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RSC advances, ISSN 2046-2069, 2018, Volume 8, Issue 27, pp. 15009 - 15020
2-arylbenzo[ ]quinolin-4(1 )-ones are developed as selective CYP1B1 inhibitors. The CYP1B1 enzyme is regarded as a potential target for cancer prevention and... 
BREAST-CANCER CELLS | CYTOCHROME-P450 | ENZYMES | DOCETAXEL-RESISTANCE | DRUG-RESISTANCE | EXPRESSION | EFFICIENT | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | 17-BETA-ESTRADIOL | 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN | Reversing | Selectivity | Inhibitors
Journal Article
Organic & biomolecular chemistry, ISSN 1477-0520, 2016, Volume 14, Issue 41, pp. 9790 - 9805
Estrone and 17β-estradiol are phenolic steroids that are known to be neuroprotective in multiple models of neuronal injury. Estrone and 17β-estradiol are... 
IN-VITRO | OXIDATIVE STRESS | NEUROSTEROID ANALOGS | PROTECTS NEURONS | ALKYLATION | ESTRADIOL | CHEMISTRY, ORGANIC | ALPHAXALONE | DERIVATIVES | ISCHEMIC DAMAGE | CELL-DEATH
Journal Article
ChemMedChem, ISSN 1860-7179, 04/2017, Volume 12, Issue 7, pp. 487 - 501
...‐relevant properties of sulfoximines. Herein we report the synthesis and in vitro characterization of a variety of sulfoximine analogues of marketed drugs and advanced... 
kinase inhibitors | pharmacophores | sulfoximines | drug design | medicinal chemistry | PHOSPHODIESTERASE-5 INHIBITORS | CHEMISTRY, MEDICINAL | ASYMMETRIC-SYNTHESIS | BUILDING-BLOCKS | DEPENDENT KINASE INHIBITOR | NH-SULFOXIMINES | POTENT INHIBITOR | LIGANDS | STRUCTURAL BASIS | CDK4/6 INHIBITOR | ABL PROTEIN | PHARMACOLOGY & PHARMACY | Estradiol - analogs & derivatives | Sulfoxides - chemical synthesis | Cyclin-Dependent Kinases - metabolism | Ataxia Telangiectasia Mutated Proteins - metabolism | Imatinib Mesylate - chemical synthesis | Pyrazoles - chemical synthesis | Pyridines - chemistry | Imatinib Mesylate - metabolism | Piperazines - metabolism | Piperazines - chemistry | Aminopyridines - metabolism | Fulvestrant | Aminopyridines - chemistry | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Vardenafil Dihydrochloride - chemistry | Drug Design | Ataxia Telangiectasia Mutated Proteins - antagonists & inhibitors | Cyclin-Dependent Kinases - antagonists & inhibitors | Purines - chemical synthesis | Estradiol - metabolism | Protein Kinase Inhibitors - chemical synthesis | Piperidines - chemistry | Piperidines - metabolism | Purines - metabolism | Pyridines - chemical synthesis | Pyrazoles - metabolism | Piperidines - chemical synthesis | Imatinib Mesylate - chemistry | Vardenafil Dihydrochloride - metabolism | Aminopyridines - chemical synthesis | Sulfoxides - chemistry | Estradiol - chemistry | Purines - chemistry | Pyridines - metabolism | Vardenafil Dihydrochloride - chemical synthesis | Sulfoxides - metabolism | Piperazines - chemical synthesis | Estradiol - chemical synthesis | Protein Kinase Inhibitors - metabolism | Drug discovery | Chemical properties | Pharmaceutical industry | Full Paper | Full Papers
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2013, Volume 8, Issue 9, p. e71935
.... However, due to its limited biological accessibility, synthetic analogues have been synthesized and tested in attempt to develop drugs with improved oral bioavailability and efficacy... 
STEROID SULFATASE INHIBITORS | BREAST-CANCER CELLS | IN-VITRO | VIVO | TUBULIN VARIANT | MULTIDISCIPLINARY SCIENCES | PROLIFERATION | CYCLE PROGRESSION | MICROTUBULE DYNAMICS | ESOPHAGEAL-CARCINOMA CELLS | MORPHOLOGY | Adenocarcinoma | Microscopy, Electron, Transmission | Estradiol - analogs & derivatives | Apoptosis - drug effects | Tubulin Modulators - pharmacology | Cytochromes c - metabolism | Humans | Caspase 3 - metabolism | Membrane Potential, Mitochondrial - drug effects | Sulfonamides - pharmacology | Cell Shape - drug effects | Microtubules - metabolism | Tubulin - metabolism | Antineoplastic Agents - pharmacology | Enzyme Activation | HeLa Cells | Tubulin - chemistry | Estradiol - pharmacology | Protein Multimerization - drug effects | Drug Screening Assays, Antitumor | Cytochrome c | Estrogen | Polymerization | Tubulins | Apoptosis | Steroids | Cytochrome | Drugs | Toxicity | Estrogens | Antibodies | Clinical trials | Cytotoxicity | Dehydrogenase | Assaying | Caspase-3 | Estradiol | Anticancer properties | Depolymerization | Mitochondria | Tubulin | Metabolites | Cell cycle | Physiology | Membrane potential | Deoxyribonucleic acid--DNA | Caspase | Lactate dehydrogenase | Exposure | Breast cancer | Bioavailability | Tumor cell lines | Metabolism | L-Lactate dehydrogenase | Sex hormones | Caspase-6 | Microscopy | Antiangiogenics | Lactic acid | Immunofluorescence | Prostate | Binding sites | Life Sciences | Cellular Biology | Cancer | Deoxyribonucleic acid | DNA
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 03/2010, Volume 69, Issue 3, pp. 238 - 244
Journal Article
Journal of biochemical and molecular toxicology, ISSN 1095-6670, 2018, Volume 32, Issue 1, pp. e21925 - n/a
The objective of the present study was to characterize the role of novel resveratrol (Res) analogs: 4‐(E)‐{(4‐hydroxyphenylimino)‐methylbenzene, 1, 2‐diol} (HPIMBD) and 4‐(E)‐{(p‐tolylimino)‐methylbenzene‐1,2‐diol} (TIMBD... 
antioxidant properties | HPIMBD | TIMBD | breast cancer | resveratrol | resveratrol analogs | oxidative stress | OXIDATIVE DNA-DAMAGE | ELEMENT-MEDIATED EXPRESSION | STATISTICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | SYRIAN-HAMSTERS | INDUCTION | CARCINOGENESIS | INHIBITION | ESTROGEN | TOXICOLOGY | STRESS | Prevention | Antioxidants | Breast cancer | RNA | Resveratrol | Cancer | Cellular manufacture | Transcription factors | Epithelial cells | DNA damage | 17β-Estradiol | Superoxide dismutase | Superoxide | Tumor cell lines | Gene expression | Analogs | Signal transduction | Sex hormones | Signaling | Deoxyguanosine | Deoxyribonucleic acid--DNA
Journal Article