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Molecular Cell, ISSN 1097-2765, 11/2016, Volume 64, Issue 3, pp. 467 - 479
Eukaryotic initiation factor 4G (eIF4G) plays a central role in translation initiation through its interactions with the cap-binding protein eIF4E. This... 
translational inhibitors | translation initiation | translational regulation | protein-protein interaction | eIF4F | 4E-BP | BIPARTITE | DOMAIN | DISSOCIATING EIF4G | MECHANISM | REPRESSION | CAP-DEPENDENT TRANSLATION | MESSENGER-RNA CAP | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING PROTEIN EIF4E | MOTIF | CELL BIOLOGY | Humans | Eukaryotic Initiation Factor-4E - metabolism | Crystallography, X-Ray | Peptide Chain Initiation, Translational | Eukaryotic Initiation Factor-4G - metabolism | Drosophila melanogaster - genetics | Drosophila melanogaster - metabolism | Thermodynamics | Cloning, Molecular | Escherichia coli - metabolism | Protein Interaction Domains and Motifs | Binding Sites | Eukaryotic Initiation Factor-4E - genetics | Recombinant Proteins - metabolism | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Sequence Homology, Amino Acid | Eukaryotic Initiation Factor-4E - chemistry | Sequence Alignment | Animals | Protein Conformation, beta-Strand | Escherichia coli - genetics | Protein Binding | Eukaryotic Initiation Factor-4G - chemistry | Eukaryotic Initiation Factor-4G - genetics | Kinetics | Mutation | Developmental biology | Analysis | Crystals | Binding proteins | Structure | Genetic translation | Protein binding
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 03/2015, Volume 57, Issue 6, pp. 1074 - 1087
The eIF4E-binding proteins (4E-BPs) represent a diverse class of translation inhibitors that are often deregulated in cancer cells. 4E-BPs inhibit translation... 
STRUCTURAL INSIGHTS | COMPLEX | MECHANISM | PHOSPHORYLATION | MESSENGER-RNA CAP | BIOCHEMISTRY & MOLECULAR BIOLOGY | FACTOR 4E | INITIATION-FACTOR EIF4E | REPRESSOR 4E-BP2 | 4E-BINDING PROTEIN | REVEALS | CELL BIOLOGY | Adaptor Proteins, Signal Transducing - chemistry | Phosphorylation | Humans | Eukaryotic Initiation Factor-4E - metabolism | Crystallography, X-Ray | Intracellular Signaling Peptides and Proteins - metabolism | Eukaryotic Initiation Factor-4G - metabolism | Drosophila Proteins - metabolism | Phosphoproteins - metabolism | Phosphoproteins - chemistry | Peptide Initiation Factors - chemistry | Molecular Mimicry | Carrier Proteins - chemistry | Binding Sites | Intracellular Signaling Peptides and Proteins - genetics | Binding, Competitive | Recombinant Proteins - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Drosophila Proteins - chemistry | Amino Acid Motifs | Peptide Initiation Factors - metabolism | Carrier Proteins - genetics | Peptide Initiation Factors - genetics | Eukaryotic Initiation Factor-4E - chemistry | Animals | Carrier Proteins - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Protein Conformation | Eukaryotic Initiation Factor-4G - chemistry | Drosophila Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Binding proteins | Protein binding | Developmental biology
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2012, Volume 48, Issue 3, pp. 375 - 386
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 2011, Volume 412, Issue 4, pp. 674 - 687
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 08/2014, Volume 111, Issue 31, pp. E3187 - E3195
Journal Article
Journal Article
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 12/2010, Volume 132, Issue 50, pp. 17831 - 17839
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2016, Volume 291, Issue 3, pp. 1501 - 1513
The eukaryotic translation initiation factor (eIF) 4G is required during protein synthesis to promote the assembly of several factors involved in the... 
YEAST | POLY(A) BINDING-PROTEIN | LOCI ENCODE | VIRUS | MESSENGER-RNA | FACTOR 4G EIF4G | LEADER SEQUENCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | POLY(A)-BINDING PROTEIN | INTERNAL INITIATION | CAP-INDEPENDENT TRANSLATION | Sigma Factor - metabolism | Protein Biosynthesis | Databases, Genetic | Molecular Sequence Data | Peptide Chain Initiation, Translational | Eukaryotic Initiation Factor-4G - metabolism | Phylogeny | Arabidopsis Proteins - metabolism | Protein Isoforms - metabolism | Protein Isoforms - chemistry | Base Sequence | Gene Expression Regulation, Plant | Conserved Sequence | Genes, Reporter | Luciferases, Firefly - metabolism | Eukaryotic Initiation Factors - chemistry | Eukaryotic Initiation Factors - genetics | Eukaryotic Initiation Factors - metabolism | Amino Acid Sequence | Arabidopsis Proteins - genetics | Plants, Genetically Modified - genetics | Arabidopsis - metabolism | Arabidopsis - genetics | DNA - chemistry | Sequence Alignment | Plants, Genetically Modified - metabolism | Arabidopsis Proteins - chemistry | Luciferases, Firefly - genetics | Eukaryotic Initiation Factor-4G - chemistry | Eukaryotic Initiation Factor-4G - genetics | Mutation | Protein Isoforms - genetics | eukaryotic translation initiation factor 4G (eIF4G) | RNA | translation initiation factors | Protein Synthesis and Degradation | translation | eIFiso4G | protein synthesis | eukaryotic translation initiation | mRNA stability
Journal Article