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1. Full Text In Vitro Combination Studies of Benzothiazinone Lead Compound BTZ043 against Mycobacterium tuberculosis
by Benoit Lechartier and Ruben C. Hartkoorn and Stewart T. Cole
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 11/2012, Volume 56, Issue 11, pp. 5790 - 5793
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
DRUGS | SYNERGY | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | ANTAGONISM | CANDIDATES | SQ109 | Fluoroquinolones | Isoniazid - pharmacology | Ethambutol - pharmacology | Aza Compounds - pharmacology | Moxifloxacin | Mycobacterium tuberculosis - drug effects | Quinolines - pharmacology | Microbial Sensitivity Tests | Spiro Compounds - chemical synthesis | Thiazines - pharmacology | Meropenem | Adamantane - analogs & derivatives | Adamantane - pharmacology | Nitroimidazoles - pharmacology | Antitubercular Agents - pharmacology | Microbial Viability | Thienamycins - pharmacology | Thiazines - chemical synthesis | Ethylenediamines - pharmacology | Drug Synergism | Diarylquinolines | Rifampin - pharmacology | Drug Combinations | Spiro Compounds - pharmacology | Mycobacterium tuberculosis - growth & development | Experimental Therapeutics
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2. Full Text Challenges facing the drug discovery pipeline for non-tuberculous mycobacteria
by Soni, Isha and De Groote, Mary Ann and Dasgupta, Arunava and Chopra, Sidharth
Journal of Medical Microbiology, ISSN 0022-2615, 01/2016, Volume 65, Issue 1, pp. 1 - 8
Non-tuberculous mycobacteria (NTM) infections are increasingly being reported worldwide. They are a major concern for healthcare professionals for multiple... 
TIGECYCLINE | CAPURAMYCIN ANALOGS | TUBERCULOSIS | CELL-WALL CORE | ABSCESSUS | RESISTANCE | BENZOTHIAZINONES | MICROBIOLOGY | CANDIDATE | CYSTIC-FIBROSIS | IN-VITRO ACTIVITY | Adamantane - pharmacology | Nitroimidazoles - pharmacology | Nontuberculous Mycobacteria - drug effects | Minocycline - pharmacology | Humans | Minocycline - analogs & derivatives | Uridine - analogs & derivatives | Clinical Trials as Topic | Diarylquinolines - pharmacology | Drug Discovery | Piperazines - pharmacology | Ethylenediamines - pharmacology | Uridine - pharmacology | Azepines - pharmacology | Aminopyridines - pharmacology | Fluoroquinolones - pharmacology | Thiazines - pharmacology | Anti-Bacterial Agents - pharmacology | Benzamides - pharmacology | Oxazoles - pharmacology | Tigecycline | Mycobacterium Infections, Nontuberculous - drug therapy | Spiro Compounds - pharmacology | Adamantane - analogs & derivatives
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3. Full Text Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis
by Li, Wei and Upadhyay, Ashutosh and Fontes, Fabio L and North, E. Jeffrey and Wang, Yuehong and Crans, Debbie C and Grzegorzewicz, Anna E and Jones, Victoria and Franzblau, Scott G and Lee, Richard E and Crick, Dean C and Jackson, Mary
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 11/2014, Volume 58, Issue 11, pp. 6413 - 6423
MmpL3, a resistance-nodulation-division (RND) superfamily transporter, has been implicated in the formation of the outer membrane of Mycobacterium... 
PYRAZINOIC ACID | TRANSPORT | NONREPLICATING PERSISTENCE | MEMBRANE | GROWTH | BIOLOGICAL EVALUATION | ANTITUBERCULAR DRUG | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | MODEL | SQ109 | DISCOVERY | Cell Membrane | Cord Factors - metabolism | Mycobacterium tuberculosis - drug effects | Vitamin K 2 - metabolism | Microbial Sensitivity Tests | Tuberculosis, Multidrug-Resistant - microbiology | Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology | Drug Resistance, Multiple, Bacterial | Proton Ionophores - pharmacology | Valinomycin - pharmacology | Adamantane - analogs & derivatives | Bacterial Proteins - antagonists & inhibitors | Adamantane - pharmacology | Antitubercular Agents - pharmacology | Carrier Proteins - antagonists & inhibitors | Piperazines - pharmacology | Ethylenediamines - pharmacology | Membrane Proteins - biosynthesis | Pyrroles - pharmacology | Membrane Proteins - antagonists & inhibitors | Membrane Transport Proteins | Mycobacterium smegmatis - drug effects | Anti-Bacterial Agents - pharmacology | Mycolic Acids - metabolism | Phenylurea Compounds - pharmacology | Tuberculosis, Multidrug-Resistant - drug therapy | Mechanisms of Action | Physiological Effects
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4. Full Text Presynaptic Modulation of Synaptic Transmission by Pregnenolone Sulfate as Studied by Optical Recordings
by Ling Chen and Masahiro Sokabe
Journal of Neurophysiology, ISSN 0022-3077, 12/2005, Volume 94, Issue 6, pp. 4131 - 4144
The effects of pregnenolone sulfate (PREGS), a putative neurosteroid, on the transmission of perforant path–granule cell synapses were investigated with an... 
TRANSMITTER RELEASE | PHYSIOLOGY | GLUTAMATE RELEASE | CALCIUM-CHANNELS | LINKED-IMMUNOSORBENT-ASSAY | NICOTINIC ACETYLCHOLINE-RECEPTOR | INCREASES HIPPOCAMPAL ACETYLCHOLINE | RAT-BRAIN | ALPHA-BUNGAROTOXIN | AGED RATS | NEUROSCIENCES | METHYL-D-ASPARTATE | Excitatory Postsynaptic Potentials - radiation effects | Synaptic Transmission - physiology | Rats, Wistar | Calcium - metabolism | 2-Amino-5-phosphonovalerate - pharmacology | Kainic Acid - analogs & derivatives | Male | Nicotinic Antagonists - pharmacology | Excitatory Postsynaptic Potentials - drug effects | Diagnostic Imaging - methods | Dose-Response Relationship, Drug | Drug Interactions | Time Factors | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Pregnenolone - pharmacology | Tetrodotoxin - pharmacology | Neurons - drug effects | Electric Stimulation - methods | Haloperidol - pharmacology | Nicotinic Agonists - pharmacology | Calcium - pharmacology | Presynaptic Terminals - drug effects | Kainic Acid - pharmacology | Rats | Excitatory Amino Acid Antagonists - pharmacology | Aconitine - analogs & derivatives | Bicuculline - pharmacology | Aconitine - pharmacology | Calcium Channel Blockers - pharmacology | Hippocampus - cytology | Ethylenediamines - pharmacology | GABA Antagonists - pharmacology | Animals | Benzylidene Compounds - pharmacology | Analysis of Variance | Dopamine Antagonists - pharmacology | Pyridines - pharmacology | In Vitro Techniques | Bungarotoxins - pharmacology
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5. Full Text Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans
by Collins, James J and Evason, Kimberley and Kornfeld, Kerry
Experimental Gerontology, ISSN 0531-5565, 2006, Volume 41, Issue 10, pp. 1032 - 1039
The identification and analysis of compounds that delay aging and extend lifespan is an important aspect of gerontology research; these studies can test... 
Aging | C. elegans | Pharmacology | Lifespan | RESVERATROL | VITAMIN-E | lifespan | SUPEROXIDE DISMUTASE/CATALASE MIMETICS | BILOBA EXTRACT EGB-761 | EXTENSION | RESTRICTION | C elegans | GERIATRICS & GERONTOLOGY | TOCOTRIENOLS | OXIDATIVE STRESS RESISTANCE | pharmacology | C-ELEGANS | aging | COENZYME-Q | Longevity - drug effects | Plant Extracts - pharmacology | Trimethadione - pharmacology | Aging - drug effects | Antioxidants - pharmacology | Stilbenes - pharmacology | Anticonvulsants - pharmacology | Ethylenediamines - pharmacology | Tocotrienols - pharmacology | Ubiquinone - pharmacology | Ginkgo biloba | Salicylates - pharmacology | Blueberry Plants | Caenorhabditis elegans - physiology | Animals | Caenorhabditis elegans - drug effects | Aging - physiology | Ethosuximide - pharmacology | Longevity - physiology | Organometallic Compounds - pharmacology | Vitamin E - pharmacology | Analysis
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6. Full Text Tuberculosis: clinical trials and new drug regimens
by Kwon, Yong-Soo and Jeong, Byeong-Ho and Koh, Won-Jung
Current Opinion in Pulmonary Medicine, ISSN 1070-5287, 05/2014, Volume 20, Issue 3, pp. 280 - 286
PURPOSE OF REVIEWRecent advances in the development of new drugs and regimens provide hope that well tolerated, effective, and shorter-duration treatments for... 
clinical trial | antitubercular agents | multidrug-resistant tuberculosis | tuberculosis | STERILIZING ACTIVITIES | INTENSIVE PHASE TREATMENT | MEROPENEM-CLAVULANATE | EARLY BACTERICIDAL ACTIVITY | TREATMENT OUTCOMES | ANTITUBERCULAR DRUG | KILL MYCOBACTERIUM-TUBERCULOSIS | IN-VITRO | RESPIRATORY SYSTEM | PULMONARY TUBERCULOSIS | Linezolid | Adamantane - pharmacology | Nitroimidazoles - pharmacology | Drug Administration Schedule | Humans | Antitubercular Agents - pharmacology | Acetamides - pharmacology | Male | Clinical Trials as Topic | Levofloxacin - pharmacology | Moxifloxacin | Diarylquinolines - pharmacology | Ethylenediamines - pharmacology | Oxazolidinones - pharmacology | Fluoroquinolones - pharmacology | Tuberculosis - drug therapy | Drug Design | Thiazines - pharmacology | Female | Oxazoles - pharmacology | Spiro Compounds - pharmacology | Adamantane - analogs & derivatives | Tuberculosis, Multidrug-Resistant - drug therapy
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7. Full Text Bioluminescence for assessing drug potency against nonreplicating Mycobacterium tuberculosis
by Vocat, Anthony and Hartkoorn, Ruben C and Lechartier, Benoit and Zhang, Ming and Dhar, Neeraj and Cole, Stewart T and Sala, Claudia
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 07/2015, Volume 59, Issue 7, pp. 4012 - 4019
Targeting dormant Mycobacterium tuberculosis represents a challenge to antituberculosis drug discovery programs. We previously reported and validated the use... 
PARA-AMINOSALICYLIC ACID | EXPRESSING FIREFLY LUCIFERASE | IN-VITRO | METABOLISM | MACROPHAGES | MEMBRANE | GROWTH | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | RAPID METHOD | OXAZOLIDINONES | DISCOVERY | Adamantane - pharmacology | Genes, Bacterial - genetics | Photorhabdus - metabolism | Antitubercular Agents - pharmacology | Luminescence | Colony Count, Microbial | Diarylquinolines - pharmacology | Drug Discovery | Mycobacterium tuberculosis - drug effects | Ethylenediamines - pharmacology | Pyrazinamide - pharmacology | Rifamycins - pharmacology | Photorhabdus - genetics | Oxazolidinones - pharmacology | Microbial Sensitivity Tests - methods | Xanthenes - pharmacology | Adamantane - analogs & derivatives | Oxazines - pharmacology | Experimental Therapeutics
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8. Sigma-1 receptor activation prevents intracellular calcium dysregulation in cortical neurons during in vitro ischemia
by Katnik, Christopher and Guerrero, Waldo R and Pennypacker, Keith R and Herrera, Yelenis and Cuevas, Javier
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 2006, Volume 319, Issue 3, pp. 1355 - 1365
Sigma receptors are putative targets for neuroprotection following ischemia; however, little is known on their mechanism of action. One of the key components... 
INTRACARDIAC NEURONS | RAT | BRAIN-INJURY | NMDA | PHARMACOLOGY & PHARMACY | ANTAGONISM | CHANNELS | HIPPOCAMPAL-NEURONS | LIGANDS ATTENUATE | MODULATION | METHYL-D-ASPARTATE | Phencyclidine - pharmacology | Calcium - metabolism | Calcium Signaling - physiology | Phencyclidine - analogs & derivatives | Analgesics, Opioid - pharmacology | Brain Ischemia - metabolism | Guanidines - pharmacology | Receptors, sigma - antagonists & inhibitors | Cerebral Cortex - cytology | Cerebral Cortex - metabolism | Female | Neurons - metabolism | Cerebral Cortex - drug effects | Tetrodotoxin - pharmacology | Cytophotometry | Receptors, N-Methyl-D-Aspartate - drug effects | Receptors, sigma - drug effects | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Pentazocine - pharmacology | Rats | Receptors, sigma - agonists | Cyclopentanes - pharmacology | Ethylenediamines - pharmacology | Pregnancy | Sodium Channel Agonists | Animals | Calcium Signaling - drug effects | Sodium Azide - pharmacology
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9. Full Text Platinum, palladium, gold and ruthenium complexes as anticancer agents: Current clinical uses, cytotoxicity studies and future perspectives
by Lazarević, Tatjana and Rilak, Ana and Bugarčić, Živadin D
European Journal of Medicinal Chemistry, ISSN 0223-5234, 12/2017, Volume 142, pp. 8 - 31
Metallodrugs offer potential for unique mechanism of drug action based on the choice of the metal, its oxidation state, the types and number of coordinated... 
Proteins | Cytotoxicity | Anticancer agents | DNA | CHEMISTRY, MEDICINAL | SACCHARINATE COMPLEX | STRUCTURAL-CHARACTERIZATION | DNA-BINDING PROPERTIES | PT(II) COMPLEXES | SUBSTITUTION-REACTIONS | ANTITUMOR-ACTIVITY | IN-VITRO CYTOTOXICITY | POLYPYRIDYL COMPLEXES | THIOREDOXIN REDUCTASE | CELLULAR PHARMACOLOGY | Humans | Antineoplastic Agents - therapeutic use | Platinum - toxicity | Platinum - chemistry | Ruthenium - chemistry | Antineoplastic Agents - toxicity | Ruthenium - therapeutic use | Coordination Complexes - pharmacology | Antineoplastic Agents - pharmacology | Platinum - pharmacology | Coordination Complexes - toxicity | Gold - toxicity | Gold - chemistry | Ruthenium - toxicity | Platinum - therapeutic use | Palladium - pharmacology | Gold - pharmacology | Antineoplastic Agents - chemistry | Coordination Complexes - chemistry | Drug Discovery | Palladium - toxicity | Ruthenium - pharmacology | Neoplasms - drug therapy | Coordination Complexes - therapeutic use | Animals | Palladium - therapeutic use | Gold - therapeutic use | Palladium - chemistry | Enzymes | Chromosomal proteins | Ruthenium | Thiols | Lung cancer | Leukemia | Albumin | Palladium | Antineoplastic agents | Ethylenediamines | Antimitotic agents | Cytokinins | Chemotherapy | Colon cancer | Gliomas | Prostate cancer | Cervical cancer | Cancer | Protein binding | Index Medicus
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10. Full Text Sigma1 receptor antagonists determine the behavioral pattern of the methamphetamine-induced stereotypy in mice
by Kitanaka, J and Kitanaka, N and Tatsuta, T and Hall, F S and Uhl, G R and Tanaka, K and Nishiyama, N and Morita, Y and Takemura, M
Psychopharmacology, ISSN 0033-3158, 5/2009, Volume 203, Issue 4, pp. 781 - 792
The effects of sigma receptor antagonists on methamphetamine (METH)-induced stereotypy have not been examined. We examined the effects of sigma antagonists on... 
Neurosciences | Biomedicine | Methamphetamine | Sigma receptor | Biting | BMY 14802 | Sigma ligand | Pharmacology/Toxicology | Psychiatry | Stereotypy | Sniffing | Methamphetamine - pharmacology | Ketotifen - pharmacology | Central Nervous System Stimulants - pharmacology | Butyrates - pharmacology | Tropanes - pharmacology | Stereotyped Behavior - drug effects | Motor Activity - drug effects | Male | Receptors, sigma - agonists | Receptors, sigma - antagonists & inhibitors | Pyrimidines - pharmacology | Mice, Inbred Strains | Piperazines - pharmacology | Ethylenediamines - pharmacology | Naphthalenes - pharmacology | Dose-Response Relationship, Drug | Phenazocine - analogs & derivatives | Animals | Drug Interactions | Pyrilamine - pharmacology | Histamine H1 Antagonists - pharmacology | Phenazocine - pharmacology | Behavior, Animal - drug effects | Mice | Methamphetamines | Antagonist drugs | Animal behavior | Psychopharmacology | Rodents | Index Medicus | methamphetamine | sniffing | biting | BMY14802 | sigma receptor | stereotypy | sigma ligand
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11. Full Text Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan
by Nguyen, Linda and Robson, Matthew J and Healy, Jason R and Scandinaro, Anna L and Matsumoto, Rae R
PLoS ONE, ISSN 1932-6203, 02/2014, Volume 9, Issue 2, p. e89985
Dextromethorphan is an antitussive with a high margin of safety that has been hypothesized to display rapid-acting antidepressant activity based on... 
DEPRESSION | LIGANDS | NOREPINEPHRINE | BEHAVIORAL DESPAIR | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | MICE | SEROTONIN | RAT-BRAIN | FORCED SWIMMING TEST | BINDING | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Dextromethorphan - pharmacology | Cytochrome P-450 Enzyme Inhibitors | Receptors, N-Methyl-D-Aspartate - metabolism | Cytochrome P-450 Enzyme System - metabolism | Behavior, Animal - physiology | Male | Adrenergic alpha-Antagonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Quinidine - pharmacology | Receptors, sigma - antagonists & inhibitors | Piperazines - pharmacology | Ethylenediamines - pharmacology | Dose-Response Relationship, Drug | Swimming - physiology | Animals | Protein Binding | Behavior, Animal - drug effects | Antidepressive Agents - pharmacology | Mice | Kinetics | Ketamine - pharmacology | Receptors, sigma - metabolism | Methyl aspartate | Dextromethorphan | Antidepressants | Analysis | Cytochrome | Glutamic acid receptors (ionotropic) | Glutamic acid receptors | Kinases | Proteins | Receptors | Metabolites | Rodents | Pretreatment | Pharmaceutical sciences | Binding | Dopamine | Serotonin | Saturation | Cytochrome P450 | Health psychology | N-Methyl-D-aspartic acid receptors | Pharmacology | Bioavailability | Metabolism | Pentazocine | Medicine | Studies | Hypotheses | Ketamine | Quinidine | Ligands | Psychiatry
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12. Full Text Superoxide dismutase mimetics elevate superoxide dismutase activity in vivo but do not retard aging in the nematode Caenorhabditis elegans
by Keaney, Michelle and Matthijssens, Filip and Sharpe, Martyn and Vanfleteren, Jacques and Gems, David
Free Radical Biology and Medicine, ISSN 0891-5849, 2004, Volume 37, Issue 2, pp. 239 - 250
According to the oxidative damage theory a primary cause of aging is the accrual of molecular damage from reactive oxygen species (ROS), particularly... 
Caenorhabditis elegans | Free radicals | Life span | Aging | Paraquat | Survival | Superoxide dismutase mimetics | CATALASE | LIFE-SPAN | free radicals | OXIDATIVE STRESS | paraquat | life span | BIOCHEMISTRY & MOLECULAR BIOLOGY | survival | EXTENSION | DAMAGE | superoxide dismutase mimetics | OXYGEN | OVEREXPRESSION | LONGEVITY | DAF-16 | ENDOCRINOLOGY & METABOLISM | aging | ADULT DROSOPHILA-MELANOGASTER | Oxidants - pharmacology | Reactive Oxygen Species | Free Radicals | Oxygen Consumption | Cyanides - pharmacology | Naphthoquinones - pharmacology | Herbicides - pharmacology | Mitochondria - metabolism | Ethylenediamines - pharmacology | Dose-Response Relationship, Drug | Salicylates - pharmacology | Animals | Biomimetics | Time Factors | Escherichia coli - metabolism | Superoxides - metabolism | Cytosol - metabolism | Antinematodal Agents - pharmacology | Manganese Compounds - pharmacology | Paraquat - pharmacology | Organometallic Compounds - pharmacology | Superoxide Dismutase - metabolism
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13. Afobazole Modulates Microglial Function via Activation of Both sigma-1 and sigma-2 Receptors
by Cuevas, J and Rodriguez, A and Behensky, A and Katnik, C
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 10/2011, Volume 339, Issue 1, pp. 161 - 172
Microglial cells play a critical role in the neuroinflammatory response that accompanies various diseases of the central nervous system, such as ischemic... 
CELLS | IN-VITRO | TRAUMATIC BRAIN-INJURY | HEAT-ACCLIMATED MICE | CORTICAL-NEURONS | LIGANDS | CEREBRAL-ARTERY OCCLUSION | RATS | ISCHEMIA | SENSOR | PHARMACOLOGY & PHARMACY | Membrane Potentials - drug effects | Purinergic P2Y Receptor Antagonists - pharmacology | Cell Survival - drug effects | Microglia - drug effects | Calcium - metabolism | Butyrates - pharmacology | Tropanes - pharmacology | Uridine Triphosphate - biosynthesis | Anti-Anxiety Agents - pharmacology | Morpholines - pharmacology | Rats | Purinergic P2X Receptor Antagonists - pharmacology | Receptors, sigma - agonists | Adenosine Triphosphate - biosynthesis | Piperazines - pharmacology | Rats, Sprague-Dawley | Ethylenediamines - pharmacology | Pregnancy | Patch-Clamp Techniques | Animals | Brain Ischemia - pathology | Benzimidazoles - pharmacology | Female | Cell Death - drug effects
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14. Full Text In Vitro Interactions between New Antitubercular Drug Candidates SQ109 and TMC207
by Venkata M. Reddy and Leo Einck and K. Andries and Carol A. Nacy
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 07/2010, Volume 54, Issue 7, pp. 2840 - 2846
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
MYCOBACTERIUM-TUBERCULOSIS | THERAPY | RIFAMPIN | PYRAZINAMIDE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | ANTAGONISM | INFECTION | DIAMINE | R207910 | Microbial Sensitivity Tests | Adamantane - pharmacology | Drug Interactions | Antitubercular Agents - pharmacology | Diarylquinolines | Rifampin - pharmacology | Mycobacterium tuberculosis - drug effects | Ethylenediamines - pharmacology | Quinolines - pharmacology | Adamantane - analogs & derivatives | Susceptibility
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