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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2006, Volume 103, Issue 4, pp. 1006 - 1011
Farnesoid X receptor (FXR) plays an important role in maintaining bile acid and cholesterol homeostasis. Here we demonstrate that FXR also regulates glucose... 
Messenger RNA | Diabetes complications | Glycogen | Liver | Adenoviruses | Mice | Liver glycogen | Insulin | Cholesterols | Blood plasma | GW4064 | triglyceride | glucose | TRIGLYCERIDE LEVELS | MYOCARDIAL-INFARCTION | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | GLYCOGEN-SYNTHASE KINASE-3 | farnesoid x receptor-VP16 | INSULIN-RESISTANCE | GENE-EXPRESSION | cholesterol | FARNESOID-X-RECEPTOR | BILE-ACID BIOSYNTHESIS | LIPID HOMEOSTASIS | CARBOHYDRATE-METABOLISM | Hepatocytes - metabolism | Receptors, Cytoplasmic and Nuclear | DNA-Binding Proteins - metabolism | Lipids - chemistry | Glycogen - metabolism | Time Factors | Adenoviridae - genetics | Diabetes Mellitus, Experimental - metabolism | Gluconeogenesis | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Hyperlipidemias - metabolism | Signal Transduction | Liver - metabolism | Mice, Inbred C57BL | Insulin Resistance | Etoposide - metabolism | Mice, Transgenic | Models, Statistical | Cholesterol - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Knockout | Triglycerides - metabolism | Hyperglycemia - metabolism | Isoxazoles - pharmacology | Transcription Factors - metabolism | Blotting, Northern | Insulin - metabolism | Animals | 3-Hydroxybutyric Acid - metabolism | Glucose - metabolism | Blood Glucose - metabolism | Glucose metabolism | Control | Genes | Rattus | Homeostasis | Rats | Physiological aspects | Research | Structure | Lipids | Diabetes | Glucose | Metabolism | Rodents | Cholesterol | Index Medicus | Biological Sciences | farnesoid X receptor-VP16
Journal Article
Nature Cell Biology, ISSN 1465-7392, 10/2009, Volume 11, Issue 10, pp. 1241 - 1246
Journal Article
Molecular and Cellular Biochemistry, ISSN 0300-8177, 2/2007, Volume 296, Issue 1, pp. 85 - 95
Many studies have been performed with the aim of developing effective resistance modulators to overcome the multidrug resistance (MDR) of human cancers. Potent... 
Life Sciences | Biochemistry, general | P-glycoprotein | tetrahydrocurcumin | multidrug resistance | ATP hydrolysis | drug transport | Oncology | Medical Biochemistry | Cardiology | chemosensitivity | ABC transporter | Drug transport | Multidrug resistance | Chemosensitivity | Tetrahydrocurcumin | MECHANISM | INVOLVEMENT | CHEMOPREVENTIVE AGENT CURCUMIN | CATALYTIC TRANSITION-STATE | CELL BIOLOGY | MICROORGANISMS | BREAST-CANCER CELLS | IN-VITRO | INHIBITION | PROTECTIVE ROLE | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Vinblastine - metabolism | Curcumin - analogs & derivatives | Fluorides - metabolism | Curcumin - chemistry | Fluoresceins - metabolism | Humans | Chlorophyll - analogs & derivatives | Fluorescent Dyes - metabolism | Drug Resistance, Neoplasm | Curcumin - metabolism | Neoplasm Proteins - metabolism | ATP-Binding Cassette, Sub-Family B, Member 1 | Organic Anion Transporters - metabolism | Antineoplastic Agents - metabolism | Beryllium - metabolism | Adenosine Triphosphate - metabolism | ATP-Binding Cassette Transporters - metabolism | Molecular Structure | Drug Resistance, Multiple - physiology | Mitoxantrone - metabolism | Etoposide - metabolism | Chlorophyll - metabolism | Antineoplastic Agents - chemistry | Rhodamine 123 - metabolism | Cell Line, Tumor | ATP Binding Cassette Transporter, Sub-Family B | Multidrug Resistance-Associated Proteins - metabolism | Proteins | Medical research | Binding sites | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2010, Volume 40, Issue 1, pp. 75 - 86
Activation of the transcription factor NF-κB by multiple genotoxic stimuli modulates cancer cell survival. This response is mediated by a conserved pathway... 
PROTEIN | POLYUBIQUITIN | ISOFORMS | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | NF-KAPPA-B | BINDING | CELL BIOLOGY | Protein-Serine-Threonine Kinases - deficiency | Humans | Male | NF-kappa B - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Ubiquitination | RNA Interference | Time Factors | Tumor Suppressor Proteins - deficiency | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - metabolism | MAP Kinase Kinase Kinases - genetics | Cell Cycle Proteins - metabolism | Etoposide - pharmacology | Ubiquitin-Conjugating Enzymes - genetics | MAP Kinase Kinase Kinases - metabolism | Ataxia Telangiectasia Mutated Proteins | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Mice | DNA Damage | Enzyme Activation | Mutation | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Pyrones - pharmacology | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | Transfection | I-kappa B Kinase - metabolism | MAP Kinase Kinase Kinases - deficiency | Mice, Mutant Strains | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Cell Line | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Morpholines - pharmacology | I-kappa B Kinase - genetics | DNA-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | X-Linked Inhibitor of Apoptosis Protein - genetics | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Adaptor Proteins, Signal Transducing - genetics | X-Linked Inhibitor of Apoptosis Protein - metabolism | Protein Binding | Adaptor Proteins, Signal Transducing - metabolism | Camptothecin - pharmacology | Ubiquitin | Ligases | Lysine | Oncology, Experimental | Automated teller machines | Research | Glutamate | Cancer | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2009, Volume 36, Issue 3, pp. 487 - 499
While activation of BAX/BAK by BH3-only molecules (BH3s) is essential for mitochondrial apoptosis, the underlying mechanisms remain unsettled. Here we... 
CELLCYCLE | CYTOCHROME-C | PROAPOPTOTIC BAX | OLIGOMERIZES BAK | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOPLASMIC-RETICULUM | SUBCELLULAR LOCATION | PROTEINS | BCL-2 FAMILY-MEMBERS | BH3 DOMAIN | CELL-DEATH | MEMBRANE PERMEABILIZATION | CELL BIOLOGY | bcl-2-Associated X Protein - chemistry | Immunoprecipitation | Apoptosis - drug effects | Protein Multimerization | bcl-2 Homologous Antagonist-Killer Protein - genetics | Immunoblotting | BH3 Interacting Domain Death Agonist Protein - genetics | Green Fluorescent Proteins - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Bcl-2-Like Protein 11 | Protein Binding - drug effects | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Fibroblasts - metabolism | Proto-Oncogene Proteins - metabolism | Green Fluorescent Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Etoposide - pharmacology | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Models, Biological | Tunicamycin - pharmacology | Fibroblasts - drug effects | Thapsigargin - pharmacology | Fibroblasts - cytology | Mice | Mutation | Microscopy, Fluorescence | Staurosporine - pharmacology | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Monomers | Apoptosis | Oligomers | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2009, Volume 106, Issue 47, pp. 19801 - 19806
Journal Article
Science, ISSN 0036-8075, 8/2006, Volume 313, Issue 5790, pp. 1122 - 1126
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2005, Volume 280, Issue 35, pp. 31230 - 31239
Journal Article
Biochemistry, ISSN 0006-2960, 04/2006, Volume 45, Issue 15, pp. 4998 - 5009
Journal Article
Mechanisms of Development, ISSN 0925-4773, 2005, Volume 122, Issue 6, pp. 835 - 847
We have characterised the transdifferentiation of human HepG2 (hepatoma) cells to pancreatic cells following introduction of an activated version of the... 
GLP-1 | Nuclear translocation | Betacellulin | XlHbox8 | Liver | Transdifferentiation | VP16 | Endocrine | Exocrine | Pancreas | Pdx-1 | X1Hbox8 | PROGENITOR CELLS | exocrine | betacellulin | liver | CONVERSION | BETA-CELLS | PDX1 | DEVELOPMENTAL BIOLOGY | GLUCAGON-LIKE PEPTIDE-1 | nuclear translocation | pancreas | transdifferentiation | INSULIN-PRODUCING CELLS | MICE | EXPRESSION | endocrine | Glucagon-Like Peptide 1 | Homeodomain Proteins - metabolism | Humans | Pancreas - cytology | Hepatocytes - metabolism | RNA, Messenger - metabolism | Cell Culture Techniques - methods | Intercellular Signaling Peptides and Proteins - metabolism | Cell Nucleus - metabolism | Time Factors | Gene Expression Regulation, Developmental | Polymerase Chain Reaction | Islets of Langerhans Transplantation | Cell Differentiation | Active Transport, Cell Nucleus | Transgenes | Somatostatin - metabolism | Peptide Fragments - metabolism | Liver - metabolism | Gene Expression Regulation | Etoposide - metabolism | Pancreas - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Pancreas - embryology | Plasmids - metabolism | Protein Precursors - metabolism | Microscopy, Confocal | Insulin - metabolism | Phenotype | Animals | Carcinoma, Hepatocellular - pathology | Cell Line, Tumor | Glucagon - metabolism | Trans-Activators - metabolism | Mice | Microscopy, Fluorescence | Proteins | Pancreatic beta cells | Cell research | Glucagon | RNA | Physiological aspects | Hypothalamic hormones | Somatostatin | Hepatoma | Glucose | Peptide hormones | Dextrose | Index Medicus
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 08/2000, Volume 192, Issue 4, pp. 571 - 579
Apaf-1(-/-) or caspase-3(-/-) cells treated with a variety of apoptosis inducers manifest apoptosis-associated alterations including the translocation of... 
Apaf-1 | Chromatin condensation | Caspases | Apoptosis-inducing factor | Caspase-activated DNase | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | caspase-activated DNase | CASPASE-3 | chromatin condensation | INTERNUCLEOSOMAL FRAGMENTATION | IMMUNOLOGY | CLEAVAGE | CELL-DEATH | DNA FRAGMENTATION |