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Nature, ISSN 0028-0836, 2014, Volume 513, Issue 7516, pp. 105 - 109
In BRAF(V600)-mutant tumours, most mechanisms of resistance to drugs that target the BRAF and/or MEK kinases rely on reactivation of the RAS-RAF-MEK-ERK... 
MESSENGER-RNA TRANSLATION | SILVESTROL | MELANOMA | INITIATION | RAF | MULTIDISCIPLINARY SCIENCES | ACQUIRED-RESISTANCE | LEUKEMIA-CELLS | MODEL | FEEDBACK INHIBITION | Triterpenes - pharmacology | Humans | Eukaryotic Initiation Factor-4E - metabolism | Eukaryotic Initiation Factor-4G - metabolism | Eukaryotic Initiation Factor-4F - metabolism | Melanoma - genetics | Protein Binding - drug effects | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Phosphorylation - drug effects | Eukaryotic Initiation Factor-4F - antagonists & inhibitors | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Sulfonamides - pharmacology | Eukaryotic Initiation Factor-4A - antagonists & inhibitors | Drug Synergism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Eukaryotic Initiation Factor-4F - chemistry | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Colonic Neoplasms - pathology | Melanoma - drug therapy | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Eukaryotic Initiation Factor-4A - metabolism | Drug Resistance, Neoplasm - drug effects | Thyroid Neoplasms - pathology | Antimitotic agents | Pharmaceutical research | Vemurafenib | Protein research | Research | Antineoplastic agents | Drug resistance | Phosphorylation | Biopsy | Melanoma | Mutation | Metastasis | Cancer therapies | Tumors | Cancer | Index Medicus | Cell and Molecular Biology | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Cell- och molekylärbiologi | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 10/2005, Volume 12, Issue 10, pp. 861 - 869
The multiprotein exon junction complex (EJC) is assembled on mRNAs as a consequence of splicing. EJC core components maintain a stable grip on mRNAs even as... 
CRYSTAL-STRUCTURE | MAGO NASHI | BIOCHEMISTRY & MOLECULAR BIOLOGY | BOX PROTEIN EIF4A | OSKAR MESSENGER-RNA | MAMMALIAN-CELLS | CELL BIOLOGY | BIOPHYSICS | HELICASE ACTIVITY | NONSENSE-MEDIATED DECAY | INITIATION-FACTOR 4A | Q-MOTIF | BINDING | Cytoplasm - chemistry | Recombinant Proteins - metabolism | Amino Acid Sequence | Nuclear Proteins - analysis | Exons | Humans | Adenosine Triphosphatases - metabolism | Molecular Sequence Data | Nuclear Proteins - metabolism | Recombinant Proteins - genetics | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | Eukaryotic Initiation Factor-4A - antagonists & inhibitors | Adenosine Triphosphatases - antagonists & inhibitors | Conserved Sequence | Neoplasm Proteins - analysis | Cell Nucleus - chemistry | HeLa Cells | Mutation | Eukaryotic Initiation Factor-4A - metabolism | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Eukaryotic Initiation Factor-4A - genetics | RNA-Binding Proteins - metabolism | Physiological aspects | Control | Messenger RNA | Research | Structure | Adenosine triphosphatase | Index Medicus | Biochemistry, Molecular Biology | Eukaryotic Initiation Factor-4A | RNA-Binding Proteins | Recombinant Proteins | Nuclear Proteins | Life Sciences | Adenosine Triphosphatases | Neoplasm Proteins | Molecular biology | RNA, Messenger | Cell Nucleus | Cytoplasm | Hela Cells
Journal Article
Science, ISSN 0036-8075, 11/2011, Volume 334, Issue 6057, pp. 821 - 824
Journal Article
Neuro-Oncology, ISSN 1522-8517, 09/2016, Volume 18, Issue 9, pp. 1265 - 1277
Journal Article
Journal Article
RNA, ISSN 1355-8382, 2012, Volume 18, Issue 7, pp. 1373 - 1384
The recruitment of ribosomes to eukaryotic cellular mRNAs requires the activity of two prototypic RNA helicases, eukaryotic initiation factor (eIF) 4AI and... 
Translation | eIF4AI | eIF4AII | DEAD-box RNA helicase | Hippuristanol | Translational control | RNA helicase | MAMMALIAN TRANSLATION | FACTOR EIF-4A | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING-PROTEIN | CROSS-LINKING | translational control | 5' END | EUKARYOTIC TRANSLATION INITIATION | MESSENGER-RNA | translation | hippuristanol | DEGRADATION | INHIBITS TRANSLATION | RNA HELICASE EIF4A | Transcription, Genetic - drug effects | Testis - metabolism | Humans | Fetus - metabolism | Male | Muscle, Skeletal - metabolism | Spleen - drug effects | Prostate - metabolism | Testis - drug effects | Brain - metabolism | Kidney - metabolism | Protein Isoforms - metabolism | Liver - drug effects | Muscle, Skeletal - drug effects | Myocardium - metabolism | Prostate - drug effects | Adult | Female | Ovary - drug effects | Lung - metabolism | Thymus Gland - metabolism | Ovary - metabolism | Sterols - pharmacology | Cell Line | Kidney - drug effects | Liver - metabolism | Pancreas - drug effects | Pancreas - metabolism | Thymus Gland - drug effects | Eukaryotic Initiation Factor-4A - antagonists & inhibitors | Brain - drug effects | Fetus - drug effects | Placenta - drug effects | Placenta - metabolism | Pregnancy | Transcription, Genetic - physiology | Spleen - metabolism | Lung - drug effects | Eukaryotic Initiation Factor-4A - metabolism | Index Medicus
Journal Article
The EMBO Journal, ISSN 0261-4189, 02/2009, Volume 28, Issue 3, pp. 274 - 285
Journal Article
Journal Article