166.e17
Red cell production is primarily determined by the action of erythropoietin. Additional erythropoiesis-regulatory factors include molecules and cellular... 
Hematology, Oncology and Palliative Medicine | Advanced Basic Science | GLOBIN GENE-EXPRESSION | SYSTEM | MEDICINE, RESEARCH & EXPERIMENTAL | PROTEIN | HEMATOPOIESIS | VEGF | BONE-MARROW | PROLIFERATION | GROWTH-FACTOR | ANEMIA | HEMATOLOGY | ERYTHROID PROGENITORS | Erythroid Precursor Cells - drug effects | Cells, Cultured - cytology | Humans | Culture Media, Conditioned - chemistry | Activin Receptors, Type II - antagonists & inhibitors | Blood Cells - metabolism | Erythropoiesis - drug effects | Gene Expression Profiling | K562 Cells - drug effects | Recombinant Fusion Proteins | RNA, Messenger - biosynthesis | Blood Cells - cytology | Stromal Cells - drug effects | Adult | Bone Marrow Cells - drug effects | Colony-Forming Units Assay | Drug Evaluation, Preclinical | Blood Cells - drug effects | Cytokines - genetics | Cells, Cultured - drug effects | Erythroid Precursor Cells - cytology | Bone Marrow Cells - cytology | Cytokines - secretion | Fetal Blood - cytology | Organ Specificity | Erythropoiesis - physiology | K562 Cells - cytology | K562 Cells - metabolism | Erythroid Precursor Cells - metabolism | Ligands | Cells, Cultured - metabolism | In Vitro Techniques | Stromal Cells - physiology | Bone Marrow Cells - metabolism | Cytokines - biosynthesis | Hemoglobin | Osteoporosis | Medical colleges | Erythropoietin | Transforming growth factors | Index Medicus
Journal Article
Cell Stem Cell, ISSN 1934-5909, 01/2009, Volume 4, Issue 1, pp. 62 - 72
Journal Article
Nature, ISSN 0028-0836, 09/2017, Volume 549, Issue 7672, pp. 389 - 393
The pathophysiology of neurodegenerative diseases is poorly understood and there are few therapeutic options. Neurodegenerative diseases are characterized by... 
DENDRITIC CELLS | PATTERN | LANGERHANS CELL HISTIOCYTOSIS | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | KINASE | MICE | MODEL | ERDHEIM-CHESTER-DISEASE | EXPRESSION | Microglia - metabolism | Clone Cells - enzymology | Humans | Male | Myeloid Progenitor Cells - enzymology | Extracellular Signal-Regulated MAP Kinases - metabolism | MAP Kinase Signaling System | Erythroid Precursor Cells - enzymology | Histiocytosis - pathology | Microglia - pathology | Female | Proto-Oncogene Proteins B-raf - metabolism | Disease Models, Animal | Histiocytosis - enzymology | Myeloid Progenitor Cells - metabolism | Neurodegenerative Diseases - pathology | Macrophages - pathology | Microglia - enzymology | Neurodegenerative Diseases - genetics | Myeloid Progenitor Cells - pathology | Histiocytosis - metabolism | Neurodegenerative Diseases - metabolism | Clone Cells - metabolism | Macrophages - enzymology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Erythroid Precursor Cells - pathology | Macrophages - metabolism | Animals | Clone Cells - pathology | Proto-Oncogene Proteins B-raf - genetics | Histiocytosis - genetics | Erythroid Precursor Cells - metabolism | Mosaicism | Mice | Mutation | Neurodegenerative Diseases - enzymology | Physiological aspects | Nervous system | Development and progression | Degeneration | Genetic aspects | Research | Histiocytosis | Mitogen-activated protein kinases | Intervention | Disease | Stem cell transplantation | Activation | Genomes | Kinases | Macrophages | Neuronal-glial interactions | Genotype & phenotype | Allografts | Neurodegeneration | Rodents | Bone marrow | Ataxia | Alzheimer's disease | Myeloid cells | Cytokines | Neurodegenerative diseases | Fetuses | Extracellular signal-regulated kinase | MAP kinase | Cell lineage | Gene expression | Patients | Amyloid precursor protein | Microglia | Organogenesis | Diseases | Neurological diseases | Gliosis | Stem cells | Neural stem cells | Index Medicus
Journal Article