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Drug Metabolism and Disposition, ISSN 0090-9556, 08/2007, Volume 35, Issue 8, pp. 1292 - 1300
Polymorphisms in the cytochrome P450 2D6 (CYP2D6) gene are a major cause of pharmacokinetic variability in human. Although the poor metabolizer phenotype is... 
IN-VITRO | 2D6 | DRUGS | CATALYTIC ACTIVITY | PHARMACOLOGY & PHARMACY | HUMAN CYTOCHROME-P450 ENZYMES | HUMAN LIVER-MICROSOMES | LOW-AFFINITY | CLINICAL-PRACTICE | DEBRISOQUINE | EXPRESSION | Microsomes - metabolism | Quinidine - chemistry | Tramadol - chemistry | Humans | Dextromethorphan - metabolism | Imipramine - chemistry | Propylamines - pharmacokinetics | Codeine - chemistry | Debrisoquin - metabolism | Enzyme Inhibitors - chemistry | Fluoxetine - analogs & derivatives | Quinidine - pharmacokinetics | Propylamines - chemistry | Cocaine - chemistry | Cytochrome P-450 CYP2D6 - genetics | Recombinant Proteins - antagonists & inhibitors | Debrisoquin - chemistry | Enzyme Inhibitors - metabolism | Hydroxylation | Cocaine - pharmacokinetics | Ethanolamines - chemistry | Tramadol - pharmacokinetics | Nortriptyline - metabolism | Fluoxetine - metabolism | Cytochrome P-450 CYP2D6 - metabolism | Kinetics | Thioridazine - metabolism | Cytochrome P-450 CYP2D6 Inhibitors | Nortriptyline - chemistry | Cocaine - metabolism | Fluoxetine - pharmacokinetics | Debrisoquin - pharmacokinetics | Ethanolamines - pharmacokinetics | Codeine - metabolism | Enzyme Inhibitors - pharmacokinetics | Thioridazine - pharmacokinetics | Atomoxetine Hydrochloride | Codeine - pharmacokinetics | Thioridazine - chemistry | Dextromethorphan - pharmacokinetics | Molecular Structure | Quinidine - metabolism | Recombinant Proteins - metabolism | Imipramine - pharmacokinetics | Nortriptyline - pharmacokinetics | Dextromethorphan - chemistry | Fluoxetine - chemistry | Tramadol - metabolism | Ethanolamines - metabolism | Imipramine - metabolism | Polymorphism, Single Nucleotide | Propylamines - metabolism
Journal Article
Journal Article
Clinical Pharmacokinetics, ISSN 0312-5963, 11/2011, Volume 50, Issue 11, pp. 705 - 723
Malaria is a serious parasitic infection, which affects millions of people worldwide. As pregnancy has been shown to alter the pharmacokinetics of many... 
Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | Mefloquine | Atovaquone | Chloroquine | Azithromycin | Pyrimethamine | Antimalarials | Pyrimethaminesulfadoxine | Quinine | Pregnancy | Proguanil | Cycloguanil-embonate | Artemether | Lumefantrine | Sulfadoxine | Artemetherlumefantrine | SUDANESE WOMEN | METABOLITES | UNCOMPLICATED FALCIPARUM-MALARIA | ARTEMETHER-LUMEFANTRINE | SULFADOXINE-PYRIMETHAMINE | PROGUANIL | PHARMACOLOGY & PHARMACY | QUININE | PHARMACODYNAMICS | CHLOROQUINE | ARTESUNATE | Quinine - pharmacokinetics | Artemisinins - pharmacokinetics | Atovaquone - therapeutic use | Humans | Fluorenes - therapeutic use | Sulfadoxine - administration & dosage | Atovaquone - pharmacokinetics | Sulfadoxine - pharmacokinetics | Anti-Bacterial Agents - therapeutic use | Quinine - therapeutic use | Ethanolamines - pharmacokinetics | Mefloquine - therapeutic use | Proguanil - pharmacokinetics | Pregnancy - metabolism | Pyrimethamine - administration & dosage | Sulfadoxine - therapeutic use | Mefloquine - pharmacokinetics | Female | Drug Therapy, Combination | Pyrimethamine - therapeutic use | Fluorenes - pharmacokinetics | Antimalarials - pharmacokinetics | Chloroquine - therapeutic use | Antimalarials - therapeutic use | Pregnancy Complications, Parasitic - metabolism | Pyrimethamine - pharmacokinetics | Pregnancy Complications, Parasitic - drug therapy | Proguanil - therapeutic use | Artemisinins - therapeutic use | Anti-Bacterial Agents - pharmacokinetics | Ethanolamines - therapeutic use | Malaria - complications | Malaria - drug therapy | Chloroquine - pharmacokinetics | Malaria | Pregnant women | Research | Diagnosis | Drug therapy | Health aspects
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 04/2015, Volume 79, Issue 4, pp. 636 - 649
Journal Article
Clinical Infectious Diseases, ISSN 1058-4838, 11/2017, Volume 65, Issue 10, pp. 1711 - 1720
Background. Administration of artemisinin-based combination therapy (ACT) to infant and young children can be challenging. A formulation with accurate dose and... 
dispersible tablet | arterolane maleate | P. falciparum | pediatric | INFECTIOUS DISEASES | ADULTS | MICROBIOLOGY | IMMUNOLOGY | COMBINATION | ANTIMALARIAL | CHILDREN | PHARMACOKINETICS | DIHYDROARTEMISININ-PIPERAQUINE | ARTESUNATE PLUS AMODIAQUINE | Quinolines - blood | Ethanolamines - adverse effects | Artemisinins - pharmacokinetics | Tablets | Humans | Fluorenes - therapeutic use | Antimalarials - blood | Child, Preschool | Infant | Male | Spiro Compounds - therapeutic use | Peroxides - therapeutic use | Spiro Compounds - adverse effects | Peroxides - pharmacokinetics | Peroxides - adverse effects | Quinolines - pharmacokinetics | Ethanolamines - pharmacokinetics | Malaria, Falciparum - mortality | Artemisinins - blood | Female | Fluorenes - adverse effects | Fluorenes - blood | Child | Antimalarials - adverse effects | Fluorenes - pharmacokinetics | Malaria, Falciparum - drug therapy | Antimalarials - pharmacokinetics | Heterocyclic Compounds, 1-Ring - pharmacokinetics | Africa | Antimalarials - therapeutic use | Spiro Compounds - pharmacokinetics | India | Ethanolamines - blood | Peroxides - blood | Artemisinins - therapeutic use | Spiro Compounds - blood | Heterocyclic Compounds, 1-Ring - adverse effects | Survival Analysis | Heterocyclic Compounds, 1-Ring - therapeutic use | Ethanolamines - therapeutic use | Quinolines - therapeutic use | Heterocyclic Compounds, 1-Ring - blood | Artemisinins - adverse effects | Drug Combinations | Quinolines - adverse effects
Journal Article
Journal of antimicrobial chemotherapy, ISSN 0305-7453, 2012, Volume 67, Issue 9, pp. 2213 - 2221
Journal Article
Journal of Infectious Diseases, ISSN 0022-1899, 10/2016, Volume 214, Issue 8, pp. 1243 - 1251
Background. The pharmacokinetics and pharmacodynamics of lumefantrine, a component of the most widely used treatment for malaria, artemether-lumefantrine, has... 
Antimalarial | Artemisinin combination therapy | Population pharmacokinetics | Trimethoprim-sulfamethoxazole | Pharmacodynamics | Malaria | Lumefantrine | Nonlinear mixed effects modeling | INFECTIOUS DISEASES | nonlinear mixed effects modeling | EFFICACY | pharmacodynamics | artemisinin combination therapy | RANDOMIZED-TRIAL | MICROBIOLOGY | ANTIRETROVIRAL THERAPY | SULFAMETHOXAZOLE | IMMUNOLOGY | antimalarial | CLINICAL PHARMACOKINETICS | lumefantrine | PLASMODIUM-FALCIPARUM MALARIA | BIOAVAILABILITY | population pharmacokinetics | TRIMETHOPRIM | trimethoprim-sulfamethoxazole | AFRICAN CHILDREN | DIHYDROARTEMISININ-PIPERAQUINE | Recurrence | Artemisinins - pharmacokinetics | Humans | Fluorenes - therapeutic use | Child, Preschool | Infant | Male | Parasitemia - drug therapy | Plasmodium falciparum - drug effects | Ethanolamines - pharmacokinetics | Female | Fluorenes - pharmacokinetics | Malaria, Falciparum - drug therapy | Trimethoprim, Sulfamethoxazole Drug Combination - pharmacokinetics | Antimalarials - pharmacokinetics | Artemisinins - administration & dosage | Treatment Outcome | Antimalarials - therapeutic use | Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use | Malaria, Falciparum - parasitology | Drug Therapy, Combination - methods | Artemisinins - therapeutic use | Parasitemia - parasitology | Ethanolamines - therapeutic use | Uganda | African Continental Ancestry Group | Care and treatment | Pharmacology | Research | Diagnosis | Children | Pharmacokinetics | Health aspects | Major and Brief Reports | Clinical Medicine | Malaria; population pharmacokinetics; lumefantrine; artemisinin combination therapy; antimalarial; nonlinear mixed effects modeling; pharmacodynamics; trimethoprim-sulfamethoxazole | Hälsa och välfärd | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin | Health and Welfare
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 04/2011, Volume 51, Issue 4, pp. 575 - 585
Drug interactions are a significant clinical concern, particularly in patients with conditions such as heart disease and hypertension, in whom coadministration... 
Nebivolol | pharmacokinetics | β‐blockers | drug‐drug interactions | CYP2D6 | vasodilating | β-blockers | Drug-drug interactions | Vasodilating | Pharmacokinetics | MANAGEMENT | beta-blockers | PREVALENCE | DISPOSITION | drug-drug interactions | PROFILE | METABOLISM | PHARMACOLOGY & PHARMACY | HYPERTENSION | Furosemide - administration & dosage | Hydrochlorothiazide - pharmacokinetics | Fluoxetine - pharmacokinetics | Humans | Middle Aged | Antihypertensive Agents - administration & dosage | Male | Ethanolamines - administration & dosage | Warfarin - administration & dosage | Ramipril - administration & dosage | Young Adult | Ethanolamines - pharmacokinetics | Drug Interactions | Adult | Female | Losartan - pharmacokinetics | Cytochrome P-450 CYP2D6 - genetics | Furosemide - pharmacokinetics | Genotype | Ramipril - pharmacokinetics | Hydrochlorothiazide - administration & dosage | Antihypertensive Agents - pharmacokinetics | Digoxin - pharmacokinetics | Warfarin - pharmacokinetics | Benzopyrans - administration & dosage | Digoxin - administration & dosage | Benzopyrans - pharmacokinetics | Fluoxetine - administration & dosage | Cytochrome P-450 CYP2D6 - metabolism | Losartan - administration & dosage | Dosage and administration | Research | Drug interactions | Hypertension | Prescription drugs | Genetics | Index Medicus | Cytochrome | Drugs | Warfarin | Fluoxetine | Cytochrome P450 | Hydrochlorothiazide | digoxin | furosemide | Drug interaction | Heart diseases | CYP2D6 protein | Genotypes
Journal Article
Journal Article
Clinical Infectious Diseases, ISSN 1058-4838, 08/2016, Volume 63, Issue 3, pp. 414 - 422
Journal Article
Journal Article