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1. Lack of improvement of impaired chemical clearance characterizes PPI-refractory reflux-related heartburn
by Frazzoni, Marzio and Frazzoni, Leonardo and Tolone, Salvatore and De Bortoli, Nicola and Savarino, Vincenzo and Savarino, Edoardo
American Journal of Gastroenterology, ISSN 0002-9270, 05/2018, Volume 113, Issue 5, pp. 670 - 676
Objective: Heartburn is the most specific symptom of reflux disease and is highly responsive to proton pump inhibitor (PPI) therapy. Some patients do not... 
THERAPY | MANAGEMENT | PROTON PUMP INHIBITOR | DISEASE | GUIDELINES | ACID-SUPPRESSION | BASE-LINE IMPEDANCE | GASTROENTEROLOGY & HEPATOLOGY | SEGMENT BARRETTS-ESOPHAGUS | ASSOCIATION | FUNCTIONAL HEARTBURN | Proton Pump Inhibitors - pharmacology | Prospective Studies | Gastroesophageal Reflux - diagnosis | Esophageal pH Monitoring | Humans | Middle Aged | Endoscopy, Gastrointestinal | Heartburn - diagnosis | Male | Treatment Outcome | Electric Impedance | Heartburn - drug therapy | Proton Pump Inhibitors - therapeutic use | Gastroesophageal Reflux - complications | Heartburn - etiology | Female | Gastroesophageal Reflux - drug therapy | Drug Resistance | Hydrogen-Ion Concentration
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2. Full Text Impairment of chemical clearance and mucosal integrity distinguishes hypersensitive esophagus from functional heartburn
by Frazzoni, Marzio and Frazzoni, Marzio and de Bortoli, Nicola and de Bortoli, Nicola and Frazzoni, Leonardo and Frazzoni, Leonardo and Furnari, Manuele and Furnari, Manuele and Martinucci, Irene and Martinucci, Irene and Tolone, Salvatore and Tolone, Salvatore and Farioli, Andrea and Farioli, Andrea and Marchi, Santino and Marchi, Santino and Fuccio, Lorenzo and Fuccio, Lorenzo and Savarino, Vincenzo and Savarino, Vincenzo and Savarino, Edoardo and Savarino, Edoardo
Journal of Gastroenterology, ISSN 0944-1174, 4/2017, Volume 52, Issue 4, pp. 444 - 451
Hypersensitive esophagus (HE) is defined by endoscopy-negative heartburn with a normal acid exposure time but positive symptom association probability (SAP)... 
GERD | Medicine & Public Health | Colorectal Surgery | Hepatology | Gastroenterology | Hypersensitive esophagus | Abdominal Surgery | Functional heartburn | pH Impedance monitoring | Surgical Oncology | 24-HOUR PH-IMPEDANCE | LINE IMPEDANCE LEVELS | SYMPTOMS | PARAMETERS | PROTON-PUMP INHIBITORS | PATHOGENESIS | THERAPY | GASTROESOPHAGEAL-REFLUX DISEASE | FUNDOPLICATION | GASTROENTEROLOGY & HEPATOLOGY | Single-Blind Method | Predictive Value of Tests | Gastroesophageal Reflux - diagnosis | Heartburn - physiopathology | Esophageal pH Monitoring | Gastroesophageal Reflux - physiopathology | Humans | Middle Aged | Male | Electric Impedance | Heartburn - drug therapy | Proton Pump Inhibitors - therapeutic use | Esophagus - physiopathology | Gastroesophageal Reflux - complications | Heartburn - etiology | Peristalsis - physiology | Sensitivity and Specificity | Adult | Female | Aged | Retrospective Studies | Gastroesophageal Reflux - drug therapy | Gastroesophageal reflux | Endoscopy | Gastrointestinal diseases | Heartburn
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3. Full Text Esophageal chemical clearance is impaired in gastro‐esophageal reflux disease – a 24‐h impedance‐pH monitoring assessment
by Frazzoni, M and Manta, R and Mirante, V. G and Conigliaro, R and Frazzoni, L and Melotti, G
Neurogastroenterology & Motility, ISSN 1350-1925, 05/2013, Volume 25, Issue 5, pp. 399 - e295
Background Impedance‐pH monitoring allows assessment of retrograde and antegrade intra‐esophageal movement of fluids and gas. Reflux is followed by volume... 
esophageal clearance | functional heartburn | impedance‐pH monitoring | refractory gastro‐esophageal reflux disease | Functional heartburn | Esophageal clearance | Refractory gastro-esophageal reflux disease | Impedance-pH monitoring | DIAGNOSIS | ACID | MANAGEMENT | impedance-pH monitoring | PROTON PUMP INHIBITORS | PATTERNS | NEUROSCIENCES | CLINICAL NEUROLOGY | MULTICHANNEL INTRALUMINAL IMPEDANCE | refractory gastro-esophageal reflux disease | FUNDOPLICATION | MANOMETRY | GASTROENTEROLOGY & HEPATOLOGY | MOTILITY | Esophagus - physiopathology | Esophageal pH Monitoring | Gastroesophageal Reflux - physiopathology | Humans | Middle Aged | Peristalsis - physiology | Female | Male | Retrospective Studies | Electric Impedance | Hydrogen-Ion Concentration | Gastroesophageal reflux | Hydrogen-ion concentration
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4. Full Text Impairment of chemical clearance is relevant to the pathogenesis of refractory reflux oesophagitis
by Frazzoni, Marzio and Bertani, Helga and Manta, Raffaele and Mirante, Vincenzo Giorgio and Frazzoni, Leonardo and Conigliaro, Rita and Melotti, Gianluigi
Digestive and Liver Disease, ISSN 1590-8658, 2014, Volume 46, Issue 7, pp. 596 - 602
Abstract Background The pathophysiological mechanisms underlying proton pump inhibitor-refractory reflux oesophagitis has been scarcely studied. Aims To assess... 
Gastroenterology and Hepatology | PPI | Refractory reflux oesophagitis | Impedance-pH monitoring | Refractory GERD | Oesophageal chemical clearance | PATHOPHYSIOLOGICAL CHARACTERISTICS | ACID | INTRALUMINAL IMPEDANCE | ABNORMALITIES | PROTON PUMP INHIBITORS | PH-IMPEDANCE | GASTROESOPHAGEAL-REFLUX | ARTICLE | NORMAL VALUES | DISEASE | GASTROENTEROLOGY & HEPATOLOGY | Esophageal pH Monitoring | Humans | Middle Aged | Male | Electric Impedance | Proton Pump Inhibitors - therapeutic use | Esophagus - chemistry | Esophagitis, Peptic - drug therapy | Time Factors | Adult | Esophagitis, Peptic - physiopathology | Female | Retrospective Studies | Drug Resistance | Gastroesophageal reflux
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5. Full Text Chemical Clearance in Infants and Children With Acid Reflux in the Physiologic Range
by Woodley, Frederick W and Machado, Rodrigo and Di Lorenzo, Carlo and Mousa, Hayat
Journal of Pediatric Gastroenterology and Nutrition, ISSN 0277-2116, 06/2015, Volume 60, Issue 6, pp. 783 - 786
BACKGROUND AND AIM:We reported that chemical clearance (CC) of acid gastroesophageal reflux (AGER) is relatively prolonged in children with cystic fibrosis... 
Gastroesophageal reflux | Pediatrics | Normal values | Acid clearance | Chemical clearance | acid clearance | ESOPHAGUS | GUIDELINES | chemical clearance | normal values | GASTROESOPHAGEAL-REFLUX | NUTRITION & DIETETICS | gastroesophageal reflux | RECOMMENDATIONS | PEDIATRIC-GASTROENTEROLOGY | SUBMUCOSAL GLANDS | IMPEDANCE | pediatrics | NORTH-AMERICAN-SOCIETY | NUTRITION | SECRETION | GASTROENTEROLOGY & HEPATOLOGY | Age Factors | Gastroesophageal Reflux - diagnosis | Esophageal pH Monitoring - methods | Cystic Fibrosis - physiopathology | Gastroesophageal Reflux - physiopathology | Humans | Child, Preschool | Infant | Male | Electric Impedance | Esophagus - physiopathology | Adolescent | Female | Child | Hydrogen-Ion Concentration
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6. Full Text Children with Cystic Fibrosis Have Prolonged Chemical Clearance of Acid Reflux Compared to Symptomatic Children Without Cystic Fibrosis
by Woodley, Frederick W and Woodley, Frederick W and Machado, Rodrigo S and Machado, Rodrigo S and Hayes Jr, Don and Hayes Jr, Don and Di Lorenzo, Carlo and Di Lorenzo, Carlo and Kaul, Ajay and Kaul, Ajay and Skaggs, Beth and Skaggs, Beth and McCoy, Karen and McCoy, Karen and Patel, Alpa and Patel, Alpa and Mousa, Hayat and Mousa, Hayat
Digestive Diseases and Sciences, ISSN 0163-2116, 3/2014, Volume 59, Issue 3, pp. 623 - 630
Few studies compare gastroesophageal reflux (GER) parameters of cystic fibrosis (CF) children and symptomatic non-CF children. We aimed to compare the... 
Biochemistry, general | Acid reflux | Medicine & Public Health | Chemical clearance | Hepatology | Gastroenterology | Oncology | Cystic fibrosis | Proximal extent | Volume clearance | Transplant Surgery | ELECTROLYTE | MECHANISMS | GASTROESOPHAGEAL-REFLUX | INFANTS | DISEASE | DIURNAL-VARIATION | GASTROENTEROLOGY & HEPATOLOGY | CFTR | BICARBONATE SECRETION | SUBMANDIBULAR SALIVA | MOTILITY | Esophageal pH Monitoring | Cystic Fibrosis - physiopathology | Gastroesophageal Reflux - physiopathology | Humans | Child, Preschool | Male | Cystic Fibrosis - complications | Plethysmography, Impedance | Case-Control Studies | Gastroesophageal Reflux - complications | Time Factors | Adolescent | Female | Child | Cohort Studies | Gastroesophageal reflux | Analysis
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7. Full Text Esophageal chemical clearance and baseline impedance values in patients with chronic autoimmune atrophic gastritis and gastro-esophageal reflux disease
by Tenca, Andrea and de Bortoli, Nicola and Mauro, Aurelio and Frazzoni, Marzio and Savarino, Edoardo and Massironi, Sara and Russo, Salvatore and Bertani, Lorenzo and Marchi, Santino and Penagini, Roberto
Digestive and Liver Disease, ISSN 1590-8658, 2017, Volume 49, Issue 9, pp. 978 - 983
Abstract Background The factors influencing new markers of gastro-esophageal reflux disease detected by impedance-pH monitoring – mean nocturnal baseline... 
Gastroenterology and Hepatology | GERD | PSPW index | Chronic autoimmune atrophic gastritis | Baseline impedance | SYMPTOM ANALYSIS | THERAPY | ACID | CLASSIFICATION | GASTROENTEROLOGY & HEPATOLOGY | ASSOCIATION | FUNCTIONAL HEARTBURN | Gastritis, Atrophic - physiopathology | Severity of Illness Index | Autoimmune Diseases - physiopathology | Heartburn - physiopathology | Esophageal pH Monitoring | Gastroesophageal Reflux - physiopathology | Humans | Middle Aged | Male | Electric Impedance | Peristalsis | Adult | Female | Italy | ROC Curve | Aged | Retrospective Studies | Endoscopy | Hydrogen-Ion Concentration | Care and treatment | Gastrointestinal diseases | Gastroesophageal reflux | Analysis | Gastritis
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8. Full Text Neoplastic progression in short‐segment Barrett's oesophagus is associated with impairment of chemical clearance, but not inadequate acid suppression by proton pump inhibitor therapy
by Frazzoni, M and Bertani, H and Conigliaro, R and Frazzoni, L and Losi, L and Melotti, G
Alimentary Pharmacology & Therapeutics, ISSN 0269-2813, 10/2014, Volume 40, Issue 7, pp. 835 - 842
Summary Background Pathophysiological mechanisms associated with neoplastic progression in patients with short‐segment Barrett's oesophagus (SSBO), who... 
PATHOPHYSIOLOGICAL CHARACTERISTICS | ENDOSCOPIC SURVEILLANCE | DIAGNOSIS | GRADE DYSPLASIA | MANAGEMENT | GASTROESOPHAGEAL-REFLUX DISEASE | IMPEDANCE | ADENOCARCINOMA | RISK | PHARMACOLOGY & PHARMACY | GASTROENTEROLOGY & HEPATOLOGY | Esophageal Neoplasms - etiology | Precancerous Conditions - etiology | Barrett Esophagus - complications | Heartburn - physiopathology | Gastroesophageal Reflux - physiopathology | Humans | Middle Aged | Male | Heartburn - drug therapy | Peristalsis | Proton Pump Inhibitors - therapeutic use | Barrett Esophagus - physiopathology | Barrett Esophagus - drug therapy | Female | Aged | Gastroesophageal Reflux - drug therapy | Gastric Acid | Antimitotic agents | Endoscopic surgery | Development and progression | Dysplasia | Endoscopy | Antineoplastic agents
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9. Full Text Diurnal Variation in the Chemical Clearance of Acid Gastroesophageal Reflux in Infants
by Woodley, Frederick W and Fernandez, Soledad and Mousa, Hayat
Clinical Gastroenterology and Hepatology, ISSN 1542-3565, 2007, Volume 5, Issue 1, pp. 37 - 43
Background & Aims: Clearance of acid gastroesophageal reflux is biphasic. During volume clearance, refluxed material is cleared from the esophagus by... 
Gastroenterology and Hepatology | APNEA | NORMAL VALUES | ESOPHAGUS | VOLUNTEERS | GASTROENTEROLOGY & HEPATOLOGY | ASSOCIATION | MULTICHANNEL INTRALUMINAL IMPEDANCE | CHILDREN | Fasting | Esophageal pH Monitoring | Gastroesophageal Reflux - physiopathology | Humans | Infant Food | Gastrointestinal Motility - physiology | Infant | Logistic Models | Male | Circadian Rhythm - physiology | Electric Impedance | Postprandial Period - physiology | Esophagus - physiopathology | Intubation, Gastrointestinal | Female | Infant, Newborn | Milk, Human | Gastroesophageal reflux
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10. Full Text Analyses of the Post-reflux Swallow-induced Peristaltic Wave Index and Nocturnal Baseline Impedance Parameters Increase the Diagnostic Yield of Impedance-pH Monitoring of Patients With Reflux Disease
by Frazzoni, Marzio and Savarino, Edoardo and de Bortoli, Nicola and Martinucci, Irene and Furnari, Manuele and Frazzoni, Leonardo and Mirante, Vincenzo Giorgio and Bertani, Helga and Marchi, Santino and Conigliaro, Rita and Savarino, Vincenzo
Clinical Gastroenterology and Hepatology, ISSN 1542-3565, 2016, Volume 14, Issue 1, pp. 40 - 46
Background & Aims Analyses of impedance parameters such as the post-reflux swallow-induced peristaltic wave (PSPW) index and the mean nocturnal baseline... 
Gastroenterology and Hepatology | ROC AUC | Esophageal Chemical Clearance | GERD | Esophageal Baseline Impedance | Heartburn | Impedance pH Monitoring | ESOPHAGEAL | GASTROENTEROLOGY & HEPATOLOGY | NERD | FUNCTIONAL HEARTBURN | Prospective Studies | Gastroesophageal Reflux - diagnosis | Esophageal pH Monitoring - methods | Gastroesophageal Reflux - pathology | Humans | Middle Aged | Male | Electric Impedance | Peristalsis | Animals | Adult | Female | Italy | Hydrogen-Ion Concentration | Swallows | Hydrogen-ion concentration | Statistics | Analysis
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11. Full Text Impedance-pH Monitoring for Diagnosis of Reflux Disease: New Perspectives
by Frazzoni, Marzio and de Bortoli, Nicola and Frazzoni, Leonardo and Tolone, Salvatore and Savarino, Vincenzo and Savarino, Edoardo
Digestive Diseases and Sciences, ISSN 0163-2116, 8/2017, Volume 62, Issue 8, pp. 1881 - 1889
Heartburn is the most specific symptom of gastroesophageal reflux disease (GERD). In clinical practice, heartburn relief by a proton pump inhibitor (PPI) trial... 
Biochemistry, general | Esophageal baseline impedance | PPI | Oncology | PSPW index | NERD | Transplant Surgery | GERD | Medicine & Public Health | Hepatology | Gastroenterology | Impedance-pH monitoring | Esophageal chemical clearance | PRACTICE GUIDELINES | PROTON PUMP INHIBITORS | BASE-LINE IMPEDANCE | MULTICHANNEL INTRALUMINAL IMPEDANCE | NONACID REFLUX | GASTROESOPHAGEAL-REFLUX | CHEMICAL CLEARANCE | GASTROENTEROLOGY & HEPATOLOGY | SEGMENT BARRETTS-ESOPHAGUS | PERISTALTIC WAVE INDEX | FUNCTIONAL HEARTBURN | Reproducibility of Results | Gastroesophageal Reflux - diagnosis | Esophageal pH Monitoring - methods | Gastroesophageal Reflux - physiopathology | Humans | Electric Impedance | Heartburn - drug therapy | Peristalsis | Proton Pump Inhibitors - therapeutic use | Esophagus - chemistry | Esophagus - physiopathology | Gastroesophageal Reflux - complications | Heartburn - etiology | Hydrogen-Ion Concentration | Gastroesophageal reflux | Medical diagnosis | Endoscopy
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12. Full Text The added diagnostic value of postreflux swallow‐induced peristaltic wave index and nocturnal baseline impedance in refractory reflux disease studied with on‐therapy impedance‐pH monitoring
by Frazzoni, M and Bortoli, N and Frazzoni, L and Tolone, S and Furnari, M and Martinucci, I and Mirante, V. G and Marchi, S and Savarino, V and Savarino, E
Neurogastroenterology & Motility, ISSN 1350-1925, 03/2017, Volume 29, Issue 3, pp. e12947 - n/a
Background On‐therapy impedance‐pH monitoring in proton pump inhibitor (PPI)‐refractory gastroesophageal reflux disease (GERD) yielded conflicting results. We... 
refractory GERD | impedance‐pH monitoring | esophageal baseline impedance | esophageal chemical clearance | impedance-pH monitoring | Gastroesophageal Reflux - diagnosis | Heartburn - physiopathology | Esophageal pH Monitoring - methods | Gastroesophageal Reflux - physiopathology | Humans | Middle Aged | Heartburn - diagnosis | Male | Electric Impedance | Deglutition - physiology | Peristalsis - physiology | Adult | Female | Retrospective Studies | Gastroesophageal reflux | Medicine, Experimental | Medical research | Hydrogen-ion concentration
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13. Full Text Vigor of peristalsis during multiple rapid swallows is inversely correlated with acid exposure time in patients with NERD
by Martinucci, I and Savarino, E. V and Pandolfino, J. E and Russo, S and Bellini, M and Tolone, S and Tutuian, R and Roman, S and Furnari, M and Frazzoni, M and Macchia, L and Savarino, V and Marchi, S and Bortoli, N
Neurogastroenterology & Motility, ISSN 1350-1925, 02/2016, Volume 28, Issue 2, pp. 243 - 250
Background Multiple rapid swallowing (MRS) during high‐resolution manometry (HRM) is increasingly utilized as provocative test to assess esophageal peristaltic... 
high‐resolution manometry | acid exposure time | gastro‐esophageal reflux disease | multiple rapid swallow | Acid exposure time | Gastro-esophageal reflux disease | Multiple rapid swallow | High-resolution manometry | INTRALUMINAL IMPEDANCE | high-resolution manometry | CLASSIFICATION | DYSMOTILITY | BARRETTS-ESOPHAGUS | gastro-esophageal reflux disease | ESOPHAGEAL MOTILITY DISORDERS | NEUROSCIENCES | JUNCTION | CLINICAL NEUROLOGY | GASTROESOPHAGEAL-REFLUX DISEASE | CHEMICAL CLEARANCE | DYSFUNCTION | GASTROENTEROLOGY & HEPATOLOGY | Manometry | Esophageal pH Monitoring | Gastroesophageal Reflux - physiopathology | Humans | Middle Aged | Peristalsis - physiology | Adult | Female | Male | Electric Impedance | Deglutition - physiology | Hydrogen-Ion Concentration
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