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1. Full Text An exposure:activity profiling method for interpreting high-throughput screening data for estrogenic activity—Proof of concept
by Becker, Richard A and Friedman, Katie Paul and Simon, Ted W and Marty, M. Sue and Patlewicz, Grace and Rowlands, J. Craig
Regulatory Toxicology and Pharmacology, ISSN 0273-2300, 04/2015, Volume 71, Issue 3, pp. 398 - 408
Rapid high throughput screening (HTS) assays are now available for characterizing dose–responses in assays that have been selected for their sensitivity in... 
Estrogen assays | Exposure:activity ratio | Genistein | Endocrine disruption | Exposure | Potency | Relative estrogenic exposure:activity quotient | ToxCast | Tox21 | Receptors, Estrogen - metabolism | Reproducibility of Results | Risk Assessment | Humans | Decision Support Techniques | Toxicity Tests - standards | Estrogens - toxicity | Endocrine Disruptors - toxicity | Dose-Response Relationship, Drug | Receptors, Estrogen - drug effects | Signal Transduction - drug effects | High-Throughput Screening Assays - standards | Toxicity Tests - methods | Genistein - toxicity | Phytoestrogens - toxicity | ENDOCRINE-DISRUPTING CHEMICALS | DOSE-RESPONSE | MEDICINE, LEGAL | ACTIVATION ASSAY T47D-KBLUC | COREGULATOR BINDING ASSAY | BREAST-CANCER RISK | IN-VIVO HAZARD | SOY ISOFLAVONES | PHARMACOLOGY & PHARMACY | BISPHENOL-A | TOXICOLOGY | POSTMENOPAUSAL WOMEN | ToxCast (TM) | EQUIVALENTS EXPERT WORKSHOP | Index Medicus
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2. Full Text Endocrine activity and developmental toxicity of cosmetic UV filters—an update
by Schlumpf, Margret and Schmid, Peter and Durrer, Stefan and Conscience, Marianne and Maerkel, Kirsten and Henseler, Manuel and Gruetter, Melanie and Herzog, Ingrid and Reolon, Sasha and Ceccatelli, Raffaella and Faass, Oliver and Stutz, Eva and Jarry, Hubertus and Wuttke, Wolfgang and Lichtensteiger, Walter
Toxicology, ISSN 0300-483X, 2004, Volume 205, Issue 1, pp. 113 - 122
UV filters represent a new class of endocrine active chemicals. In vitro, 8/9 chemicals showed estrogenic (MCF-7 cells), and 2/9 antiandrogenic activity... 
Toxicity | Development | UV filters | Estrogenic | 3-Benzylidene camphor (3-BC) | Gene expression | 4-Methylbenzylidene camphor (4-MBC) | toxicity | 3-benzylidene camphor (3-BC) | development | 3-BENZYLIDENE CAMPHOR | 4-methylbenzylidene camphor (4-MBC) | REPORTER GENE ASSAY | RECEPTOR MESSENGER-RNA | REPRODUCTIVE-BEHAVIOR | estrogenic | ESTROGENIC ACTIVITY | IN-VITRO | FEMALE RATS | IMMATURE RAT | PHARMACOLOGY & PHARMACY | TOXICOLOGY | SEX-DIFFERENCES | gene expression | HYPOTHALAMUS | Uterus - pathology | Endocrine Glands - drug effects | Receptors, Estrogen - metabolism | Cosmetics - toxicity | Filtration | Humans | Rats, Long-Evans | Uterus - drug effects | Rats | Male | Fetus - drug effects | Gene Expression Regulation - drug effects | Animals | Ultraviolet Rays | Female | Sunscreening Agents - toxicity
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3. Full Text Isoflavones: estrogenic activity, biological effect and bioavailability
by Vitale, Daniela Cristina and Piazza, Cateno and Melilli, Barbara and Drago, Filippo and Salomone, Salvatore
European Journal of Drug Metabolism and Pharmacokinetics, ISSN 0378-7966, 3/2013, Volume 38, Issue 1, pp. 15 - 25
Isoflavones are phytoestrogens with potent estrogenic activity; genistein, daidzein and glycitein are the most active isoflavones found in soy beans.... 
Phytoestrogens | Human Physiology | Genistein | Medical Biochemistry | Bioavailability | Biomedicine | Pharmacy | Pharmaceutical Sciences/Technology | Biological effect | Daidzein | Pharmacology/Toxicology | Estrogenic activity | Isoflavones | SOYBEAN ISOFLAVONES | SMALL-INTESTINE | IN-VITRO | BONE LOSS | ORAL BIOAVAILABILITY | PROSTATE-CANCER | DOUBLE-BLIND | SOY ISOFLAVONES | PHYTO-ESTROGENS | PHARMACOLOGY & PHARMACY | DIETARY PHYTOESTROGENS | Drug Administration Routes | Humans | Isoflavones - pharmacokinetics | Isoflavones - pharmacology | Phytoestrogens - chemistry | Solubility | Phytoestrogens - pharmacokinetics | Biological Availability | Isoflavones - chemistry | Permeability | Chemistry, Pharmaceutical | Intestinal Absorption | Tissue Distribution | Animals | Biotransformation | Drug Design | Drug Compounding | Dosage Forms | Phytoestrogens - administration & dosage | Isoflavones - administration & dosage | Phytoestrogens - pharmacology
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4. Full Text Phytoestrogens and mycoestrogens in surface waters — Their sources, occurrence, and potential contribution to estrogenic activity
by Jarošová, Barbora and Javůrek, Jakub and Adamovský, Ondřej and Hilscherová, Klára
Environment International, ISSN 0160-4120, 08/2015, Volume 81, pp. 26 - 44
This review discusses the potential contribution of phytoestrogens and mycoestrogens to estrogenic activities occurring in surface waters and estrogenic... 
Phytoestrogen | Flavonoids | Relative potency | Estrogenic equivalent | Surface waters | Phytosterols | Estrogenicity | Mycoestrogen | Sterol | AQUATIC ENVIRONMENT | ENVIRONMENTAL SCIENCES | REPRODUCTIVE CONSEQUENCES | BETA-SITOSTEROL | WASTE-WATER | MYCOTOXIN ZEARALENONE | WOOD-RELATED STEROLS | GENE-EXPRESSION | IN-VITRO ASSAYS | ORGANIC CONTAMINANTS | AQUEOUS ENVIRONMENTAL-SAMPLES | Isoflavones - toxicity | Animals | Water Pollutants, Chemical - toxicity | Isoflavones - analysis | Water Pollutants, Chemical - analysis | Phytoestrogens - analysis | Phytoestrogens - toxicity | Analysis | Estrogen | Isoflavones | Index Medicus | Surgical implants | Biomedical materials | Phytoestrogens | In vivo testing | Surface water | In vivo tests | Biocompatibility | In vitro testing
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5. Full Text EADB: An estrogenic activity database for assessing potential endocrine activity
by Shen, J and Xu, Lei and Fang, Hong and Richard, Ann M and Bray, Jeffrey D and Judson, Richard S and Zhou, Guangxu and Colatsky, Thomas J and Aungst, Jason L and Teng, Christina and Harris, Steve C and Ge, Weigong and Dai, Susie Y and Su, Zhenqiang and Jacobs, Abigail C and Harrouk, Wafa and Perkins, Roger and Tong, Weida and Hong, Huixiao
Toxicological Sciences, ISSN 1096-6080, 10/2013, Volume 135, Issue 2, pp. 277 - 291
Endocrine-active chemicals can potentially have adverse effects on both humans and wildlife. They can interfere with the bodys endocrine system through direct... 
Database | Estrogen receptor | Endocrine disruptor | Estrogenic activity | SIGNALING PATHWAYS | estrogen receptor | BINDING AFFINITIES | INFORMATION | estrogenic activity | MECHANISMS | TOXICITY | DISCOVERY | database | DISRUPTING CHEMICALS | LIGANDS | endocrine disruptor | RECEPTOR MODULATORS | UPDATE | TOXICOLOGY | Endocrine Glands - drug effects | Animals | Estrogens - pharmacology | Databases, Chemical | Humans | Endocrine Disruptors - toxicity
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6. Full Text Bisphenol S and F: A systematic review and comparison of the hormonal activity of bisphenol a substitutes
by Rochester, Johanna R and Bolden, Ashley L
Environmental Health Perspectives, ISSN 0091-6765, 07/2015, Volume 123, Issue 7, pp. 643 - 650
BACKGROUND: Increasing concern over bisphenol A (BPA) as an endocrine-disrupting chemical and its possible effects on human health have prompted the removal of... 
ENDOCRINE-DISRUPTING CHEMICALS | UNITED-STATES | ANDROGEN RECEPTOR | ENVIRONMENTAL SCIENCES | IN-VITRO | LABORATORY RODENT | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | HUMAN EXPOSURE | ESTROGENIC CHEMICALS | NONMONOTONIC DOSE RESPONSES | UTEROTROPHIC ASSAY | TOXICOLOGY | MOLECULAR-MECHANISMS | Animals | Sulfones - toxicity | Benzhydryl Compounds - toxicity | Phenols - toxicity | Humans | Endocrine Disruptors - toxicity | Studies | Urine | Bisphenol A | Epoxy resins | Quality | Environmental health | Food packaging | Physiology | Software | Chemicals | Food | Index Medicus | Review
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7. Full Text Predicting anti-androgenic activity of bisphenols using molecular docking and quantitative structure-activity relationships
by Yang, Qian and Yang, Xianhai and Liu, Jining and Liu, Huihui and Chen, Jingwen and Shi, Lili
Chemosphere, ISSN 0045-6535, 11/2016, Volume 163, pp. 373 - 381
Both and assay indicated that bisphenols can inhibit the androgen receptor. However, the underlying antagonistic mechanism is unclear. In this study, molecular... 
Anti-androgenic activity | Quantitative structure-activity relationships (QSAR) | Bisphenols | Molecular docking | Endocrine disrupting chemical (EDC) | Human androgen receptor (hAR) | ENDOCRINE-DISRUPTING CHEMICALS | UNITED-STATES | INDOOR DUST | ZEBRAFISH DANIO-RERIO | HORMONAL BALANCE | DIPHENYL ETHERS | BETA IN-VITRO | ESTROGENIC ACTIVITY | ENVIRONMENTAL SCIENCES | HUMAN EXPOSURE | A SUBSTITUTES | Androgen Antagonists - chemistry | Hydrogen Bonding | Humans | Receptors, Androgen - metabolism | Androgen Antagonists - pharmacology | Hydrophobic and Hydrophilic Interactions | Models, Molecular | Ligands | Phenols - chemistry | Quantitative Structure-Activity Relationship | Phenols - pharmacology | Phenols | Structure | Hydrogen | Analysis | Crystals | Glutamine | Bisphenol-A
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8. Full Text Methylated polycyclic aromatic hydrocarbons and/or their metabolites are important contributors to the overall estrogenic activity of polycyclic aromatic hydrocarbon–contaminated soils
by Lam, Monika M and Engwall, Magnus and Denison, Michael S and Larsson, Maria and Institutionen för naturvetenskap och teknik and Örebro universitet
Environmental Toxicology and Chemistry, ISSN 0730-7268, 02/2018, Volume 37, Issue 2, pp. 385 - 397
In the present study 42 polycyclic aromatic compounds (PACs) were investigated for their estrogenic potential using the VM7Luc4E2 transactivation assay.... 
Relative potency | Metabolite | Estrogen receptor–mediated activity | VM7Luc4E2 transactivation assay | Mass‐balance analysis | Mass-balance analysis | ASSAY | Estrogen receptor-mediated activity | RECEPTOR-ALPHA | REPORTER | ESTROGENIC/ANTIESTROGENIC ACTIVITIES | ENVIRONMENTAL SCIENCES | CELL BIOASSAYS | ENDOCRINE DISRUPTORS | GENE-EXPRESSION | H4IIE-LUC BIOASSAY | RIVER SEDIMENTS | TOXICOLOGY | MCF-7 CELLS | Estradiol - analogs & derivatives | Luciferases - metabolism | Polycyclic Aromatic Hydrocarbons - toxicity | Humans | Metabolome | Estrogens - toxicity | Cytochrome P-450 CYP1A1 - metabolism | Fulvestrant | Soil Pollutants - toxicity | Animals | Estradiol - toxicity | Polycyclic Aromatic Hydrocarbons - metabolism | Polycyclic Aromatic Hydrocarbons - analysis | Soil - chemistry | Benzoflavones - toxicity | Cell Line, Tumor | Methylation | Acridine | Chemical analysis | Estrogens | Bioassays | Cytochrome P450 | Estrogen | Soil investigations | Estrogen receptors | Sediment pollution | Industrial areas | Alkylation | Inhibitors | Xenoestrogens | Metabolites | Polycyclic aromatic hydrocarbons | Aromatic compounds | Soil analysis | Naphthoflavone | Estrogenic activity | Soil contamination | Index Medicus | Miljövetenskap | Naturvetenskap | Estrogen receptor–mediated activity; Relative potency; Metabolite; VM7Luc4E2 transactivation assay; Mass-balance analysis | Natural Sciences | Earth and Related Environmental Sciences | Environmental Sciences | Geovetenskap och miljövetenskap
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9. Full Text An Approach for Using In Vitro and In Silico Data to Identify Pharmaceuticals with Potential (Anti‐)Estrogenic Activity in Aquatic Vertebrates at Environmentally Relevant Concentrations
by Pinto, Caroline Lucia and Bloom, Raanan A and Laurenson, James P
Environmental Toxicology and Chemistry, ISSN 0730-7268, 10/2019, Volume 38, Issue 10, pp. 2154 - 2168
Endocrine‐active pharmaceuticals can cause adverse reproductive and developmental effects in nontarget organisms. Aquatic vertebrates may be susceptible to the... 
Endocrine disruptors | aquatic toxicology | In vitro toxicology | Estrogenic compounds | Computational toxicology | Pharmaceuticals | Ethinyl estradiol | Estradiol | Analysis | Environmental impact analysis | Environmental assessment | Drugs | Ethinylestradiol | Nontarget organisms | Environmental regulations | Endocrine system | Estrogens | Menopause | Estrogen receptors | Antagonists | Environmental impact | Vertebrates | Sex hormones | Receptors | Xenoestrogens | Animal tissues | Fish | Agonists | Raloxifene | Acetic acid | Estrogenic activity
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10. Estrogen -- mystery drug for the brain?
: the neuroprotective activities of the female sex hormone
by Behl, Christian
2001, ISBN 9783211835395, xv, 228
Brain | Receptors | Neurons | Chemoprevention | Estrogen | Endocrine aspects | Physiological effect | Diseases
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11. Full Text Thyroid hormone-disrupting activity and ecological risk assessment of phosphorus-containing flame retardants by in vitro, in vivo and in silico approaches
by Zhang, Quan and Ji, Chenyang and Yin, Xiaohui and Yan, Lu and Lu, Meiya and Zhao, Meirong
Environmental Pollution, ISSN 0269-7491, 03/2016, Volume 210, pp. 27 - 33
In recent years, phosphorus-containing flame retardants (PFRs) have been frequently detected in various environmental media and biota - and in humans - as the... 
Reporter gene assay | Phosphorus-containing flame retardants | Thyroid hormone-disrupting effects | Ecological risks | TRIPHENYL PHOSPHATE | RECEPTOR | CELL-LINES | ZEBRAFISH EMBRYOS/LARVAE | ESTROGENIC ACTIVITY | ENVIRONMENTAL SCIENCES | T-SCREEN | REPORTER GENE ASSAYS | ENDOCRINE DISRUPTION | TRIS(1,3-DICHLORO-2-PROPYL) PHOSPHATE | POLYCHLORINATED-BIPHENYLS | Xenopus | Flame Retardants - analysis | Cricetulus | Risk Assessment | Humans | Thyroid Hormone Receptors beta - antagonists & inhibitors | Rats | Ecology | Flame Retardants - toxicity | Animals | Computer Simulation | Environment | Organophosphates - chemistry | Molecular Docking Simulation | Organophosphates - toxicity | CHO Cells | Phosphates | Environmental aspects | Hormones | Fireproofing agents | Risk assessment | Green technology
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12. Full Text Removal of pharmaceutical’ estrogenic activity of sequencing batch reactor effluents assessed in the T47D-KBluc reporter gene assay
by Kasonga, Teddy Kabeya and Coetzee, Martie A.A and Van Zijl, Catherina and Momba, Maggy Ndombo Benteke
Journal of Environmental Management, ISSN 0301-4797, 06/2019, Volume 240, pp. 209 - 218
Various water treatment processes may be ineffective to remove pharmaceutical compounds (PhCs) and their by-products, leading to endocrine-disruptive activity... 
T47D-KBluc reporter gene assay | Pharmaceutical compounds | Estrogenic activity | Effluents | EDCs | DICLOFENAC | VALIDATION | CARBAMAZEPINE | PRETORIA | CULTURE | ENVIRONMENTAL SCIENCES | METABOLISM | PRODUCTS | WASTE-WATER | DEGRADATION | WASTEWATERS | Oxidases | Biodegradation | Lignin | Sewage | Purification | Metabolites | Genes | Genetic research | Hormones, Sex | Bioremediation | Wastewater
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