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2012, Progress in Molecular Biology and Translational Science, ISBN 0123964563, Volume 106, 32
The unfolded protein response, also known as endoplasmic reticulum (ER) stress, has been implicated in numerous human diseases, including atherosclerosis,... 
DIABETES-MELLITUS | INDUCED GENE-EXPRESSION | MESSENGER-RNA TRANSLATION | UNFOLDED PROTEIN RESPONSE | FACTOR 2-ALPHA EIF2-ALPHA | ER STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA-CELL FAILURE | ENDOPLASMIC-RETICULUM STRESS | QUALITY-CONTROL | INDUCIBLE PROTEIN | Neoplasms - metabolism | Guanabenz - therapeutic use | Thiourea - therapeutic use | Humans | Phosphoprotein Phosphatases - metabolism | Eukaryotic Cells - metabolism | Thiourea - pharmacology | Endoplasmic Reticulum Stress - genetics | Molecular Targeted Therapy | Neurodegenerative Diseases - drug therapy | Protein Processing, Post-Translational - drug effects | Protein Folding - drug effects | Eukaryotic Initiation Factor-2 - metabolism | Phosphorylation - drug effects | Unfolded Protein Response - drug effects | Atherosclerosis - drug therapy | Endoplasmic Reticulum Stress - drug effects | Unfolded Protein Response - genetics | Diabetes Mellitus - drug therapy | Diabetes Mellitus - metabolism | Mice, Transgenic | Phosphoprotein Phosphatases - antagonists & inhibitors | Neurodegenerative Diseases - metabolism | Cinnamates - pharmacology | Atherosclerosis - metabolism | Gene Knock-In Techniques | Mice, Knockout | Neoplasms - drug therapy | Guanabenz - pharmacology | Animals | Models, Biological | Protein Biosynthesis - drug effects | Mice | Proteasome Endopeptidase Complex - metabolism | Cinnamates - therapeutic use | Thiourea - analogs & derivatives | Endoplasmic Reticulum Stress - physiology
Book Chapter
Journal of Biological Chemistry, ISSN 0021-9258, 06/2008, Volume 283, Issue 24, pp. 16591 - 16601
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 2012, Volume 485, Issue 7399, pp. 507 - 511
.... One arm of this pathway results in the transient shutdown of protein translation, through phosphorylation of the alpha-subunit of eukaryotic translation initiation factor, eIF2... 
UNFOLDED PROTEIN RESPONSE | TOXICITY IN-VIVO | ALZHEIMERS-DISEASE | ER STRESS | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | MICE | ENDOPLASMIC-RETICULUM STRESS | DYSFUNCTION | PRP | PROTEOSTASIS | Neurons - pathology | Neuroprotective Agents | Phosphorylation | Prions - genetics | Eukaryotic Initiation Factor-2 - chemistry | Neurodegenerative Diseases - etiology | PrPSc Proteins - analysis | Synapses - pathology | Thiourea - pharmacology | Phosphoproteins - metabolism | Repressor Proteins - analysis | PrPSc Proteins - metabolism | Synapses - metabolism | Phosphoproteins - analysis | Protein Folding - drug effects | Protein Phosphatase 1 - genetics | Eukaryotic Initiation Factor-2 - metabolism | Synaptic Transmission - drug effects | Cell Death - drug effects | PrPSc Proteins - toxicity | Neurons - drug effects | Repressor Proteins - metabolism | Prions - metabolism | Synapses - drug effects | Repressor Proteins - chemistry | Neurodegenerative Diseases - pathology | Mice, Inbred C57BL | Kaplan-Meier Estimate | Hippocampus - pathology | Prion Diseases - pathology | Neurodegenerative Diseases - metabolism | Hippocampus - cytology | Cinnamates - pharmacology | Eukaryotic Initiation Factor-2 - analysis | Hippocampus - metabolism | Protein Phosphatase 1 - metabolism | Animals | Prions - biosynthesis | Protein Biosynthesis - drug effects | Mice | Unfolded Protein Response - physiology | Thiourea - analogs & derivatives
Journal Article
Molecular cell, ISSN 1097-2765, 07/2016, Volume 63, Issue 2, pp. 206 - 217
mRNA translation initiation in eukaryotes requires the cooperation of a dozen eukaryotic initiation factors (eIFs... 
ribosome | eukaryotic translation initiation | eIF3 peripheral subunits | cryo-EM | eIF3 | PROTEIN DHX29 | EUKARYOTIC TRANSLATION INITIATION | MOLECULAR-DYNAMICS | INHIBITION | SCANNING MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | PURIFICATION | RIBOSOMAL-SUBUNITS | CELL-PROLIFERATION | ELECTRON-MICROGRAPHS | 43S PREINITIATION COMPLEX | CELL BIOLOGY | Protein Subunits | Protein Biosynthesis | Eukaryotic Initiation Factor-2 - chemistry | Eukaryotic Initiation Factor-3 - chemistry | Humans | Multiprotein Complexes | Ribosomes - metabolism | Structure-Activity Relationship | RNA, Messenger - metabolism | Eukaryotic Initiation Factor-2 - metabolism | Eukaryotic Initiation Factor-1 - chemistry | Eukaryotic Initiation Factor-1 - metabolism | Nucleic Acid Conformation | RNA, Transfer - chemistry | Binding Sites | Rabbits | RNA, Transfer - metabolism | RNA, Messenger - genetics | Ribosomes - chemistry | Models, Molecular | Eukaryotic Initiation Factor-3 - metabolism | Codon, Initiator | Animals | beta-Globins - metabolism | Protein Binding | Protein Conformation | RNA, Messenger - chemistry | beta-Globins - chemistry | RNA | Genetic translation | Analysis | Biochemistry, Molecular Biology | Ribosomes | Eukaryotic Initiation Factor-1 | Eukaryotic Initiation Factor-2 | Eukaryotic Initiation Factor-3 | RNA, Transfer | beta-Globins | Life Sciences | Molecular biology | RNA, Messenger
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2005, Volume 280, Issue 14, pp. 14189 - 14202
.... In this study we addressed the role of phosphorylation of the alpha- subunit eukaryotic initiation factor- 2 ( eIF2... 
INDUCED GENE-EXPRESSION | MESSENGER-RNA TRANSLATION | TARGETED DISRUPTION | KINASE GCN2 | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | ENDOPLASMIC-RETICULUM STRESS | BINDING PROTEIN | CELL-SURVIVAL | NF-KAPPA-B | Protein Kinases - metabolism | Phosphorylation | Protein Biosynthesis | Protein Kinases - genetics | Ubiquitin - metabolism | Activating Transcription Factor 4 | Protein Subunits - metabolism | Antineoplastic Agents - metabolism | DNA-Binding Proteins - metabolism | RNA Splicing | Transcription Factor CHOP | Trans-Activators - genetics | Eukaryotic Initiation Factor-2 - metabolism | Membrane Proteins - metabolism | CCAAT-Enhancer-Binding Proteins - genetics | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Protein Subunits - genetics | CCAAT-Enhancer-Binding Proteins - metabolism | Membrane Proteins - genetics | Cells, Cultured | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Regulatory Factor X Transcription Factors | Mice, Knockout | Transcription Factors - metabolism | Animals | Eukaryotic Initiation Factor-2 - genetics | Trans-Activators - metabolism | Fibroblasts - cytology | Mice | Apoptosis - physiology | Proteasome Endopeptidase Complex - metabolism | Proteasome Inhibitors
Journal Article
Nature (London), ISSN 1476-4687, 2015, Volume 525, Issue 7570, pp. 491 - 495
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2010, Volume 107, Issue 34, pp. 15163 - 15168
Journal Article