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Steroids, ISSN 0039-128X, 2004, Volume 69, Issue 13, pp. 795 - 801
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 2006, Volume 248, Issue 1, pp. 126 - 135
Endometrial cancer is the most common malignancy of the female genital tract. Its incidence correlates with prolonged estrogen stimulation unopposed by... 
Short-chain dehydrogenase reductase | 17β-Hydroxysteroid dehydrogenase | 20α-Hydroxysteroid dehydrogenase | Aldo-keto reductase | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE-2 | HYDROXYSTEROID DEHYDROGENASES | ER-BETA | short-chain dehydrogenase reductase | RECEPTOR-B | CELL BIOLOGY | INACTIVATION | CARCINOGENESIS | KETO REDUCTASE SUPERFAMILY | ENDOCRINOLOGY & METABOLISM | 20 alpha-hydroxysteroid dehydrogenase | aldo-keto reductase | 17 beta-hydroxysteroid dehydrogenase | EXPRESSION | CARCINOMA | HORMONES | Humans | Endometrial Neoplasms - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Estrogens - analysis | Endometrial Neoplasms - genetics | Isoenzymes - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | Progesterone - biosynthesis | Tumor Cells, Cultured | Estradiol - biosynthesis | Endometrium - metabolism | Progesterone - analysis | 20-Hydroxysteroid Dehydrogenases - genetics | Estrogens - biosynthesis | Endometrial Neoplasms - chemistry | Oxidoreductases - metabolism | Isoenzymes - genetics | 20-Hydroxysteroid Dehydrogenases - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Endometrium - chemistry | Animals | Aldo-Keto Reductase Family 1 Member C3 | Estradiol Dehydrogenases | 3-Hydroxysteroid Dehydrogenases - genetics | 17-Hydroxysteroid Dehydrogenases - metabolism | Enzymes | Care and treatment | Endometrial cancer | Phenols | Hormones | Progesterone | Estradiol | Cancer | Index Medicus
Journal Article
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 02/2009, Volume 296, Issue 2, pp. 244 - 255
The objective was to examine pathways of androgen metabolism in abdominal adipose tissue in women. Abdominal subcutaneous (SC) and omental (OM) adipose tissue... 
Omental visceral fat | Adipocyte differentiation | Short-chain dehydrogenases | Aldo-keto reductases | Estrogen | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASES | AROMATASE-ACTIVITY | estrogen | PHYSIOLOGY | short-chain dehydrogenases | adipocyte differentiation | omental visceral fat | HUMAN PREADIPOCYTES | 20-ALPHA-HYDROXYSTEROID DEHYDROGENASE | ESTROGEN-RECEPTOR-BETA | OBESITY | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | aldo-keto reductases | DIFFERENTIATION | STROMAL CELLS | Adipose Tissue - physiology | Humans | Middle Aged | Gene Expression Regulation, Enzymologic - physiology | Hydroxyprostaglandin Dehydrogenases - metabolism | Adipogenesis - physiology | Adipose Tissue - metabolism | Subcutaneous Fat - metabolism | Omentum - enzymology | 3-Hydroxysteroid Dehydrogenases - metabolism | Adult | Female | Hydroxysteroid Dehydrogenases - metabolism | Metabolic Networks and Pathways - physiology | Body Fat Distribution | Adipogenesis - genetics | Cells, Cultured | Hydroxysteroid Dehydrogenases - genetics | Omentum - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Abdominal Fat - metabolism | Metabolic Networks and Pathways - genetics | Aldo-Keto Reductase Family 1 Member C3 | Estradiol Dehydrogenases | Models, Biological | 17-Hydroxysteroid Dehydrogenases - genetics | Abdominal Fat - enzymology | Adipose Tissue - enzymology | 3-Hydroxysteroid Dehydrogenases - genetics | Androgens - metabolism | 17-Hydroxysteroid Dehydrogenases - metabolism | Subcutaneous Fat - enzymology | Women | Tissue | Enzymes | Androgens | Body fat | Metabolism | Ribonucleic acid--RNA | Index Medicus
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 09/2017, Volume 172, pp. 36 - 45
This study addresses first the role of human 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) in breast cancer (BC) cells. The enzyme has a high... 
Enzyme substrate inhibition | Reductive 17β-hydroxysteroid dehydrogenases | Breast cancer | Estradiol regulation of 17β-hydroxysteroid dehydrogenase type 7 | Enzymology | Reductive | CANCER CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN ESTROGENIC 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | 17 beta-hydroxysteroid dehydrogenases | PROLIFERATION | ESTRONE REDUCTION | Estradiol regulation of 17 beta-hydroxysteroid dehydrogenase type 7 | 3-DIMENSIONAL STRUCTURE | ENZYME | STEROID DEHYDROGENASE | ESTRADIOL | ENDOCRINOLOGY & METABOLISM | TYPE-1 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | HUMAN-BREAST-CARCINOMA | RNA, Small Interfering - genetics | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Humans | Substrate Specificity | 17-Hydroxysteroid Dehydrogenases - isolation & purification | MCF-7 Cells | Dihydrotestosterone - pharmacology | Female | Placenta - chemistry | Epithelial Cells - cytology | Binding Sites | Estradiol - pharmacology | Dihydrotestosterone - metabolism | Estradiol - metabolism | Gene Expression | Protein Structure, Secondary | 17-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Models, Molecular | Pregnancy | Feedback, Physiological | 17-Hydroxysteroid Dehydrogenases - genetics | Cell Line, Tumor | Protein Binding | Kinetics | 17-Hydroxysteroid Dehydrogenases - metabolism | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 06/2008, Volume 93, Issue 6, pp. 2366 - 2374
Context: Experimental and clinical studies in a variety of nonprimate species demonstrate that progesterone withdrawal leads to changes in gene expression that... 
17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE-2 | UTERINE CERVIX | ENDOCRINOLOGY & METABOLISM | PRETERM BIRTH | 5-ALPHA-REDUCTASE TYPE-1 | DEHYDROGENASE-ACTIVITY | HUMAN-ENDOMETRIUM | GUINEA-PIG | RECEPTOR-A | EXPRESSION | INTERLEUKIN-8 PRODUCTION | Cervical Ripening - metabolism | Cervix Uteri - metabolism | Humans | RNA, Messenger - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Myometrium - metabolism | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | Hydroxysteroid Dehydrogenases - metabolism | Estrogens - metabolism | 20-Hydroxysteroid Dehydrogenases - genetics | Oxidoreductases - metabolism | Oxidoreductases - genetics | Cervix Uteri - enzymology | Parturition - genetics | Hydroxysteroid Dehydrogenases - genetics | 20-Hydroxysteroid Dehydrogenases - metabolism | Gestational Age | Hydroxyprostaglandin Dehydrogenases - genetics | Gene Expression Regulation, Enzymologic | Pregnancy | Animals | Aldo-Keto Reductase Family 1 Member C3 | Estradiol Dehydrogenases | Models, Biological | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | Cervix Uteri - physiology | Progesterone - metabolism | Mice | 3-Hydroxysteroid Dehydrogenases - genetics | 17-Hydroxysteroid Dehydrogenases - metabolism | Parturition - metabolism | Index Medicus | Abridged Index Medicus | Original
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 02/2013, Volume 202, Issue 1-3, pp. 210 - 217
► In endometrial cancer progesterone biosynthesis genes are down-regulated. ► Expression of most progesterone metabolism genes is not altered in cancerous... 
Steroidogenic acute regulatory protein | 5α-Reductase | Pre-receptor metabolism | Side-chain cleavage enzyme | 3-Keto/20-keto-reductase | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASES | ADENOCARCINOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | STEROID 5-ALPHA-REDUCTASE | RECEPTOR-A | 5 alpha-Reductase | ER-ALPHA | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | KETO REDUCTASE SUPERFAMILY | ESTROGEN | PHARMACOLOGY & PHARMACY | TOXICOLOGY | YOUNG-WOMEN | TYPE-2 | Cholesterol Side-Chain Cleavage Enzyme - metabolism | Progesterone Reductase - metabolism | Humans | Middle Aged | Endometrial Neoplasms - metabolism | Multienzyme Complexes - metabolism | Receptors, Progesterone - genetics | Hydroxyprostaglandin Dehydrogenases - metabolism | Receptors, Progesterone - metabolism | Cholesterol Side-Chain Cleavage Enzyme - genetics | Endometrial Neoplasms - genetics | Phosphoproteins | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | Aged, 80 and over | 3-Hydroxysteroid Dehydrogenases - metabolism | Adult | Female | Progesterone - biosynthesis | Membrane Proteins - metabolism | Steroid Isomerases - genetics | Endometrium - metabolism | 20-Hydroxysteroid Dehydrogenases - genetics | Membrane Proteins - genetics | Steroid Isomerases - metabolism | RNA, Messenger - genetics | Multienzyme Complexes - genetics | Progesterone Reductase - genetics | 20-Hydroxysteroid Dehydrogenases - metabolism | Down-Regulation - genetics | Hydroxyprostaglandin Dehydrogenases - genetics | Aldo-Keto Reductase Family 1 Member C3 | Estradiol Dehydrogenases - genetics | 17-Hydroxysteroid Dehydrogenases - genetics | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | Estradiol Dehydrogenases - metabolism | Progesterone - metabolism | Aged | Progesterone - genetics | 3-Hydroxysteroid Dehydrogenases - genetics | 17-Hydroxysteroid Dehydrogenases - metabolism | Endometrial cancer | RNA | Genes | Cytochrome P-450 | Physiological aspects | Genetic aspects | Progesterone | Cancer | Index Medicus
Journal Article
Genomics, ISSN 0888-7543, 12/2006, Volume 88, Issue 6, pp. 820 - 830
Human short-chain dehydrogenases/reductases with dual retinol/sterol substrate specificity (RODH-like enzymes) are thought to contribute to the oxidation of... 
Origin | Vertebrates | 3α-Hydroxysteroids | Phylogenetics | Orthologs | Dehydrogenase | Retinol | Homologs | MOLECULAR CHARACTERIZATION | INTACT-CELLS | homologs | 17-BETA-HYDROXYSTEROID DEHYDROGENASES | origin | dehydrogenase | orthologs | 3 alpha-hydroxysteroids | vertebrates | retinol | FUNDUS-ALBIPUNCTATUS | MESSENGER-RNA | MICROSOMAL 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ALCOHOL-DEHYDROGENASE | TISSUE DISTRIBUTION | GENETICS & HEREDITY | ALL-TRANS-RETINOL | phylogenetics | CDNA CLONING | Genomics | Humans | Molecular Sequence Data | Substrate Specificity | Phylogeny | Oxidoreductases - chemistry | Vitamin A - metabolism | Alcohol Oxidoreductases - genetics | 11-beta-Hydroxysteroid Dehydrogenase Type 2 - chemistry | 3-Hydroxysteroid Dehydrogenases - metabolism | 11-beta-Hydroxysteroid Dehydrogenase Type 2 - genetics | Estradiol Dehydrogenases - chemistry | Alcohol Dehydrogenase - chemistry | Alcohol Dehydrogenase - metabolism | Amino Acid Sequence | Hydroxysteroids - metabolism | Oxidoreductases - metabolism | Oxidoreductases - genetics | Alcohol Oxidoreductases - metabolism | Animals | Alcohol Oxidoreductases - chemistry | Estradiol Dehydrogenases - genetics | 11-beta-Hydroxysteroid Dehydrogenase Type 2 - metabolism | Alcohol Dehydrogenase - genetics | Estradiol Dehydrogenases - metabolism | 3-Hydroxysteroid Dehydrogenases - chemistry | 3-Hydroxysteroid Dehydrogenases - genetics | Molecular genetics | Physiological aspects | Genetic research | Evolution | Oxidoreductases | Comparative analysis | Amphibians | Tretinoin | Steroids | Enzymes | Medical colleges | Index Medicus
Journal Article
Journal Article
The FEBS Journal, ISSN 1742-464X, 06/2019, Volume 286, Issue 11, pp. 2155 - 2166
Human 17β‐hydroxysteroid dehydrogenase type 1 (17β‐HSD1) catalyses the activation of estrogen and is thus involved in estrogen‐dependent diseases. Here we... 
HSD | crystal structure | dead‐end complex | substrate inhibition | 17β | reverse binding | Enzymes | Data banks | Dehydrogenases | Estrogens | Substrate inhibition | Dehydrogenase | Estradiol | Substrates | Sex hormones | Inhibitors | Enzymatic activity | Estrone | NADP | Inhibition | Crystal structure | Structural analysis
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 02/2013, Volume 202, Issue 1-3, pp. 218 - 225
► Genes encoding P4 metabolizing enzymes are expressed in Z-12 endometriotic cells. ► Treatments with progesterone and dydrogesterone decrease expression. ►... 
Dydrogesterone | Peritoneal endometriosis | Medroxyprogesterone acetate | Pre-receptor metabolism | Progesterone resistance | Dienogest | 3-Hydroxysteroid Dehydrogenases - biosynthesis | Epithelial Cells - metabolism | Endometriosis - genetics | Epithelial Cells - drug effects | Humans | Endometrium - drug effects | Medroxyprogesterone Acetate - pharmacology | Receptors, Progesterone - genetics | Hydroxyprostaglandin Dehydrogenases - metabolism | Receptors, Progesterone - metabolism | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | Hydroxysteroid Dehydrogenases - biosynthesis | Hydroxysteroid Dehydrogenases - metabolism | Membrane Proteins - metabolism | Progesterone - pharmacology | Endometrium - metabolism | 20-Hydroxysteroid Dehydrogenases - genetics | Membrane Proteins - genetics | RNA, Messenger - genetics | Cells, Cultured | Nandrolone - analogs & derivatives | Progestins - pharmacology | Hydroxyprostaglandin Dehydrogenases - biosynthesis | Hydroxysteroid Dehydrogenases - genetics | 20-Hydroxysteroid Dehydrogenases - metabolism | Down-Regulation - drug effects | Down-Regulation - genetics | Hydroxyprostaglandin Dehydrogenases - genetics | Membrane Proteins - biosynthesis | Aldo-Keto Reductase Family 1 Member C3 | Estradiol Dehydrogenases - genetics | Nandrolone - pharmacology | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - biosynthesis | Dydrogesterone - pharmacology | Endometriosis - metabolism | Estradiol Dehydrogenases - metabolism | 3-Hydroxysteroid Dehydrogenases - genetics | Receptors, Progesterone - biosynthesis | Medroxyprogesterone | Physiological aspects | Progesterone | RNA | Index Medicus
Journal Article
Carcinogenesis, ISSN 0143-3334, 11/2011, Volume 32, Issue 11, pp. 1648 - 1654
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, pp. e97448 - e97448
G1-phase cell cycle defects, such as alterations in cyclin D1 or cyclin-dependent kinase (cdk) levels, are seen in most tumors. For example, increased cyclin... 
CDK6 | ETS2 TRANSCRIPTION FACTOR | DEHYDROGENASE ISOFORMS | MULTIDISCIPLINARY SCIENCES | ALDO-KETO REDUCTASES | MAST-CELLS | REVEALS ROLES | RECEPTOR | PROLIFERATION | STEROID-HORMONE | G PHASE | Cyclin D1 - metabolism | Cytochrome P-450 CYP1B1 - genetics | Cell Proliferation | Cyclin-Dependent Kinase 4 - genetics | Humans | Gene Expression Regulation, Neoplastic | Aromatase - metabolism | Cytochrome P-450 CYP1B1 - metabolism | Mammary Glands, Human - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Aromatase - genetics | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | Hydroxysteroid Dehydrogenases - metabolism | G1 Phase - genetics | Estrogens - metabolism | Estradiol - metabolism | 20-Hydroxysteroid Dehydrogenases - genetics | Signal Transduction | Cyclin-Dependent Kinase 6 - genetics | Mammary Glands, Human - pathology | Cyclin-Dependent Kinase 6 - metabolism | Hydroxysteroid Dehydrogenases - genetics | 20-Hydroxysteroid Dehydrogenases - metabolism | Cyclin-Dependent Kinase 4 - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Cyclin D1 - genetics | Aldo-Keto Reductase Family 1 Member C3 | Estradiol Dehydrogenases - genetics | Estrone - metabolism | Estradiol Dehydrogenases - metabolism | Cell Line, Tumor | 3-Hydroxysteroid Dehydrogenases - genetics | Genes | Estrogen | Cytochrome P-450 | Physiological aspects | Phenols | Breast cancer | Small and medium sized companies | Phosphotransferases | Cytochrome | Cell proliferation | Cell culture | Pediatrics | Phosphorylation | Transcription | Estrogens | Homology | Biology | Kinases | Cyclin D1 | Experiments | Estradiol | Cyclin-dependent kinase 4 | Proteins | Cyclin-dependent kinase | Alterations | Cell growth | Xenoestrogens | Rodents | Aromatase | Cell cycle | Enzymes | Tumor cells | Cyclin-dependent kinases | Cytochrome P450 | Tumor cell lines | Metabolism | Gene expression | Aldo-keto reductase | Sex hormones | Gene amplification | Breast | Estrone | Tumors | Cancer | Index Medicus
Journal Article
MOLECULAR AND CELLULAR ENDOCRINOLOGY, ISSN 0303-7207, 04/2004, Volume 218, Issue 1-2, pp. 7 - 20
Journal Article