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Vaccine, ISSN 0264-410X, 2013, Volume 31, Issue 20, pp. 2457 - 2464
Highlights • We developed and tested a new oral ETEC vaccine in mice, alone and with an adjuvant. • The vaccine contains E. coli overexpressing CFA/I, CS3, CS5... 
Allergy and Immunology | Vaccine | Mucosal immunity | Immune responses | ETEC | dmLT | Colonization factors | DmLT | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNITY | DIARRHEA | PREVENTION | IMMUNOLOGY | VIBRIO-CHOLERAE | CELL CHOLERA VACCINE | TRAVELERS | CONSTRUCTION | ENTEROTOXIGENIC ESCHERICHIA-COLI | INTRANASAL IMMUNIZATION | ANTIBODY-RESPONSES | Immunity, Mucosal - immunology | Adjuvants, Immunologic - administration & dosage | Immunoglobulin G - blood | Escherichia coli Infections - prevention & control | Antigens, Bacterial - immunology | Antigens, Bacterial - genetics | Intestines - immunology | Enterotoxins - immunology | Escherichia coli Proteins - administration & dosage | Immunoglobulin G - immunology | Cholera Toxin - immunology | Bacterial Toxins - genetics | Female | Escherichia coli Proteins - immunology | Immunoglobulin G - analysis | Mutant Proteins - immunology | Fimbriae Proteins - immunology | Cholera Toxin - administration & dosage | Antibody Formation - immunology | Vaccines, Inactivated - genetics | Administration, Oral | Bacterial Toxins - immunology | Escherichia coli Infections - microbiology | Enterotoxigenic Escherichia coli - immunology | Escherichia coli Vaccines - administration & dosage | Mutant Proteins - administration & dosage | Enterotoxins - administration & dosage | Vaccines, Inactivated - adverse effects | Enterotoxins - genetics | Vaccines, Inactivated - immunology | Animals | Escherichia coli Vaccines - adverse effects | Fimbriae Proteins - genetics | Vaccines, Inactivated - administration & dosage | Cholera Toxin - genetics | Immunoglobulin A - immunology | Escherichia coli Proteins - genetics | Immunoglobulin A - blood | Bacterial Toxins - administration & dosage | Escherichia coli Infections - immunology | Escherichia coli Vaccines - genetics | Mice | Mice, Inbred BALB C | Escherichia coli Vaccines - immunology | Immunoglobulin A - analysis | Antigens | Safety and security measures | Analysis | Escherichia coli | Bacteria | Vaccines | Contamination | Proteins | Studies | Immunology | E coli | Rodents | Index Medicus | Basic Medicine | Medicinska grundvetenskaper
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2015, Volume 16, Issue 16, pp. 1677 - 1690
Journal Article
Clinical and Vaccine Immunology, ISSN 1556-6811, 04/2011, Volume 18, Issue 4, pp. 546 - 551
Journal Article
Infection and Immunity, ISSN 0019-9567, 2015, Volume 83, Issue 12, pp. 4555 - 4564
Globally, enterotoxigenic Escherichia coli (ETEC) is a leading cause of childhood and travelers' diarrhea, for which an effective vaccine is needed. Prevalent... 
COLONIZATION FACTOR ANTIGENS | HEAT-LABILE TOXIN | INFECTIOUS DISEASES | IMMUNOGENICITY | TRAVELERS DIARRHEA | DNA VACCINE | CFA/I FIMBRIAE | INFANT MOUSE MODEL | DOUBLE-BLIND | IMMUNOLOGY | VIRULENCE | SUBUNIT | Escherichia coli Infections - mortality | Milk - chemistry | Dose-Response Relationship, Immunologic | Immune Sera - chemistry | Escherichia coli Infections - prevention & control | Immunoglobulin A - biosynthesis | Adhesins, Bacterial - genetics | Escherichia coli Infections - genetics | Antibodies, Bacterial - biosynthesis | Escherichia coli Proteins - administration & dosage | Immunoglobulin G - biosynthesis | Cattle | Female | Mice, Inbred DBA | Escherichia coli Proteins - immunology | Fimbriae, Bacterial - immunology | Milk - immunology | Enterotoxigenic Escherichia coli - genetics | Fimbriae Proteins - immunology | Gene Expression | Adhesins, Bacterial - administration & dosage | Enterotoxigenic Escherichia coli - drug effects | Fimbriae, Bacterial - chemistry | Enterotoxigenic Escherichia coli - immunology | Escherichia coli Vaccines - administration & dosage | Pregnancy | Animals | Fimbriae Proteins - genetics | Survival Analysis | Vaccines, Attenuated | Escherichia coli Proteins - genetics | Immunization, Passive | Escherichia coli Infections - immunology | Escherichia coli Vaccines - genetics | Fimbriae Proteins - administration & dosage | Mice | Adhesins, Bacterial - immunology | Escherichia coli Vaccines - immunology | Microbial Immunity and Vaccines
Journal Article
Vaccine, ISSN 0264-410X, 2014, Volume 32, Issue 52, pp. 7077 - 7084
Highlights • We have tested a new oral killed ETEC vaccine ± dmLT adjuvant in Swedish adults. • The vaccine contained E. coli bacteria overexpressing common... 
Allergy and Immunology | Intestinal immunity | Human | IgA | Vaccine | ETEC | dmLT | DmLT | MEDICINE, RESEARCH & EXPERIMENTAL | COLONIZATION FACTORS | BACTERIA | DIARRHEA | VOLUNTEERS | IMMUNOLOGY | TRIAL | INFECTION | ANTIBODY-RESPONSES | CELL | DEVELOPING-COUNTRIES | EPIDEMIOLOGY | Adjuvants, Immunologic - administration & dosage | Escherichia coli Infections - prevention & control | Humans | Immunity, Mucosal | Male | Antibodies, Bacterial - analysis | Young Adult | Sweden | Escherichia coli Proteins - administration & dosage | Adjuvants, Immunologic - genetics | Adult | Bacterial Toxins - genetics | Female | Placebos - administration & dosage | Double-Blind Method | Administration, Oral | Mutant Proteins - genetics | Enterotoxigenic Escherichia coli - immunology | Escherichia coli Vaccines - administration & dosage | Mutant Proteins - administration & dosage | Enterotoxins - administration & dosage | Enterotoxins - genetics | Antibody-Producing Cells - immunology | Feces - chemistry | Escherichia coli Vaccines - adverse effects | Adolescent | Escherichia coli Proteins - genetics | Bacterial Toxins - administration & dosage | Escherichia coli Vaccines - immunology | Immunoglobulin A - analysis | Clinical trials | Bacteria | Safety and security measures | Vaccines | Escherichia coli | Immunologi inom det medicinska området | Medicine | Research & Experimental | Immunology | Immunology in the medical area
Journal Article
by Yu, M and Qi, R and Chen, C and Yin, J and Ma, S and Shi, W and Wu, Y and Ge, J and Jiang, Y and Tang, L and Xu, Y and Li, Y
Journal of Applied Microbiology, ISSN 1364-5072, 02/2017, Volume 122, Issue 2, pp. 506 - 515
Aims The aims of this study were to develop an effective oral vaccine against enterotoxigenic Escherichia coli (ETEC) infection and to design new and more... 
heat‐labile enterotoxin A subunit | Lactobacillus casei | fimbriae adhesin FaeG | heat‐labile enterotoxin B subunit | immunogenicity | heat-labile enterotoxin A subunit | heat-labile enterotoxin B subunit | VIRUS | PROTECTION | VACCINE | MICROBIOLOGY | MUCOSAL | IMMUNIZATION | EPITOPE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IMMUNE-RESPONSES | PIGLETS | SUBUNIT | ANTIGEN | Adjuvants, Immunologic - administration & dosage | Escherichia coli Infections - prevention & control | Immunity, Mucosal | Adhesins, Escherichia coli - genetics | Lymphocytes - immunology | Enterotoxins - immunology | Escherichia coli Proteins - administration & dosage | Swine | Adhesins, Escherichia coli - immunology | Female | Escherichia coli Infections - veterinary | Escherichia coli Proteins - immunology | Lactobacillus casei - genetics | Fimbriae, Bacterial | Specific Pathogen-Free Organisms | Administration, Oral | Bacterial Toxins - immunology | Swine Diseases - immunology | Lymphocytes - cytology | Swine Diseases - prevention & control | Enterotoxigenic Escherichia coli - immunology | Escherichia coli Vaccines - administration & dosage | Enterotoxins - administration & dosage | Animals | Bacterial Toxins - administration & dosage | Escherichia coli Infections - immunology | Mice | Mice, Inbred BALB C | Escherichia coli Vaccines - immunology | Enterotoxigenic Escherichia coli - classification | Toxins | Bacterial infections | Vaccines | E coli | Microbiology
Journal Article
Medical Microbiology and Immunology, ISSN 0300-8584, 02/2019, Volume 208, Issue 1, pp. 89 - 100
Escherichia coli O157:H7 with its traits such as intestinal colonization and fecal-oral route of transmission demands mucosal vaccine development. E. coli... 
E. coli O157 | Immunization | Intranasal administration | Feces | Vaccines | Ruminants | UNITED-STATES | GAMMA | FUSION | III SECRETED PROTEINS | CATTLE | VACCINATION | RECEPTOR | MICROBIOLOGY | IMMUNOLOGY | TIGHT JUNCTIONS | O157/H7 | coli O157 | Adjuvants, Immunologic - administration & dosage | Immunoglobulin G - blood | Escherichia coli Infections - prevention & control | Humans | Immunity, Mucosal | Th2 Cells - immunology | Antibodies, Bacterial - analysis | Feces - microbiology | Bacterial Shedding | Escherichia coli Proteins - administration & dosage | Immunity, Humoral | Escherichia coli Proteins - immunology | Disease Transmission, Infectious | Bacterial Adhesion - drug effects | Antibodies, Bacterial - blood | Caco-2 Cells | Cholera Toxin - administration & dosage | Bacterial Outer Membrane Proteins - immunology | Mutant Proteins - genetics | Bacterial Outer Membrane Proteins - administration & dosage | Escherichia coli Infections - microbiology | Administration, Intranasal | Escherichia coli Vaccines - administration & dosage | Recombinant Proteins - administration & dosage | Mutant Proteins - administration & dosage | Animals | Recombinant Proteins - immunology | Cholera Toxin - genetics | Escherichia coli Infections - immunology | Mice, Inbred BALB C | Escherichia coli Vaccines - immunology | Escherichia coli O157 - immunology | Immunoglobulin A - analysis | Water-borne diseases | Shedding | Mucosal immunity | Pathogenesis | Immunoglobulin G | Vaccination | Membrane permeability | Lymphocytes T | Immunoglobulin A | Proteins | Reduction | Interleukin 4 | E coli | Intestine | Rodents | Toxicity testing | Recombinant | Immune system | Pathogens | Streptomycin | Immune response | Cytokines | Adjuvants | Protein B | Adjuvanticity | Immunogenicity | γ-Interferon | Interleukin 10 | Mice | Colonization | Vibrio
Journal Article
Vaccine, ISSN 0264-410X, 2011, Volume 29, Issue 23, pp. 3962 - 3968
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2014, Volume 9, Issue 11, p. e112802
Recombinant subunit vaccine engineering increasingly focuses on the development of more effective delivery platforms. However, current recombinant vaccines... 
Recombinant Fusion Proteins - immunology | Hemolysin Proteins - immunology | Species Specificity | Bacterial Vaccines - genetics | Hemolysin Proteins - genetics | Antigens, Bacterial - immunology | Th1 Cells - immunology | Antigens, Bacterial - genetics | Probiotics - chemistry | Hemolysin Proteins - administration & dosage | Cell Membrane - chemistry | Immunity, Cellular - drug effects | Antibodies, Bacterial - biosynthesis | Escherichia coli Proteins - administration & dosage | Female | Escherichia coli Proteins - immunology | Bacterial Outer Membrane Proteins - genetics | Recombinant Fusion Proteins - administration & dosage | Gene Expression | Immunization | Vaccines, Subunit | Bacterial Outer Membrane Proteins - immunology | Bacterial Outer Membrane Proteins - administration & dosage | Escherichia coli - immunology | Antigens, Bacterial - administration & dosage | Escherichia coli - chemistry | Animals | Bacterial Vaccines - administration & dosage | Bacterial Vaccines - immunology | Escherichia coli Proteins - genetics | Immunity, Humoral - drug effects | Recombinant Fusion Proteins - genetics | Vaccines, Synthetic | Cell Membrane - immunology | Mice | Mice, Inbred BALB C | Th1 Cells - cytology | Veterinary colleges | Drug delivery systems | Vaccination | Lymphocytes T | Vaccines | Kinases | Veterinary medicine | Immunity | Immunity (cell-mediated) | Nanoparticles | Proteins | Engineering | Vesicles | Immunology | E coli | Cell cycle | Bacteria | Immunity (humoral) | Immunomodulators | Public health | ClyA protein | Biomedical engineering | Recombinant | Immune system | Antigens | Pathogens | Immune response | Cytokines | Immunomodulation | Membrane vesicles | T cell receptors | Adaptive immunity | Carriers | Probiotics
Journal Article
Journal Article
PLoS Neglected Tropical Diseases, ISSN 1935-2727, 2015, Volume 9, Issue 8, p. e0003924
Journal Article
Journal of Immunology, ISSN 0022-1767, 05/2011, Volume 186, Issue 10, pp. 5896 - 5906
Escherichia coli heat-labile enterotoxin (LT) is a powerful mucosal adjuvant; however, it is associated with toxic effects when delivered intranasally, and its... 
NONTOXIC AB COMPLEX | DENDRITIC CELLS | CELLULAR-IMMUNITY | IL-17-PRODUCING T-CELLS | INFLUENZA VACCINE | IMMUNOLOGY | BORDETELLA-PERTUSSIS | SIGNAL-REGULATED KINASE | CHOLERA-TOXIN | MUCOSAL ADJUVANTS | NALP3 INFLAMMASOME | B7-2 Antigen - genetics | B7-1 Antigen - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Dendritic Cells - immunology | Interleukin-17 - immunology | Bordetella pertussis - immunology | Caspase 1 - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Interleukin-1 - biosynthesis | CD4-Positive T-Lymphocytes - immunology | Enterotoxins - immunology | Escherichia coli Proteins - administration & dosage | Interleukin-1 - immunology | Escherichia coli Proteins - immunology | Dendritic Cells - metabolism | Bacterial Toxins - immunology | Mice, Inbred C57BL | Escherichia coli - immunology | Interleukin-17 - genetics | Escherichia coli Proteins - metabolism | Interleukin-23 - immunology | Mice, Knockout | Enterotoxins - administration & dosage | Interleukin-5 - immunology | Cell Differentiation - immunology | Interleukin-4 - immunology | Bacterial Toxins - metabolism | Animals | Carrier Proteins - metabolism | Interferon-gamma - immunology | Enterotoxins - metabolism | Interleukin-23 - biosynthesis | Th17 Cells - immunology | Bacterial Toxins - administration & dosage | Mice | Mice, Inbred BALB C | Mutation | Interleukin-10 - immunology | Index Medicus | Abridged Index Medicus
Journal Article