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1. Full Text Translation from unconventional 5′ start sites drives tumour initiation
by Sendoel, Ataman and Dunn, Joshua G and Rodriguez, Edwin H and Naik, Shruti and Gomez, Nicholas C and Hurwitz, Brian and Levorse, John and Dill, Brian D and Schramek, Daniel and Molina, Henrik and Weissman, Jonathan S and Fuchs, Elaine
Nature (London), ISSN 0028-0836, 01/2017, Volume 541, Issue 7638, pp. 494 - 499
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Genetic aspects | Metastasis | Genetic translation | Health aspects | Tumors | Proteins | Phosphorylation | Peptides | Protein synthesis | Genomes | Tumorigenesis | Cancer | Index Medicus
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2. Full Text Hypoxia-Inducible mir-210 Regulates Normoxic Gene Expression Involved in Tumor Initiation
by Huang, Xin and Ding, Lianghao and Bennewith, Kevin L and Tong, Ricky T and Welford, Scott M and Ang, K. Kian and Story, Michael and Le, Quynh-Thu and Giaccia, Amato J
Molecular cell, ISSN 1097-2765, 2009, Volume 35, Issue 6, pp. 856 - 867
RNA | CELLCYCLE | SIGNALING | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Receptor, Fibroblast Growth Factor, Type 5 - metabolism | Neoplasm Transplantation | Up-Regulation | Cell Proliferation | Immunoprecipitation | Pancreatic Neoplasms - metabolism | Oligonucleotide Array Sequence Analysis | Homeodomain Proteins - metabolism | Humans | Gene Expression Regulation, Neoplastic | Molecular Sequence Data | Male | MicroRNAs - metabolism | Receptor, Fibroblast Growth Factor, Type 5 - genetics | Head and Neck Neoplasms - metabolism | Cell Hypoxia | Time Factors | Cell Transformation, Neoplastic - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Base Sequence | Eukaryotic Initiation Factor-2 - metabolism | Transcription, Genetic | Reproducibility of Results | Transduction, Genetic | Response Elements | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Stress, Physiological - genetics | Pancreatic Neoplasms - pathology | Gene Silencing | Gene Expression Profiling - methods | Pancreatic Neoplasms - genetics | Transcription Factors - genetics | Cell Transformation, Neoplastic - metabolism | Homeodomain Proteins - genetics | Head and Neck Neoplasms - pathology | Transcription Factors - metabolism | Animals | Mice, Nude | Cell Line, Tumor | Protein Binding | Head and Neck Neoplasms - genetics | Mice | Cell Transformation, Neoplastic - pathology | Analysis | Pancreatic cancer | Radiation | Genetic research | DNA binding proteins | Gene expression | Index Medicus | Hypoxia | microRNA | mir-210 | tumor initiation | gene expression
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3. Full Text Small-Molecule Inhibition of the Interaction between the Translation Initiation Factors eIF4E and eIF4G
by Moerke, Nathan J and Aktas, Huseyin and Chen, Han and Cantel, Sonia and Reibarkh, Mikhail Y and Fahmy, Amr and Gross, John D and Degterev, Alexei and Yuan, Junying and Chorev, Michael and Halperin, Jose A and Wagner, Gerhard
Cell (Cambridge), ISSN 0092-8674, 2007, Volume 128, Issue 2, pp. 257 - 267
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Binding - genetics | Humans | Nitro Compounds - chemistry | Eukaryotic Initiation Factor-4E - metabolism | Peptide Fragments - pharmacology | Eukaryotic Initiation Factor-4G - drug effects | Eukaryotic Initiation Factor-4G - metabolism | Fluorescence Polarization Immunoassay - methods | Thiazoles - isolation & purification | Antineoplastic Agents - isolation & purification | Cell Transformation, Neoplastic - genetics | Protein Binding - drug effects | Nitro Compounds - pharmacology | Antineoplastic Agents - pharmacology | Protein Biosynthesis - genetics | Gene Expression Regulation, Neoplastic - drug effects | Eukaryotic Initiation Factor-4E - genetics | Peptide Fragments - genetics | Gene Expression Regulation, Neoplastic - genetics | RNA, Messenger - drug effects | Drug Evaluation, Preclinical - methods | Oncogenes - genetics | Peptide Fragments - metabolism | Jurkat Cells | RNA, Messenger - genetics | Hydrazones | Models, Molecular | Antineoplastic Agents - chemistry | Cell Transformation, Neoplastic - metabolism | Eukaryotic Initiation Factor-4E - drug effects | Nitro Compounds - isolation & purification | Animals | Cell Line, Tumor | Oncogenes - drug effects | Feedback, Physiological - drug effects | Protein Biosynthesis - drug effects | Thiazoles - chemistry | Eukaryotic Initiation Factor-4G - genetics | Mice | Thiazoles - pharmacology | Cell Transformation, Neoplastic - drug effects | Feedback, Physiological - physiology | Cell Line, Transformed | Index Medicus | Peptide Fragments | Protein Biosynthesis | Gene Expression Regulation, Neoplastic | Eukaryotic Initiation Factor-4E | Chemical Sciences | Fluorescence Polarization Immunoassay | Life Sciences | Thiazoles | Drug Evaluation, Preclinical | Feedback, Biochemical | Oncogenes | Analytical chemistry | Biochemistry, Molecular Biology | Antineoplastic Agents | Organic chemistry | Eukaryotic Initiation Factor-4G | Cell Transformation, Neoplastic | Nitro Compounds | Protein Binding | RNA, Messenger
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4. Full Text Comprehensive Genetic Landscape of Uveal Melanoma by Whole-Genome Sequencing
by Royer-Bertrand, Beryl and Torsello, Matteo and Rimoldi, Donata and El Zaoui, Ikram and Cisarova, Katarina and Pescini-Gobert, Rosanna and Raynaud, Franck and Zografos, Leonidas and Schalenbourg, Ann and Speiser, Daniel and Nicolas, Michael and Vallat, Laureen and Klein, Robert and Leyvraz, Serge and Ciriello, Giovanni and Riggi, Nicolò and Moulin, Alexandre P and Rivolta, Carlo
American journal of human genetics, ISSN 0002-9297, 11/2016, Volume 99, Issue 5, pp. 1190 - 1198
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Melanoma - diagnosis | Exons | Humans | Middle Aged | Male | Phosphoproteins - metabolism | Case-Control Studies | RNA Splicing Factors - metabolism | DNA Copy Number Variations | Melanoma - genetics | Melanocytes - pathology | Tumor Suppressor Proteins - genetics | Aged, 80 and over | Ubiquitin Thiolesterase - metabolism | Adult | Female | Membrane Proteins - metabolism | Eukaryotic Initiation Factor-1 - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Tumor Suppressor p53-Binding Protein 1 - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - genetics | Uveal Neoplasms - genetics | Genome-Wide Association Study | Tumor Suppressor Proteins - metabolism | GTP-Binding Protein alpha Subunits - metabolism | Tumor Suppressor p53-Binding Protein 1 - genetics | Membrane Proteins - genetics | Eukaryotic Initiation Factor-1 - genetics | Ubiquitin-Protein Ligases - metabolism | GTP-Binding Protein alpha Subunits - genetics | Phosphoproteins - genetics | RNA Splicing Factors - genetics | Ubiquitin Thiolesterase - genetics | Skin Neoplasms | Uveal Neoplasms - diagnosis | Aged | Mutation | Ubiquitin-Protein Ligases - genetics | Genetic aspects | Nucleotide sequencing | Methods | Melanoma | DNA sequencing | Metastasis | Pathogenesis | Genomics | Deoxyribonucleic acid--DNA | Index Medicus | Report
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5. Full Text Dynamic interaction of eukaryotic initiation factor 4G1 (eIF4G1) with eIF4E and eIF1 underlies scanning-dependent and -independent translation
by Haimov, Ora and Sehrawat, Urmila and Harush, Ana Tamarkin-Ben and Bahat, Anat and Uzonyi, Anna and Will, Alexander and Hiraishi, Hiroyuki and Asano, Katsura and Dikstein, Rivka
Molecular and cellular biology, ISSN 0270-7306, 09/2018, Volume 38, Issue 18
Leaky scanning | TISU | EIF4E | Translation initiation | EIF1 | EIF4G1 | Humans | Eukaryotic Initiation Factor-4E - metabolism | Ribosomes - metabolism | Peptide Chain Initiation, Translational | Eukaryotic Initiation Factor-4G - metabolism | Neoplasm Proteins - metabolism | RNA Caps - metabolism | RNA, Messenger - metabolism | Nerve Tissue Proteins - chemistry | HEK293 Cells | Eukaryotic Initiation Factor-1 - chemistry | Protein Interaction Domains and Motifs | Eukaryotic Initiation Factor-1 - metabolism | Neoplasm Proteins - genetics | Binding Sites | Eukaryotic Initiation Factor-4E - genetics | RNA Caps - genetics | Eukaryotic Initiation Factors - chemistry | Eukaryotic Initiation Factors - genetics | Eukaryotic Initiation Factors - metabolism | Amino Acid Sequence | RNA, Messenger - genetics | Eukaryotic Initiation Factor-1 - genetics | Models, Molecular | Neoplasm Proteins - chemistry | Saccharomyces cerevisiae Proteins - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Eukaryotic Initiation Factor-4E - chemistry | 5' Untranslated Regions | Models, Biological | Saccharomyces cerevisiae Proteins - metabolism | Eukaryotic Initiation Factor-4G - chemistry | Eukaryotic Initiation Factor-4G - genetics | Saccharomyces cerevisiae Proteins - chemistry | Index Medicus
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6. 'Ribozoomin' - translation initiation from the perspective of the ribosome-bound eukaryotic initiation factors (eIFs)
by Valášek, Leoš Shivaya
Current protein & peptide science, ISSN 1389-2037, 2012, Volume 13, Issue 4, pp. 305 - 330
AUG | eIF | GCN4 | Ribosome | Translation initiation | mRNA | Translational control | Reinitiation | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Eukaryotic Initiation Factors - metabolism | Peptide Chain Initiation, Translational - genetics | Animals | Humans | Models, Molecular | Protein Binding | Ribosomes - metabolism | Eukaryota - metabolism | Initiation factors | Ribosomal subunits | Translation | Gene regulation | Protein biosynthesis | Mutation
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7. Full Text Structural and Functional Insights into Human Re-initiation Complexes
by Weisser, Melanie and Schäfer, Tanja and Leibundgut, Marc and Böhringer, Daniel and Aylett, Christopher Herbert Stanley and Ban, Nenad
Molecular cell, ISSN 1097-2765, 08/2017, Volume 67, Issue 3, pp. 447 - 456.e7
eIF2D | ligatin | start codon recognition | translation initiation | DENR | ribosomal recycling | translation regulation | translation re-initiation | MCT-1 | initiator tRNA | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Oncogene Proteins - genetics | Ribosome Subunits, Small, Eukaryotic - chemistry | Eukaryotic Initiation Factor-2 - chemistry | Humans | Multiprotein Complexes | Crystallography, X-Ray | Structure-Activity Relationship | RNA, Messenger - metabolism | Cell Cycle Proteins - chemistry | Transfection | HEK293 Cells | Cell Cycle Proteins - genetics | Eukaryotic Initiation Factor-2 - metabolism | RNA, Transfer - genetics | Transcription Initiation, Genetic | Nucleic Acid Conformation | RNA, Transfer - chemistry | Binding Sites | Ribosome Subunits, Small, Eukaryotic - genetics | Eukaryotic Initiation Factors - chemistry | Eukaryotic Initiation Factors - genetics | Eukaryotic Initiation Factors - metabolism | Oncogene Proteins - chemistry | RNA, Transfer - metabolism | RNA, Messenger - genetics | Cell Cycle Proteins - metabolism | Oncogene Proteins - metabolism | Cryoelectron Microscopy | Eukaryotic Initiation Factor-2 - genetics | Transcription Initiation Site | Protein Binding | Protein Conformation | RNA, Messenger - chemistry | Molecular Docking Simulation | Mutation | Ribosome Subunits, Small, Eukaryotic - metabolism | RNA | Molecular biology | Binding proteins | Genetic translation | Protein binding | Index Medicus
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8. Full Text Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1): A master regulator of mRNA translation involved in tumorigenesis
by Musa, J and Orth, M.F and Dallmayer, M and Baldauf, M and Pardo, C and Rotblat, B and Kirchner, T and Leprivier, G and Grünewald, T.G.P
Oncogene, ISSN 0950-9232, 09/2016, Volume 35, Issue 36, pp. 4675 - 4688
Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Proliferation - genetics | Phosphorylation | Protein Biosynthesis | Signal Transduction | Humans | RNA, Messenger - genetics | Carcinogenesis - genetics | Gene Expression Regulation, Neoplastic | Phosphoproteins - genetics | Neoplasms - genetics | Adaptor Proteins, Signal Transducing - genetics | Protein Binding | Neoplasms - pathology | Eukaryotic Initiation Factor-4E - genetics | Transcription factors | Tumor suppressor genes | Genetic aspects | Properties | Binding proteins | Identification and classification | Carcinogenesis | Proteins | Eukaryotes | Tumorigenesis | Ribonucleic acid--RNA | Protein synthesis | Binding sites | Index Medicus
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