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Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 11, p. e79977
... to the transition into reproductive senescence. The deficit in brain metabolism was sustained thereafter... 
MECHANISM | ASTROCYTE | MULTIDISCIPLINARY SCIENCES | LACTATE | DISEASE | HIPPOCAMPAL | ESTRADIOL | COGNITIVE IMPAIRMENT | ENERGY-METABOLISM | EXPRESSION | OLIGODENDROCYTES | Adaptation, Physiological | Ketone Oxidoreductases - metabolism | Neurons - pathology | Humans | Ketone Bodies - metabolism | Astrocytes - pathology | Glucose Transporter Type 1 - metabolism | Alzheimer Disease - pathology | Biological Transport, Active | Monocarboxylic Acid Transporters - metabolism | Aging - genetics | Female | Neurons - metabolism | Hexokinase - genetics | Disease Models, Animal | Gene Expression | Lactic Acid - metabolism | Mice, Transgenic | Hippocampus - pathology | Mitochondria - metabolism | Ketone Oxidoreductases - genetics | Aging - pathology | Blood-Brain Barrier - metabolism | Hippocampus - metabolism | Animals | Energy Metabolism | Glucose Transporter Type 1 - genetics | Alzheimer Disease - metabolism | Glucose - metabolism | Mice | Monocarboxylic Acid Transporters - genetics | Alzheimer Disease - genetics | Hexokinase - metabolism | Aging - metabolism | Astrocytes - metabolism | Lactates | Glucose metabolism | Enzymes | Brain | Neurons | Glucose | Alzheimer's disease | Dextrose | Neurosciences | Senescence | Adaptive systems | Dehydrogenases | Pyruvic acid | Ketone bodies | Fuels | Mitochondria | Bioenergetics | Blood-brain barrier | Rodents | Aging | Pharmaceutical sciences | Age | Glucose transporter | Phenotypes | Medical imaging | Neurodegenerative diseases | Ketones | Astrocytes | Pharmacology | Metabolism | Glucose transport | Fatty acids | Hexokinase | Utilization | Pharmacy | Glycolysis | Lactic acid | Laboratory animals | Alzheimers disease | Axonal transport | Transporter | Hippocampus | Animal cognition
Journal Article
Drug metabolism and disposition, ISSN 1521-009X, 2010, Volume 38, Issue 1, pp. 168 - 176
This study investigated the role of a multispecific organic anion transporter, Oatp1a4/ Slco1a4 , in drug transport across the blood-brain barrier. In vitro... 
LOCALIZATION | INVOLVEMENT | POLYPEPTIDE-2 | PENETRATION | PHARMACOLOGY & PHARMACY | RAT-BRAIN | OATP2 | BCRP/ABCG2 | 17-BETA-ESTRADIOL-D-17-BETA-GLUCURONIDE | CANCER RESISTANCE PROTEIN | P-GLYCOPROTEIN | Fluorobenzenes - pharmacokinetics | Gene Expression - genetics | Pyrimidines - blood | Humans | Ion Pumps - genetics | Fluorobenzenes - administration & dosage | Quinolines - administration & dosage | Pyrimidines - metabolism | Brain - metabolism | Quinolines - pharmacokinetics | Choroid Plexus - blood supply | ATP-Binding Cassette Transporters - genetics | Ochratoxins - administration & dosage | Cell Membrane - metabolism | Cerebral Cortex - drug effects | Capillaries - metabolism | Fluorobenzenes - metabolism | Tetrahydroisoquinolines - pharmacology | Organic Cation Transport Proteins - metabolism | Pravastatin - metabolism | Liver - metabolism | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Taurocholic Acid - administration & dosage | Pravastatin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - administration & dosage | Pyrimidines - pharmacokinetics | Mice | Kinetics | Organic Cation Transport Proteins - genetics | Pravastatin - pharmacokinetics | Sulfonamides - administration & dosage | Quinolines - blood | Digoxin - metabolism | Taurocholic Acid - metabolism | Choroid Plexus - metabolism | Taurocholic Acid - blood | Ochratoxins - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Ochratoxins - metabolism | Cerebral Cortex - metabolism | Organic Anion Transporters - metabolism | Brain - blood supply | Sulfonamides - blood | Organic Anion Transporters - genetics | Transfection | Fluorobenzenes - blood | Enkephalin, D-Penicillamine (2,5)- - pharmacokinetics | Recombinant Proteins - metabolism | Cell Line | Pyrimidines - administration & dosage | Mice, Inbred C57BL | Recombinant Proteins - genetics | Blood-Brain Barrier - drug effects | Digoxin - pharmacokinetics | Quinolines - metabolism | Taurocholic Acid - pharmacokinetics | Liver - blood supply | Pharmaceutical Preparations - metabolism | Animals | Digoxin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - metabolism | Acridines - pharmacology | Sulfonamides - metabolism
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 3, p. e59825
... substrate availability and metabolism in a mouse model of familial Alzheimer's (3xTgAD). Results of these analyses indicated that ovarian hormones deprivation by ovariectomy (OVX... 
POSITRON-EMISSION-TOMOGRAPHY | HORMONE-THERAPY | MULTIDISCIPLINARY SCIENCES | BRAIN GLUCOSE-METABOLISM | AEROBIC GLYCOLYSIS | IN-VIVO | A-BETA | HEXOKINASE-ACTIVITY | AMYLOID-BETA-PROTEIN | RAT-BRAIN | ENERGY-METABOLISM | L-Lactate Dehydrogenase - metabolism | Body Weight | Positron-Emission Tomography | X-Ray Microtomography | Isoenzymes - metabolism | Amyloid beta-Peptides - metabolism | Female | Neurons - metabolism | Estrogens - metabolism | Skin Temperature | Disease Models, Animal | Ovary - metabolism | Estradiol - metabolism | Ovariectomy | Gene Expression Regulation | Mice, Transgenic | Mitochondria - metabolism | Hippocampus - metabolism | Animals | Lactates - metabolism | Brain - pathology | Glucose - metabolism | Glycolysis | Mice | Alzheimer Disease - genetics | Brain | Glucose metabolism | Neurons | Physiological aspects | Genetic engineering | Genetic aspects | Glucose | Gene expression | Estradiol | Alzheimer's disease | Dextrose | Cytochrome | Energy metabolism | Estrogens | Ketone bodies | Hormones | Proteins | Mitochondria | Bioenergetics | Aging | Availability | Glucose transporter | Preservation | Neurodegenerative diseases | Metabolism | Glucose transport | Substrates | Neurology | Sex hormones | Pharmacy | Transporter | Neuroimaging | Neurosciences | Senescence | 17β-Estradiol | Kinases | Energy resources | Rodents | Pharmaceutical sciences | Deprivation | Medical imaging | Ketones | Transgenic mice | CoA transferase | Pharmacology | Fuel technology | Hexokinase | Lactic acid | Respiration | Laboratory animals | Alzheimers disease | Alternative fuels
Journal Article
International journal of cancer, ISSN 0020-7136, 2012, Volume 131, Issue 11, pp. 2553 - 2561
Estrogen receptor‐beta (ERβ) has been suggested to exert anti‐inflammatory and anti‐tumorigenic effects in the colon, providing a translational potential to... 
dextran sodium sulfate | estrogen receptor‐beta | colon cancer | azoxymethane | inflammatory bowel disease | estrogen receptor-beta | Estradiol - blood | Mucin-2 - genetics | Neoplasms - metabolism | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Colitis - genetics | Colorectal Neoplasms - genetics | Tumor Necrosis Factor-alpha - genetics | Colitis - pathology | NF-kappa B - metabolism | Interferon-gamma - metabolism | Inflammatory Bowel Diseases - metabolism | Estrogen Receptor beta - metabolism | Cell Differentiation - genetics | Inflammation - metabolism | Estrogen Receptor beta - genetics | Proliferating Cell Nuclear Antigen - genetics | Neoplasms - genetics | Inflammatory Bowel Diseases - pathology | Inflammatory Bowel Diseases - genetics | Female | Interferon-gamma - genetics | Interleukin-6 - metabolism | Colorectal Neoplasms - metabolism | Mucin-2 - metabolism | Mucin-1 - metabolism | Interleukin-6 - genetics | Colon - pathology | Mice, Inbred C57BL | Caveolin 1 - genetics | Interleukin-17 - genetics | beta Catenin - metabolism | Colon - metabolism | beta Catenin - genetics | Mice, Knockout | Caveolin 1 - metabolism | Interleukin-17 - metabolism | Animals | NF-kappa B - genetics | Nitric Oxide Synthase Type II - genetics | Colitis - metabolism | Inflammation - genetics | Mice | Colorectal Neoplasms - pathology | Neoplasms - pathology | Proliferating Cell Nuclear Antigen - metabolism | Mucin-1 - genetics | Nitric Oxide Synthase Type II - metabolism | Estrogen receptor-beta
Journal Article
Drug metabolism and disposition, ISSN 0090-9556, 02/2013, Volume 41, Issue 2, pp. 256 - 262
.... Although much has been learned, significant gaps still exist in our understanding of the spectrum of drug metabolism and transport genes affected, gestational age-dependent changes in the activity... 
WOMEN | METFORMIN | CLEARANCE | IN-VITRO | PHARMACOKINETICS | PLASMA-CONCENTRATIONS | 3RD TRIMESTER | ZIDOVUDINE | PHARMACOLOGY & PHARMACY | HUMAN-IMMUNODEFICIENCY-VIRUS | EXPRESSION | Smoking - adverse effects | Estrogens - pharmacology | Liver - enzymology | Cholestasis - metabolism | Minor Histocompatibility Antigens | Taurocholic Acid - metabolism | Humans | Kidney - enzymology | Cytochrome P-450 Enzyme System - metabolism | Male | Hepatocytes - metabolism | Organic Anion Transporters - metabolism | Intestine, Small - enzymology | Lung - enzymology | Glucuronosyltransferase - genetics | RNA, Messenger - biosynthesis | Kidney - metabolism | Estrogen Receptor alpha - agonists | Liver - drug effects | Cotinine - metabolism | Maternal Behavior | ATP-Binding Cassette Transporters - metabolism | Female | Membrane Transport Proteins - metabolism | Pesticides - metabolism | Adrenal Glands - enzymology | Progesterone - pharmacology | Estradiol - pharmacology | Hepatocytes - drug effects | Retinoic Acid 4-Hydroxylase | Multidrug Resistance-Associated Proteins - drug effects | Gene Expression Regulation, Developmental - drug effects | Placenta - enzymology | Ethinyl Estradiol - pharmacology | Aryldialkylphosphatase - metabolism | Carboxylesterase - metabolism | Fetus - drug effects | Placenta - drug effects | Pregnancy | Animals | Glucuronosyltransferase - metabolism | Cytochrome P-450 Enzyme System - biosynthesis | Cytochrome P-450 Enzyme System - genetics | Hydroxyprogesterones - metabolism | Special Section on Drug Metabolizing Enzymes and Transporters in Pregnancy
Journal Article
Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 08/2007, Volume 34, Issue 8, pp. 801 - 808
SUMMARY • Cerebral vessels express oestrogen receptors (ER) in both the smooth muscle and endothelial cell layers of cerebral blood vessels. Levels of ERα are... 
prostacyclin | mitochondria | reactive oxygen species | vascular inflammation | oestrogen receptors | nitric oxide synthase | 17β-oestradiol | cerebral circulation | endothelial dysfunction | 17β‐oestradiol | Mitochondria | Reactive oxygen species | Cerebral circulation | Endothelial dysfunction | Nitric oxide synthase | Prostacyclin | Vascular inflammation | Oestrogen receptors | MENSTRUAL-CYCLE | CEREBRAL BLOOD-VESSELS | PHYSIOLOGY | 17 beta-oestradiol | NITRIC-OXIDE SYNTHASE | RECEPTOR-ALPHA | TRANSIENT FOREBRAIN ISCHEMIA | HYPERPOLARIZING FACTOR | PIAL ARTERIOLAR DILATION | ENDOTHELIAL-CELLS | PHARMACOLOGY & PHARMACY | DEPENDENT MECHANISMS | OVARIECTOMIZED FEMALE RATS | Cerebrovascular Disorders - physiopathology | Epoprostenol - metabolism | Receptors, Estrogen - metabolism | Oxidative Stress | Signal Transduction | Blood Vessels - metabolism | Humans | Cerebrovascular Circulation | Cerebrovascular Disorders - metabolism | Mitochondria - metabolism | Vasodilation | Brain - blood supply | Inflammation - metabolism | Animals | Energy Metabolism | Vasodilator Agents - metabolism | Female | Estrogens - metabolism | Nitric Oxide - metabolism | Aging - metabolism | Inflammation - physiopathology | Brain, blood supply | Cerebrovascular Disorders, physiopathology | Receptors, Estrogen, metabolism | Nitric Oxide, metabolism | Cerebrovascular Disorders, metabolism | Inflammation, physiopathology | Blood Vessels, metabolism | Inflammation, metabolism | Estrogens, metabolism | Mitochondria, metabolism | Vasodilator Agents, metabolism | Epoprostenol, metabolism | Aging, metabolism | Nitric oxide | Estrogen
Journal Article
Journal Article
The journal of clinical endocrinology and metabolism, ISSN 1945-7197, 2017, Volume 102, Issue 6, pp. 1807 - 1815
Context: In type 2 diabetes mellitus, fracture risk is increased despite preserved areal bone mineral density. Although this apparent paradox may in part be... 
SERUM-INSULIN | OBESE CHILDREN | HOMEOSTASIS MODEL ASSESSMENT | SKELETAL-MUSCLE MASS | HEALTHY MALE SIBLINGS | ENDOCRINOLOGY & METABOLISM | PHYSICAL-ACTIVITY | POSTMENOPAUSAL WOMEN | TYPE-2 DIABETES-MELLITUS | FRACTURE RISK | BETA-CELL FUNCTION | Body Composition | Radius - pathology | Humans | Leptin - metabolism | Middle Aged | Male | Tomography, X-Ray Computed | Cortical Bone - pathology | Tibia - pathology | Tandem Mass Spectrometry | Testosterone - metabolism | Peptides - metabolism | Parathyroid Hormone - metabolism | Chromatography, Liquid | Adiponectin - metabolism | Adult | Muscle Strength | Estradiol - metabolism | Peptide Fragments - metabolism | Bone Density | Collagen Type I - metabolism | Osteocalcin - metabolism | Insulin Resistance | Tibia - diagnostic imaging | Organ Size | Sex Hormone-Binding Globulin - metabolism | Procollagen - metabolism | Absorptiometry, Photon | Insulin - metabolism | Muscle, Skeletal - diagnostic imaging | Vitamin D - analogs & derivatives | Vitamin D - metabolism | Muscle, Skeletal - pathology | Blood Glucose - metabolism | Cortical Bone - diagnostic imaging | Insulin-Like Growth Factor I - metabolism | Radius - diagnostic imaging | Serum Albumin - metabolism | Radius | Sex | Homeostasis | Population studies | Bone (trabecular) | Body composition | Adiponectin | Computed tomography | Body composition (biology) | Bone (cortical) | Age | Bone composition | Dual energy X-ray absorptiometry | Diabetes mellitus | Health risks | Muscles | Excavation | Bone turnover | Insulin | Geometry | Bone mass | Leptin | Body size | Men | Insulin resistance | Bone mineral density
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2011, Volume 331, Issue 6019, pp. 912 - 916
During pregnancy, progesterone inhibits the growth-promoting actions of estrogen in the uterus. However, the mechanism for this is not clear. The attenuation... 
Pregnancy | Phosphorylation | Messenger RNA | Uterus | Epithelial cells | Stromal cells | REPORTS | Mice | Epithelium | Embryos | Vehicles | INHIBITION | IMPLANTATION | MULTIDISCIPLINARY SCIENCES | RECEPTOR | PROLIFERATION | GROWTH-FACTOR | MOUSE UTERUS | CANCER | Cell Proliferation | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Endometrium - drug effects | Fibroblast Growth Factors - genetics | Gene Expression Profiling | Extracellular Signal-Regulated MAP Kinases - metabolism | Receptors, Progesterone - metabolism | Fibroblast Growth Factors - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Estrogen Receptor alpha - metabolism | Female | Transcription, Genetic | Epithelial Cells - cytology | Progesterone - pharmacology | Endometrium - metabolism | Estradiol - metabolism | Mucin-1 - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Embryo Implantation - physiology | Epithelium - metabolism | Signal Transduction | Progesterone - antagonists & inhibitors | Mice, Inbred C57BL | Stromal Cells - metabolism | Mice, Knockout | Animals | Receptors, Fibroblast Growth Factor - metabolism | Progesterone - metabolism | Mifepristone - pharmacology | Stromal Cells - cytology | Cell proliferation | Physiological aspects | Fibroblast growth factors | Research | Progesterone
Journal Article