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International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2012, Volume 83, Issue 3, pp. 878 - 886
Purpose To analyze the long-term survival and tumor control outcomes after stereotactic body radiotherapy (SBRT) for metastases limited in number and extent.... 
Radiology | Hematology, Oncology and Palliative Medicine | Stereotactic body radiotherapy | Breast cancer | Oligometastases | Survival | Metastases | ACR PRACTICE GUIDELINES | PHASE I/II TRIAL | HEPATIC RESECTION | CELL LUNG-CANCER | LIVER METASTASES | ONCOLOGY ASTRO | ONCOLOGY | COLORECTAL-CANCER | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | AMERICAN SOCIETY | RADIATION-THERAPY SBRT | TUMOR VOLUME | Bone Neoplasms - mortality | Sarcoma - secondary | Prospective Studies | Follow-Up Studies | Lung Neoplasms - mortality | Humans | Middle Aged | Bone Neoplasms - secondary | Carcinoma, Squamous Cell - surgery | Liver Neoplasms - mortality | Radiosurgery - adverse effects | Brain Neoplasms - surgery | Esophageal Neoplasms - pathology | Brain Neoplasms - secondary | Carcinoma, Squamous Cell - mortality | Lung Neoplasms - secondary | Sarcoma - mortality | Aged, 80 and over | Adult | Female | Brain Neoplasms - mortality | Liver Neoplasms - secondary | Radiosurgery - methods | Colorectal Neoplasms - mortality | Neoplasm Metastasis - radiotherapy | Liver Neoplasms - surgery | Lymphatic Metastasis | Bone Neoplasms - surgery | Adenocarcinoma - secondary | Head and Neck Neoplasms - pathology | Breast Neoplasms - pathology | Sarcoma - surgery | Breast Neoplasms - mortality | Carcinoma, Squamous Cell - secondary | Lung Neoplasms - surgery | Aged | Head and Neck Neoplasms - mortality | Colorectal Neoplasms - pathology | Adenocarcinoma - mortality | Adenocarcinoma - surgery | Radiotherapy | Nuclear radiation | Analysis | Radiation | Index Medicus | MULTIVARIATE ANALYSIS | PATIENTS | MAMMARY GLANDS | NEOPLASMS | METASTASES | RADIOLOGY AND NUCLEAR MEDICINE | DEATH | REGRESSION ANALYSIS | RADIOTHERAPY | HAZARDS | SKELETON
Journal Article
British Journal of Cancer, ISSN 0007-0920, 02/2018, Volume 118, Issue 3, pp. 428 - 434
Background: Periodontal pathogens have been linked to oral and gastrointestinal (orodigestive) carcinogenesis. However, the exact mechanisms remain unknown.... 
chymotrypsin-like proteinase | Treponema denticola | periodontopathogen | COLLAGENASE-2 MMP-8 | PORPHYROMONAS-GINGIVALIS | PANCREATIC-CANCER | TISSUE INHIBITORS | PERIODONTAL-DISEASE | METALLOPROTEINASES | ONCOLOGY | gastrointestinal cancer | ALPHA-1-ANTITRYPSIN | EXPRESSION | oral cancer | HUMAN NEUTROPHIL | PROGRESSION | Digestive System Neoplasms - metabolism | Pancreatic Neoplasms - chemistry | Adenocarcinoma - pathology | Pancreatic Neoplasms - metabolism | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Treponema denticola - enzymology | Mouth Neoplasms - metabolism | Stomach Neoplasms - pathology | Tonsillar Neoplasms - chemistry | Complement C1q - metabolism | Colonic Neoplasms - metabolism | Head and Neck Neoplasms - metabolism | Esophageal Neoplasms - pathology | Tonsillar Neoplasms - metabolism | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Head and Neck Neoplasms - chemistry | Matrix Metalloproteinase 9 - metabolism | Adenocarcinoma - metabolism | Matrix Metalloproteinase 8 - metabolism | Esophageal Neoplasms - metabolism | Digestive System Neoplasms - pathology | Colonic Neoplasms - chemistry | Stomach Neoplasms - chemistry | Adenocarcinoma - chemistry | Esophageal Neoplasms - chemistry | Tonsillar Neoplasms - pathology | Pancreatic Neoplasms - pathology | Carcinoma, Squamous Cell - chemistry | Mouth Neoplasms - chemistry | Head and Neck Neoplasms - pathology | Cell Transformation, Neoplastic - immunology | Digestive System Neoplasms - chemistry | alpha 1-Antichymotrypsin - metabolism | Colonic Neoplasms - pathology | Chymases - analysis | Mouth Neoplasms - pathology | Immunohistochemistry | Proteinase | Virulence | Tissue inhibitor of metalloproteinase 2 | Tissues | Tissue inhibitor of metalloproteinase 1 | Carcinogenesis | Proteins | Carcinogens | Pancreatic carcinoma | Bacteria | Colon | Pancreas | Gastric cancer | Squamous cell carcinoma | Tonsil | Immunomodulation | Teeth | Proteinase inhibitors | Esophagus | Complement component C1q | Chymotrypsin | Periodontitis | Neutrophil collagenase | Tumors | Index Medicus | Molecular Diagnostics
Journal Article
The Journal of Pathology, ISSN 0022-3417, 07/2013, Volume 230, Issue 3, pp. 261 - 269
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 02/2016, Volume 34, Issue 5, pp. 443 - 451
Journal Article
Gastroenterology, ISSN 0016-5085, 2016, Volume 151, Issue 5, pp. 860 - 869.e7
Background & Aims Some patients develop multiple squamous cell carcinomas (SCCs) in the upper aerodigestive tract, attributed to field cancerization; alcohol... 
Gastroenterology and Hepatology | Drinking Alcohol | Genetics Methods | Risk Factor | Carcinogenesis | ENDOSCOPIC MUCOSAL RESECTION | SUBMUCOSAL DISSECTION | CANCER | REGION | ALDEHYDE DEHYDROGENASE GENOTYPES | PATTERN | LUGOL-VOIDING LESIONS | MEN | GASTROENTEROLOGY & HEPATOLOGY | ASSOCIATION | Esophageal Neoplasms - etiology | Optical Imaging | Prospective Studies | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Male | Carcinoma, Squamous Cell - diagnostic imaging | Neoplasms, Multiple Primary - diagnostic imaging | Esophageal Neoplasms - epidemiology | Esophageal Neoplasms - pathology | Esophagoscopy | Incidence | Neoplasm Grading | Head and Neck Neoplasms - epidemiology | Aged, 80 and over | Adult | Esophagus - diagnostic imaging | Female | Esophageal Squamous Cell Carcinoma | Neoplasms, Multiple Primary - etiology | Carcinoma, Squamous Cell - epidemiology | Head and Neck Neoplasms - diagnostic imaging | Risk Factors | Kaplan-Meier Estimate | Proportional Hazards Models | Alcohol Abstinence | Neoplasms, Multiple Primary - epidemiology | Neoplasms, Multiple Primary - pathology | Alcohol Drinking - adverse effects | Head and Neck Neoplasms - pathology | Neoplasms, Second Primary - epidemiology | Neoplasms, Second Primary - etiology | Carcinoma, Squamous Cell - etiology | Esophagus - pathology | Head and Neck Neoplasms - etiology | Aged | Neoplasms, Second Primary - diagnostic imaging | Longitudinal Studies | Neoplasms, Second Primary - pathology | Esophageal Neoplasms - diagnostic imaging | Smoking Cessation | Medical colleges | Squamous cell carcinoma | Oncology, Experimental | Research | Endoscopy | Drinking of alcoholic beverages | Esophageal cancer | Risk factors | Cancer | Index Medicus | Abridged Index Medicus
Journal Article
American Journal of Surgical Pathology, ISSN 0147-5185, 09/2009, Volume 33, Issue 9, pp. 1401 - 1408
Gastrointestinal stromal tumors (GISTs), KIT or platelet derived growth factor receptor alpha (PDGFRA) signaling driven mesenchymal tumors of the... 
PDGFRA | Chloride channel protein | Sarcoma | DOG1 | KIT | Mutation | Gastrointestinal stromal tumor | PDGFRA MUTATIONS | GASTRIC TUMORS | SURGERY | sarcoma | MARKER | KINASE-C-THETA | MONOCLONAL-ANTIBODY | PATHOLOGY | mutation | chloride channel protein | gastrointestinal stromal tumor | TERM-FOLLOW-UP | EXPRESSION | PKC-THETA | MORPHOLOGY | Immunohistochemistry | Myenteric Plexus - pathology | Predictive Value of Tests | Anoctamin-1 | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Stomach Neoplasms - metabolism | Leiomyoma - metabolism | Myenteric Plexus - metabolism | Neoplasm Proteins - metabolism | Proto-Oncogene Proteins c-kit - metabolism | Esophageal Neoplasms - pathology | Leiomyoma - pathology | Chloride Channels | Gastrointestinal Stromal Tumors - diagnosis | Esophageal Neoplasms - metabolism | Mesenchymoma - diagnosis | Biomarkers, Tumor - metabolism | Membrane Proteins - metabolism | Intestinal Neoplasms - diagnosis | Colorectal Neoplasms - metabolism | Peritoneal Neoplasms - pathology | Mesenchymoma - metabolism | Diagnosis, Differential | Stomach Neoplasms - diagnosis | Intestinal Neoplasms - metabolism | Sarcoma, Synovial - metabolism | Peritoneal Neoplasms - metabolism | Gastrointestinal Stromal Tumors - metabolism | Mesenchymoma - secondary | Colorectal Neoplasms - pathology | Sarcoma, Synovial - pathology | Index Medicus
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2014, Volume 15, Issue 11, pp. 1224 - 1235
Summary Background VEGFR-2 has a role in gastric cancer pathogenesis and progression. We assessed whether ramucirumab, a monoclonal antibody VEGFR-2... 
Hematology, Oncology and Palliative Medicine | SUPPORTIVE CARE | ONCOLOGY | BEVACIZUMAB | CLINICAL-TRIALS | GROWTH | 2ND-LINE CHEMOTHERAPY | OPEN-LABEL | 1ST-LINE THERAPY | COMBINATION | CANCER | III TRIAL | Confidence Intervals | Adenocarcinoma - pathology | Prognosis | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Stomach Neoplasms - pathology | Esophageal Neoplasms - pathology | Dose-Response Relationship, Drug | Esophageal Neoplasms - mortality | Adult | Female | Remission Induction - methods | Paclitaxel - administration & dosage | Double-Blind Method | Drug Administration Schedule | Kaplan-Meier Estimate | Proportional Hazards Models | Esophagogastric Junction - pathology | Paclitaxel - adverse effects | Treatment Outcome | Stomach Neoplasms - drug therapy | Adenocarcinoma - drug therapy | Disease-Free Survival | Maximum Tolerated Dose | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Survival Analysis | Aged | Esophageal Neoplasms - drug therapy | Stomach Neoplasms - mortality | Adenocarcinoma - mortality | Antimitotic agents | Care and treatment | Hospitals | Clinical trials | Monoclonal antibodies | Product development | Antineoplastic agents | Vascular endothelial growth factor | Esophageal cancer | Index Medicus
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 01/2018, Volume 110, Issue 1, pp. 109 - 120
Background: Cancer-associated fibroblasts (CAFs) are tumor-promoting and correlate with poor survival in many cancers, which has led to their emergence as... 
CELL LUNG-CANCER | PHASE-II TRIAL | OXIDATIVE STRESS | ONCOLOGY | NAB-PACLITAXEL | ACTIVATION PROTEIN | DEPENDENT INVASION | PANCREATIC-CANCER | MONOCLONAL-ANTIBODY | DIFFERENTIATION | STROMAL CELLS | Lung Neoplasms - drug therapy | Up-Regulation | Pyrazoles - therapeutic use | Reactive Oxygen Species - metabolism | Cell Count | Humans | Middle Aged | Male | Oropharyngeal Neoplasms - pathology | Head and Neck Neoplasms - chemistry | RNA Interference | Cancer-Associated Fibroblasts - chemistry | Aged, 80 and over | NADPH Oxidases - genetics | Adenocarcinoma - chemistry | Esophageal Neoplasms - chemistry | Lung Neoplasms - chemistry | NADPH Oxidases - antagonists & inhibitors | Head and Neck Neoplasms - drug therapy | Carcinoma, Squamous Cell - chemistry | Survival Rate | Adenocarcinoma - drug therapy | Disease Progression | Phenotype | Carcinoma, Squamous Cell - drug therapy | Head and Neck Neoplasms - genetics | Mice | Neoplasm Transplantation | Carcinoma, Non-Small-Cell Lung - chemistry | Carcinoma, Squamous Cell - genetics | Colorectal Neoplasms - chemistry | Cell Transdifferentiation - genetics | Myofibroblasts - chemistry | Actins - analysis | Cell Transdifferentiation - drug effects | Adult | Female | Adenocarcinoma - genetics | Cancer-Associated Fibroblasts - physiology | Pyridines - therapeutic use | Lung Neoplasms - genetics | Myofibroblasts - pathology | Carcinoma, Non-Small-Cell Lung - genetics | NADPH Oxidases - analysis | Mouth Neoplasms - chemistry | NADPH Oxidase 4 | Cancer-Associated Fibroblasts - pathology | Animals | Esophageal Neoplasms - genetics | Mouth Neoplasms - pathology | Oropharyngeal Neoplasms - chemistry | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Colorectal Neoplasms - pathology | Esophageal Neoplasms - drug therapy | Index Medicus
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2013, Volume 14, Issue 6, pp. 481 - 489
Summary Background EGFR overexpression occurs in 27–55% of oesophagogastric adenocarcinomas, and correlates with poor prognosis. We aimed to assess addition of... 
Hematology, Oncology and Palliative Medicine | GROWTH-FACTOR RECEPTOR | 1ST-LINE TREATMENT | CETUXIMAB | PROSPECTIVE MULTICENTER | ONCOLOGY | GASTRIC-CANCER | PROGNOSTIC-SIGNIFICANCE | CELL-LINES | METASTATIC COLORECTAL-CANCER | ESOPHAGEAL ADENOCARCINOMA | III TRIAL | Multivariate Analysis | Adenocarcinoma - pathology | Capecitabine | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Stomach Neoplasms - pathology | Epirubicin - administration & dosage | Molecular Targeted Therapy | Esophageal Neoplasms - pathology | Early Termination of Clinical Trials | Organoplatinum Compounds - administration & dosage | Receptor, Epidermal Growth Factor - metabolism | Fluorouracil - administration & dosage | Time Factors | Biomarkers, Tumor - metabolism | Esophageal Neoplasms - mortality | Female | Biomarkers, Tumor - antagonists & inhibitors | Odds Ratio | Stomach Neoplasms - enzymology | Fluorouracil - analogs & derivatives | Deoxycytidine - administration & dosage | Adenocarcinoma - enzymology | Kaplan-Meier Estimate | Proportional Hazards Models | Logistic Models | Treatment Outcome | United Kingdom | Stomach Neoplasms - drug therapy | Chi-Square Distribution | Adenocarcinoma - drug therapy | Disease-Free Survival | Protein Kinase Inhibitors - administration & dosage | Esophageal Neoplasms - enzymology | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Intention to Treat Analysis | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Aged | Esophageal Neoplasms - drug therapy | Stomach Neoplasms - mortality | Deoxycytidine - analogs & derivatives | Adenocarcinoma - mortality | Care and treatment | Anthracyclines | Product development | Cancer | Index Medicus
Journal Article
Human Pathology, ISSN 0046-8177, 2012, Volume 43, Issue 10, pp. 1755 - 1763
Summary Mucin 16 (cancer antigen 125) is a cell surface glycoprotein that plays a role in promoting cancer cell growth in ovarian cancer. The aims of this... 
Pathology | Digestive tract adenocarcinoma | MUC16 | CA125 | DIAGNOSIS | TUMOR-MARKERS | SERUM CA125 | CA 125 | PERITONEAL METASTASIS | BARRETTS-ESOPHAGUS | PATHOLOGY | IDENTIFICATION | MESOTHELIN | MEMBRANE-BOUND MUCINS | GASTRIC-CANCER | OVARIAN | Immunohistochemistry | Digestive System Neoplasms - metabolism | Adenocarcinoma - pathology | Digestive System Neoplasms - mortality | Pancreatic Neoplasms - metabolism | Prognosis | Humans | Middle Aged | Stomach Neoplasms - metabolism | Male | Stomach Neoplasms - pathology | Colonic Neoplasms - metabolism | Membrane Proteins - analysis | Esophageal Neoplasms - pathology | Adenocarcinoma - metabolism | CA-125 Antigen - biosynthesis | Esophageal Neoplasms - metabolism | Digestive System Neoplasms - pathology | Esophageal Neoplasms - mortality | Female | CA-125 Antigen - analysis | Pancreatic Neoplasms - mortality | Colonic Neoplasms - mortality | Biomarkers, Tumor - analysis | Pancreatic Neoplasms - pathology | Kaplan-Meier Estimate | Blotting, Western | Membrane Proteins - biosynthesis | Colonic Neoplasms - pathology | Cell Line, Tumor | Aged | Neoplasm Staging | Stomach Neoplasms - mortality | Adenocarcinoma - mortality | Antigens | Patient outcomes | Pancreatic cancer | Oncology, Experimental | Colorectal cancer | Mucins | Research | Esophageal cancer | Cancer | Proteins | Tumors | Ovarian cancer | Index Medicus
Journal Article