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1. Full Text In Vitro Combination Studies of Benzothiazinone Lead Compound BTZ043 against Mycobacterium tuberculosis
by Benoit Lechartier and Ruben C. Hartkoorn and Stewart T. Cole
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 11/2012, Volume 56, Issue 11, pp. 5790 - 5793
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Biological and medical sciences | Medical sciences | Antibacterial agents | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Fluoroquinolones | Isoniazid - pharmacology | Ethambutol - pharmacology | Aza Compounds - pharmacology | Moxifloxacin | Mycobacterium tuberculosis - drug effects | Quinolines - pharmacology | Microbial Sensitivity Tests | Spiro Compounds - chemical synthesis | Thiazines - pharmacology | Meropenem | Adamantane - analogs & derivatives | Adamantane - pharmacology | Nitroimidazoles - pharmacology | Antitubercular Agents - pharmacology | Microbial Viability | Thienamycins - pharmacology | Thiazines - chemical synthesis | Ethylenediamines - pharmacology | Drug Synergism | Diarylquinolines | Rifampin - pharmacology | Drug Combinations | Spiro Compounds - pharmacology | Mycobacterium tuberculosis - growth & development | Index Medicus | Experimental Therapeutics
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2. Full Text Challenges facing the drug discovery pipeline for non-tuberculous mycobacteria
by Soni, Isha and De Groote, Mary Ann and Dasgupta, Arunava and Chopra, Sidharth
Journal of medical microbiology, ISSN 0022-2615, 01/2016, Volume 65, Issue 1, pp. 1 - 8
Life Sciences & Biomedicine | Microbiology | Science & Technology | Adamantane - pharmacology | Nitroimidazoles - pharmacology | Nontuberculous Mycobacteria - drug effects | Minocycline - pharmacology | Humans | Minocycline - analogs & derivatives | Uridine - analogs & derivatives | Clinical Trials as Topic | Diarylquinolines - pharmacology | Drug Discovery | Piperazines - pharmacology | Ethylenediamines - pharmacology | Uridine - pharmacology | Azepines - pharmacology | Aminopyridines - pharmacology | Fluoroquinolones - pharmacology | Thiazines - pharmacology | Anti-Bacterial Agents - pharmacology | Benzamides - pharmacology | Oxazoles - pharmacology | Tigecycline | Mycobacterium Infections, Nontuberculous - drug therapy | Spiro Compounds - pharmacology | Adamantane - analogs & derivatives | Index Medicus
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3. Full Text Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis
by Li, Wei and Upadhyay, Ashutosh and Fontes, Fabio L and North, E. Jeffrey and Wang, Yuehong and Crans, Debbie C and Grzegorzewicz, Anna E and Jones, Victoria and Franzblau, Scott G and Lee, Richard E and Crick, Dean C and Jackson, Mary
Antimicrobial agents and chemotherapy, ISSN 0066-4804, 11/2014, Volume 58, Issue 11, pp. 6413 - 6423
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Cell Membrane | Cord Factors - metabolism | Mycobacterium tuberculosis - drug effects | Vitamin K 2 - metabolism | Microbial Sensitivity Tests | Tuberculosis, Multidrug-Resistant - microbiology | Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology | Drug Resistance, Multiple, Bacterial | Proton Ionophores - pharmacology | Valinomycin - pharmacology | Adamantane - analogs & derivatives | Bacterial Proteins - antagonists & inhibitors | Adamantane - pharmacology | Antitubercular Agents - pharmacology | Carrier Proteins - antagonists & inhibitors | Piperazines - pharmacology | Ethylenediamines - pharmacology | Membrane Proteins - biosynthesis | Pyrroles - pharmacology | Membrane Proteins - antagonists & inhibitors | Membrane Transport Proteins | Mycobacterium smegmatis - drug effects | Anti-Bacterial Agents - pharmacology | Mycolic Acids - metabolism | Phenylurea Compounds - pharmacology | Tuberculosis, Multidrug-Resistant - drug therapy | Index Medicus | Mechanisms of Action | Physiological Effects
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4. Full Text Bioluminescence for assessing drug potency against nonreplicating Mycobacterium tuberculosis
by Vocat, Anthony and Hartkoorn, Ruben C and Lechartier, Benoit and Zhang, Ming and Dhar, Neeraj and Cole, Stewart T and Sala, Claudia
Antimicrobial agents and chemotherapy, ISSN 0066-4804, 07/2015, Volume 59, Issue 7, pp. 4012 - 4019
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Adamantane - pharmacology | Genes, Bacterial - genetics | Photorhabdus - metabolism | Antitubercular Agents - pharmacology | Luminescence | Colony Count, Microbial | Diarylquinolines - pharmacology | Drug Discovery | Mycobacterium tuberculosis - drug effects | Ethylenediamines - pharmacology | Pyrazinamide - pharmacology | Rifamycins - pharmacology | Photorhabdus - genetics | Oxazolidinones - pharmacology | Microbial Sensitivity Tests - methods | Xanthenes - pharmacology | Adamantane - analogs & derivatives | Oxazines - pharmacology | Index Medicus | Experimental Therapeutics
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5. Full Text Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans
by Collins, James J and Evason, Kimberley and Kornfeld, Kerry
Experimental gerontology, ISSN 0531-5565, 2006, Volume 41, Issue 10, pp. 1032 - 1039
Aging | C. elegans | Pharmacology | Lifespan | Life Sciences & Biomedicine | Geriatrics & Gerontology | Science & Technology | Longevity - drug effects | Plant Extracts - pharmacology | Trimethadione - pharmacology | Aging - drug effects | Antioxidants - pharmacology | Stilbenes - pharmacology | Anticonvulsants - pharmacology | Ethylenediamines - pharmacology | Tocotrienols - pharmacology | Ubiquinone - pharmacology | Ginkgo biloba | Salicylates - pharmacology | Blueberry Plants | Caenorhabditis elegans - physiology | Animals | Caenorhabditis elegans - drug effects | Aging - physiology | Ethosuximide - pharmacology | Longevity - physiology | Organometallic Compounds - pharmacology | Vitamin E - pharmacology | Analysis | Index Medicus
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6. Full Text Presynaptic Modulation of Synaptic Transmission by Pregnenolone Sulfate as Studied by Optical Recordings
by Ling Chen and Masahiro Sokabe
Journal of Neurophysiology, ISSN 0022-3077, 12/2005, Volume 94, Issue 6, pp. 4131 - 4144
Neurosciences | Physiology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Excitatory Postsynaptic Potentials - radiation effects | Synaptic Transmission - physiology | Rats, Wistar | Calcium - metabolism | 2-Amino-5-phosphonovalerate - pharmacology | Kainic Acid - analogs & derivatives | Male | Nicotinic Antagonists - pharmacology | Excitatory Postsynaptic Potentials - drug effects | Diagnostic Imaging - methods | Dose-Response Relationship, Drug | Drug Interactions | Time Factors | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Pregnenolone - pharmacology | Tetrodotoxin - pharmacology | Neurons - drug effects | Electric Stimulation - methods | Haloperidol - pharmacology | Nicotinic Agonists - pharmacology | Calcium - pharmacology | Presynaptic Terminals - drug effects | Kainic Acid - pharmacology | Rats | Excitatory Amino Acid Antagonists - pharmacology | Aconitine - analogs & derivatives | Bicuculline - pharmacology | Aconitine - pharmacology | Calcium Channel Blockers - pharmacology | Hippocampus - cytology | Ethylenediamines - pharmacology | GABA Antagonists - pharmacology | Animals | Benzylidene Compounds - pharmacology | Analysis of Variance | Dopamine Antagonists - pharmacology | Pyridines - pharmacology | In Vitro Techniques | Bungarotoxins - pharmacology | Index Medicus
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7. Full Text Platinum, palladium, gold and ruthenium complexes as anticancer agents: Current clinical uses, cytotoxicity studies and future perspectives
by Lazarević, Tatjana and Rilak, Ana and Bugarčić, Živadin D
European journal of medicinal chemistry, ISSN 0223-5234, 12/2017, Volume 142, pp. 8 - 31
Proteins | Cytotoxicity | Anticancer agents | DNA | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Humans | Antineoplastic Agents - therapeutic use | Platinum - toxicity | Platinum - chemistry | Ruthenium - chemistry | Antineoplastic Agents - toxicity | Ruthenium - therapeutic use | Coordination Complexes - pharmacology | Antineoplastic Agents - pharmacology | Platinum - pharmacology | Coordination Complexes - toxicity | Gold - toxicity | Gold - chemistry | Ruthenium - toxicity | Platinum - therapeutic use | Palladium - pharmacology | Gold - pharmacology | Antineoplastic Agents - chemistry | Coordination Complexes - chemistry | Drug Discovery | Palladium - toxicity | Ruthenium - pharmacology | Neoplasms - drug therapy | Coordination Complexes - therapeutic use | Animals | Palladium - therapeutic use | Gold - therapeutic use | Palladium - chemistry | Enzymes | Chromosomal proteins | Ruthenium | Thiols | Lung cancer | Leukemia | Albumin | Palladium | Antineoplastic agents | Ethylenediamines | Antimitotic agents | Cytokinins | Chemotherapy | Colon cancer | Gliomas | Prostate cancer | Cervical cancer | Cancer | Protein binding | Index Medicus
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8. Full Text In Vitro Interactions between New Antitubercular Drug Candidates SQ109 and TMC207
by Venkata M. Reddy and Leo Einck and K. Andries and Carol A. Nacy
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 07/2010, Volume 54, Issue 7, pp. 2840 - 2846
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Microbial Sensitivity Tests | Adamantane - pharmacology | Drug Interactions | Antitubercular Agents - pharmacology | Diarylquinolines | Rifampin - pharmacology | Mycobacterium tuberculosis - drug effects | Ethylenediamines - pharmacology | Quinolines - pharmacology | Adamantane - analogs & derivatives | Index Medicus | Susceptibility
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9. Full Text Theoretical Investigations and Density Functional Theory Based Quantitative Structure–Activity Relationships Model for Novel Cytotoxic Platinum(IV) Complexes
by Varbanov, Hristo P and Jakupec, Michael A and Roller, Alexander and Jensen, Frank and Galanski, Markus and Keppler, Bernhard K
Journal of medicinal chemistry, ISSN 0022-2623, 01/2013, Volume 56, Issue 1, pp. 330 - 344
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Carboplatin - chemistry | Cisplatin - analogs & derivatives | Ethylamines - pharmacology | Ethylenediamines - chemistry | Humans | Molecular Conformation | Models, Molecular | Crystallography, X-Ray | Cisplatin - pharmacology | Antineoplastic Agents - chemistry | Coordination Complexes - chemistry | Ethylenediamines - pharmacology | Organoplatinum Compounds - pharmacology | Thermodynamics | Cisplatin - chemistry | Platinum | Cell Line, Tumor | Coordination Complexes - pharmacology | Antineoplastic Agents - pharmacology | Ethylamines - chemistry | Carboplatin - pharmacology | Quantitative Structure-Activity Relationship | Drug Screening Assays, Antitumor | Organoplatinum Compounds - chemistry | Index Medicus
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10. Full Text Sigma1 receptor antagonists determine the behavioral pattern of the methamphetamine-induced stereotypy in mice
by Kitanaka, J and Kitanaka, J and Kitanaka, N and Kitanaka, N and Tatsuta, T and Tatsuta, T and Hall, F S and Hall, F S and Uhl, G R and Uhl, G R and Tanaka, K and Tanaka, K and Nishiyama, N and Nishiyama, N and Morita, Y and Morita, Y and Takemura, M and Takemura, M
Psychopharmacology, ISSN 0033-3158, 5/2009, Volume 203, Issue 4, pp. 781 - 792
Neurosciences | Biomedicine | Methamphetamine | Sigma receptor | Biting | BMY 14802 | Sigma ligand | Pharmacology/Toxicology | Psychiatry | Stereotypy | Sniffing | Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer | Psychology. Psychoanalysis. Psychiatry | Psychopharmacology | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Neuropharmacology | Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) | Methamphetamine - pharmacology | Ketotifen - pharmacology | Central Nervous System Stimulants - pharmacology | Butyrates - pharmacology | Tropanes - pharmacology | Stereotyped Behavior - drug effects | Motor Activity - drug effects | Male | Receptors, sigma - agonists | Receptors, sigma - antagonists & inhibitors | Pyrimidines - pharmacology | Mice, Inbred Strains | Piperazines - pharmacology | Ethylenediamines - pharmacology | Naphthalenes - pharmacology | Dose-Response Relationship, Drug | Phenazocine - analogs & derivatives | Animals | Drug Interactions | Pyrilamine - pharmacology | Histamine H1 Antagonists - pharmacology | Phenazocine - pharmacology | Behavior, Animal - drug effects | Mice | Antagonist drugs | Animal behavior | Rodents | Index Medicus | methamphetamine | sniffing | biting | BMY14802 | sigma receptor | stereotypy | sigma ligand
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