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Nature, ISSN 0028-0836, 2014, Volume 513, Issue 7519, pp. 517 - 522
The ribosome is a molecular machine responsible for protein synthesis and a major target for small-molecule inhibitors. Compared to the wealth of structural... 
YEAST | CRYPTOPLEURINE RESISTANCE | CELLS | CRYSTAL-STRUCTURE | BLASTICIDIN S | MULTIDISCIPLINARY SCIENCES | TRANSLATION INITIATION | TRANSFER-RNA | PROTEIN-SYNTHESIS | SACCHAROMYCES-CEREVISIAE | AMINOGLYCOSIDE ANTIBIOTICS | Eukaryotic Cells - chemistry | Protein Synthesis Inhibitors - chemistry | Molecular Weight | Species Specificity | Ribosomes - metabolism | Substrate Specificity | Crystallography, X-Ray | Molecular Targeted Therapy | RNA, Messenger - metabolism | Ribosome Subunits, Large, Eukaryotic - metabolism | Base Sequence | Macrolides - pharmacology | RNA, Transfer - genetics | Protein Synthesis Inhibitors - pharmacology | Binding Sites - drug effects | Eukaryotic Cells - enzymology | Peptidyl Transferases - metabolism | RNA, Transfer - metabolism | Ribosome Subunits, Large, Eukaryotic - chemistry | Peptidyl Transferases - chemistry | RNA, Messenger - genetics | Ribosomes - chemistry | Models, Molecular | Drug Resistance - drug effects | Peptide Chain Elongation, Translational - drug effects | Piperidones - pharmacology | Cycloheximide - pharmacology | Saccharomyces cerevisiae - chemistry | Eukaryotic Cells - drug effects | Ribosomes - drug effects | Ribosome Subunits, Large, Eukaryotic - drug effects | Kinetics | Eukaryotes | Analysis | Ribosomes | Ribonucleoproteins | Research | Health aspects | Transfer RNA | Proteins | Yeast | Peptides | Antibiotics | Protein synthesis | Bacteria | Drug resistance | Binding sites
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 4/2003, Volume 161, Issue 2, pp. 267 - 280
The Aurora/Ipl1 family of protein kinases plays multiple roles in mitosis and cytokinesis. Here, we describe ZM447439, a novel selective Aurora kinase... 
Mitotic index | Mitosis | Kinetochores | Microtubules | DNA | Cell lines | HeLa cells | Cultured cells | Chromosomes | Cells | Chemical biology | Aneuploidy | Spindle checkpoint | ZM447439 | KINASE-ACTIVITY | LOCALIZATION | BUDDING YEAST | PHOSPHORYLATION | TENSION | mitosis | MAMMALIAN-CELLS | CELL BIOLOGY | chemical biology | CENTROSOME AMPLIFICATION | HISTONE H3 | aneuploidy | spindle checkpoint | Protein Kinases - metabolism | Protein Kinases - genetics | Paclitaxel - pharmacology | DNA Replication - drug effects | Humans | Chromosome Segregation - drug effects | Mitosis - genetics | Tumor Suppressor Protein p53 - genetics | Aurora Kinase B | Spindle Apparatus - genetics | Eukaryotic Cells - ultrastructure | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Benzamides - pharmacology | Mad2 Proteins | Phosphorylation - drug effects | Calcium-Binding Proteins - metabolism | Eukaryotic Cells - enzymology | Chromosomal Proteins, Non-Histone - metabolism | Kinetochores - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | Genes, cdc - drug effects | Aurora Kinases | Tumor Suppressor Protein p53 - drug effects | Anaphase - drug effects | Chromosomal Proteins, Non-Histone - genetics | Anaphase - genetics | Eukaryotic Cells - drug effects | Mitosis - drug effects | DNA Replication - genetics | Repressor Proteins - drug effects | Kinetochores - drug effects | Spindle Apparatus - drug effects | HeLa Cells | Quinazolines - pharmacology | Cell Cycle Proteins | Calcium-Binding Proteins - genetics | Chromosome Segregation - genetics | Research | Cytokinesis | Protein kinases | mitosis; spindle checkpoint; chemical biology; aneuploidy; ZM447439
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 510, Issue 7504, pp. 268 - 272
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2016, Volume 113, Issue 6, pp. E679 - E688
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 4/2003, Volume 161, Issue 2, pp. 281 - 294
The proper segregation of sister chromatids in mitosis depends on bipolar attachment of all chromosomes to the mitotic spindle. We have identified the small... 
Mitosis | Kinetochores | Chromatids | Microtubules | HeLa cells | Cellular immunity | Chromosomes | Anaphase | Cells | Mitotic spindle apparatus | Chemical biology | Spindle assembly checkpoint | Chromosome segregation | KINASE-ACTIVITY | MAD2 | BUDDING YEAST | spindle assembly checkpoint | TENSION | G/M TRANSITION | mitosis | HISTONE H3 PHOSPHORYLATION | MAMMALIAN-CELLS | CELL BIOLOGY | kinetochores | chromosome segregation | chemical biology | VERTEBRATE SOMATIC-CELLS | Cell Cycle Proteins - drug effects | Protein Kinases - metabolism | RNA, Small Interfering - genetics | Paclitaxel - pharmacology | Humans | Nocodazole - pharmacology | Chromosome Segregation - drug effects | Mitosis - genetics | Aurora Kinase B | Microtubules - drug effects | Spindle Apparatus - genetics | Cell Cycle Proteins - genetics | Genes, cdc - physiology | Indoles - pharmacology | Kinetochores - enzymology | Protein-Serine-Threonine Kinases - metabolism | Aneugens - pharmacology | Eukaryotic Cells - enzymology | Polyploidy | Protein Kinases - drug effects | Separase | Protein-Serine-Threonine Kinases - genetics | Genes, cdc - drug effects | Aurora Kinases | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Anaphase - drug effects | Phenotype | Anaphase - genetics | Animals | Eukaryotic Cells - drug effects | Mitosis - drug effects | Microtubules - genetics | Microtubules - enzymology | Protein-Serine-Threonine Kinases - drug effects | Eukaryotic Cells - cytology | Kinetochores - drug effects | Spindle Apparatus - drug effects | HeLa Cells | Thiones - pharmacology | Endopeptidases | Chromosome Segregation - genetics | Spindle Apparatus - enzymology | Research | mitosis; chromosome segregation; kinetochores; spindle assembly checkpoint; chemical biology
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 2/2003, Volume 160, Issue 3, pp. 321 - 328
The protective antigen (PA) of the anthrax toxin binds to a cell surface receptor and thereby allows lethal factor (LF) to be taken up and exert its toxic... 
Receptors | Anthrax | B lymphocytes | Rafts | Antibodies | HeLa cells | Lipids | Reports | Toxins | Cell membranes | CHO cells | Anthrax toxin | Protective antigen | Clustering | Microdomains | rafts | PROTEOLYTIC ACTIVATION | CELL-SURFACE | EUKARYOTIC CELLS | ANCHORED PROTEINS | CELL BIOLOGY | anthrax toxin | KINASE-KINASE | microdomains | MEMBRANE MICRODOMAINS | EPITHELIAL-CELLS | LETHAL FACTOR | protective antigen | SERINE PALMITOYLTRANSFERASE | clustering | Dynamins - metabolism | Membrane Microdomains - metabolism | Eukaryotic Cells - metabolism | Caveolins - metabolism | Phosphoproteins - metabolism | Receptors, Peptide - drug effects | Membrane Microdomains - ultrastructure | MAP Kinase Kinase 1 | Mitogen-Activated Protein Kinase Kinases - metabolism | Caveolin 1 | Transport Vesicles - drug effects | Eukaryotic Cells - microbiology | Protein-Serine-Threonine Kinases - metabolism | CHO Cells | Calcium-Binding Proteins - metabolism | Cricetinae | Endocytosis - drug effects | Anthrax - metabolism | Antigens, Bacterial | Microscopy, Electron | Clathrin - metabolism | Anthrax - physiopathology | Endocytosis - physiology | Macromolecular Substances | Bacterial Toxins - metabolism | Animals | Carrier Proteins - metabolism | Eukaryotic Cells - drug effects | Membrane Microdomains - drug effects | Transport Vesicles - metabolism | Mitogen-Activated Protein Kinase Kinases - drug effects | Protein-Serine-Threonine Kinases - drug effects | Transport Vesicles - ultrastructure | Receptors, Peptide - metabolism | Antigens | Endocytosis | Cell research | Analysis | Physiological aspects | Genetic aspects | Cytoplasm | anthrax toxin; rafts; microdomains; clustering; protective antigen | Report
Journal Article