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Environmental health perspectives, ISSN 0091-6765, 8/2009, Volume 117, Issue 8, pp. 1210 - 1218
...: Our aim was to characterize and compare the agonistic and antagonistic activities of principle PBDE congeners and their HO and MeO metabolites against human nuclear hormone receptors. Methods... 
Hormone receptors | Hormone metabolism | Receptors | Dose response relationship | Cellular metabolism | Halogenated diphenyl ethers | Plasmids | Congeners | Flame retardants | Research | Ethers | Estrogen receptor | Androgen receptor | Glucocorticoid receptor | Reporter gene assay | Brominated diphenyl ether | Thyroid hormone receptor | Chinese hamster ovary cells | glucocorticoid receptor | ESTROGEN-RECEPTORS | estrogen receptor | THYROID-HORMONE | ALPHA | brominated diphenyl ether | reporter gene assay | BETA | ENVIRONMENTAL SCIENCES | IN-VITRO | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | androgen receptor | thyroid hormone receptor | BROMINATED FLAME RETARDANTS | REPORTER GENE ASSAYS | 200 PESTICIDES | TOXICOLOGY | EXPOSURE | Androgen Receptor Antagonists | Cricetinae | Receptors, Glucocorticoid - antagonists & inhibitors | Cricetulus | Humans | Thyroid Hormone Receptors beta - antagonists & inhibitors | Estrogen Receptor alpha - antagonists & inhibitors | Thyroid Hormone Receptors alpha - antagonists & inhibitors | Receptors, Cytoplasmic and Nuclear - agonists | Halogenated Diphenyl Ethers - chemistry | Receptors, Glucocorticoid - agonists | Halogenated Diphenyl Ethers - metabolism | Androgens | Animals | Estrogen Receptor alpha - agonists | Estrogen Receptor beta - agonists | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Thyroid Hormone Receptors beta - agonists | Molecular Structure | Thyroid Hormone Receptors alpha - agonists | Estrogen Receptor beta - antagonists & inhibitors | CHO Cells | Receptors, Cytoplasmic and Nuclear - metabolism | Physiological aspects | Metabolites | Health aspects | Polybrominated biphenyls
Journal Article
Environmental health perspectives, ISSN 1552-9924, 2011, Volume 119, Issue 8, pp. 1142 - 1148
... format against a panel of 10 human nuclear receptors (AR, ER[alpha], FXR, GR, LXR[beta], PPAR[gamma], PPAR[delta], RXR[alpha], TR[beta], and VDR) for reproducibility... 
Chemical hazards | Receptors | Genomics | Environmental health | Agonists | Ligands | Cytotoxicity | Libraries | Environmental agencies | Research | Nuclear receptors | Chemical genomics | qHTS | Assay performance | Tox21 | assay performance | TOXICITY | ANTAGONISM | IDENTIFICATION | ESTROGEN-RECEPTOR | nuclear receptors | ENVIRONMENTAL SCIENCES | IN-VITRO | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | EVOLUTION | DISEASE | ASSAYS | SUPERFAMILY | HEALTH | chemical genomics | cytotoxicity | Peroxisome Proliferator-Activated Receptors - agonists | Cell Line | Retinoid X Receptor alpha - metabolism | Peroxisome Proliferator-Activated Receptors - antagonists & inhibitors | Humans | Orphan Nuclear Receptors - agonists | Receptors, Androgen - metabolism | Receptors, Cytoplasmic and Nuclear - agonists | Orphan Nuclear Receptors - metabolism | PPAR gamma - metabolism | Receptors, Thrombin - antagonists & inhibitors | Retinoid X Receptor alpha - agonists | Fragile X Mental Retardation Protein | Orphan Nuclear Receptors - antagonists & inhibitors | Retinoid X Receptor alpha - antagonists & inhibitors | PPAR gamma - antagonists & inhibitors | Receptors, Thrombin - agonists | Liver X Receptors | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Peroxisome Proliferator-Activated Receptors - metabolism | Receptors, Thrombin - metabolism | Estrogen Receptor alpha - metabolism | Environmental Pollutants - toxicity | Receptors, Cytoplasmic and Nuclear - metabolism | Environmental aspects | Physiological aspects | Cell receptors | Health aspects | Chemicals | Index Medicus
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 1/2014, Volume 111, Issue 3, pp. 1180 - 1185
Journal Article
Journal Article
Toxicology (Amsterdam), ISSN 0300-483X, 2017, Volume 387, pp. 95 - 107
.... Most PFAAs are activators of peroxisome proliferator-activated receptor α (PPARα), although the biological effects of these compounds are likely mediated by other factors in addition to PPARα... 
Emergency | Peroxisome proliferator-activated receptor α | STAT5B | Peroxisome proliferator-activated receptor γ | Perfluoroalkyl acid | Transcript profiling | Liver | Estrogen receptor alpha | ToxCast | Constitutive activated receptor | SPRAGUE-DAWLEY RATS | Peroxisome proliferator-activated receptor gamma | HEPATOCELLULAR HYPERTROPHY | NUCLEAR RECEPTORS | Peroxisome proliferator-activated receptor alpha | CELL-PROLIFERATION | PROLIFERATOR-ACTIVATED-RECEPTOR | AMMONIUM PERFLUOROOCTANOATE | PERFLUOROOCTANE SULFONATE PFOS | DEVELOPMENTAL TOXICITY | IN-VIVO | PHARMACOLOGY & PHARMACY | TOXICOLOGY | PERFLUORINATED COMPOUNDS | Hepatomegaly - pathology | Fluorocarbons - toxicity | Transcription, Genetic - drug effects | Liver - pathology | Estrogens - pharmacology | Oligonucleotide Array Sequence Analysis | Humans | Databases, Genetic | Male | Mice, 129 Strain | PPAR gamma - metabolism | STAT5 Transcription Factor - metabolism | Estrogen Receptor alpha - agonists | Liver - drug effects | Estrogen Receptor alpha - metabolism | Chemical and Drug Induced Liver Injury - pathology | PPAR gamma - genetics | Liver - metabolism | Computational Biology | Gene Expression Regulation | Gene Expression Profiling - methods | PPAR alpha - genetics | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | Chemical and Drug Induced Liver Injury - genetics | Hepatomegaly - genetics | Pyrimidines - pharmacology | Sulfonic Acids - toxicity | Mice, Knockout | PPAR alpha - deficiency | Animals | Estrogen Receptor alpha - genetics | Signal Transduction - drug effects | Chemical and Drug Induced Liver Injury - metabolism | Hepatomegaly - chemically induced | PPAR gamma - agonists | PPAR alpha - agonists | Hepatomegaly - metabolism | Anticholesteremic Agents - pharmacology | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus | peroxisome proliferator | liver | constitutive activated receptor | activated receptor γ | estrogen receptor alpha | perfluoroalkyl acid | transcript profiling | peroxisome proliferator-activated receptor α
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2017, Volume 292, Issue 44, pp. 18178 - 18191
Unlike age-matched men, premenopausal women benefit from cardiovascular protection. Estrogens protect against apoptosis of endothelial cells (ECs), one of the... 
Endothelium, Vascular - cytology | Tumor Necrosis Factor-alpha - metabolism | Apoptosis - drug effects | Humans | Receptor, Notch1 - chemistry | Endothelium, Vascular - drug effects | Estrogen Receptor beta - metabolism | Protease Inhibitors - pharmacology | Estrogen Receptor alpha - agonists | Estrogen Receptor beta - agonists | Estrogen Receptor beta - genetics | Protein Processing, Post-Translational - drug effects | RNA Interference | Receptor, Notch1 - agonists | Human Umbilical Vein Endothelial Cells - cytology | Estrogen Receptor alpha - metabolism | Protein Interaction Domains and Motifs | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Estrogen Receptor beta - antagonists & inhibitors | Peptide Fragments - genetics | Endothelium, Vascular - immunology | Recombinant Proteins - metabolism | Estradiol - metabolism | Peptide Fragments - metabolism | Cells, Cultured | Recombinant Proteins - chemistry | Estrogen Receptor alpha - antagonists & inhibitors | Receptor, Notch1 - metabolism | Amyloid Precursor Protein Secretases - metabolism | Peptide Fragments - chemistry | Estrogen Receptor alpha - genetics | Signal Transduction - drug effects | Endothelium, Vascular - metabolism | Peptide Fragments - agonists | Proto-Oncogene Proteins c-akt - agonists | Protein Kinase Inhibitors - pharmacology | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Receptor, Notch1 - genetics | Tumor Necrosis Factor-alpha - antagonists & inhibitors | estrogen | Notch pathway | tumor necrosis factor (TNF) | ERβ | estrogen receptor | Notch1 | apoptosis | Akt | endothelial dysfunction | Cell Biology
Journal Article
PloS one, ISSN 1932-6203, 01/2017, Volume 12, Issue 1, p. e0169607
The flexible hydrophobic ligand binding pocket (LBP) of estrogen receptor alpha (ER alpha) allows the binding of a wide variety of endocrine disruptors... 
ENDOCRINE-DISRUPTING CHEMICALS | DOMAIN | LIGAND-BINDING | QSAR | DOCKING | MULTIDISCIPLINARY SCIENCES | HUMANS | WI