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eukaryotic initiation factor-4g - metabolism (443) 443
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animals (384) 384
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protein biosynthesis (295) 295
eukaryotic initiation factor-4g (241) 241
eukaryotic initiation factor-4g - genetics (215) 215
translation initiation (205) 205
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peptide initiation factors - metabolism (193) 193
rna, messenger - metabolism (191) 191
phosphorylation (176) 176
messenger-rna (173) 173
molecular sequence data (154) 154
eukaryotic initiation factor-4e - metabolism (151) 151
amino acid sequence (137) 137
rna, messenger - genetics (134) 134
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eif4g (102) 102
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protein synthesis (83) 83
rna-binding proteins - metabolism (82) 82
carrier proteins - metabolism (78) 78
protein structure, tertiary (76) 76
eukaryotic initiation factor-4e (75) 75
mutation (74) 74
base sequence (72) 72
messenger rna (72) 72
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factor 4g eif4g (65) 65
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rna caps - metabolism (64) 64
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peptide chain initiation, translational (63) 63
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protein biosynthesis - drug effects (56) 56
eif4e (54) 54
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saccharomyces cerevisiae - metabolism (53) 53
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messenger-rna translation (52) 52
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saccharomyces cerevisiae - genetics (49) 49
cap-dependent translation (48) 48
genetic aspects (48) 48
gene expression regulation (47) 47
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initiation factor eif-4g (47) 47
cells (46) 46
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sequence homology, amino acid (43) 43
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Cell, ISSN 0092-8674, 2007, Volume 128, Issue 2, pp. 257 - 267
Assembly of the eIF4E/eIF4G complex has a central role in the regulation of gene expression at the level of translation initiation. This complex is regulated... 
FACTOR EIF-4E | HUMAN-DISEASE | MALIGNANT-TRANSFORMATION | CAP-DEPENDENT TRANSLATION | MESSENGER-RNA CAP | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING PROTEIN EIF4E | EUKARYOTIC TRANSLATION | SECONDARY STRUCTURE | MTOR INHIBITORS | CANCER-THERAPY | CELL BIOLOGY | Protein Binding - genetics | Humans | Nitro Compounds - chemistry | Eukaryotic Initiation Factor-4E - metabolism | Peptide Fragments - pharmacology | Eukaryotic Initiation Factor-4G - drug effects | Eukaryotic Initiation Factor-4G - metabolism | Fluorescence Polarization Immunoassay - methods | Thiazoles - isolation & purification | Antineoplastic Agents - isolation & purification | Cell Transformation, Neoplastic - genetics | Protein Binding - drug effects | Nitro Compounds - pharmacology | Antineoplastic Agents - pharmacology | Protein Biosynthesis - genetics | Gene Expression Regulation, Neoplastic - drug effects | Eukaryotic Initiation Factor-4E - genetics | Peptide Fragments - genetics | Gene Expression Regulation, Neoplastic - genetics | RNA, Messenger - drug effects | Drug Evaluation, Preclinical - methods | Oncogenes - genetics | Peptide Fragments - metabolism | Jurkat Cells | RNA, Messenger - genetics | Hydrazones | Models, Molecular | Antineoplastic Agents - chemistry | Cell Transformation, Neoplastic - metabolism | Eukaryotic Initiation Factor-4E - drug effects | Nitro Compounds - isolation & purification | Animals | Cell Line, Tumor | Oncogenes - drug effects | Feedback, Physiological - drug effects | Protein Biosynthesis - drug effects | Thiazoles - chemistry | Eukaryotic Initiation Factor-4G - genetics | Mice | Thiazoles - pharmacology | Cell Transformation, Neoplastic - drug effects | Feedback, Physiological - physiology | Cell Line, Transformed | Peptide Fragments | Protein Biosynthesis | Gene Expression Regulation, Neoplastic | Eukaryotic Initiation Factor-4E | Chemical Sciences | Fluorescence Polarization Immunoassay | Life Sciences | Thiazoles | Drug Evaluation, Preclinical | Feedback, Biochemical | Oncogenes | Analytical chemistry | Biochemistry, Molecular Biology | Antineoplastic Agents | Organic chemistry | Eukaryotic Initiation Factor-4G | Cell Transformation, Neoplastic | Nitro Compounds | Protein Binding | RNA, Messenger
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2011, Volume 108, Issue 8, pp. 3383 - 3388
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2016, Volume 64, Issue 3, pp. 467 - 479
Eukaryotic initiation factor 4G (eIF4G) plays a central role in translation initiation through its interactions with the cap-binding protein eIF4E. This... 
translational inhibitors | translation initiation | translational regulation | protein-protein interaction | eIF4F | 4E-BP | BIPARTITE | DOMAIN | DISSOCIATING EIF4G | MECHANISM | REPRESSION | CAP-DEPENDENT TRANSLATION | MESSENGER-RNA CAP | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING PROTEIN EIF4E | MOTIF | CELL BIOLOGY | Humans | Eukaryotic Initiation Factor-4E - metabolism | Crystallography, X-Ray | Peptide Chain Initiation, Translational | Eukaryotic Initiation Factor-4G - metabolism | Drosophila melanogaster - genetics | Drosophila melanogaster - metabolism | Thermodynamics | Cloning, Molecular | Escherichia coli - metabolism | Protein Interaction Domains and Motifs | Binding Sites | Eukaryotic Initiation Factor-4E - genetics | Recombinant Proteins - metabolism | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Sequence Homology, Amino Acid | Eukaryotic Initiation Factor-4E - chemistry | Sequence Alignment | Animals | Protein Conformation, beta-Strand | Escherichia coli - genetics | Protein Binding | Eukaryotic Initiation Factor-4G - chemistry | Eukaryotic Initiation Factor-4G - genetics | Kinetics | Mutation | Developmental biology | Analysis | Crystals | Binding proteins | Structure | Genetic translation | Protein binding
Journal Article
Nature Cell Biology, ISSN 1465-7392, 07/2009, Volume 11, Issue 7, pp. 903 - 908
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 2011, Volume 412, Issue 4, pp. 674 - 687
Journal Article
Journal Article
Journal of Virology, ISSN 0022-538X, 07/2011, Volume 85, Issue 13, pp. 6381 - 6389
Journal Article
Cell Metabolism, ISSN 1550-4131, 07/2011, Volume 14, Issue 1, pp. 55 - 66
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2016, Volume 291, Issue 3, pp. 1501 - 1513
The eukaryotic translation initiation factor (eIF) 4G is required during protein synthesis to promote the assembly of several factors involved in the... 
YEAST | POLY(A) BINDING-PROTEIN | LOCI ENCODE | VIRUS | MESSENGER-RNA | FACTOR 4G EIF4G | LEADER SEQUENCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | POLY(A)-BINDING PROTEIN | INTERNAL INITIATION | CAP-INDEPENDENT TRANSLATION | Sigma Factor - metabolism | Protein Biosynthesis | Databases, Genetic | Molecular Sequence Data | Peptide Chain Initiation, Translational | Eukaryotic Initiation Factor-4G - metabolism | Phylogeny | Arabidopsis Proteins - metabolism | Protein Isoforms - metabolism | Protein Isoforms - chemistry | Base Sequence | Gene Expression Regulation, Plant | Conserved Sequence | Genes, Reporter | Luciferases, Firefly - metabolism | Eukaryotic Initiation Factors - chemistry | Eukaryotic Initiation Factors - genetics | Eukaryotic Initiation Factors - metabolism | Amino Acid Sequence | Arabidopsis Proteins - genetics | Plants, Genetically Modified - genetics | Arabidopsis - metabolism | Arabidopsis - genetics | DNA - chemistry | Sequence Alignment | Plants, Genetically Modified - metabolism | Arabidopsis Proteins - chemistry | Luciferases, Firefly - genetics | Eukaryotic Initiation Factor-4G - chemistry | Eukaryotic Initiation Factor-4G - genetics | Mutation | Protein Isoforms - genetics | eukaryotic translation initiation factor 4G (eIF4G) | RNA | translation initiation factors | Protein Synthesis and Degradation | translation | eIFiso4G | protein synthesis | eukaryotic translation initiation | mRNA stability
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, p. e0122519
In eukaryotes, post-transcriptional regulation of gene expression has a key role in many cellular and developmental processes. Spermatogenesis involves a... 
DON-JUAN | POSTMEIOTIC TRANSCRIPTION | GERM-CELLS | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | MELANOGASTER SPERMATOGENESIS | MECHANISMS | MEIOTIC CELL-CYCLE | SPERMATID DIFFERENTIATION | PROTEINS | CDC25 HOMOLOG | Testis - metabolism | Spermatocytes - metabolism | Spermatogenesis | Eukaryotic Initiation Factor-4E - metabolism | Male | Meiosis | Eukaryotic Initiation Factor-4G - metabolism | Germ Cells - growth & development | Drosophila Proteins - metabolism | Eukaryotic Initiation Factor-4E - antagonists & inhibitors | Chromosomes - physiology | Eukaryotic Initiation Factor-4G - antagonists & inhibitors | Animals | RNA Interference | Cytokinesis - physiology | Eukaryotic Initiation Factor-4G - genetics | Drosophila - metabolism | Drosophila Proteins - genetics | Drosophila Proteins - antagonists & inhibitors | Eukaryotic Initiation Factor-4E - genetics | RNA, Small Interfering - metabolism | Proteins | Genetic transcription | RNA | Genetic translation | Analysis | Drosophila | Post-transcription | Germ cells | Sperm | Gene regulation | Genomics | Initiation factors | Eukaryotes | Spermatocytes | Developmental stages | Fertility | Cell cycle | Divisions | Elongation | Function analysis | Translation | RNA-mediated interference | Translation initiation | Gene expression | Cytokinesis | Ribonucleic acid--RNA | Cysts | Insects | Somatic cells | Stem cells | Initiation factor eIF-4E | Testes | Initiation factor eIF-4G | Ribonucleic acid
Journal Article