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Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 18, pp. 30552 - 30562
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 07/2017, Volume 171, pp. 270 - 280
17beta-hydroxysteroid dehydrogenase type 5 (17β-HSD5) is an important enzyme associated with sex steroid metabolism in hormone-dependent cancer. However,... 
GRP78 | PGK1 | 17β-HSD5 | Cell viability | Breast cancer cell proteome | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | C-MYC | 17 beta-HSD5 | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | KETO REDUCTASE SUPERFAMILY | ENDOCRINOLOGY & METABOLISM | RESISTANCE | MYC ONCOGENE EXPRESSION | PROGNOSTIC MARKER | PHOSPHOGLYCERATE KINASE | CARCINOMA | PROTEOMICS | Receptors, Estrogen - metabolism | Cell Proliferation | Humans | Two-Dimensional Difference Gel Electrophoresis | Gene Expression Regulation, Neoplastic | Heat-Shock Proteins - antagonists & inhibitors | Neoplasm Proteins - antagonists & inhibitors | Gene Expression Profiling | Neoplasm Proteins - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | NM23 Nucleoside Diphosphate Kinases - genetics | NM23 Nucleoside Diphosphate Kinases - metabolism | Breast Neoplasms - metabolism | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Heat-Shock Proteins - genetics | Phosphoglycerate Kinase - chemistry | MCF-7 Cells | RNA Interference | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | Proteomics - methods | Hydroxyprostaglandin Dehydrogenases - chemistry | Neoplasm Proteins - genetics | Phosphoglycerate Kinase - genetics | NM23 Nucleoside Diphosphate Kinases - chemistry | Cell Survival | Heat-Shock Proteins - metabolism | Neoplasm Proteins - chemistry | Proto-Oncogene Proteins c-myc - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Hydroxyprostaglandin Dehydrogenases - antagonists & inhibitors | Image Processing, Computer-Assisted | Aldo-Keto Reductase Family 1 Member C3 | Breast Neoplasms - pathology | 3-Hydroxysteroid Dehydrogenases - chemistry | Proto-Oncogene Proteins c-myc - genetics | Enzyme Activation | 3-Hydroxysteroid Dehydrogenases - genetics | Proto-Oncogene Proteins c-myc - chemistry | Heat-Shock Proteins - chemistry | Phosphoglycerate Kinase - metabolism | Ubiquitin | Care and treatment | Breast cancer | Cancer | Apoptosis | Analysis | Physiological aspects | Development and progression | Cellular signal transduction | Metastasis | Gene expression | Estradiol | Mass spectrometry
Journal Article
Toxicological Sciences, ISSN 1096-6080, 2011, Volume 119, Issue 1, pp. 209 - 217
Journal Article
Cell Reports, ISSN 2211-1247, 09/2015, Volume 12, Issue 12, pp. 1968 - 1977
Breast cancers (BCs) typically express estrogen receptors (ERs) but frequently exhibit de novo or acquired resistance to hormonal therapies. Here, we show that... 
NOTCH | ESTROGEN | ADJUVANT TAMOXIFEN | RECEPTOR | CELL BIOLOGY | Estradiol - analogs & derivatives | Receptors, Estrogen - metabolism | Neoplastic Stem Cells - drug effects | Receptors, Notch - metabolism | Homeodomain Proteins - metabolism | Humans | Retinal Dehydrogenase - metabolism | p-Aminoazobenzene - analogs & derivatives | Receptors, Notch - genetics | Receptors, Notch - antagonists & inhibitors | Basic Helix-Loop-Helix Transcription Factors - metabolism | Neoplastic Stem Cells - metabolism | Serrate-Jagged Proteins | p-Aminoazobenzene - pharmacology | Neoplastic Stem Cells - pathology | Estradiol - pharmacology | Jagged-1 Protein | Basic Helix-Loop-Helix Transcription Factors - genetics | Signal Transduction | Isoenzymes - genetics | Membrane Proteins - genetics | Cell Cycle Proteins - metabolism | Benzazepines - pharmacology | Retinal Dehydrogenase - genetics | Breast Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | Breast Neoplasms - genetics | Survival Analysis | Cell Line, Tumor | Retinal Dehydrogenase - antagonists & inhibitors | Mice | Calcium-Binding Proteins - genetics | Transcription Factor HES-1 | Gene Expression Regulation, Neoplastic | Cell Cycle Proteins - antagonists & inhibitors | Estrogen Receptor Antagonists - pharmacology | Intercellular Signaling Peptides and Proteins - metabolism | Isoenzymes - metabolism | Cell Cycle Proteins - genetics | Female | Membrane Proteins - metabolism | Calcium-Binding Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Receptors, Estrogen - genetics | Antineoplastic Agents, Hormonal - pharmacology | Intercellular Signaling Peptides and Proteins - genetics | Proto-Oncogene Proteins - genetics | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Homeodomain Proteins - genetics | Xenograft Model Antitumor Assays | Animals | Breast Neoplasms - pathology | Homeodomain Proteins - antagonists & inhibitors | Tamoxifen - pharmacology | Breast Neoplasms - mortality | Cell Proliferation - drug effects | Isoenzymes - antagonists & inhibitors | Receptor, Notch4 | Drug Resistance, Neoplasm - drug effects | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Cancer and Oncology | Medicin och hälsovetenskap | Cancer och onkologi
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 09/2017, Volume 172, pp. 36 - 45
This study addresses first the role of human 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) in breast cancer (BC) cells. The enzyme has a high... 
Enzyme substrate inhibition | Reductive 17β-hydroxysteroid dehydrogenases | Breast cancer | Estradiol regulation of 17β-hydroxysteroid dehydrogenase type 7 | Enzymology | Reductive | CANCER CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN ESTROGENIC 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | 17 beta-hydroxysteroid dehydrogenases | PROLIFERATION | ESTRONE REDUCTION | Estradiol regulation of 17 beta-hydroxysteroid dehydrogenase type 7 | 3-DIMENSIONAL STRUCTURE | ENZYME | STEROID DEHYDROGENASE | ESTRADIOL | ENDOCRINOLOGY & METABOLISM | TYPE-1 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | HUMAN-BREAST-CARCINOMA | RNA, Small Interfering - genetics | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Humans | Substrate Specificity | 17-Hydroxysteroid Dehydrogenases - isolation & purification | MCF-7 Cells | Dihydrotestosterone - pharmacology | Female | Placenta - chemistry | Epithelial Cells - cytology | Binding Sites | Estradiol - pharmacology | Dihydrotestosterone - metabolism | Estradiol - metabolism | Gene Expression | Protein Structure, Secondary | 17-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Models, Molecular | Pregnancy | Feedback, Physiological | 17-Hydroxysteroid Dehydrogenases - genetics | Cell Line, Tumor | Protein Binding | Kinetics | 17-Hydroxysteroid Dehydrogenases - metabolism | RNA, Small Interfering - metabolism
Journal Article
Journal of Biochemistry, ISSN 0021-924X, 02/2015, Volume 158, Issue 5, pp. 425 - 434
The cDNAs for morphine 6-dehydrogenase (AKR1C34) and its homologous aldo-keto reductase (AKR1C35) were cloned from golden hamster liver, and their enzymatic... 
aldo-keto reductase | flavonoid | morphine 6-dehydrogenase | sexually dimorphic expression | 3β-hydroxysteroid dehydrogenase | SITE | INHIBITOR SENSITIVITY | PROTEIN | RAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | 20-ALPHA-HYDROXYSTEROID DEHYDROGENASE | 3beta-hydroxysteroid dehydrogenase | IDENTIFICATION | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE | SUBSTRATE-SPECIFICITY | TISSUE DISTRIBUTION | SUPERFAMILY | Liver - enzymology | Substrate Specificity | Male | RNA, Messenger - metabolism | Alcohol Oxidoreductases - genetics | Estradiol Dehydrogenases - antagonists & inhibitors | Isoenzymes - metabolism | Alcohol Oxidoreductases - antagonists & inhibitors | Mesocricetus | Female | Flavonoids - pharmacology | NAD - metabolism | Binding, Competitive | Recombinant Proteins - metabolism | Mutagenesis, Site-Directed | Enzyme Inhibitors - metabolism | Oxidation-Reduction | Isoenzymes - genetics | 17-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Liver - metabolism | Enzyme Inhibitors - pharmacology | Recombinant Proteins - chemistry | Alcohol Oxidoreductases - metabolism | Mutant Proteins - metabolism | Sex Characteristics | Organ Specificity | Animals | Estradiol Dehydrogenases - genetics | 17-Hydroxysteroid Dehydrogenases - genetics | Flavonoids - metabolism | Estradiol Dehydrogenases - metabolism | 17-Hydroxysteroid Dehydrogenases - metabolism | Isoenzymes - antagonists & inhibitors | Amino Acid Substitution
Journal Article