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Journal of the National Cancer Institute, ISSN 0027-8874, 01/2018, Volume 110, Issue 1, pp. 109 - 120
Background: Cancer-associated fibroblasts (CAFs) are tumor-promoting and correlate with poor survival in many cancers, which has led to their emergence as... 
CELL LUNG-CANCER | PHASE-II TRIAL | OXIDATIVE STRESS | ONCOLOGY | NAB-PACLITAXEL | ACTIVATION PROTEIN | DEPENDENT INVASION | PANCREATIC-CANCER | MONOCLONAL-ANTIBODY | DIFFERENTIATION | STROMAL CELLS | Lung Neoplasms - drug therapy | Up-Regulation | Pyrazoles - therapeutic use | Reactive Oxygen Species - metabolism | Cell Count | Humans | Middle Aged | Male | Oropharyngeal Neoplasms - pathology | Head and Neck Neoplasms - chemistry | RNA Interference | Cancer-Associated Fibroblasts - chemistry | Aged, 80 and over | NADPH Oxidases - genetics | Adenocarcinoma - chemistry | Esophageal Neoplasms - chemistry | Lung Neoplasms - chemistry | NADPH Oxidases - antagonists & inhibitors | Head and Neck Neoplasms - drug therapy | Carcinoma, Squamous Cell - chemistry | Survival Rate | Adenocarcinoma - drug therapy | Disease Progression | Phenotype | Carcinoma, Squamous Cell - drug therapy | Head and Neck Neoplasms - genetics | Mice | Neoplasm Transplantation | Carcinoma, Non-Small-Cell Lung - chemistry | Carcinoma, Squamous Cell - genetics | Colorectal Neoplasms - chemistry | Cell Transdifferentiation - genetics | Myofibroblasts - chemistry | Actins - analysis | Cell Transdifferentiation - drug effects | Adult | Female | Adenocarcinoma - genetics | Cancer-Associated Fibroblasts - physiology | Pyridines - therapeutic use | Lung Neoplasms - genetics | Myofibroblasts - pathology | Carcinoma, Non-Small-Cell Lung - genetics | NADPH Oxidases - analysis | Mouth Neoplasms - chemistry | NADPH Oxidase 4 | Cancer-Associated Fibroblasts - pathology | Animals | Esophageal Neoplasms - genetics | Mouth Neoplasms - pathology | Oropharyngeal Neoplasms - chemistry | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Colorectal Neoplasms - pathology | Esophageal Neoplasms - drug therapy | Index Medicus
Journal Article
British Journal of Cancer, ISSN 0007-0920, 02/2018, Volume 118, Issue 3, pp. 428 - 434
Background: Periodontal pathogens have been linked to oral and gastrointestinal (orodigestive) carcinogenesis. However, the exact mechanisms remain unknown.... 
chymotrypsin-like proteinase | Treponema denticola | periodontopathogen | COLLAGENASE-2 MMP-8 | PORPHYROMONAS-GINGIVALIS | PANCREATIC-CANCER | TISSUE INHIBITORS | PERIODONTAL-DISEASE | METALLOPROTEINASES | ONCOLOGY | gastrointestinal cancer | ALPHA-1-ANTITRYPSIN | EXPRESSION | oral cancer | HUMAN NEUTROPHIL | PROGRESSION | Digestive System Neoplasms - metabolism | Pancreatic Neoplasms - chemistry | Adenocarcinoma - pathology | Pancreatic Neoplasms - metabolism | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Treponema denticola - enzymology | Mouth Neoplasms - metabolism | Stomach Neoplasms - pathology | Tonsillar Neoplasms - chemistry | Complement C1q - metabolism | Colonic Neoplasms - metabolism | Head and Neck Neoplasms - metabolism | Esophageal Neoplasms - pathology | Tonsillar Neoplasms - metabolism | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Head and Neck Neoplasms - chemistry | Matrix Metalloproteinase 9 - metabolism | Adenocarcinoma - metabolism | Matrix Metalloproteinase 8 - metabolism | Esophageal Neoplasms - metabolism | Digestive System Neoplasms - pathology | Colonic Neoplasms - chemistry | Stomach Neoplasms - chemistry | Adenocarcinoma - chemistry | Esophageal Neoplasms - chemistry | Tonsillar Neoplasms - pathology | Pancreatic Neoplasms - pathology | Carcinoma, Squamous Cell - chemistry | Mouth Neoplasms - chemistry | Head and Neck Neoplasms - pathology | Cell Transformation, Neoplastic - immunology | Digestive System Neoplasms - chemistry | alpha 1-Antichymotrypsin - metabolism | Colonic Neoplasms - pathology | Chymases - analysis | Mouth Neoplasms - pathology | Immunohistochemistry | Proteinase | Virulence | Tissue inhibitor of metalloproteinase 2 | Tissues | Tissue inhibitor of metalloproteinase 1 | Carcinogenesis | Proteins | Carcinogens | Pancreatic carcinoma | Bacteria | Colon | Pancreas | Gastric cancer | Squamous cell carcinoma | Tonsil | Immunomodulation | Teeth | Proteinase inhibitors | Esophagus | Complement component C1q | Chymotrypsin | Periodontitis | Neutrophil collagenase | Tumors | Index Medicus | Molecular Diagnostics
Journal Article
The Journal of Pathology, ISSN 0022-3417, 07/2013, Volume 230, Issue 3, pp. 261 - 269
Journal Article
Journal Article
Asian Cardiovascular and Thoracic Annals, ISSN 0218-4923, 11/2017, Volume 25, Issue 9, pp. 645 - 648
We report the case of a 60-year-old man with 4 concurrent primary cancers: thyroid papillary carcinoma, esophageal squamous cell carcinoma, lung... 
Esophageal carcinoma | Gastrointestinal stromal tumors | Thyroid papillary carcinoma | multi-organ primary carcinoma | Non-small cell lung cancer | Neoplasms, Multiple Primary - surgery | Adenocarcinoma - pathology | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Thyroid Neoplasms - chemistry | Male | Tomography, X-Ray Computed | Esophageal Neoplasms - pathology | Esophageal Neoplasms - surgery | Goiter, Nodular - pathology | Stomach Neoplasms - chemistry | Adenocarcinoma - chemistry | Carcinoma, Papillary - chemistry | Esophageal Squamous Cell Carcinoma | Carcinoma, Papillary - diagnostic imaging | Esophageal Neoplasms - chemistry | Gastrointestinal Stromal Tumors - surgery | Stomach Neoplasms - diagnostic imaging | Lung Neoplasms - chemistry | Carcinoma, Squamous Cell - chemistry | Gastrectomy | Carcinoma, Papillary - surgery | Thyroidectomy | Thyroid Cancer, Papillary | Lung Neoplasms - diagnostic imaging | Lung Neoplasms - surgery | Adenocarcinoma - diagnostic imaging | Esophageal Neoplasms - diagnostic imaging | Adenocarcinoma - surgery | Lymph Node Excision | Adenocarcinoma of Lung | Thyroid Neoplasms - diagnostic imaging | Gastrointestinal Stromal Tumors - diagnostic imaging | Carcinoma, Squamous Cell - surgery | Lung Neoplasms - pathology | Stomach Neoplasms - pathology | Carcinoma, Squamous Cell - diagnostic imaging | Neoplasms, Multiple Primary - diagnostic imaging | Pneumonectomy | Gastrointestinal Stromal Tumors - pathology | Endoscopy, Digestive System | Goiter, Nodular - diagnostic imaging | Goiter, Nodular - surgery | Thyroid Neoplasms - surgery | Biomarkers, Tumor - analysis | Esophagectomy | Treatment Outcome | Neoplasms, Multiple Primary - pathology | Carcinoma, Papillary - pathology | Biopsy | Gastrointestinal Stromal Tumors - chemistry | Neoplasms, Multiple Primary - chemistry | Stomach Neoplasms - surgery | Thyroid Neoplasms - pathology | Index Medicus
Journal Article
Science, ISSN 0036-8075, 1/1998, Volume 279, Issue 5350, pp. 577 - 580
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the human digestive tract, but their molecular etiology and cellular origin... 
Complementary DNA | Lymphocytes | Cell lines | Reports | Mice | Mast cells | Genetic mutation | Small intestine | Summarization | Endothelial cells | Tumors | LIGAND-INDEPENDENT ACTIVATION | HUMAN SMALL-INTESTINE | W-LOCUS | POSSIBLE INVOLVEMENT | CONSTITUTIVE ACTIVATION | MULTIDISCIPLINARY SCIENCES | BONE-MARROW | MAST-CELLS | SUBMUCOSAL BORDER | RECEPTOR TYROSINE KINASE | INTERSTITIAL-CELLS | Sequence Deletion | Antigens, CD34 - analysis | Phosphorylation | Gastrointestinal Neoplasms - genetics | Humans | Molecular Sequence Data | Stomach Neoplasms - metabolism | Stomach Neoplasms - pathology | Proto-Oncogene Proteins c-kit - metabolism | Esophageal Neoplasms - pathology | Phosphotyrosine - metabolism | Gastrointestinal Neoplasms - pathology | Transfection | Esophageal Neoplasms - metabolism | Stem Cell Factor - pharmacology | Proto-Oncogene Proteins c-kit - genetics | Intestinal Neoplasms - genetics | Stomach Neoplasms - genetics | Amino Acid Sequence | Cell Line | Recombinant Proteins - pharmacology | Proto-Oncogene Proteins c-kit - analysis | Intestinal Neoplasms - pathology | Gastrointestinal Neoplasms - chemistry | Animals | Esophageal Neoplasms - genetics | Cell Transformation, Neoplastic | Mice, Nude | Ligands | Mutation | Intestinal Neoplasms - chemistry | Proto-Oncogene Proteins c-kit - chemistry | DNA, Complementary | Digestive System - cytology | Mesentery | Research | Gastrointestinal tumors | Proteins | Digestive system | Deoxyribonucleic acid | DNA | Index Medicus
Journal Article
Mayo Clinic Proceedings, ISSN 0025-6196, 2012, Volume 87, Issue 5, pp. 430 - 436
Abstract Objective To evaluate the relationship between the use of zolpidem and subsequent cancer risk in Taiwanese patients. Methods We used data from the... 
Internal Medicine | INSOMNIA | MEDICINE, GENERAL & INTERNAL | SLEEP | VIRUS | PREVALENCE | EPIDEMIOLOGY | Confidence Intervals | Hypnotics and Sedatives - adverse effects | Lung Neoplasms - chemically induced | Humans | Middle Aged | Liver Neoplasms - chemically induced | Male | Hypnotics and Sedatives - therapeutic use | Esophageal Neoplasms - epidemiology | Young Adult | Liver Neoplasms - epidemiology | Mouth Neoplasms - chemically induced | Pyridines - adverse effects | Neoplasms - chemically induced | Adult | Female | Odds Ratio | Urinary Bladder Neoplasms - epidemiology | Breast Neoplasms - epidemiology | Pyridines - therapeutic use | Esophageal Neoplasms - chemically induced | Risk Factors | Mouth Neoplasms - epidemiology | Lung Neoplasms - epidemiology | Taiwan - epidemiology | Sex Distribution | Urinary Bladder Neoplasms - chemistry | Breast Neoplasms - chemically induced | Sleep Initiation and Maintenance Disorders - drug therapy | Population Surveillance | Neoplasms - epidemiology | Cohort Studies | Zolpidem | Complications and side effects | Research | Risk factors | Cancer | Index Medicus | Abridged Index Medicus | NHRI, National Health Research Institute | CI, confidence interval | NHI, National Health Insurance | HR, hazard ratio | CIN, cervical intraepithelial neoplasia | CIS, carcinoma in situ | Original | NHIRD, National Health Insurance Research Database | ICD-9-CM, International Classification of Diseases, Ninth Revision, Clinical Modification
Journal Article
British Journal of Cancer, ISSN 0007-0920, 06/2017, Volume 116, Issue 12, pp. 1526 - 1535
Journal Article
The American Journal of Surgical Pathology, ISSN 0147-5185, 01/2014, Volume 38, Issue 1, pp. 72 - 77
Journal Article
International Journal of Cancer, ISSN 0020-7136, 08/2012, Volume 131, Issue 3, pp. 558 - 569
Journal Article
The Journal of Pathology, ISSN 0022-3417, 11/2013, Volume 231, Issue 3, pp. 301 - 310
The incidence of oesophagogastric junctional ( OGJ ) adenocarcinoma is rising rapidly in western countries, in contrast to the declining frequency of distal... 
drug targets | exome sequencing | actionable mutations | subclonal mutations | oesophagogastric junctional adenocarcinoma | EXOME | GASTROESOPHAGEAL CANCER | MICROSATELLITE INSTABILITY | PATHOLOGY | TUMORS | SOMATIC MUTATIONS | ESOPHAGEAL ADENOCARCINOMA | ONCOLOGY | GASTRIC-CANCER | COLORECTAL-CANCER | GENES | CARCINOMA | Immunohistochemistry | MutL Protein Homolog 1 | Microsatellite Instability | Adenocarcinoma - pathology | Nuclear Proteins - analysis | Prospective Studies | Humans | Middle Aged | MutL Proteins | DNA Repair Enzymes - genetics | DNA-Binding Proteins - analysis | Male | Stomach Neoplasms - pathology | Esophageal Neoplasms - pathology | Loss of Heterozygosity - genetics | Polymerase Chain Reaction - methods | Adenosine Triphosphatases - analysis | DNA Mutational Analysis | Adult | Female | Adenocarcinoma - genetics | Mismatch Repair Endonuclease PMS2 | Stomach Neoplasms - chemistry | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Adenocarcinoma - chemistry | Esophageal Neoplasms - chemistry | Stomach Neoplasms - genetics | Esophagogastric Junction - pathology | DNA Copy Number Variations - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | DNA Repair Enzymes - analysis | Genome, Human - genetics | Adaptor Proteins, Signal Transducing - analysis | Exome - genetics | Esophageal Neoplasms - genetics | Adaptor Proteins, Signal Transducing - genetics | Neoplasm Proteins - analysis | Adenosine Triphosphatases - genetics | Aged | DNA, Neoplasm - genetics | Neoplasm Staging | Genetic aspects | Cancer | Tumors | Index Medicus
Journal Article