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Journal Article
Biology of Reproduction, ISSN 0006-3363, 12/2009, Volume 81, Issue 6, pp. 1216 - 1225
The brain mechanism regulating gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) release is sexually differentiated in rodents. Kisspeptin neurons... 
Luteinizing hormone | Kiss1 | Metastin | Sexual differentiation | GPR54 | Kiss1r | POSITIVE FEEDBACK ACTION | LUTEINIZING-HORMONE RELEASE | sexual differentiation | luteinizing hormone | SEXUALLY DIMORPHIC DISTRIBUTION | GONADOTROPIN-RELEASE | MEDIAL PREOPTIC AREA | REPRODUCTIVE BIOLOGY | MESSENGER-RNA | PROTEIN-COUPLED RECEPTOR | FEMALE RATS | IMMUNOREACTIVE CELLS | metastin | METASTASIS SUPPRESSOR GENE | Immunohistochemistry | Hypothalamus - growth & development | gamma-Aminobutyric Acid - metabolism | Cell Count | Glutamic Acid - genetics | Dopamine - genetics | Male | Luteinizing Hormone - metabolism | RNA, Messenger - metabolism | Hypothalamo-Hypophyseal System - growth & development | Galanin - metabolism | Kisspeptins | Neurotensin - metabolism | In Situ Hybridization | Female | Neurons - metabolism | Hypothalamus - drug effects | Dopamine - metabolism | Estradiol - pharmacology | RNA, Messenger - drug effects | Animals, Newborn | gamma-Aminobutyric Acid - genetics | Estradiol - metabolism | Hypothalamo-Hypophyseal System - drug effects | Ovariectomy | RNA, Messenger - genetics | Gene Expression Regulation, Developmental - drug effects | Rats | Reverse Transcriptase Polymerase Chain Reaction | Hypothalamo-Hypophyseal System - metabolism | Orchiectomy | Proteins - genetics | Neurotensin - genetics | Sex Differentiation - physiology | Animals | Hypothalamus - metabolism | Proteins - metabolism | Analysis of Variance | Gonadotropin-Releasing Hormone - metabolism | Glutamic Acid - metabolism | Androgens - metabolism | Galanin - genetics
Journal Article
ChemMedChem, ISSN 1860-7179, 04/2017, Volume 12, Issue 7, pp. 487 - 501
Sulfoximines have gained considerable recognition as an important structural motif in drug discovery of late. In particular, the clinical kinase inhibitors for... 
kinase inhibitors | pharmacophores | sulfoximines | drug design | medicinal chemistry | PHOSPHODIESTERASE-5 INHIBITORS | CHEMISTRY, MEDICINAL | ASYMMETRIC-SYNTHESIS | DIELS-ALDER REACTIONS | DEPENDENT KINASE INHIBITOR | BREAST-CANCER | POTENT INHIBITOR | STRUCTURAL BASIS | CDK4/6 INHIBITOR | PHARMACOLOGY & PHARMACY | ERECTILE DYSFUNCTION | Estradiol - analogs & derivatives | Sulfoxides - chemical synthesis | Cyclin-Dependent Kinases - metabolism | Ataxia Telangiectasia Mutated Proteins - metabolism | Imatinib Mesylate - chemical synthesis | Pyrazoles - chemical synthesis | Pyridines - chemistry | Imatinib Mesylate - metabolism | Piperazines - metabolism | Piperazines - chemistry | Aminopyridines - metabolism | Fulvestrant | Aminopyridines - chemistry | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Vardenafil Dihydrochloride - chemistry | Drug Design | Ataxia Telangiectasia Mutated Proteins - antagonists & inhibitors | Cyclin-Dependent Kinases - antagonists & inhibitors | Purines - chemical synthesis | Estradiol - metabolism | Protein Kinase Inhibitors - chemical synthesis | Piperidines - chemistry | Piperidines - metabolism | Purines - metabolism | Pyridines - chemical synthesis | Pyrazoles - metabolism | Piperidines - chemical synthesis | Imatinib Mesylate - chemistry | Vardenafil Dihydrochloride - metabolism | Aminopyridines - chemical synthesis | Sulfoxides - chemistry | Estradiol - chemistry | Purines - chemistry | Pyridines - metabolism | Vardenafil Dihydrochloride - chemical synthesis | Sulfoxides - metabolism | Piperazines - chemical synthesis | Estradiol - chemical synthesis | Protein Kinase Inhibitors - metabolism | Drug discovery | Chemical properties | Pharmaceutical industry | Full Paper | Full Papers
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 12/2005, Volume 97, Issue 23, pp. 1746 - 1759
Journal Article
Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, 06/2010, Volume 88, Issue 6, pp. 682 - 691
To evaluate potential mechanisms of clinical hepatotoxicity, 4 endothelin receptor antagonists (ERAs) were examined for substrate activity and inhibition of... 
Hepatic transport | BSEP | Endothelin | Transporter substrate | Pulmonary artery hypertension | Endothelin receptor antagonists | OATP | PHARMACOKINETIC INTERACTION | PHYSIOLOGY | pulmonary artery hypertension | RAT HEPATOCYTES | PULMONARY ARTERIAL-HYPERTENSION | SALT EXPORT PUMP | transporter substrate | HEPATIC-UPTAKE | endothelin receptor antagonists | CLINICAL-PRACTICE GUIDELINES | endothelin | CYCLOSPORINE-A | THERAPY | BILIARY-EXCRETION | KETOCONAZOLE | PHARMACOLOGY & PHARMACY | hepatic transport | Antihypertensive Agents - pharmacology | Estradiol - analogs & derivatives | Taurocholic Acid - metabolism | Humans | Middle Aged | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Male | Thiophenes - metabolism | Antihypertensive Agents - metabolism | Hepatocytes - metabolism | Pyridazines - pharmacology | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Organic Anion Transporters - metabolism | Pyrimidines - metabolism | Young Adult | Phenylpropionates - metabolism | Symporters - antagonists & inhibitors | ATP-Binding Cassette Transporters - metabolism | Adult | Female | Pyridazines - metabolism | Biological Transport - drug effects | Cell Culture Techniques | Endothelin Receptor Antagonists | Hepatocytes - drug effects | Estradiol - metabolism | Organic Anion Transporters - antagonists & inhibitors | Isoxazoles - metabolism | Organic Anion Transporters, Sodium-Dependent - antagonists & inhibitors | Cells, Cultured | Thiophenes - pharmacology | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Symporters - metabolism | Isoxazoles - pharmacology | Phenylpropionates - pharmacology | ATP Binding Cassette Subfamily B Member 11 | Enkephalin, D-Penicillamine (2,5)- - metabolism | Adolescent | Sulfonamides - metabolism | Aged | Multidrug Resistance-Associated Proteins - metabolism | Organic Anion Transporters, Sodium-Dependent - metabolism | ATP-Binding Cassette Transporters - antagonists & inhibitors | Cell receptors | Genetic aspects | Research | Diagnosis | Properties | Health aspects | Liver cells | Pulmonary hypertension
Journal Article
Vitamins and Hormones, ISSN 0083-6729, 12/2017, Volume 103, pp. 27 - 52
Estrogens exert profound effects on the expression of anxiety in humans and rodents; however, the directionality of these effects varies considerably within... 
Oxytocin | Serotonin | GPR30 | HPA | Anxiety | Estrogen receptor alpha | Estradiol | Beta | ER-BETA | FEMALE RATS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | CENTRAL-NERVOUS-SYSTEM | DORSAL RAPHE NUCLEI | BETA MESSENGER-RNA | KNOCKOUT MICE | G-PROTEIN | OVARIECTOMIZED RATS | PLASMA-MEMBRANE | Receptors, Estrogen - metabolism | Estrogens - pharmacology | Receptors, G-Protein-Coupled - metabolism | Humans | Anxiety - drug therapy | Receptors, G-Protein-Coupled - agonists | Receptors, Oxytocin - agonists | Oxytocin - metabolism | Serotonergic Neurons - metabolism | Estrogens - therapeutic use | Estrogen Receptor beta - metabolism | Estrogen Receptor alpha - agonists | Estrogen Receptor beta - agonists | Estrogen Receptor alpha - metabolism | Anxiety Disorders - metabolism | Neurons - metabolism | Anti-Anxiety Agents - therapeutic use | Anxiety Disorders - drug therapy | Estrogens - metabolism | Neurons - drug effects | Anxiety - metabolism | Hypothalamo-Hypophyseal System - drug effects | Pituitary-Adrenal System - drug effects | Serotonergic Neurons - drug effects | Pituitary-Adrenal System - metabolism | Nerve Tissue Proteins - agonists | Anti-Anxiety Agents - pharmacology | Hypothalamo-Hypophyseal System - metabolism | Nerve Tissue Proteins - metabolism | Receptors, Oxytocin - metabolism | Animals | Active Transport, Cell Nucleus - drug effects
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2008, Volume 3, Issue 4, pp. e2069 - e2069
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 03/2014, Volume 306, Issue 6, pp. E606 - E614
Ghrelin is a metabolic signal regulating energy homeostasis. Circulating ghrelin levels rise during starvation and fall after a meal, and therefore, ghrelin... 
Kisspeptin | Growth hormone secretagogue receptor | Reproduction | Hypothalamus | Metabolism | GNRH PULSE-GENERATOR | PHYSIOLOGY | kisspeptin | GONADOTROPIN-RELEASING-HORMONE | POSITIVE FEEDBACK | RAT HYPOTHALAMUS | ARCUATE NUCLEUS | NEUROKININ-B | MESSENGER-RIBONUCLEIC-ACID | FEMALE RATS | ESTROGEN-RECEPTOR-ALPHA | ENDOCRINOLOGY & METABOLISM | metabolism | growth hormone secretagogue receptor | SEXUAL-BEHAVIORS | hypothalamus | reproduction | Estradiol - blood | Estrogen Replacement Therapy | Ovariectomy - adverse effects | Receptors, Ghrelin - agonists | Green Fluorescent Proteins - genetics | Receptors, Ghrelin - genetics | Kisspeptins - genetics | Estrogen Receptor alpha - agonists | Arcuate Nucleus of Hypothalamus - drug effects | Receptors, Ghrelin - metabolism | Estrogen Receptor alpha - metabolism | Female | Neurons - metabolism | Hypothalamus - drug effects | Neurons - drug effects | Acylation | Recombinant Proteins - metabolism | Estradiol - metabolism | Green Fluorescent Proteins - metabolism | Estradiol - therapeutic use | Arcuate Nucleus of Hypothalamus - metabolism | Mice, Inbred C57BL | Nerve Tissue Proteins - agonists | Rats | Ghrelin - pharmacology | Mice, Transgenic | Recombinant Proteins - genetics | Kisspeptins - metabolism | Nerve Tissue Proteins - genetics | Gene Expression Regulation - drug effects | Ghrelin - metabolism | Nerve Tissue Proteins - metabolism | Animals | Hypothalamus - metabolism | Signal Transduction - drug effects | Mice | Physiological aspects | Somatotropin | Ghrelin | Neurons | Estradiol
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 05/2013, Volume 135, Issue 1, pp. 15 - 23
Journal Article