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eukaryotic initiation factor-4g - metabolism (356) 356
humans (355) 355
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animals (283) 283
biochemistry & molecular biology (280) 280
protein biosynthesis (254) 254
eukaryotic initiation factor-4g - genetics (212) 212
cell biology (182) 182
rna, messenger - metabolism (180) 180
eukaryotic initiation factor-4g (179) 179
protein binding (169) 169
translation initiation (158) 158
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peptide initiation factors - metabolism (137) 137
rna, messenger - genetics (134) 134
molecular sequence data (132) 132
amino acid sequence (115) 115
eukaryotic initiation factor-4e - metabolism (114) 114
phosphorylation (113) 113
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translation (92) 92
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peptide initiation factors - genetics (90) 90
gene expression (86) 86
eif4g (85) 85
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environment and public health (55) 55
phosphoproteins - metabolism (55) 55
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eukaryotic initiation factor-4e - genetics (54) 54
models, molecular (54) 54
peptide chain initiation, translational (54) 54
female (51) 51
rna caps - metabolism (51) 51
carrier proteins - metabolism (50) 50
factor 4g eif4g (50) 50
apoptosis (49) 49
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molecular biology (49) 49
binding (47) 47
expression (47) 47
genetic aspects (47) 47
saccharomyces cerevisiae - genetics (47) 47
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multidisciplinary sciences (45) 45
eif4e (44) 44
initiation (44) 44
eukaryotic initiation factor-4e (43) 43
gene expression regulation (42) 42
messenger-rna translation (41) 41
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eukaryotic initiation factor-4a - metabolism (40) 40
peptide fragments - metabolism (40) 40
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initiation factor eif-4g (39) 39
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initiation-factor 4g (36) 36
protein biosynthesis - genetics (36) 36
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saccharomyces cerevisiae proteins - metabolism (36) 36
sequence homology, amino acid (36) 36
transfection (36) 36
cap-independent translation (35) 35
complex (35) 35
dependent translation (35) 35
physiological aspects (35) 35
recombinant fusion proteins - metabolism (35) 35
recombinant proteins - metabolism (35) 35
rna-binding proteins - genetics (35) 35
sequence alignment (35) 35
eukaryotic translation (34) 34
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Cell, ISSN 0092-8674, 2007, Volume 128, Issue 2, pp. 257 - 267
Assembly of the eIF4E/eIF4G complex has a central role in the regulation of gene expression at the level of translation initiation. This complex is regulated... 
FACTOR EIF-4E | HUMAN-DISEASE | MALIGNANT-TRANSFORMATION | CAP-DEPENDENT TRANSLATION | MESSENGER-RNA CAP | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING PROTEIN EIF4E | EUKARYOTIC TRANSLATION | SECONDARY STRUCTURE | MTOR INHIBITORS | CANCER-THERAPY | CELL BIOLOGY | Protein Binding - genetics | Humans | Nitro Compounds - chemistry | Eukaryotic Initiation Factor-4E - metabolism | Peptide Fragments - pharmacology | Eukaryotic Initiation Factor-4G - drug effects | Eukaryotic Initiation Factor-4G - metabolism | Fluorescence Polarization Immunoassay - methods | Thiazoles - isolation & purification | Antineoplastic Agents - isolation & purification | Cell Transformation, Neoplastic - genetics | Protein Binding - drug effects | Nitro Compounds - pharmacology | Antineoplastic Agents - pharmacology | Protein Biosynthesis - genetics | Gene Expression Regulation, Neoplastic - drug effects | Eukaryotic Initiation Factor-4E - genetics | Peptide Fragments - genetics | Gene Expression Regulation, Neoplastic - genetics | RNA, Messenger - drug effects | Drug Evaluation, Preclinical - methods | Oncogenes - genetics | Peptide Fragments - metabolism | Jurkat Cells | RNA, Messenger - genetics | Hydrazones | Models, Molecular | Antineoplastic Agents - chemistry | Cell Transformation, Neoplastic - metabolism | Eukaryotic Initiation Factor-4E - drug effects | Nitro Compounds - isolation & purification | Animals | Cell Line, Tumor | Oncogenes - drug effects | Feedback, Physiological - drug effects | Protein Biosynthesis - drug effects | Thiazoles - chemistry | Eukaryotic Initiation Factor-4G - genetics | Mice | Thiazoles - pharmacology | Cell Transformation, Neoplastic - drug effects | Feedback, Physiological - physiology | Cell Line, Transformed | Peptide Fragments | Protein Biosynthesis | Gene Expression Regulation, Neoplastic | Eukaryotic Initiation Factor-4E | Chemical Sciences | Fluorescence Polarization Immunoassay | Life Sciences | Thiazoles | Drug Evaluation, Preclinical | Feedback, Biochemical | Oncogenes | Analytical chemistry | Biochemistry, Molecular Biology | Antineoplastic Agents | Organic chemistry | Eukaryotic Initiation Factor-4G | Cell Transformation, Neoplastic | Nitro Compounds | Protein Binding | RNA, Messenger
Journal Article
Nature Cell Biology, ISSN 1465-7392, 07/2009, Volume 11, Issue 7, pp. 903 - 908
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2016, Volume 64, Issue 3, pp. 467 - 479
Eukaryotic initiation factor 4G (eIF4G) plays a central role in translation initiation through its interactions with the cap-binding protein eIF4E. This... 
translational inhibitors | translation initiation | translational regulation | protein-protein interaction | eIF4F | 4E-BP | BIPARTITE | DOMAIN | DISSOCIATING EIF4G | MECHANISM | REPRESSION | CAP-DEPENDENT TRANSLATION | MESSENGER-RNA CAP | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING PROTEIN EIF4E | MOTIF | CELL BIOLOGY | Humans | Eukaryotic Initiation Factor-4E - metabolism | Crystallography, X-Ray | Peptide Chain Initiation, Translational | Eukaryotic Initiation Factor-4G - metabolism | Drosophila melanogaster - genetics | Drosophila melanogaster - metabolism | Thermodynamics | Cloning, Molecular | Escherichia coli - metabolism | Protein Interaction Domains and Motifs | Binding Sites | Eukaryotic Initiation Factor-4E - genetics | Recombinant Proteins - metabolism | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Sequence Homology, Amino Acid | Eukaryotic Initiation Factor-4E - chemistry | Sequence Alignment | Animals | Protein Conformation, beta-Strand | Escherichia coli - genetics | Protein Binding | Eukaryotic Initiation Factor-4G - chemistry | Eukaryotic Initiation Factor-4G - genetics | Kinetics | Mutation | Developmental biology | Analysis | Crystals | Binding proteins | Structure | Genetic translation | Protein binding
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 09/2018, Volume 38, Issue 18
Translation initiation of most mRNAs involves m7G-cap binding, ribosomal scanning, and AUG selection. Initiation from an m7G-cap-proximal AUG can be bypassed... 
Leaky scanning | TISU | EIF4E | Translation initiation | EIF1 | EIF4G1 | eIF1 | eIF4E | eIF4G1 | COMPLEX | 40S RIBOSOMAL-SUBUNIT | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | translation initiation | CELL BIOLOGY | MESSENGER-RNAS | ALLOSTERIC MECHANISM | AUG SELECTION | UPSTREAM AUG | START CODON SELECTION | IN-VIVO | BINDING | leaky scanning | Humans | Eukaryotic Initiation Factor-4E - metabolism | Ribosomes - metabolism | Peptide Chain Initiation, Translational | Eukaryotic Initiation Factor-4G - metabolism | Neoplasm Proteins - metabolism | RNA Caps - metabolism | RNA, Messenger - metabolism | Nerve Tissue Proteins - chemistry | HEK293 Cells | Eukaryotic Initiation Factor-1 - chemistry | Protein Interaction Domains and Motifs | Eukaryotic Initiation Factor-1 - metabolism | Neoplasm Proteins - genetics | Binding Sites | Eukaryotic Initiation Factor-4E - genetics | RNA Caps - genetics | Eukaryotic Initiation Factors - chemistry | Eukaryotic Initiation Factors - genetics | Eukaryotic Initiation Factors - metabolism | Amino Acid Sequence | RNA, Messenger - genetics | Eukaryotic Initiation Factor-1 - genetics | Models, Molecular | Neoplasm Proteins - chemistry | Saccharomyces cerevisiae Proteins - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Eukaryotic Initiation Factor-4E - chemistry | 5' Untranslated Regions | Models, Biological | Saccharomyces cerevisiae Proteins - metabolism | Eukaryotic Initiation Factor-4G - chemistry | Eukaryotic Initiation Factor-4G - genetics | Saccharomyces cerevisiae Proteins - chemistry
Journal Article
Cell Metabolism, ISSN 1550-4131, 07/2011, Volume 14, Issue 1, pp. 55 - 66
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 09/2011, Volume 89, Issue 3, pp. 398 - 406
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2012, Volume 48, Issue 3, pp. 375 - 386
Journal Article
Journal of Virology, ISSN 0022-538X, 2016, Volume 90, Issue 24, pp. 11106 - 11121
Journal Article
Journal Article
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