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Journal Article
PLoS ONE, ISSN 1932-6203, 08/2018, Volume 13, Issue 8, p. e0201092
We screened a library of botanical compounds purified from plants of Vietnam for modulators of the activity of a two-pore domain K+ channel, TREK-1, and we... 
RILUZOLE | INHIBITION | ANXIETY | MULTIDISCIPLINARY SCIENCES | COUMARIN | PLANTS | REGULATIONS | STRESS | K+ CHANNELS | BEHAVIORS | POTASSIUM CHANNEL | Humans | Ether-A-Go-Go Potassium Channels - metabolism | Kv1.4 Potassium Channel - metabolism | Male | Anxiety - drug therapy | Brain - metabolism | Dose-Response Relationship, Drug | Kv1.4 Potassium Channel - antagonists & inhibitors | Depression - drug therapy | Depression - metabolism | Neurotransmitter Agents - pharmacology | HEK293 Cells | Potassium Channels, Inwardly Rectifying - antagonists & inhibitors | Antidepressive Agents - pharmacology | Drug Evaluation, Preclinical | Anxiety - metabolism | Potassium Channels, Tandem Pore Domain - metabolism | Nerve Tissue Proteins - antagonists & inhibitors | Anti-Anxiety Agents - pharmacology | Potassium Channels, Tandem Pore Domain - agonists | Mice, Inbred ICR | Brain - drug effects | Ether-A-Go-Go Potassium Channels - antagonists & inhibitors | Nerve Tissue Proteins - metabolism | Umbelliferones - pharmacology | Animals | Potassium Channels, Tandem Pore Domain - antagonists & inhibitors | Amlodipine - pharmacology | Phytochemicals - pharmacology | Potassium Channels, Inwardly Rectifying - metabolism | Care and treatment | Depression, Mental | Analysis | Dosage and administration | Research | Potassium channels | T cells | Antianxiety agents | Neurosciences | Amygdala | Mental disorders | Mental depression | Paraventricular nucleus | Nuclei | Channels | Modulators | Antidepressants | Dorsal raphe nucleus | Rodents | Rectifiers | Raphe nuclei | Physiology | Life sciences | Anxiety | Potassium channels (voltage-gated) | Behavior | Inhibition | c-Fos protein | Serotonin | Potassium channels (inwardly-rectifying) | Immunomodulation | Septum | Chemistry | Mood | Anxieties | Natural products | Psychopharmacology | KCNQ1 protein | Immunoreactivity | Potassium
Journal Article
Nature, ISSN 0028-0836, 03/2011, Volume 471, Issue 7337, pp. 225 - 229
Journal Article
Cardiovascular Research, ISSN 0008-6363, 7/2011, Volume 91, Issue 1, pp. 53 - 61
Journal Article
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 01/2014, Volume 171, Issue 1, pp. 92 - 106
Background and Purpose Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with an increased risk for stroke, heart failure and... 
atrial fibrillation | Kv1.5 | electrophysiology | resveratrol | ion channels | pharmacology | 1.5 | ACTIVATED PROTEIN-KINASE | POTASSIUM CHANNELS | K+ CURRENT | HEART-FAILURE | THERAPEUTIC IMPLICATIONS | ARRIVE GUIDELINES | K(v)1 | CARDIAC-HYPERTROPHY | PHARMACOLOGY & PHARMACY | OUTWARD CURRENT | DYSFUNCTION | CALORIE RESTRICTION | Anti-Arrhythmia Agents - pharmacology | Humans | Middle Aged | Ether-A-Go-Go Potassium Channels - metabolism | Myocardial Contraction - drug effects | Male | NAV1.5 Voltage-Gated Sodium Channel - metabolism | Stilbenes - pharmacology | Atrial Fibrillation - physiopathology | ERG1 Potassium Channel | Action Potentials | Dose-Response Relationship, Drug | Transfection | NAV1.5 Voltage-Gated Sodium Channel - drug effects | HEK293 Cells | Kv1.5 Potassium Channel - genetics | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Adult | NAV1.5 Voltage-Gated Sodium Channel - genetics | G Protein-Coupled Inwardly-Rectifying Potassium Channels - antagonists & inhibitors | Potassium Channel Blockers - pharmacology | Disease Models, Animal | Animals, Newborn | Excitation Contraction Coupling - drug effects | Atrial Fibrillation - drug therapy | NFATC Transcription Factors - metabolism | Rats | Sodium Channel Blockers - pharmacology | Antioxidants - pharmacology | Ether-A-Go-Go Potassium Channels - genetics | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Rats, Sprague-Dawley | Ether-A-Go-Go Potassium Channels - antagonists & inhibitors | Atrial Fibrillation - metabolism | Animals | Myocytes, Cardiac - drug effects | Dogs | Kv1.5 Potassium Channel - metabolism | Myocytes, Cardiac - metabolism | Kv1.5 Potassium Channel - antagonists & inhibitors | Aged | NFATC Transcription Factors - antagonists & inhibitors | Heart failure | Heart | Antioxidants | Analysis | Atrial fibrillation | Mortality | Resveratrol | Chemical properties | Genetic transcription | Drug therapy | Research Papers
Journal Article
Journal Article