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American Journal of Managed Care, ISSN 1088-0224, 2014, Volume 20, Issue 3, pp. e90 - e97
Objectives: A "chiral switch" occurs in the pharmaceutical market when a drug made up of 2 enantiomer forms is replaced with a purified single-enantiomer... 
MEDICATION | NAMES | MULTICENTER | EROSIVE ESOPHAGITIS | OMEPRAZOLE | RANDOMIZED CONTROLLED-TRIAL | 8-WEEK COMPARATIVE TRIAL | MEDICINE, GENERAL & INTERNAL | COST | HEALTH CARE SCIENCES & SERVICES | DOUBLE-BLIND | HEALTH POLICY & SERVICES | HEALTH | Proton Pump Inhibitors - economics | Formoterol Fumarate | Hypnotics and Sedatives - chemistry | Medicaid - economics | Stereoisomerism | United States | Humans | Dexmethylphenidate Hydrochloride - chemistry | Drugs, Generic - economics | Piperazines - economics | Esomeprazole - chemistry | Drug Approval | Piperazines - chemistry | Esomeprazole - economics | Eszopiclone | Azabicyclo Compounds - chemistry | Benzhydryl Compounds - chemistry | Antidotes - economics | Bronchodilator Agents - chemistry | Levoleucovorin - chemistry | Histamine H1 Antagonists, Non-Sedating - economics | Dexmethylphenidate Hydrochloride - economics | Dexlansoprazole - chemistry | Retrospective Studies | Central Nervous System Stimulants - economics | United States Food and Drug Administration | Wakefulness-Promoting Agents - chemistry | Levoleucovorin - economics | Antidotes - chemistry | Bronchodilator Agents - economics | Azabicyclo Compounds - economics | Benzhydryl Compounds - economics | Cetirizine - chemistry | Cetirizine - economics | Ethanolamines - economics | Ethanolamines - chemistry | Patents as Topic | Hypnotics and Sedatives - economics | Wakefulness-Promoting Agents - economics | Drug Prescriptions - statistics & numerical data | Proton Pump Inhibitors - chemistry | Central Nervous System Stimulants - chemistry | Dexlansoprazole - economics | Histamine H1 Antagonists, Non-Sedating - chemistry
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 08/2007, Volume 35, Issue 8, pp. 1292 - 1300
Polymorphisms in the cytochrome P450 2D6 (CYP2D6) gene are a major cause of pharmacokinetic variability in human. Although the poor metabolizer phenotype is... 
IN-VITRO | 2D6 | DRUGS | CATALYTIC ACTIVITY | PHARMACOLOGY & PHARMACY | HUMAN CYTOCHROME-P450 ENZYMES | HUMAN LIVER-MICROSOMES | LOW-AFFINITY | CLINICAL-PRACTICE | DEBRISOQUINE | EXPRESSION | Microsomes - metabolism | Quinidine - chemistry | Tramadol - chemistry | Humans | Dextromethorphan - metabolism | Imipramine - chemistry | Propylamines - pharmacokinetics | Codeine - chemistry | Debrisoquin - metabolism | Enzyme Inhibitors - chemistry | Fluoxetine - analogs & derivatives | Quinidine - pharmacokinetics | Propylamines - chemistry | Cocaine - chemistry | Cytochrome P-450 CYP2D6 - genetics | Recombinant Proteins - antagonists & inhibitors | Debrisoquin - chemistry | Enzyme Inhibitors - metabolism | Hydroxylation | Cocaine - pharmacokinetics | Ethanolamines - chemistry | Tramadol - pharmacokinetics | Nortriptyline - metabolism | Fluoxetine - metabolism | Cytochrome P-450 CYP2D6 - metabolism | Kinetics | Thioridazine - metabolism | Cytochrome P-450 CYP2D6 Inhibitors | Nortriptyline - chemistry | Cocaine - metabolism | Fluoxetine - pharmacokinetics | Debrisoquin - pharmacokinetics | Ethanolamines - pharmacokinetics | Codeine - metabolism | Enzyme Inhibitors - pharmacokinetics | Thioridazine - pharmacokinetics | Atomoxetine Hydrochloride | Codeine - pharmacokinetics | Thioridazine - chemistry | Dextromethorphan - pharmacokinetics | Molecular Structure | Quinidine - metabolism | Recombinant Proteins - metabolism | Imipramine - pharmacokinetics | Nortriptyline - pharmacokinetics | Dextromethorphan - chemistry | Fluoxetine - chemistry | Tramadol - metabolism | Ethanolamines - metabolism | Imipramine - metabolism | Polymorphism, Single Nucleotide | Propylamines - metabolism
Journal Article
Journal of Organic Chemistry, ISSN 0022-3263, 06/2014, Volume 79, Issue 11, pp. 5386 - 5389
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2006, Volume 281, Issue 6, pp. 3017 - 3024
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2011, Volume 7, Issue 9, pp. 602 - 609
Journal Article
Journal Article