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Lancet Oncology, The, ISSN 1470-2045, 2013, Volume 14, Issue 6, pp. 481 - 489
Summary Background EGFR overexpression occurs in 27–55% of oesophagogastric adenocarcinomas, and correlates with poor prognosis. We aimed to assess addition of... 
Hematology, Oncology and Palliative Medicine | GROWTH-FACTOR RECEPTOR | 1ST-LINE TREATMENT | CETUXIMAB | PROSPECTIVE MULTICENTER | ONCOLOGY | GASTRIC-CANCER | PROGNOSTIC-SIGNIFICANCE | CELL-LINES | METASTATIC COLORECTAL-CANCER | ESOPHAGEAL ADENOCARCINOMA | III TRIAL | Multivariate Analysis | Adenocarcinoma - pathology | Capecitabine | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Stomach Neoplasms - pathology | Epirubicin - administration & dosage | Molecular Targeted Therapy | Esophageal Neoplasms - pathology | Early Termination of Clinical Trials | Organoplatinum Compounds - administration & dosage | Receptor, Epidermal Growth Factor - metabolism | Fluorouracil - administration & dosage | Time Factors | Biomarkers, Tumor - metabolism | Esophageal Neoplasms - mortality | Female | Biomarkers, Tumor - antagonists & inhibitors | Odds Ratio | Stomach Neoplasms - enzymology | Fluorouracil - analogs & derivatives | Deoxycytidine - administration & dosage | Adenocarcinoma - enzymology | Kaplan-Meier Estimate | Proportional Hazards Models | Logistic Models | Treatment Outcome | United Kingdom | Stomach Neoplasms - drug therapy | Chi-Square Distribution | Adenocarcinoma - drug therapy | Disease-Free Survival | Protein Kinase Inhibitors - administration & dosage | Esophageal Neoplasms - enzymology | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Intention to Treat Analysis | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Aged | Esophageal Neoplasms - drug therapy | Stomach Neoplasms - mortality | Deoxycytidine - analogs & derivatives | Adenocarcinoma - mortality | Care and treatment | Anthracyclines | Product development | Cancer
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2014, Volume 124, Issue 12, pp. 5145 - 5158
Patients with gastric and esophageal (GE) adenocarcinoma tumors in which the oncogene ERBB2 has been amplified are routinely treated with a combination of... 
BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | GROWTH-FACTOR RECEPTOR | LUNG-CANCER | GASTRIC-CANCER | TYROSINE KINASE | RESISTANCE | GENOMIC ALTERATIONS | COPY-NUMBER ALTERATION | HER2 | KINASE ACTIVATION | Receptor, Epidermal Growth Factor - genetics | Adenocarcinoma - pathology | Receptor, ErbB-2 - genetics | Humans | Receptor, ErbB-2 - metabolism | Drug Resistance, Neoplasm | Esophageal Neoplasms - diet therapy | Male | Stomach Neoplasms - pathology | Phosphatidylinositol 3-Kinases - metabolism | Antineoplastic Agents - administration & dosage | Esophageal Neoplasms - pathology | Receptor, Epidermal Growth Factor - metabolism | Antibodies, Monoclonal, Humanized - administration & dosage | Biomarkers, Tumor - metabolism | Female | Adenocarcinoma - genetics | Stomach Neoplasms - enzymology | Stomach Neoplasms - genetics | Adenocarcinoma - enzymology | Stomach Neoplasms - drug therapy | Adenocarcinoma - drug therapy | Gene Amplification - drug effects | Phosphatidylinositol 3-Kinases - genetics | Esophageal Neoplasms - enzymology | Esophageal Neoplasms - genetics | Biomarkers, Tumor - genetics | Gene Amplification - genetics | Trastuzumab | Physiological aspects | Genetic aspects | Research | Drug therapy | Esophageal cancer | Oncogenes | Studies | Cloning | Response rates | Breast cancer | Genomes | Kinases | Cancer therapies | Patients | Tumors
Journal Article
International Journal of Cancer, ISSN 0020-7136, 10/2016, Volume 139, Issue 7, pp. 1626 - 1631
Journal Article
BMC Cancer, ISSN 1471-2407, 08/2018, Volume 18, Issue 1, pp. 796 - 10
Journal Article
European Journal of Cancer, ISSN 0959-8049, 2015, Volume 51, Issue 5, pp. 569 - 576
Abstract Introduction Human epidermal growth factor receptor 2 (HER2) amplification is present in a subgroup of gastroo-esophageal cancers (GCs). HER2... 
Hematology, Oncology and Palliative Medicine | Lapatinib | HER2 | Gastric cancer | EGFR | SURVIVAL | PLACEBO | OPEN-LABEL | KINASE INHIBITOR | CHEMOTHERAPY | PACLITAXEL | SUPPORTIVE CARE | ONCOLOGY | GW572016 | ADVANCED GASTRIC-CANCER | Adenocarcinoma - pathology | Receptor, ErbB-2 - genetics | Capecitabine | Humans | Middle Aged | Receptor, ErbB-2 - metabolism | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Stomach Neoplasms - pathology | Protein Kinase Inhibitors - adverse effects | Esophageal Neoplasms - pathology | Fluorouracil - administration & dosage | Time Factors | Esophageal Neoplasms - mortality | Adult | Female | Quinazolines - administration & dosage | Adenocarcinoma - genetics | Receptor, ErbB-2 - antagonists & inhibitors | Stomach Neoplasms - enzymology | Stomach Neoplasms - genetics | Drug Administration Schedule | Fluorouracil - analogs & derivatives | Signal Transduction | Deoxycytidine - administration & dosage | Adenocarcinoma - enzymology | Kaplan-Meier Estimate | Proportional Hazards Models | Treatment Outcome | Gene Dosage | Stomach Neoplasms - drug therapy | Adenocarcinoma - drug therapy | Disease Progression | Disease-Free Survival | Protein Kinase Inhibitors - administration & dosage | Esophageal Neoplasms - enzymology | Gene Amplification | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Quinazolines - adverse effects | Aged | Esophageal Neoplasms - drug therapy | Stomach Neoplasms - mortality | Deoxycytidine - analogs & derivatives | Germany | Adenocarcinoma - mortality | Antimitotic agents | Epidermal growth factor | Clinical trials | Product development | Metastasis | Antineoplastic agents | Esophageal cancer
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 07/2010, Volume 70, Issue 13, pp. 5567 - 5576
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2014, Volume 9, Issue 2, p. e87675
Over the last two decades, cell surface proteases belonging to the type II transmembrane serine protease (TTSP) family have emerged as important enzymes in the... 
SURVIVAL | MATRIPTASE | ACTIVATION | MULTIDISCIPLINARY SCIENCES | HEPATOCYTE GROWTH-FACTOR | ICHTHYOSIS | BARRIER FUNCTION | RELEASE | Immunohistochemistry | Carcinoma, Squamous Cell - genetics | Humans | Gene Expression Regulation, Neoplastic | Molecular Sequence Data | Gene Expression Profiling | Neoplasms - genetics | HEK293 Cells | Serine Endopeptidases - genetics | Female | Adenocarcinoma - genetics | Cell Membrane - metabolism | Membrane Proteins - metabolism | Mouth Neoplasms - genetics | Mouth Neoplasms - enzymology | Amino Acid Sequence | Carcinoma, Squamous Cell - enzymology | Epithelium - pathology | Uterine Cervical Neoplasms - enzymology | Epithelium - metabolism | Membrane Proteins - genetics | Tongue Neoplasms - genetics | Adenocarcinoma - enzymology | Neoplasms - enzymology | Reverse Transcriptase Polymerase Chain Reaction | Uterine Cervical Neoplasms - genetics | Gene Expression Regulation, Enzymologic | Esophageal Neoplasms - enzymology | Animals | Tongue Neoplasms - enzymology | Esophageal Neoplasms - genetics | Serine Endopeptidases - metabolism | COS Cells | Thrombin | Trypsin | Protease inhibitors | Serine | Cells | Cancer | Cell culture | Transformation | Transcription | Epithelial cells | Genes | Homeostasis | Oncology | Confocal microscopy | Tissue analysis | Confocal | Tissues | Cell surface | Mammalian cells | Respiratory tract | Proteins | Protease | Rodents | Head and neck | Physiology | Head and neck carcinoma | Growth factors | Head | Hepatocyte growth factor | Cloning | Proteinase inhibitors | Pharmacology | Mammals | Esophagus | Medicine | Oral cavity | Microscopy | Proteases | Serine proteinase
Journal Article
Anticancer Research, ISSN 0250-7005, 01/2017, Volume 37, Issue 1, pp. 47 - 55
Journal Article