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1. Full Text Tumor pH-responsive flower-like micelles of poly( l-lactic acid)- b-poly(ethylene glycol)- b-poly( l-histidine)
by Lee, Eun Seong and Oh, Kyung Taek and Kim, Dongin and Youn, Yu Seok and Bae, You Han
Journal of Controlled Release, ISSN 0168-3659, 2007, Volume 123, Issue 1, pp. 19 - 26
Polymeric micelles were constructed from poly( -lactic acid) (PLA; 3K)- -poly(ethylene glycol) (PEG; 2K)- -poly( -histidine) (polyHis; 5K) as a tumor... 
Flower-like micelle | Triggered drug release | Poly( l-histidine)- b-PEG- b-poly( l-lactic acid) triblock copolymer | Tumor pH | Poly(l-histidine)-b-PEG-b-poly(l-lactic acid) triblock copolymer | ASSOCIATIVE POLYMERS | SENSITIVE POLYMERIC MICELLES | SOLID TUMORS | poly(L-histidine)-b-PEG-b-poly(L-lactic acid) triblock copolymer | BLOCK-COPOLYMER MICELLES | CHEMISTRY, MULTIDISCIPLINARY | triggered drug release | IN-VITRO | DEPENDENT AGGREGATION | ACETATE NANOPARTICLES PAN | PHARMACOLOGY & PHARMACY | tumor pH | POORLY SOLUBLE DRUGS | EXTRACELLULAR PH | DRUG-DELIVERY SYSTEMS | flower-like micelle | Histidine - administration & dosage | Cell Survival - drug effects | Polymers - administration & dosage | Lactic Acid - chemistry | Humans | Polyethylene Glycols - chemistry | Antineoplastic Agents - administration & dosage | Antineoplastic Agents - chemistry | Polyethylene Glycols - administration & dosage | Neoplasms - drug therapy | Hydrogen-Ion Concentration - drug effects | Micelles | Cell Line, Tumor | Polyesters | Polymers - chemistry | Histidine - chemistry | Neoplasms - pathology | Lactic Acid - administration & dosage | Cell Survival - physiology | Drugs | Ethylene glycol | Drug delivery systems | Block copolymers | Organic acids | Vehicles | Tumors | Poly(L-histidine)-b-PEG-b-poly(L-lactic acid) triblock copolymer
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2. Full Text PEGylation as a strategy for improving nanoparticle-based drug and gene delivery
by Suk, Jung Soo and Xu, Qingguo and Kim, Namho and Hanes, Justin and Ensign, Laura M
Advanced Drug Delivery Reviews, ISSN 0169-409X, 04/2016, Volume 99, Issue Pt A, pp. 28 - 51
Coating the surface of nanoparticles with polyethylene glycol (PEG), or “PEGylation”, is a commonly used approach for improving the efficiency of drug and gene... 
Stealth coatings | Mononuclear phagocyte system (MPS) | Enhanced permeability and retention (EPR) effect | Liposomes | Mucosal delivery | POLYETHYLENE-GLYCOL PEG | COMPACTED DNA NANOPARTICLES | POLYMER-BASED NANOPARTICLE | SOLID LIPID NANOPARTICLES | PLASMA-PROTEIN ADSORPTION | HUMAN CERVICOVAGINAL MUCUS | POLY(ETHYLENE GLYCOL) | ACCELERATED BLOOD CLEARANCE | PHARMACOLOGY & PHARMACY | CYSTIC-FIBROSIS SPUTUM | MUCUS-PENETRATING PARTICLES | Gene Transfer Techniques | Animals | Nanoparticles - chemistry | Humans | Surface Properties | Polyethylene Glycols - chemistry | Nanoparticles - administration & dosage | Polyethylene Glycols - administration & dosage | Drug Delivery Systems | Drugs | Proteins | Drug delivery systems | Polyethylene glycol | Genes | Genetic research | Polyols | Vehicles | Medical colleges | Permeability | Biomedical engineering | mononuclear phagocyte system (MPS) | stealth coatings | liposomes | enhanced permeability and retention (EPR) effect
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3. Full Text The accelerated blood clearance (ABC) phenomenon: Clinical challenge and approaches to manage
by Abu Lila, Amr S and Kiwada, Hiroshi and Ishida, Tatsuhiro
Journal of Controlled Release, ISSN 0168-3659, 11/2013, Volume 172, Issue 1, pp. 38 - 47
Despite the clinical introduction of an increasing number of polyethylene glycol (PEG)-conjugated substances, PEG has been named as the cause of an unexpected... 
Anti-PEG IgM | Polyethylene glycol(PEG) | Repeated administration | Accelerated blood clearance (ABC) phenomenon | Splenic B cells | Accelerated blood clearance (ABC) | phenomenon | PEGYLATED LIPOSOMAL DOXORUBICIN | IMMUNE-RESPONSE | COVALENT ATTACHMENT | MARGINAL ZONE | PEG IgM | ANTITUMOR-ACTIVITY | REPEATED INJECTION | CHEMISTRY, MULTIDISCIPLINARY | PEG | PHARMACOKINETICS | POLY(ETHYLENE GLYCOL) | PHARMACOLOGY & PHARMACY | POLYETHYLENE-GLYCOL | Anti | Spleen - immunology | Complement Activation | Humans | Drug Carriers - administration & dosage | Polyethylene Glycols - chemistry | Immunoglobulin M - immunology | Drug Carriers - chemistry | Polyethylene Glycols - administration & dosage | Liposomes - chemistry | Animals | Immunoglobulin M - blood | Liposomes - blood | Liposomes - immunology | Polyols | Television broadcasting industry | B cells | Polyethylene glycol | Pharmacy | Blood
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4. Full Text Biodistribution of PEG-modified gold nanoparticles following intratracheal instillation and intravenous injection
by Lipka, Jens and Semmler-Behnke, Manuela and Sperling, Ralph A and Wenk, Alexander and Takenaka, Shinji and Schleh, Carsten and Kissel, Thomas and Parak, Wolfgang J and Kreyling, Wolfgang G
Biomaterials, ISSN 0142-9612, 2010, Volume 31, Issue 25, pp. 6574 - 6581
Abstract Besides toxicity tests, biokinetic studies are a fundamental part of investigations to evaluate a safe and sustainable use of nanoparticles. Today,... 
Advanced Basic Science | Dentistry | Radio-labeled gold nanoparticle | Surface modification | Biokinetics | Polyethyleneglycol | MATERIALS SCIENCE, BIOMATERIALS | DRUG-DELIVERY | ENGINEERING, BIOMEDICAL | SIZE | TOXICITY | PARAMETERS | MAMMALIAN-CELLS | QUANTUM DOTS | POLY(ETHYLENE GLYCOL) | DEGRADATION | CYTOTOXICITY | PEGYLATION | Gold - chemistry | Gold - administration & dosage | Injections, Intravenous | Nanoparticles - chemistry | Polyethylene Glycols - pharmacokinetics | Rats | Rats, Inbred WKY | Polyethylene Glycols - chemistry | Trachea - metabolism | Polyethylene Glycols - administration & dosage | Tissue Distribution | Gold - pharmacokinetics | Animals | Female | Nanoparticles - administration & dosage | Nanoparticles | Ethylene glycol | Spleen | Surgical implants | Gold | Toxicity | Tools | Glycols | Circulation | Biomaterials | Index Medicus | Indexing in process
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5. Full Text Angiopep-2-conjugated poly(ethylene glycol)-co-poly(ε-caprolactone) polymersomes for dual-targeting drug delivery to glioma in rats
by Lu, Fei and Pang, Zhiyong and Zhao, Jingjing and Jin, Kai and Li, Haichun and Pang, Qiang and Zhang, Long and Pang, Zhiqing
International Journal of Nanomedicine, ISSN 1176-9114, 03/2017, Volume 12, pp. 2117 - 2127
The blood-brain barrier is a formidable obstacle for glioma chemotherapy due to its compact structure and drug efflux ability. In this study, a dual-targeting... 
Biodegradable polymersomes | Angiopep-2 | Glioma treatment | Dual targeting | Doxorubicin | SOLID TUMORS | PENETRATION | NANOSCIENCE & NANOTECHNOLOGY | dual targeting | glioma treatment | BLOOD-BRAIN-BARRIER | CHEMOTHERAPY | ADJUVANT TEMOZOLOMIDE | GLIOBLASTOMA | PHARMACOLOGY & PHARMACY | biodegradable polymersomes | doxorubicin | RADIOTHERAPY | BLOCK-COPOLYMER | DENSITY-LIPOPROTEIN RECEPTOR | Rats, Wistar | Drug Carriers - administration & dosage | Male | Polyethylene Glycols - chemistry | Doxorubicin - chemistry | Drug Carriers - chemistry | Peptides - administration & dosage | Antibiotics, Antineoplastic - chemistry | Polyesters - administration & dosage | Antibiotics, Antineoplastic - pharmacokinetics | Doxorubicin - administration & dosage | Peptides - chemistry | Receptors, LDL - metabolism | Permeability | Blood-Brain Barrier - drug effects | Polyethylene Glycols - administration & dosage | Blood-Brain Barrier - metabolism | Antibiotics, Antineoplastic - administration & dosage | Polyesters - chemistry | Animals | Drug Carriers - pharmacokinetics | Cryoelectron Microscopy - methods | Drug Delivery Systems - methods | Glioma - drug therapy | Hydrogen-Ion Concentration | Drugs | Ethylene glycol | Usage | Drug delivery systems | Gliomas | Physiological aspects | Research | Drug therapy | Vehicles
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6. Full Text State of the art in PEGylation: The great versatility achieved after forty years of research
by Pasut, Gianfranco and Veronese, Francesco M
Journal of Controlled Release, ISSN 0168-3659, 07/2012, Volume 161, Issue 2, pp. 461 - 472
In the recent years, protein PEGylation has become an established and highly refined technology by moving forward from initial simple random coupling... 
Protein conjugation | Drug delivery | PEGylation | PEG | POLY(ETHYLENE GLYCOL) PRODRUGS | CONTROLLED-RELEASE | SITE-SPECIFIC PEGYLATION | CHEMISTRY, MULTIDISCIPLINARY | GENETIC-CODE | HUMAN GROWTH-HORMONE | PYRROLINE-CARBOXY-LYSINE | PROTEIN MODIFICATION | PHARMACOLOGY & PHARMACY | PHARMACOKINETIC PROPERTIES | POLYETHYLENE-GLYCOL | DRUG-DELIVERY SYSTEMS | Animals | Humans | Proteins - administration & dosage | Pharmaceutical Preparations - chemistry | Biomedical Research | Polyethylene Glycols - chemistry | Proteins - chemistry | Pharmaceutical Preparations - administration & dosage | Chemistry, Pharmaceutical | Polyethylene Glycols - administration & dosage | Drugs | Enzymes | Drug delivery systems | Polysaccharides | Lysine | Genetically modified organisms | Amino acids | Vehicles | Cysteine | Preservation | N-Terminus | Genetic engineering | Glycoproteins | C-Terminus | Isomers | Controlled release | Amino acid substitution | Glutamine
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7. Full Text Pharmacokinetic study of 3-in-1 poly(ethylene glycol)-block-poly(D, L-lactic acid) micelles carrying paclitaxel, 17-allylamino-17-demethoxygeldanamycin, and rapamycin
by Shin, Ho-Chul and Cho, Hyunah and Lai, Tsz Chung and Kozak, Kevin R and Kolesar, Jill M and Kwon, Glen S
Journal of Controlled Release, ISSN 0168-3659, 10/2012, Volume 163, Issue 1, pp. 93 - 99
Concurrent delivery of multiple poorly water-soluble anticancer drugs has been a great challenge due to the toxicities exerted by different surfactants or... 
Rapamycin | 17-Allylamino-17-demethoxygeldanamycin (17-AAG) | PEG-b-PLA micelles | Pharmacokinetics | Paclitaxel | CONTROLLING DRUG RATIOS | CANCER CELLS | AKT | COMBINATION | FORMULATION | TUMORS | CHEMISTRY, MULTIDISCIPLINARY | CHEMOTHERAPY | INHIBITION | METABOLISM | PHARMACOLOGY & PHARMACY | Benzoquinones - administration & dosage | Area Under Curve | Antineoplastic Combined Chemotherapy Protocols | Drug Carriers - administration & dosage | Polyethylene Glycols - pharmacokinetics | Paclitaxel - pharmacokinetics | Sirolimus - pharmacokinetics | Antineoplastic Agents - administration & dosage | Lactates - pharmacokinetics | Polyethylene Glycols - administration & dosage | Benzoquinones - pharmacokinetics | Dose-Response Relationship, Drug | Sirolimus - administration & dosage | Animals | Lactams, Macrocyclic - pharmacokinetics | Lactates - administration & dosage | Micelles | Female | Lactams, Macrocyclic - administration & dosage | Antineoplastic Agents - pharmacokinetics | Drug Carriers - pharmacokinetics | Mice | Paclitaxel - administration & dosage | Drug Combinations | Ethylene glycol | Polyethylene | Surface active agents | Organic acids | Index Medicus
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8. Full Text PEG‑b‑PCL Copolymer Micelles with the Ability of pH-Controlled Negative-to-Positive Charge Reversal for Intracellular Delivery of Doxorubicin
by Deng, Hongzhang and Liu, Jinjian and Zhao, Xuefei and Zhang, Yuming and Liu, Jianfeng and Xu, Shuxin and Deng, Liandong and Dong, Anjie and Zhang, Jianhua
Biomacromolecules, ISSN 1525-7797, 11/2014, Volume 15, Issue 11, pp. 4281 - 4292
The application of PEG-b-PCL micelles was dampened by their inherent low drug-loading capability and relatively poor cell uptake efficiency. In this study, a... 
POLYMER SCIENCE | BLOCK-COPOLYMERS | GENE DELIVERY | DRUG-DELIVERY | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | NANOCARRIERS | CHEMISTRY, ORGANIC | RELEASE | POLYMERIC MICELLES | NANOPARTICLES | POLY(ETHYLENE GLYCOL) | EFFICIENT | Polyethylene Glycols - metabolism | Cell Survival - drug effects | Humans | Polyethylene Glycols - chemistry | Doxorubicin - chemistry | Lactones - metabolism | Polyethylene Glycols - administration & dosage | Hep G2 Cells | Antibiotics, Antineoplastic - administration & dosage | Intracellular Fluid - drug effects | Antibiotics, Antineoplastic - chemistry | Lactones - administration & dosage | Micelles | Surface Properties - drug effects | Doxorubicin - metabolism | Antibiotics, Antineoplastic - metabolism | Drug Delivery Systems - methods | Cell Survival - physiology | Intracellular Fluid - metabolism | Doxorubicin - administration & dosage | Hydrogen-Ion Concentration | Lactones - chemistry
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9. Full Text Paclitaxel-loaded polymeric micelles based on poly(ɛ-caprolactone)-poly(ethylene glycol)-poly(ɛ-caprolactone) triblock copolymers: in vitro and in vivo evaluation
by Zhang, Linhua, MD and He, Yingna, PhD and Ma, Guilei, PhD and Song, Cunxian, MD and Sun, Hongfan, MD
Nanomedicine: Nanotechnology, Biology, and Medicine, ISSN 1549-9634, 2012, Volume 8, Issue 6, pp. 925 - 934
Abstract The purpose of this study was to develop polymeric nanoscale drug-delivery system (nano-DDS) for paclitaxel (PTX) from... 
Internal Medicine | Pharmacokinetics | Polymeric micelles | Anti-tumoral activity | Paclitaxel | PCL-PEG-PCL | MEDICINE, RESEARCH & EXPERIMENTAL | DIBLOCK COPOLYMERS | DIAGNOSIS | DRUG-DELIVERY | AMPHIPHILIC BLOCK-COPOLYMER | NANOSCIENCE & NANOTECHNOLOGY | NANOPARTICLES | THERAPY | POLY(ETHYLENE GLYCOL) | FORMULATIONS | TAXOL | METASTATIC BREAST-CANCER | Cell Survival - drug effects | Rats | Antineoplastic Agents, Phytogenic - chemistry | Male | Treatment Outcome | Nanocapsules - chemistry | Rats, Sprague-Dawley | Polyethylene Glycols - administration & dosage | Neoplasms, Experimental - pathology | Paclitaxel - chemistry | Antineoplastic Agents, Phytogenic - administration & dosage | Animals | Micelles | Polyesters - administration & dosage | Cell Line, Tumor | Female | Mice | Mice, Inbred BALB C | Polyesters - chemical synthesis | Polyethylene Glycols - chemical synthesis | Diffusion | Paclitaxel - administration & dosage | Neoplasms, Experimental - drug therapy
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10. Full Text Development and characterisation of chitosan films impregnated with insulin loaded PEG-b-PLA nanoparticles (NPs): A potential approach for buccal delivery of macromolecules
by Giovino, Concetta and Ayensu, Isaac and Tetteh, John and Boateng, Joshua S
International Journal of Pharmaceutics, ISSN 0378-5173, 05/2012, Volume 428, Issue 1-2, pp. 143 - 151
Mucoadhesive chitosan based films, incorporated with insulin loaded nanoparticles (NPs) made of poly(ethylene glycol)methyl ether-block-polylactide (PEG- -PLA)... 
Nanoparticles | Chitosan films | Buccal delivery | Insulin | Poly(ethylene glycol)methyl ether-block-polylactide | PROTEIN | ACID | DRUG-DELIVERY | CONTROLLED-RELEASE | POLY(D,L-LACTIDE-CO-GLYCOLIDE) | CARRIERS | IN-VITRO | DEVICES | SYSTEMS | PHARMACOLOGY & PHARMACY | Chemistry, Pharmaceutical - methods | Nanoparticles - chemistry | Emulsions - chemistry | Macromolecular Substances - administration & dosage | Chitosan - administration & dosage | Drug Carriers - administration & dosage | Insulin - administration & dosage | Polyethylene Glycols - chemistry | Administration, Buccal | Drug Carriers - chemistry | Polyethylene Glycols - administration & dosage | Particle Size | Chitosan - chemistry | Lactates - administration & dosage | Macromolecular Substances - chemistry | Emulsions - administration & dosage | Insulin - chemistry | Nanoparticles - administration & dosage | Dosage Forms | Tissue Adhesives - metabolism | Drug Delivery Systems - methods | Lactates - chemistry | Hydrogen-Ion Concentration | Phosphates | Ethylene glycol |