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Vaccine, ISSN 0264-410X, 2013, Volume 31, Issue 20, pp. 2457 - 2464
Highlights • We developed and tested a new oral ETEC vaccine in mice, alone and with an adjuvant. • The vaccine contains E. coli overexpressing CFA/I, CS3, CS5... 
Allergy and Immunology | Vaccine | Mucosal immunity | Immune responses | ETEC | dmLT | Colonization factors | DmLT | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNITY | DIARRHEA | PREVENTION | IMMUNOLOGY | VIBRIO-CHOLERAE | CELL CHOLERA VACCINE | TRAVELERS | CONSTRUCTION | ENTEROTOXIGENIC ESCHERICHIA-COLI | INTRANASAL IMMUNIZATION | ANTIBODY-RESPONSES | Immunity, Mucosal - immunology | Adjuvants, Immunologic - administration & dosage | Immunoglobulin G - blood | Escherichia coli Infections - prevention & control | Antigens, Bacterial - immunology | Antigens, Bacterial - genetics | Intestines - immunology | Enterotoxins - immunology | Escherichia coli Proteins - administration & dosage | Immunoglobulin G - immunology | Cholera Toxin - immunology | Bacterial Toxins - genetics | Female | Escherichia coli Proteins - immunology | Immunoglobulin G - analysis | Mutant Proteins - immunology | Fimbriae Proteins - immunology | Cholera Toxin - administration & dosage | Antibody Formation - immunology | Vaccines, Inactivated - genetics | Administration, Oral | Bacterial Toxins - immunology | Escherichia coli Infections - microbiology | Enterotoxigenic Escherichia coli - immunology | Escherichia coli Vaccines - administration & dosage | Mutant Proteins - administration & dosage | Enterotoxins - administration & dosage | Vaccines, Inactivated - adverse effects | Enterotoxins - genetics | Vaccines, Inactivated - immunology | Animals | Escherichia coli Vaccines - adverse effects | Fimbriae Proteins - genetics | Vaccines, Inactivated - administration & dosage | Cholera Toxin - genetics | Immunoglobulin A - immunology | Escherichia coli Proteins - genetics | Immunoglobulin A - blood | Bacterial Toxins - administration & dosage | Escherichia coli Infections - immunology | Escherichia coli Vaccines - genetics | Mice | Mice, Inbred BALB C | Escherichia coli Vaccines - immunology | Immunoglobulin A - analysis | Antigens | Safety and security measures | Analysis | Escherichia coli | Bacteria | Vaccines | Contamination | Proteins | Studies | Immunology | E coli | Rodents | Index Medicus | Basic Medicine | Medicinska grundvetenskaper
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 06/2016, Volume 62, Issue 6, pp. 824 - 833
Bacteria and archaea employ adaptive immunity against foreign genetic elements using CRISPR-Cas systems. To generate immunological memory, the Cas1-Cas2... 
NUCLEOID-ASSOCIATED PROTEINS | MECHANISTIC BASIS | DNA-BINDING | FOREIGN DNA | CAS ADAPTIVE IMMUNITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | SITES | REPEATS | RETROVIRAL INTEGRATION | SPACER ACQUISITION | CELL BIOLOGY | Endodeoxyribonucleases - immunology | Endonucleases - genetics | DNA, Bacterial - metabolism | DNA, Bacterial - immunology | DNA, Bacterial - chemistry | Structure-Activity Relationship | Endonucleases - metabolism | Integration Host Factors - metabolism | Time Factors | Endodeoxyribonucleases - metabolism | Escherichia coli - metabolism | Clustered Regularly Interspaced Short Palindromic Repeats - immunology | Escherichia coli Proteins - immunology | Nucleic Acid Conformation | Binding Sites | Adaptive Immunity | CRISPR-Associated Proteins - immunology | CRISPR-Cas Systems - immunology | CRISPR-Associated Proteins - genetics | Endonucleases - immunology | Escherichia coli - immunology | Escherichia coli Proteins - metabolism | Integration Host Factors - genetics | Endodeoxyribonucleases - genetics | DNA, Bacterial - genetics | Escherichia coli - genetics | CRISPR-Associated Proteins - metabolism | Escherichia coli Proteins - genetics | Protein Binding | Immunologic Memory | Integration Host Factors - immunology | Bacteria | Microbiology | Escherichia coli | Genomics | Cells | Protein binding | Index Medicus
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2014, Volume 289, Issue 6, pp. 3555 - 3570
Journal Article
Journal Article
Vaccine, ISSN 0264-410X, 2012, Volume 31, Issue 8, pp. 1210 - 1216
Highlights ► We describe the first UTI vaccine formulations based on the FliC or Montanide. ► FliC or Montanide induced strong humoral and cell immune... 
Allergy and Immunology | Flagellin | Urinary tract infection | Adjuvant | Vaccine | Montanide | FimH | MEDICINE, RESEARCH & EXPERIMENTAL | UROPATHOGENIC ESCHERICHIA-COLI | EFFECTIVE ADJUVANT | INNATE | TYPHIMURIUM | COLONIZATION | MUCOSAL | IMMUNOLOGY | IMMUNIZATION | INTRACELLULAR BACTERIAL COMMUNITIES | EXPRESSION | FUSION PROTEINS | Recombinant Fusion Proteins - immunology | Adjuvants, Immunologic - administration & dosage | Immunoglobulin G - blood | Escherichia coli Infections - prevention & control | Molecular Sequence Data | Urinary Tract Infections - prevention & control | Vaccines, Synthetic - immunology | Uropathogenic Escherichia coli - immunology | Adhesins, Escherichia coli - genetics | Vaccination - methods | Adhesins, Escherichia coli - immunology | Female | Escherichia coli Proteins - immunology | Urinary Bladder - microbiology | Antibodies, Bacterial - blood | Fimbriae Proteins - immunology | Disease Models, Animal | Interferon-gamma - secretion | Vaccines, Synthetic - genetics | Uropathogenic Escherichia coli - genetics | Sequence Analysis, DNA | Escherichia coli Vaccines - administration & dosage | Interleukin-4 - secretion | Animals | Fimbriae Proteins - genetics | Escherichia coli Proteins - genetics | Recombinant Fusion Proteins - genetics | Escherichia coli Infections - immunology | T-Lymphocytes - immunology | Escherichia coli Vaccines - genetics | Mice | Mice, Inbred BALB C | Vaccines, Synthetic - administration & dosage | Escherichia coli Vaccines - immunology | Urinary Tract Infections - immunology | Urinary tract infections | Health aspects | Immunoglobulin G | Vaccination | Medical research | Antigens | Candidates | Cytokines | Bladder | Infections | Vaccines | Urinary tract diseases | Proteins | Studies | Cell growth | Urogenital system | Immune system | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2018, Volume 115, Issue 14, pp. 3692 - 3697
Journal Article
Journal of Immunology, ISSN 0022-1767, 05/2011, Volume 186, Issue 10, pp. 5896 - 5906
Escherichia coli heat-labile enterotoxin (LT) is a powerful mucosal adjuvant; however, it is associated with toxic effects when delivered intranasally, and its... 
NONTOXIC AB COMPLEX | DENDRITIC CELLS | CELLULAR-IMMUNITY | IL-17-PRODUCING T-CELLS | INFLUENZA VACCINE | IMMUNOLOGY | BORDETELLA-PERTUSSIS | SIGNAL-REGULATED KINASE | CHOLERA-TOXIN | MUCOSAL ADJUVANTS | NALP3 INFLAMMASOME | B7-2 Antigen - genetics | B7-1 Antigen - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Dendritic Cells - immunology | Interleukin-17 - immunology | Bordetella pertussis - immunology | Caspase 1 - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Interleukin-1 - biosynthesis | CD4-Positive T-Lymphocytes - immunology | Enterotoxins - immunology | Escherichia coli Proteins - administration & dosage | Interleukin-1 - immunology | Escherichia coli Proteins - immunology | Dendritic Cells - metabolism | Bacterial Toxins - immunology | Mice, Inbred C57BL | Escherichia coli - immunology | Interleukin-17 - genetics | Escherichia coli Proteins - metabolism | Interleukin-23 - immunology | Mice, Knockout | Enterotoxins - administration & dosage | Interleukin-5 - immunology | Cell Differentiation - immunology | Interleukin-4 - immunology | Bacterial Toxins - metabolism | Animals | Carrier Proteins - metabolism | Interferon-gamma - immunology | Enterotoxins - metabolism | Interleukin-23 - biosynthesis | Th17 Cells - immunology | Bacterial Toxins - administration & dosage | Mice | Mice, Inbred BALB C | Mutation | Interleukin-10 - immunology | Index Medicus | Abridged Index Medicus
Journal Article
Infection and Immunity, ISSN 0019-9567, 01/2013, Volume 81, Issue 1, pp. 259 - 270
Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
MOLECULAR CHARACTERIZATION | INTESTINAL COLONIZATION | OUTER-MEMBRANE VESICLES | VACCINE CANDIDATES | MURINE MODEL | INFECTIOUS DISEASES | HEAT-LABILE ENTEROTOXIN | TOXIN DELIVERY | IMMUNE-RESPONSES | CYCLIC DI-GMP | IMMUNOLOGY | MAMMALIAN-CELLS | Epithelial Cells - metabolism | Gene Expression - genetics | Adhesins, Bacterial - genetics | Humans | Virulence | Intestines - metabolism | Transcriptome - immunology | Cyclic GMP - immunology | Promoter Regions, Genetic - genetics | Intestines - immunology | Host-Pathogen Interactions - immunology | DNA-Binding Proteins - metabolism | Adhesins, Bacterial - metabolism | Receptors, Cyclic AMP - metabolism | Escherichia coli Infections - genetics | Cyclic GMP - analogs & derivatives | Enterotoxigenic Escherichia coli - pathogenicity | Gene Expression - immunology | Antigens, Surface - metabolism | Escherichia coli Proteins - immunology | Receptors, Cyclic AMP - genetics | Enterotoxigenic Escherichia coli - genetics | Caco-2 Cells | DNA-Binding Proteins - immunology | Antigens, Surface - genetics | Escherichia coli Infections - microbiology | Escherichia coli Proteins - metabolism | Escherichia coli Infections - metabolism | Transcriptome - genetics | DNA-Binding Proteins - genetics | Enterotoxigenic Escherichia coli - immunology | Intestines - microbiology | Cyclic GMP - metabolism | Host-Pathogen Interactions - genetics | Epithelial Cells - immunology | Epithelial Cells - microbiology | Cyclic GMP - genetics | Cell Line, Tumor | Escherichia coli Proteins - genetics | Transcription, Genetic - immunology | Escherichia coli Infections - immunology | Promoter Regions, Genetic - immunology | Transcription, Genetic - genetics | Adhesins, Bacterial - immunology | Receptors, Cyclic AMP - immunology | Antigens, Surface - immunology | Index Medicus | Cellular Microbiology | Pathogen-Host Cell Molecular Interactions
Journal Article
Infection and Immunity, ISSN 0019-9567, 2015, Volume 83, Issue 12, pp. 4555 - 4564
Globally, enterotoxigenic Escherichia coli (ETEC) is a leading cause of childhood and travelers' diarrhea, for which an effective vaccine is needed. Prevalent... 
COLONIZATION FACTOR ANTIGENS | HEAT-LABILE TOXIN | INFECTIOUS DISEASES | IMMUNOGENICITY | TRAVELERS DIARRHEA | DNA VACCINE | CFA/I FIMBRIAE | INFANT MOUSE MODEL | DOUBLE-BLIND | IMMUNOLOGY | VIRULENCE | SUBUNIT | Escherichia coli Infections - mortality | Milk - chemistry | Dose-Response Relationship, Immunologic | Immune Sera - chemistry | Escherichia coli Infections - prevention & control | Immunoglobulin A - biosynthesis | Adhesins, Bacterial - genetics | Escherichia coli Infections - genetics | Antibodies, Bacterial - biosynthesis | Escherichia coli Proteins - administration & dosage | Immunoglobulin G - biosynthesis | Cattle | Female | Mice, Inbred DBA | Escherichia coli Proteins - immunology | Fimbriae, Bacterial - immunology | Milk - immunology | Enterotoxigenic Escherichia coli - genetics | Fimbriae Proteins - immunology | Gene Expression | Adhesins, Bacterial - administration & dosage | Enterotoxigenic Escherichia coli - drug effects | Fimbriae, Bacterial - chemistry | Enterotoxigenic Escherichia coli - immunology | Escherichia coli Vaccines - administration & dosage | Pregnancy | Animals | Fimbriae Proteins - genetics | Survival Analysis | Vaccines, Attenuated | Escherichia coli Proteins - genetics | Immunization, Passive | Escherichia coli Infections - immunology | Escherichia coli Vaccines - genetics | Fimbriae Proteins - administration & dosage | Mice | Adhesins, Bacterial - immunology | Escherichia coli Vaccines - immunology | Index Medicus | Microbial Immunity and Vaccines
Journal Article