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1. Full Text The mechanism of eukaryotic translation initiation and principles of its regulation
by Pestova, Tatyana V and Hellen, Christopher U. T and Jackson, Richard J
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 02/2010, Volume 11, Issue 2, pp. 113 - 127
Protein synthesis is principally regulated at the initiation stage (rather than during elongation or termination), allowing rapid, reversible and spatial... 
MESSENGER-RNA TRANSLATION | OPEN READING FRAME | 40S RIBOSOMAL-SUBUNIT | FUNCTIONAL INTERACTION | BINDING COMPLEX ELF4F | START CODON SELECTION | IN-VIVO | POLY(A)-BINDING PROTEIN | DEPENDENT TRANSLATION | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | Eukaryotic Initiation Factors - chemistry | Eukaryotic Initiation Factors - genetics | Eukaryotic Initiation Factors - metabolism | RNA-Binding Proteins - genetics | Protein Biosynthesis | Humans | Eukaryota - chemistry | Gene Expression Regulation | Eukaryota - metabolism | Animals | Eukaryota - genetics | MicroRNAs - genetics | RNA-Binding Proteins - metabolism | Physiological aspects | Protein biosynthesis | Research | Binding proteins | Genetic translation
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2. Full Text The mechanism of eukaryotic translation initiation: New insights and challenges
by Hinnebusch, Alan G and Lorsch, Jon R
Cold Spring Harbor Perspectives in Biology, ISSN 1943-0264, 10/2012, Volume 4, Issue 10, pp. a011544 - a011544
Translation initiation in eukaryotes is a highly regulated and complex stage of gene expression. It requires the action of at least 12 initiation factors, many... 
STRINGENT AUG SELECTION | 40S RIBOSOMAL-SUBUNIT | TRANSFER-RNA BINDING | MESSENGER-RNA | MULTIFACTOR COMPLEX | CRYSTAL-STRUCTURE | START CODON SELECTION | IN-VIVO | GUANINE-NUCLEOTIDE EXCHANGE | PREINITIATION COMPLEX | CELL BIOLOGY | Eukaryotic Initiation Factors - genetics | Eukaryotic Initiation Factors - metabolism | Ribosome Subunits - physiology | Gene Expression Regulation | Ribosomes - metabolism | Eukaryotic Cells - physiology | Ribosomes - genetics | Eukaryotic Initiation Factors - physiology | Peptide Chain Initiation, Translational - physiology | Models, Genetic | Ribosome Subunits - genetics | Ribosome Subunits - metabolism | Ribosomes - physiology | 078
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3. Full Text Eukaryotic translation initiation factor 2B‐beta (eIF2Bβ), a new class of plant virus resistance gene
by Shopan, Jannat and Mou, Haipeng and Zhang, Lili and Zhang, Changtong and Ma, Weiwei and Walsh, John A and Hu, Zhongyuan and Yang, Jinghua and Zhang, Mingfang
The Plant Journal, ISSN 0960-7412, 06/2017, Volume 90, Issue 5, pp. 929 - 940
Recessive resistances to plant viruses in the Potyvirus genus have been found to be based on mutations in the plant eukaryotic translation initiation factors,... 
new resistance gene | mustard | eIF | Turnip mosaic virus | virus resistance | Brassica juncea | eIF2Bβ | SUSCEPTIBILITY | eIF2B beta | IDENTIFICATION | TURNIP-MOSAIC-VIRUS | PLANT SCIENCES | YEAST | POTYVIRUS | NAPUS | CHINESE-CABBAGE | BRASSICA-RAPA | SEQUENCE | INFECTION | Eukaryotic Initiation Factors - genetics | Eukaryotic Initiation Factors - metabolism | Plant Proteins - genetics | Guanine Nucleotide Exchange Factors - genetics | Guanine Nucleotide Exchange Factors - metabolism | Genotype | Plant Diseases - genetics | Plant Proteins - metabolism | Plant Viruses - physiology | Disease Resistance - genetics | Drug resistance in microorganisms | Analysis | Genes | Plant genetics | Genetic research | Genetic translation | Health aspects | Protein binding | GTP-binding protein | Translation | Sequences | Marker-assisted selection | Translation initiation | Editing | Viruses | Genomes | Infections | Guanine | Initiation factors | Disease resistance | Brassica | Genotyping | Isoforms | Alleles | New classes | Mustard | Mutation | Initiation factor eIF-4E | Guanine nucleotide exchange factor | Plant viruses | Chromosomes | Initiation factor eIF-4G
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4. Full Text Translational control in cancer
by Schneider, Robert J and Formenti, Silvia C and Silvera, Deborah
Nature Reviews Cancer, ISSN 1474-175X, 04/2010, Volume 10, Issue 4, pp. 254 - 266
Remarkable progress has been made in defining a new understanding of the role of mRNA translation and protein synthesis in human cancer. Translational control... 
INTERNAL RIBOSOME ENTRY | CAP-BINDING PROTEIN | ONCOLOGY | MALIGNANT-TRANSFORMATION | TUMOR-SUPPRESSOR PDCD4 | SQUAMOUS-CELL CARCINOMA | DEPENDENT PROTEIN-KINASE | EUKARYOTIC TRANSLATION | INFLAMMATORY BREAST-CANCER | INITIATION-FACTORS 4E | MULTIPLE-MYELOMA CELLS | Protein Biosynthesis | Humans | RNA, Messenger - genetics | Neoplasms - therapy | Prokaryotic Initiation Factors - genetics | Neoplasms - genetics | Ribosomes - genetics | Cell Transformation, Neoplastic - genetics | Eukaryotic Initiation Factor-3 - genetics | Models, Genetic | Neoplasm Staging | Neoplasms - pathology | Homeostasis - genetics | Physiological aspects | Genetic aspects | Research | Metastasis | Genetic translation | Cancer
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5. Full Text Autism-related deficits via dysregulated eIF4E-dependent translational control
by Gkogkas, Christos G and Khoutorsky, Arkady and Ran, Israeli and Rampakakis, Emmanouil and Nevarko, Tatiana and Weatherill, Daniel B and Vasuta, Cristina and Yee, Stephanie and Truitt, Morgan and Dallaire, Paul and Major, François and Lasko, Paul and Ruggero, Davide and Nader, Karim and Lacaille, Jean-Claude and Sonenberg, Nahum
Nature, ISSN 0028-0836, 01/2013, Volume 493, Issue 7432, pp. 371 - 377
Hyperconnectivity of neuronal circuits due to increased synaptic protein synthesis is thought to cause autism spectrum disorders (ASDs). The mammalian target... 
INHIBITORY SYNAPSES | LEARNING-DEFICITS | MULTIDISCIPLINARY SCIENCES | ULTRASONIC VOCALIZATIONS | FRAGILE-X-SYNDROME | SPECTRUM DISORDERS | REPRESSOR 4E-BP2 | SYNAPTIC PLASTICITY | TUBEROUS-SCLEROSIS | MOUSE MODELS | COPY-NUMBER VARIATION | Autistic Disorder - genetics | Eukaryotic Initiation Factors - genetics | Eukaryotic Initiation Factors - metabolism | Protein Biosynthesis | Autistic Disorder - physiopathology | Eukaryotic Initiation Factor-4E - metabolism | Male | Eukaryotic Initiation Factor-4E - antagonists & inhibitors | Cell Adhesion Molecules, Neuronal - genetics | Mice, Knockout | Phenotype | Animals | Synapses - metabolism | Eukaryotic Initiation Factors - deficiency | Cell Adhesion Molecules, Neuronal - metabolism | Mice | Animal experimentation | Translational research | Usage | Pervasive developmental disorders | Causes of | Neural transmission | Research | Methods | Proteins | Autism | Hypotheses | Social interaction | Anxieties | Rodents | Genetics | Mutation | Behavior | Animal care
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6. Full Text DENR-MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth
by Schleich, Sibylle and Strassburger, Katrin and Janiesch, Philipp Christoph and Koledachkina, Tatyana and Miller, Katharine K and Haneke, Katharina and Cheng, Yong-Sheng and Küchler, Katrin and Stoecklin, Georg and Duncan, Kent E and Teleman, Aurelio A
Nature, ISSN 0028-0836, 08/2014, Volume 512, Issue 7513, pp. 208 - 212
During cap-dependent eukaryotic translation initiation, ribosomes scan messenger RNA from the 5' end to the first AUG start codon with favourable sequence... 
INSULIN-RECEPTOR | OPEN READING FRAMES | PROTEIN | MECHANISM | MULTIDISCIPLINARY SCIENCES | MSL-2 MESSENGER-RNA | GENE-EXPRESSION | SEX-LETHAL | CANDIDATE ONCOGENE | DROSOPHILA | MCT-1 | Eukaryotic Initiation Factors - genetics | Eukaryotic Initiation Factors - metabolism | Cell Proliferation | Signal Transduction | Gene Expression Regulation - genetics | Open Reading Frames | Cells, Cultured | Drosophila melanogaster - cytology | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Animals | Drosophila melanogaster - growth & development | Protein Biosynthesis - genetics | Drosophila Proteins - genetics | Physiological aspects | Control systems | Research | T cells | Genetic translation | Proteins | Tissue | Cell growth | Ribonucleic acid--RNA
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7. Full Text Dynamic interaction of eukaryotic initiation factor 4G1 (eIF4G1) with eIF4E and eIF1 underlies scanning-dependent and -independent translation
by Haimov, Ora and Sehrawat, Urmila and Harush, Ana Tamarkin-Ben and Bahat, Anat and Uzonyi, Anna and Will, Alexander and Hiraishi, Hiroyuki and Asano, Katsura and Dikstein, Rivka
Molecular and Cellular Biology, ISSN 0270-7306, 09/2018, Volume 38, Issue 18
Translation initiation of most mRNAs involves m7G-cap binding, ribosomal scanning, and AUG selection. Initiation from an m7G-cap-proximal AUG can be bypassed... 
Leaky scanning | TISU | EIF4E | Translation initiation | EIF1 | EIF4G1 | eIF1 | eIF4E | eIF4G1 | COMPLEX | 40S RIBOSOMAL-SUBUNIT | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | translation initiation | CELL BIOLOGY | MESSENGER-RNAS | ALLOSTERIC MECHANISM | AUG SELECTION | UPSTREAM AUG | START CODON SELECTION | IN-VIVO | BINDING | leaky scanning | Humans | Eukaryotic Initiation Factor-4E - metabolism | Ribosomes - metabolism | Peptide Chain Initiation, Translational | Eukaryotic Initiation Factor-4G - metabolism | Neoplasm Proteins - metabolism | RNA Caps - metabolism | RNA, Messenger - metabolism | Nerve Tissue Proteins - chemistry | HEK293 Cells | Eukaryotic Initiation Factor-1 - chemistry | Protein Interaction Domains and Motifs | Eukaryotic Initiation Factor-1 - metabolism | Neoplasm Proteins - genetics | Binding Sites | Eukaryotic Initiation Factor-4E - genetics | RNA Caps - genetics | Eukaryotic Initiation Factors - chemistry | Eukaryotic Initiation Factors - genetics | Eukaryotic Initiation Factors - metabolism | Amino Acid Sequence | RNA, Messenger - genetics | Eukaryotic Initiation Factor-1 - genetics | Models, Molecular | Neoplasm Proteins - chemistry | Saccharomyces cerevisiae Proteins - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Eukaryotic Initiation Factor-4E - chemistry | 5' Untranslated Regions | Models, Biological | Saccharomyces cerevisiae Proteins - metabolism | Eukaryotic Initiation Factor-4G - chemistry | Eukaryotic Initiation Factor-4G - genetics | Saccharomyces cerevisiae Proteins - chemistry
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8. Full Text Structural and Functional Insights into Human Re-initiation Complexes
by Weisser, Melanie and Schäfer, Tanja and Leibundgut, Marc and Böhringer, Daniel and Aylett, Christopher Herbert Stanley and Ban, Nenad
Molecular Cell, ISSN 1097-2765, 08/2017, Volume 67, Issue 3, pp. 447 - 456.e7
After having translated short upstream open reading frames, ribosomes can re-initiate translation on the same mRNA. This process, referred to as re-initiation,... 
eIF2D | ligatin | start codon recognition | translation initiation | DENR | ribosomal recycling | translation regulation | translation re-initiation | MCT-1 | initiator tRNA | P-SITE | EUKARYOTIC TRANSLATION INITIATION | 40S RIBOSOMAL-SUBUNIT | OPEN READING FRAMES | MESSENGER-RNA | UPSTREAM | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEQUENCE | CRYO-EM STRUCTURE | PROTEIN-SYNTHESIS | CELL BIOLOGY | Oncogene Proteins - genetics | Ribosome Subunits, Small, Eukaryotic - chemistry | Eukaryotic Initiation Factor-2 - chemistry | Humans | Multiprotein Complexes | Crystallography, X-Ray | Structure-Activity Relationship | RNA, Messenger - metabolism | Cell Cycle Proteins - chemistry | Transfection | HEK293 Cells | Cell Cycle Proteins - genetics | Eukaryotic Initiation Factor-2 - metabolism | RNA, Transfer - genetics | Transcription Initiation, Genetic | Nucleic Acid Conformation | RNA, Transfer - chemistry | Binding Sites | Ribosome Subunits, Small, Eukaryotic - genetics | Eukaryotic Initiation Factors - chemistry | Eukaryotic Initiation Factors - genetics | Eukaryotic Initiation Factors - metabolism | Oncogene Proteins - chemistry | RNA, Transfer - metabolism | RNA, Messenger - genetics | Cell Cycle Proteins - metabolism | Oncogene Proteins - metabolism | Cryoelectron Microscopy | Eukaryotic Initiation Factor-2 - genetics | Transcription Initiation Site | Protein Binding | Protein Conformation | RNA, Messenger - chemistry | Molecular Docking Simulation | Mutation | Ribosome Subunits, Small, Eukaryotic - metabolism | RNA | Molecular biology | Binding proteins | Genetic translation | Protein binding
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