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PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, pp. e79977 - e79977
We previously demonstrated that mitochondrial bioenergetic deficits in the female brain accompanied reproductive senescence and was accompanied by a shift from... 
MECHANISM | ASTROCYTE | MULTIDISCIPLINARY SCIENCES | LACTATE | DISEASE | HIPPOCAMPAL | ESTRADIOL | COGNITIVE IMPAIRMENT | ENERGY-METABOLISM | EXPRESSION | OLIGODENDROCYTES | Adaptation, Physiological | Ketone Oxidoreductases - metabolism | Neurons - pathology | Humans | Ketone Bodies - metabolism | Astrocytes - pathology | Glucose Transporter Type 1 - metabolism | Alzheimer Disease - pathology | Biological Transport, Active | Monocarboxylic Acid Transporters - metabolism | Aging - genetics | Female | Neurons - metabolism | Hexokinase - genetics | Disease Models, Animal | Gene Expression | Lactic Acid - metabolism | Mice, Transgenic | Hippocampus - pathology | Mitochondria - metabolism | Ketone Oxidoreductases - genetics | Aging - pathology | Blood-Brain Barrier - metabolism | Hippocampus - metabolism | Animals | Energy Metabolism | Glucose Transporter Type 1 - genetics | Alzheimer Disease - metabolism | Glucose - metabolism | Mice | Monocarboxylic Acid Transporters - genetics | Alzheimer Disease - genetics | Hexokinase - metabolism | Aging - metabolism | Astrocytes - metabolism | Lactates | Glucose metabolism | Enzymes | Brain | Neurons | Glucose | Alzheimer's disease | Dextrose | Neurosciences | Senescence | Adaptive systems | Dehydrogenases | Pyruvic acid | Ketone bodies | Fuels | Mitochondria | Bioenergetics | Blood-brain barrier | Rodents | Aging | Pharmaceutical sciences | Age | Glucose transporter | Phenotypes | Medical imaging | Neurodegenerative diseases | Ketones | Astrocytes | Pharmacology | Metabolism | Glucose transport | Fatty acids | Hexokinase | Utilization | Pharmacy | Glycolysis | Lactic acid | Laboratory animals | Transport | Alzheimers disease | Axonal transport | Transporter | Hippocampus | Animal cognition | Index Medicus
Journal Article
The Plant Journal, ISSN 0960-7412, 08/2012, Volume 71, Issue 3, pp. 479 - 491
Arabidopsis thaliana PHO1 is primarily expressed in the root vascular cylinder and is involved in the transfer of inorganic phosphate (Pi) from roots to... 
Arabidopsis | phosphate | Golgi network | Golgi | export | PHO1 | trans | trans-Golgi network | TRANSFORMATION | NA+/H+ ANTIPORTERS | ATPASE ACTIVITY | TRANSPORTER | PROTEIN | IDENTIFICATION | ENDOCYTOSIS | PLANT SCIENCES | GENE FAMILY | VECTOR SET | Protoplasts | Homeostasis | Plant Roots - genetics | Seedlings - genetics | Promoter Regions, Genetic - genetics | Plant Roots - ultrastructure | Recombinant Fusion Proteins | Arabidopsis Proteins - metabolism | Onions - genetics | trans-Golgi Network - metabolism | Biological Transport | Plants, Genetically Modified | Cell Membrane - metabolism | Plant Shoots - genetics | Plant Shoots - ultrastructure | Arabidopsis Proteins - genetics | Gene Expression | Plant Roots - metabolism | Tobacco - metabolism | Arabidopsis - ultrastructure | Gene Expression Regulation, Plant - genetics | Onions - metabolism | Arabidopsis - metabolism | Seedlings - ultrastructure | Arabidopsis - genetics | Nitrates - metabolism | Phosphates - metabolism | Plant Leaves - genetics | Plant Leaves - metabolism | Plant Shoots - metabolism | Tobacco - genetics | Golgi Apparatus - metabolism | Plant Leaves - ultrastructure | Seedlings - metabolism | Phosphates | Arabidopsis thaliana | Fluorescence | Cyanides | Estradiol | Cells | Proteins | Cellular biology | Gene expression | Transgenic plants | Index Medicus
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 168 - 176
This study investigated the role of a multispecific organic anion transporter, Oatp1a4/ Slco1a4 , in drug transport across the blood-brain barrier. In vitro... 
LOCALIZATION | INVOLVEMENT | POLYPEPTIDE-2 | PENETRATION | PHARMACOLOGY & PHARMACY | RAT-BRAIN | OATP2 | BCRP/ABCG2 | 17-BETA-ESTRADIOL-D-17-BETA-GLUCURONIDE | CANCER RESISTANCE PROTEIN | P-GLYCOPROTEIN | Fluorobenzenes - pharmacokinetics | Gene Expression - genetics | Pyrimidines - blood | Humans | Ion Pumps - genetics | Fluorobenzenes - administration & dosage | Quinolines - administration & dosage | Pyrimidines - metabolism | Brain - metabolism | Quinolines - pharmacokinetics | Choroid Plexus - blood supply | ATP-Binding Cassette Transporters - genetics | Ochratoxins - administration & dosage | Cell Membrane - metabolism | Cerebral Cortex - drug effects | Capillaries - metabolism | Fluorobenzenes - metabolism | Tetrahydroisoquinolines - pharmacology | Organic Cation Transport Proteins - metabolism | Pravastatin - metabolism | Liver - metabolism | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Taurocholic Acid - administration & dosage | Pravastatin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - administration & dosage | Pyrimidines - pharmacokinetics | Mice | Kinetics | Organic Cation Transport Proteins - genetics | Pravastatin - pharmacokinetics | Sulfonamides - administration & dosage | Quinolines - blood | Digoxin - metabolism | Taurocholic Acid - metabolism | Choroid Plexus - metabolism | Taurocholic Acid - blood | Ochratoxins - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Ochratoxins - metabolism | Cerebral Cortex - metabolism | Organic Anion Transporters - metabolism | Brain - blood supply | Sulfonamides - blood | Organic Anion Transporters - genetics | Transfection | Fluorobenzenes - blood | Enkephalin, D-Penicillamine (2,5)- - pharmacokinetics | Recombinant Proteins - metabolism | Cell Line | Pyrimidines - administration & dosage | Mice, Inbred C57BL | Recombinant Proteins - genetics | Blood-Brain Barrier - drug effects | Digoxin - pharmacokinetics | Quinolines - metabolism | Taurocholic Acid - pharmacokinetics | Liver - blood supply | Pharmaceutical Preparations - metabolism | Animals | Digoxin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - metabolism | Acridines - pharmacology | Sulfonamides - metabolism | Index Medicus
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 2010, Volume 118, Issue 3, pp. 177 - 187
Aldo-keto reductase (AKR) 1C3 (type 5 17β-hydroxysteroid dehydrogenase and prostaglandin F synthase), may stimulate proliferation via steroid hormone and... 
Estrogen receptor | Peroxisome proliferator activated receptor γ | Prostaglandin F synthase | Prostaglandin D 2 | 17β-Hydroxysteroid dehydrogenase | Prostaglandin D | SIGNALING PATHWAYS | 17-BETA-HYDROXYSTEROID DEHYDROGENASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | AKR1C3 | PROLIFERATOR-ACTIVATED RECEPTOR | RISK | Prostaglandin D-2 | CELECOXIB | ENDOCRINOLOGY & METABOLISM | PROGNOSTIC MARKER | F SYNTHASE | INHIBITORS | 17 beta-Hydroxysteroid dehydrogenase | AROMATASE | Peroxisome proliferator activated receptor | gamma | Up-Regulation | Prostaglandins - pharmacology | Humans | Gene Expression Regulation, Neoplastic | Dinoprost - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Androstenedione - metabolism | Breast Neoplasms - metabolism | Testosterone - metabolism | Breast Neoplasms - enzymology | Transfection | Prostaglandin D2 - metabolism | Prostaglandin D2 - analogs & derivatives | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | 5-alpha-Dihydroprogesterone - metabolism | Dinoprost - pharmacology | Etiocholanolone - metabolism | Estradiol - pharmacology | Dihydrotestosterone - metabolism | Recombinant Proteins - metabolism | Estradiol - metabolism | Estrone - pharmacology | Gonadal Steroid Hormones - metabolism | Biocatalysis | Etiocholanolone - analogs & derivatives | Gonadal Steroid Hormones - pharmacology | Progesterone - analogs & derivatives | Recombinant Proteins - genetics | 20-alpha-Dihydroprogesterone - metabolism | Androsterone - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Breast Neoplasms - genetics | Aldo-Keto Reductase Family 1 Member C3 | Estrone - metabolism | Progesterone - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Prostaglandin D2 - pharmacology | Ketosteroids - metabolism | Kinetics | 3-Hydroxysteroid Dehydrogenases - genetics | Prostaglandins - metabolism | Physiological aspects | Testosterone | Breast cancer | Progesterone | Estradiol | Synthetic prostaglandins F | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, pp. e59825 - e59825
Previously, we demonstrated that reproductive senescence in female triple transgenic Alzheimer's (3xTgAD) mice was paralleled by a shift towards a ketogenic... 
POSITRON-EMISSION-TOMOGRAPHY | HORMONE-THERAPY | MULTIDISCIPLINARY SCIENCES | BRAIN GLUCOSE-METABOLISM | AEROBIC GLYCOLYSIS | IN-VIVO | A-BETA | HEXOKINASE-ACTIVITY | AMYLOID-BETA-PROTEIN | RAT-BRAIN | ENERGY-METABOLISM | L-Lactate Dehydrogenase - metabolism | Body Weight | Positron-Emission Tomography | X-Ray Microtomography | Isoenzymes - metabolism | Amyloid beta-Peptides - metabolism | Female | Neurons - metabolism | Estrogens - metabolism | Skin Temperature | Disease Models, Animal | Ovary - metabolism | Estradiol - metabolism | Ovariectomy | Gene Expression Regulation | Mice, Transgenic | Mitochondria - metabolism | Hippocampus - metabolism | Animals | Lactates - metabolism | Brain - pathology | Glucose - metabolism | Glycolysis | Mice | Alzheimer Disease - genetics | Brain | Glucose metabolism | Neurons | Physiological aspects | Genetic engineering | Genetic aspects | Glucose | Gene expression | Estradiol | Alzheimer's disease | Dextrose | Cytochrome | Neuroimaging | Energy metabolism | Neurosciences | Senescence | Estrogens | Ketone bodies | Hormones | Kinases | Proteins | Mitochondria | Energy resources | Bioenergetics | Rodents | Aging | Pharmaceutical sciences | Availability | Glucose transporter | Deprivation | Medical imaging | Preservation | Neurodegenerative diseases | Ketones | Transgenic mice | CoA transferase | Pharmacology | Fuel technology | Metabolism | Glucose transport | Substrates | Hexokinase | Neurology | Sex hormones | Pharmacy | Lactic acid | Respiration | Laboratory animals | Alzheimers disease | Transporter | Alternative fuels | Index Medicus
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 09/2013, Volume 377, Issue 1-2, pp. 147 - 158
The molecular mechanisms underlying the effects of selective ER subtype activation on lipogenesis, adipogenesis, lipid utilization and storage as well as... 
Obesity | Glucose uptake | Lipid metabolism | Lipogenesis | Genistein | Estrogen receptor subtype-selective agonist | PEROXISOME-PROLIFERATOR | DIETARY ISOFLAVONES | QUANTITATIVE-ANALYSIS | CELL BIOLOGY | RESPONSE ELEMENT | GLUCOSE-HOMEOSTASIS | ESTROGEN-RECEPTOR-ALPHA | ENDOCRINOLOGY & METABOLISM | REPLACEMENT THERAPY | POSTMENOPAUSAL WOMEN | PHYTOESTROGEN GENISTEIN | ADIPOSE-TISSUE | Rats, Wistar | Insulin - blood | PPAR gamma - metabolism | RNA, Messenger - metabolism | fas Receptor - metabolism | Obesity - genetics | Estrogen Receptor beta - metabolism | Adipose Tissue - metabolism | Estrogen Receptor alpha - agonists | Estrogen Receptor beta - agonists | Liver - drug effects | fas Receptor - genetics | Isotope Labeling | Estrogen Receptor alpha - metabolism | Female | Homeostasis - drug effects | Energy Metabolism - genetics | Muscles - metabolism | Lipoprotein Lipase - metabolism | Estradiol - pharmacology | Sterol Regulatory Element Binding Protein 1 - metabolism | PPAR gamma - genetics | Lipoprotein Lipase - genetics | Liver - metabolism | RNA, Messenger - genetics | Insulin Resistance | Rats | Obesity - metabolism | Triglycerides - metabolism | Gene Expression Regulation - drug effects | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | Muscles - drug effects | Genistein - pharmacology | Blood Glucose - metabolism | Adipose Tissue - drug effects | Energy Metabolism - drug effects | Homeostasis - genetics | Glucose metabolism | Glucose | Dextrose | Index Medicus | Utilization | Muscles | Lipids | Females | Insulin
Journal Article
International Journal of Cancer, ISSN 0020-7136, 12/2012, Volume 131, Issue 11, pp. 2553 - 2561
Estrogen receptor‐beta (ERβ) has been suggested to exert anti‐inflammatory and anti‐tumorigenic effects in the colon, providing a translational potential to... 
dextran sodium sulfate | estrogen receptor‐beta | colon cancer | azoxymethane | inflammatory bowel disease | estrogen receptor-beta | Estradiol - blood | Mucin-2 - genetics | Neoplasms - metabolism | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Colitis - genetics | Colorectal Neoplasms - genetics | Tumor Necrosis Factor-alpha - genetics | Colitis - pathology | NF-kappa B - metabolism | Interferon-gamma - metabolism | Inflammatory Bowel Diseases - metabolism | Estrogen Receptor beta - metabolism | Cell Differentiation - genetics | Inflammation - metabolism | Estrogen Receptor beta - genetics | Proliferating Cell Nuclear Antigen - genetics | Neoplasms - genetics | Inflammatory Bowel Diseases - pathology | Inflammatory Bowel Diseases - genetics | Female | Interferon-gamma - genetics | Interleukin-6 - metabolism | Colorectal Neoplasms - metabolism | Mucin-2 - metabolism | Mucin-1 - metabolism | Interleukin-6 - genetics | Colon - pathology | Mice, Inbred C57BL | Caveolin 1 - genetics | Interleukin-17 - genetics | beta Catenin - metabolism | Colon - metabolism | beta Catenin - genetics | Mice, Knockout | Caveolin 1 - metabolism | Interleukin-17 - metabolism | Animals | NF-kappa B - genetics | Nitric Oxide Synthase Type II - genetics | Colitis - metabolism | Inflammation - genetics | Mice | Colorectal Neoplasms - pathology | Neoplasms - pathology | Proliferating Cell Nuclear Antigen - metabolism | Mucin-1 - genetics | Nitric Oxide Synthase Type II - metabolism | Index Medicus | Estrogen receptor-beta
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 02/2013, Volume 41, Issue 2, pp. 256 - 262
There is increasing evidence that pregnancy alters the function of drug-metabolizing enzymes and drug transporters in a gestational-stage and tissue-specific... 
WOMEN | METFORMIN | CLEARANCE | IN-VITRO | PHARMACOKINETICS | PLASMA-CONCENTRATIONS | 3RD TRIMESTER | ZIDOVUDINE | PHARMACOLOGY & PHARMACY | HUMAN-IMMUNODEFICIENCY-VIRUS | EXPRESSION | Smoking - adverse effects | Estrogens - pharmacology | Liver - enzymology | Cholestasis - metabolism | Minor Histocompatibility Antigens | Taurocholic Acid - metabolism | Humans | Kidney - enzymology | Cytochrome P-450 Enzyme System - metabolism | Male | Hepatocytes - metabolism | Organic Anion Transporters - metabolism | Intestine, Small - enzymology | Lung - enzymology | Glucuronosyltransferase - genetics | RNA, Messenger - biosynthesis | Kidney - metabolism | Estrogen Receptor alpha - agonists | Liver - drug effects | Cotinine - metabolism | Maternal Behavior | ATP-Binding Cassette Transporters - metabolism | Female | Membrane Transport Proteins - metabolism | Pesticides - metabolism | Adrenal Glands - enzymology | Progesterone - pharmacology | Estradiol - pharmacology | Hepatocytes - drug effects | Retinoic Acid 4-Hydroxylase | Multidrug Resistance-Associated Proteins - drug effects | Gene Expression Regulation, Developmental - drug effects | Placenta - enzymology | Ethinyl Estradiol - pharmacology | Aryldialkylphosphatase - metabolism | Carboxylesterase - metabolism | Fetus - drug effects | Placenta - drug effects | Pregnancy | Animals | Glucuronosyltransferase - metabolism | Cytochrome P-450 Enzyme System - biosynthesis | Cytochrome P-450 Enzyme System - genetics | Hydroxyprogesterones - metabolism | Index Medicus | Special Section on Drug Metabolizing Enzymes and Transporters in Pregnancy
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 06/2017, Volume 102, Issue 6, pp. 1807 - 1815
Context: In type 2 diabetes mellitus, fracture risk is increased despite preserved areal bone mineral density. Although this apparent paradox may in part be... 
SERUM-INSULIN | OBESE CHILDREN | HOMEOSTASIS MODEL ASSESSMENT | SKELETAL-MUSCLE MASS | HEALTHY MALE SIBLINGS | ENDOCRINOLOGY & METABOLISM | PHYSICAL-ACTIVITY | POSTMENOPAUSAL WOMEN | TYPE-2 DIABETES-MELLITUS | FRACTURE RISK | BETA-CELL FUNCTION | Body Composition | Radius - pathology | Humans | Leptin - metabolism | Middle Aged | Male | Tomography, X-Ray Computed | Cortical Bone - pathology | Tibia - pathology | Tandem Mass Spectrometry | Testosterone - metabolism | Peptides - metabolism | Parathyroid Hormone - metabolism | Chromatography, Liquid | Adiponectin - metabolism | Adult | Muscle Strength | Estradiol - metabolism | Peptide Fragments - metabolism | Bone Density | Collagen Type I - metabolism | Osteocalcin - metabolism | Insulin Resistance | Tibia - diagnostic imaging | Organ Size | Sex Hormone-Binding Globulin - metabolism | Procollagen - metabolism | Absorptiometry, Photon | Insulin - metabolism | Muscle, Skeletal - diagnostic imaging | Vitamin D - analogs & derivatives | Vitamin D - metabolism | Muscle, Skeletal - pathology | Blood Glucose - metabolism | Cortical Bone - diagnostic imaging | Insulin-Like Growth Factor I - metabolism | Radius - diagnostic imaging | Serum Albumin - metabolism | Radius | Sex | Homeostasis | Population studies | Bone (trabecular) | Body composition | Adiponectin | Computed tomography | Body composition (biology) | Bone (cortical) | Age | Bone composition | Dual energy X-ray absorptiometry | Diabetes mellitus | Health risks | Muscles | Excavation | Bone turnover | Insulin | Fracture toughness | Geometry | Bone mass | Leptin | Body size | Men | Insulin resistance | Bone mineral density | Bone | Index Medicus | Abridged Index Medicus
Journal Article
Science, ISSN 0036-8075, 1/2008, Volume 319, Issue 5860, pp. 202 - 206
Journal Article