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Journal of Bone and Mineral Research, ISSN 0884-0431, 03/2019, Volume 34, Issue 3, pp. 497 - 507
Journal Article
Journal of Molecular Structure, ISSN 0022-2860, 02/2018, Volume 1154, pp. 39 - 50
Nitrosourea plays an important role in the treatment of cancer. -ethyl- -nitrosourea, also known as ENU, (chemical formula C H N O ), is a highly potent... 
DFT | N-ethyl-N-nitrosourea | FT-Raman | AIM | FT-IR | NBO | Molecular docking | APT charges | BEHAVIOR | ATOMIC CHARGES | CHEMISTRY, PHYSICAL | FORCE-FIELDS | VIBRATIONAL-SPECTRA | INFRARED-SPECTRA | DENSITY-FUNCTIONAL COMPUTATIONS | OFT | THERMODYNAMIC FUNCTIONS | GEOMETRY | Antimitotic agents | Care and treatment | Analysis | Nucleic acids | Raman spectroscopy | Antineoplastic agents | Investigations | Cancer
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, pp. e0167916 - e0167916
Non-syndromic kyphosis is a common disorder that is associated with significant morbidity and has a strong genetic involvement; however, the causative genes... 
ETIOLOGY | MUTAGENESIS | SKELETAL GROWTH | GENE | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | VERTEBRAL SEGMENTATION | DYSPLASIA | DWARFISM | SCHEUERMANN-DISEASE | Bone Density | Kyphosis - metabolism | Spine - metabolism | Tibia - diagnostic imaging | Cercopithecus aethiops | Ethylnitrosourea - toxicity | Male | Glycosylation | Mutation, Missense | Kyphosis - genetics | MAP Kinase Signaling System | Spine - diagnostic imaging | Animals | Receptors, Atrial Natriuretic Factor - genetics | Female | Mice | Mice, Inbred BALB C | Protein Processing, Post-Translational | Tibia - metabolism | COS Cells | Kyphosis - pathology | Disease Models, Animal | Immunohistochemistry | Kyphosis | Care and treatment | Usage | Gene mutations | Analysis | Risk factors | Drinking water | Peptides | Spine | Signal transduction | Conserved sequence | Genetics | Physiology | Bone (endochondral) | C-Type natriuretic peptide | Deoxyribonucleic acid--DNA | Medical research | Vertebrae | Neuromuscular diseases | MAP kinase | Heredity | Metabolism | Radiography | Bone mineral content | Studies | Chondrocytes | Mutation | Endoplasmic reticulum | Endocrinology | Alkaline phosphatase | Recombination | Phosphorylation | Genes | Body length | Genomes | Activation | Kinases | Dwarfism | Missense mutation | Rodents | Elongation | Dual energy X-ray absorptiometry | Nucleotide sequence | Morbidity | Medicine | Progeny | Signaling | Ethyl nitrosourea | Protein kinase | Potash | Bone | Diabetes | Gene mapping | Females | Potassium | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Environmental and Molecular Mutagenesis, ISSN 0893-6692, 12/2011, Volume 52, Issue 9, pp. 699 - 710
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, pp. e0122650 - e0122650
Ectopic calcification (EC), which is the pathological deposition of calcium and phosphate in extra-skeletal tissues, may be associated with hypercalcaemic and... 
FAMILIAL TUMORAL CALCINOSIS | MUTANT MICE | PROTEIN | GALNT3 | HYPERPHOSPHATEMIA | MULTIDISCIPLINARY SCIENCES | ARTERIAL CALCIFICATION | 1-ALPHA-HYDROXYLASE | MISSENSE MUTATION | DRIVEN | FGF23 | Longevity - drug effects | Humans | Glucuronidase - metabolism | Cercopithecus aethiops | Endoplasmic Reticulum - metabolism | Ethylnitrosourea - toxicity | Fibroblast Growth Factors - genetics | Molecular Sequence Data | Male | Genetic Loci | Mutation, Missense | Kidney - metabolism | N-Acetylgalactosaminyltransferases - genetics | Phosphates - blood | Calcinosis - metabolism | Disease Models, Animal | Amino Acid Sequence | Mice, Inbred C57BL | Genotype | Glucuronidase - chemistry | Codon, Nonsense | Vitamin D - blood | Phenotype | Sequence Alignment | Animals | Glucuronidase - genetics | Fibroblast Growth Factors - blood | Alleles | Vitamin D - analogs & derivatives | Mice | Polymorphism, Single Nucleotide | Calcinosis - pathology | COS Cells | Gene mutations | Genetic variation | Calcification | Causes of | Physiological aspects | Genetic aspects | Research | Calcification (ectopic) | Phosphates | Fibroblast growth factor | Animal models | Calcium | Fibroblast growth factor 23 | Disorders | Mapping | Metastasis | Proteins | Rodents | Tomography | Aging | Genetics | Growth factors | Deoxyribonucleic acid--DNA | Chronic illnesses | Medical research | Enzymes | Phenotypes | Nucleotide sequence | Abnormalities | Dihydroxyvitamin D | Chromosome 5 | Metabolism | Mutants | Mineral metabolism | Calcium phosphates | Medicine | Organic chemistry | Progeny | Ethyl nitrosourea | Councils | Life span | Calcinosis | Klotho protein | Metabolic pathways | Diabetes | Mutation | Gene mapping | Endoplasmic reticulum | Endocrinology | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Molecular Biology Reports, ISSN 0301-4851, 12/2018, Volume 45, Issue 6, pp. 2571 - 2584
N-ethyl-N-nitrosourea (ENU) is highly used in rodent models of tumerogenesis/carcinogenesis. Xenografting human-cancer tissues/cells with estradiol (E2)... 
Estrogen sulfotransferase | Oxidative stress | Hepatocellular toxicity | N-ethyl-N-nitrosourea (ENU) | Xenograft-estradiol | SPRAGUE-DAWLEY RATS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLUTATHIONE-PEROXIDASE | INDUCED MAMMARY-TUMORS | SPECIAL EMPHASIS | GAMMA-GLUTAMYL-TRANSPEPTIDASE | REDOX REGULATION | GENE-EXPRESSION | PRENEOPLASTIC LESIONS | SUPEROXIDE-DISMUTASE | Estradiol - blood | Catalase - drug effects | Rats, Wistar | Antioxidants - metabolism | Humans | Oxidants - metabolism | Superoxide Dismutase-1 - drug effects | Breast Neoplasms - metabolism | Sulfotransferases - drug effects | Heterografts | Female | Estradiol - pharmacology | DNA Damage - drug effects | Sulfotransferases - genetics | Estradiol - metabolism | Oxidation-Reduction | Liver - metabolism | Rats | Xenograft Model Antitumor Assays - methods | Breast Neoplasms - drug therapy | Ethylnitrosourea - pharmacology | Catalase - metabolism | Ethylnitrosourea - metabolism | Animals | Oxidative Stress - drug effects | Antioxidants | Phosphatases | Arsenic | Phenols | Genetic research | Breast cancer | Glutamate | Estradiol | Alkaline phosphatase | Animal models | Toxicity | DNA damage | Liver | Acetylcysteine | Estrone sulfotransferase | Pyruvic acid | Superoxide dismutase | Carcinogenesis | Catalase | Rodents | Xenografts | Peroxidase | Bioinformatics | Enzyme-linked immunosorbent assay | Free radicals | Gynecology | Data processing | Exploration | Ethyl nitrosourea | Peritoneum | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, pp. e31012 - e31012
Cerebral malaria (CM) is a lethal neurological complication of malaria. We implemented a genome-wide screen in mutagenized mice to identify host proteins... 
ENU MUTAGENESIS | TUMOR-NECROSIS-FACTOR | PLASMODIUM-BERGHEI ANKA | CYTOKINE PRODUCTION | INTERFERON-GAMMA | JANUS KINASES | IFN-GAMMA | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY LOCUS | CITROBACTER-RODENTIUM | T-CELLS | Chromosomes, Mammalian - genetics | Plasmodium berghei - physiology | Molecular Sequence Data | Male | Adoptive Transfer | Mice, Neurologic Mutants | Janus Kinase 3 - chemistry | Ethylnitrosourea | Female | Malaria, Cerebral - genetics | Spleen - pathology | Protein Structure, Tertiary | Amino Acid Sequence | Genetic Predisposition to Disease | Malaria, Cerebral - enzymology | Mycobacterium - physiology | Malaria, Cerebral - immunology | Immunophenotyping | Mutation - genetics | Malaria, Cerebral - prevention & control | Citrobacter - physiology | Homozygote | Phenotype | Animals | Pedigree | Janus Kinase 3 - genetics | Heterozygote | Mice | Genes, Dominant - genetics | Proteins | Malaria | Lymphocytes | Genomics | Genomes | Genetic aspects | Health aspects | Pathogenesis | CD8 antigen | Heterozygotes | Lymphocytes T | Parasites | Homozygosity | Adoptive transfer | Gene sequencing | Thymus | Splenocytes | Rodents | Janus kinase 3 | Complementation | Natural killer cells | Chromosomes | Vector-borne diseases | Homozygotes | Ethyl nitrosourea | Lymphocytes B | γ-Interferon | Chromosome 8 | Mutation | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2012, Volume 7, Issue 8, pp. e43205 - e43205
Mutations of UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetyl galactosaminyl transferase 3 (GALNT3) result in familial tumoural calcinosis (FTC) and the... 
PHOSPHATE | HYPERCALCIURIA | INTACT FIBROBLAST-GROWTH-FACTOR-23 | TARGETED INACTIVATION | METABOLISM | MULTIDISCIPLINARY SCIENCES | GENE LEADS | ALPHA-D-GALACTOSAMINE | HOMOZYGOUS MISSENSE MUTATION | GLYCOSYLATION | FGF23 | Calcinosis - genetics | Genes, Recessive - genetics | Cercopithecus aethiops | Ethylnitrosourea - toxicity | Apoptosis - genetics | Male | Green Fluorescent Proteins - genetics | Hyperostosis, Cortical, Congenital - pathology | Sertoli Cells - pathology | Mutation, Missense - genetics | Hyperphosphatemia - pathology | Fibroblast Growth Factors - metabolism | Bone and Bones - metabolism | N-Acetylgalactosaminyltransferases - genetics | Mutation, Missense - drug effects | N-Acetylgalactosaminyltransferases - metabolism | Disease Models, Animal | Green Fluorescent Proteins - metabolism | Spermatozoa - pathology | Testis - cytology | Hyperostosis, Cortical, Congenital - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Animals | Hyperphosphatemia - genetics | Mice | Calcinosis - pathology | COS Cells | Phosphates | Medical research | Phosphatases | Analysis | Cytochrome P-450 | Fluorescence | Physiological aspects | Medicine, Experimental | DNA polymerases | Genetic aspects | Nucleotide sequencing | DNA sequencing | Spermatozoa | Disorders | Males | Animal tissues | Fibroblasts | Growth factors | Deoxyribonucleic acid--DNA | Polypeptides | Hydroxylase | Rheumatology | Heredity | Dihydroxyvitamin D | Glycosylation | Metabolism | Chromosome 2 | Polymerase chain reaction | Hospitals | D-Galactosamine | Sodium | Councils | Calcification | Mutation | Clinical medicine | Endoplasmic reticulum | Endocrinology | Calcification (ectopic) | Alkaline phosphatase | Calcium | Fibroblast growth factor 23 | Science | Homeostasis | Calcium (blood) | Missense mutation | Rodents | Bones | Parathyroid | 25-Hydroxyvitamin D | Phenotypes | Kidneys | Nucleotide sequence | Medicine | Progeny | Ethyl nitrosourea | Calcinosis | Green fluorescent protein | In vivo methods and tests | Diabetes | Gene mapping | Apoptosis | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Carcinogenesis, ISSN 0143-3334, 07/2010, Volume 31, Issue 10, pp. 1718 - 1725
Journal Article