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Journal Article
Molecular Cell, ISSN 1097-2765, 06/2018, Volume 70, Issue 6, pp. 1089 - 1100.e8
Journal Article
SEMINARS IN CANCER BIOLOGY, ISSN 1044-579X, 06/2006, Volume 16, Issue 3, pp. 225 - 234
The 14-3-3 sigma (sigma) protein, a unique member of 14-3-3 family, is a negative regulator of the cell cycle and is induced by p53 to initiate cell cycle... 
14-3-3 | FORKHEAD TRANSCRIPTION FACTOR | SUPPRESSES TUMOR-GROWTH | P53 UBIQUITINATION | cell cycle | CRYSTAL-STRUCTURE | DNA-DAMAGE | DOWN-REGULATION | tumor suppressor | ATM-DEPENDENT PHOSPHORYLATION | p53 | NEGATIVE REGULATOR | GENETIC INSTABILITY | ONCOLOGY | STRUCTURAL BASIS | Mdm2 | Exoribonucleases | Humans | Neoplasm Proteins - metabolism | Tripartite Motif-Containing Protein 28 | DNA-Binding Proteins - metabolism | Exonucleases - genetics | Biomarkers, Tumor - metabolism | Exonucleases - metabolism | Neoplasm Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Gene Expression Regulation, Neoplastic - physiology | Proto-Oncogene Proteins c-mdm2 - metabolism | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Endopeptidases - metabolism | Tumor Suppressor Proteins - metabolism | Cell Cycle Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Ubiquitin-Protein Ligases - metabolism | PTEN Phosphohydrolase - metabolism | Neoplasm Proteins - chemistry | Ataxia Telangiectasia Mutated Proteins | Exonucleases - chemistry | Animals | Signal Transduction - physiology | 14-3-3 Proteins | Biomarkers, Tumor - genetics | Proteasome Endopeptidase Complex - metabolism | Biomarkers, Tumor - chemistry | Tumor Suppressor Protein p14ARF - metabolism | Ubiquitin Thiolesterase | Ubiquitin-Specific Peptidase 7 | Protein Binding - physiology
Journal Article
Journal of Immunology, ISSN 0022-1767, 09/2015, Volume 195, Issue 5, pp. 1939 - 1943
Detection of intracellular DNA triggers activation of the stimulator of IFN genes dependent IFN-stimulatory DNA (ISD) pathway, which is essential for antiviral... 
CYCLIC GMP-AMP | INTRACELLULAR DNA | LUPUS | DENDRITIC CELLS | GENE | DNA EXONUCLEASE TREX1 | CYTOSOLIC DNA | INNATE IMMUNE SENSOR | MUTATIONS | IMMUNOLOGY | RETROVIRUSES | Nucleotides, Cyclic - metabolism | Phosphoproteins - immunology | Exodeoxyribonucleases - immunology | Interferon-beta - immunology | Nervous System Malformations - immunology | Gene Expression - drug effects | Autoantibodies - blood | Humans | Immunoblotting | Interferons - immunology | Phosphoproteins - metabolism | Inflammation - metabolism | Nervous System Malformations - metabolism | Autoimmune Diseases of the Nervous System - genetics | Gene Expression - immunology | Interferon-beta - genetics | Exodeoxyribonucleases - genetics | Nucleotidyltransferases - metabolism | Autoimmune Diseases of the Nervous System - metabolism | Nervous System Malformations - genetics | Macrophages - immunology | Disease Models, Animal | Fibroblasts - metabolism | Interferons - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Inflammation - immunology | Phosphoproteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Autoimmune Diseases of the Nervous System - immunology | Autoantibodies - immunology | Macrophages - metabolism | Animals | Interferon-beta - metabolism | Embryo, Mammalian - cytology | Fibroblasts - drug effects | Exodeoxyribonucleases - metabolism | Inflammation - genetics | Nucleotidyltransferases - genetics | Fibroblasts - immunology | Macrophages - drug effects | Nucleotidyltransferases - immunology | Nucleotides, Cyclic - immunology
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2013, Volume 52, Issue 2, pp. 173 - 183
Journal Article
Cancer Research, ISSN 0008-5472, 03/2011, Volume 71, Issue 6, pp. 2328 - 2338
Pancreatic cancer is an exceptionally aggressive disease in great need of more effective therapeutic options. Epithelial-mesenchymal transition (EMT) plays a... 
INITIATING CELLS | ONCOLOGY | GROWTH | GENES | NOTCH | ACUTE MYELOID-LEUKEMIA | IDENTIFICATION | EXPRESSION | PROGRESSION | CANCER STEM-CELLS | BRAIN-TUMORS | Immunohistochemistry | ras Proteins - genetics | Pancreatic Neoplasms - metabolism | Exoribonucleases | Vimentin - metabolism | Humans | ras Proteins - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Epithelial-Mesenchymal Transition - genetics | Zinc Finger E-box Binding Homeobox 2 | RNA Interference | Biomarkers, Tumor - metabolism | Exonucleases - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Gene Expression | Pancreatic Neoplasms - pathology | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | Mice, Transgenic | Pancreatic Neoplasms - genetics | Receptor, Notch1 - metabolism | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Proto-Oncogene Proteins c-myc - metabolism | Homeodomain Proteins - genetics | 14-3-3 Proteins - metabolism | Animals | Twist-Related Protein 1 - genetics | Cell Line, Tumor | Mice | MicroRNAs - genetics | Proto-Oncogene Proteins c-myc - genetics | Mutation | Receptor, Notch1 - genetics | Zinc Finger E-box-Binding Homeobox 1 | epithelial-mesenchymal transition (EMT) | pancreatic intraepithelial neoplasia (PanIN) | Cancer Stem Cell Marker | miR-144 | 14-3-3 σ | Let-7a | vimentin | miR-200a | DCAMKL-1 | Dclk-1 | Notch-1
Journal Article
Nature, ISSN 0028-0836, 05/2018, Volume 557, Issue 7703, pp. 57 - 61
SAMHD1 was previously characterized as a dNTPase that protects cells from viral infections. Mutations in SAMHD1 are implicated in cancer development and in a... 
NUCLEASE ACTIVITY | REPAIR | PROTEIN | HIV-1 RESTRICTION | AICARDI-GOUTIERES SYNDROME | STABILITY | MULTIDISCIPLINARY SCIENCES | CYTOSOLIC DNA SENSOR | END RESECTION | RESTRICTION FACTOR SAMHD1 | MAMMALIAN-CELLS | SAM Domain and HD Domain-Containing Protein 1 - metabolism | RecQ Helicases - metabolism | DNA, Single-Stranded - metabolism | Humans | DNA Replication | Inflammation - immunology | SAM Domain and HD Domain-Containing Protein 1 - deficiency | Interferon Type I - immunology | Checkpoint Kinase 1 - metabolism | Inflammation - metabolism | HEK293 Cells | Interferon Type I - metabolism | Cytosol - metabolism | Inflammation - prevention & control | Membrane Proteins - metabolism | HeLa Cells | Nucleotidyltransferases - metabolism | MRE11 Homologue Protein - metabolism | Physiological aspects | DNA replication | Interferon | Observations | Cytokines | Single-stranded DNA | DNA damage | CHK1 protein | Genomes | Kinases | DNA repair | Cytosol | Replication forks | DNA biosynthesis | Exonuclease | Microscopy | MRE11 protein | Cell lines | Replication | Mutation | Deoxyribonucleic acid--DNA | Cellular stress response | Cancer | Life Sciences | Genetics | Cell and Molecular Biology | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Cell- och molekylärbiologi | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Genes and Development, ISSN 0890-9369, 02/2011, Volume 25, Issue 4, pp. 350 - 362
Repair of dsDNA breaks requires processing to produce 3'-terminated ssDNA. We biochemically reconstituted DNA end resection using purified human proteins:... 
BLM helicase | DNA2 nuclease | DNA break repair | EXO1 nuclease | DNA end resection | Homologous recombination | NUCLEASE ACTIVITY | PROTEIN | HUMAN EXONUCLEASE 1 | MISMATCH REPAIR | DEVELOPMENTAL BIOLOGY | CELL BIOLOGY | XENOPUS DNA2 | homologous recombination | SGS1 | GENETICS & HEREDITY | BLOOM-SYNDROME | 5' STRAND RESECTION | MRE11 NUCLEASE | RecQ Helicases - metabolism | Humans | DNA Repair Enzymes - genetics | Replication Protein A - physiology | Multiprotein Complexes - genetics | RecQ Helicases - genetics | DNA Repair - genetics | DNA Breaks, Double-Stranded | DNA Breaks, Single-Stranded | DNA-Binding Proteins - metabolism | MRE11 Homologue Protein | Multiprotein Complexes - metabolism | Replication Protein A - genetics | DNA Repair Enzymes - metabolism | Cell Cycle Proteins - genetics | Exodeoxyribonucleases - genetics | Nuclear Proteins - genetics | DNA Helicases - genetics | RecQ Helicases - physiology | DNA Repair Enzymes - physiology | DNA-Binding Proteins - physiology | Cell Cycle Proteins - metabolism | Nuclear Proteins - metabolism | Replication Protein A - metabolism | DNA-Binding Proteins - genetics | Multiprotein Complexes - physiology | DNA Helicases - metabolism | Models, Biological | Exodeoxyribonucleases - metabolism | Exodeoxyribonucleases - physiology | Nuclear Proteins - physiology | In Vitro Techniques | Cell Cycle Proteins - physiology | DNA Helicases - physiology | Protein Binding - physiology | Research Paper
Journal Article
The FEBS Journal, ISSN 1742-464X, 02/2010, Volume 277, Issue 3, pp. 627 - 641
Journal Article