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Nature, ISSN 0028-0836, 2014, Volume 513, Issue 7516, pp. 105 - 109
In BRAF(V600)-mutant tumours, most mechanisms of resistance to drugs that target the BRAF and/or MEK kinases rely on reactivation of the RAS-RAF-MEK-ERK... 
MESSENGER-RNA TRANSLATION | SILVESTROL | MELANOMA | INITIATION | RAF | MULTIDISCIPLINARY SCIENCES | ACQUIRED-RESISTANCE | LEUKEMIA-CELLS | MODEL | FEEDBACK INHIBITION | Triterpenes - pharmacology | Humans | Eukaryotic Initiation Factor-4E - metabolism | Eukaryotic Initiation Factor-4G - metabolism | Eukaryotic Initiation Factor-4F - metabolism | Melanoma - genetics | Protein Binding - drug effects | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Phosphorylation - drug effects | Eukaryotic Initiation Factor-4F - antagonists & inhibitors | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Sulfonamides - pharmacology | Eukaryotic Initiation Factor-4A - antagonists & inhibitors | Drug Synergism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Eukaryotic Initiation Factor-4F - chemistry | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Colonic Neoplasms - pathology | Melanoma - drug therapy | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Eukaryotic Initiation Factor-4A - metabolism | Drug Resistance, Neoplasm - drug effects | Thyroid Neoplasms - pathology | Antimitotic agents | Pharmaceutical research | Vemurafenib | Protein research | Research | Antineoplastic agents | Drug resistance | Phosphorylation | Biopsy | Melanoma | Mutation | Metastasis | Cancer therapies | Tumors | Cancer | Index Medicus | Cell and Molecular Biology | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Cell- och molekylärbiologi | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Journal Article
Journal Article
Journal Article
Journal Article
Molecular Systems Biology, ISSN 1744-4292, 07/2013, Volume 9, Issue 1, pp. 635 - n/a
Rate control analysis defines the in vivo control map governing yeast protein synthesis and generates an extensively parameterized digital model of the... 
in vivo | rate control | eukaryotic translation machinery | gene duplication | system modularity | post‐transcriptional gene expression | post-transcriptional gene expression | in vivo rate control | INITIATION-FACTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | POLY(A)-BINDING PROTEIN | DEPENDENT TRANSLATION | SACCHAROMYCES-CEREVISIAE | PROTEIN-SYNTHESIS | RIBOSOMAL-SUBUNIT | PHOSPHORYLATION SITES | TERMINAL REGION | GENE-EXPRESSION | ABSOLUTE QUANTIFICATION | Gene Duplication | Protein Biosynthesis | Saccharomyces cerevisiae - genetics | RNA, Messenger - metabolism | Eukaryotic Initiation Factor-4F - metabolism | Saccharomyces cerevisiae - metabolism | Computer Simulation | Eukaryotic Initiation Factor-2 - metabolism | RNA, Transfer - genetics | DEAD-box RNA Helicases - metabolism | Ribosome Subunits, Small, Eukaryotic - genetics | Gene Expression Regulation, Fungal | Peptide Termination Factors - genetics | RNA, Transfer - metabolism | RNA, Messenger - genetics | Eukaryotic Initiation Factor-4F - genetics | Saccharomyces cerevisiae Proteins - genetics | Peptide Termination Factors - metabolism | Nucleocytoplasmic Transport Proteins - genetics | DEAD-box RNA Helicases - genetics | Nucleocytoplasmic Transport Proteins - metabolism | Eukaryotic Initiation Factor-2 - genetics | Saccharomyces cerevisiae Proteins - metabolism | Ribosome Subunits, Small, Eukaryotic - metabolism | Saccharomyces cerevisiae - growth & development | Index Medicus
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 08/2016, Volume 44, Issue 14, pp. 6949 - 6960
Stress-induced angiogenin (ANG)-mediated tRNA cleavage promotes a cascade of cellular events that starts with production of tRNA-derived stress-induced RNAs... 
BINDING-PROTEIN YB-1 | MESSENGER-RNA | INITIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSFER-RNA FRAGMENTS | DEPENDENT TRANSLATION | EUKARYOTIC TRANSLATION | MESENCHYMAL TRANSITION | PROMOTES | EXPRESSION | PROGRESSION | Index Medicus | RNA
Journal Article
Cell Reports, ISSN 2211-1247, 04/2012, Volume 1, Issue 4, pp. 325 - 333
The energetically demanding process of translation is linked to multiple signaling events through mTOR-mediated regulation of eukar