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Nature (London), ISSN 1476-4687, 2011, Volume 471, Issue 7339, pp. 467 - 472
Multiple myeloma is an incurable malignancy of plasma cells, and its pathogenesis is poorly understood. Here we report the massively parallel sequencing of 38... 
PATHOGENESIS | B-CELL LYMPHOMA | BLIMP-1 | GENE | MULTIDISCIPLINARY SCIENCES | STRESS-RESPONSE | EXOSOME | CLASSIFICATION | DIFFERENTIATION | HUMAN CANCER | SOMATIC MUTATIONS | Ribonucleases - genetics | Ribonucleases - chemistry | Genomics | Humans | Molecular Sequence Data | NF-kappa B - metabolism | DNA Repair - genetics | Multiple Myeloma - drug therapy | DNA Mutational Analysis | Protein Biosynthesis - genetics | Multiple Myeloma - enzymology | Proto-Oncogene Proteins B-raf - metabolism | Amino Acid Sequence | Oncogenes - genetics | Models, Molecular | Exons - genetics | Signal Transduction - genetics | Multiple Myeloma - metabolism | Mutation - genetics | Open Reading Frames - genetics | Genome, Human - genetics | Homeodomain Proteins - genetics | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | RNA Processing, Post-Transcriptional - genetics | Proto-Oncogene Proteins B-raf - genetics | CpG Islands - genetics | Blood Coagulation - genetics | Protein Conformation | Histones - metabolism | Transcription, Genetic - genetics | Exosome Multienzyme Ribonuclease Complex | Methylation | Homeostasis - genetics | Multiple Myeloma - genetics | Usage | Multiple myeloma | Development and progression | Genetic aspects | Research | Nucleotide sequencing | Methods | Cancer | Proteins | Pathogenesis | Homeostasis | Genetics | Genomes | Mutation | Kinases | Mass spectrometry
Journal Article
Nature (London), ISSN 0028-0836, 10/2014, Volume 514, Issue 7522, pp. 389 - 393
The vast majority of the mammalian genome has the potential to express noncoding RNA (ncRNA). The 11-subunit RNA exosome complex is the main source of cellular... 
SOMATIC HYPERMUTATION | DNA | MULTIDISCIPLINARY SCIENCES | PROMOTER DIRECTIONALITY | EXOSOME | POLYMERASE-II | TERMINATION | SEQUENCING REVEALS | GENOME | CHROMOSOMAL REARRANGEMENTS | LYMPHOCYTES | Exosome Multienzyme Ribonuclease Complex - deficiency | Exosomes - metabolism | RNA-Binding Proteins - genetics | RNA, Untranslated - metabolism | Genome - genetics | Substrate Specificity | Male | DNA Breaks, Double-Stranded | RNA, Untranslated - genetics | DNA, Single-Stranded - genetics | RNA, Antisense - chemistry | Female | RNA, Untranslated - chemistry | Exosome Multienzyme Ribonuclease Complex - genetics | B-Lymphocytes - metabolism | Genomic Instability - genetics | Nucleic Acid Hybridization | DNA, Single-Stranded - metabolism | RNA, Antisense - biosynthesis | DNA, Single-Stranded - chemistry | Animals | Base Pairing | RNA, Untranslated - biosynthesis | Cytidine Deaminase - metabolism | RNA, Antisense - metabolism | Transcription Initiation Site | Mice | Transcription, Genetic - genetics | Somatic Hypermutation, Immunoglobulin - genetics | Immunoglobulin Class Switching - genetics | Immunoglobulin Heavy Chains - genetics | RNA, Antisense - genetics | Translocation, Genetic - genetics | Animal genetics | Genetic transcription | B cells | Research | Analysis | Proteins | Genomes | Mutation | RNA polymerase | Gene expression | Ribonucleic acid--RNA | Deoxyribonucleic acid--DNA | Immune system
Journal Article
Journal Article
Nature structural & molecular biology, ISSN 1545-9985, 2013, Volume 20, Issue 7, pp. 851 - 858
Many Saccharomyces cerevisiae genes encode antisense transcripts, some of which are unstable and degraded by the exosome component Rrp6. Loss of Rrp6 results... 
CRYPTIC UNSTABLE TRANSCRIPTS | PERVASIVE TRANSCRIPTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTERGENIC TRANSCRIPTION | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | BIOPHYSICS | BINDING PROTEINS NRD1 | GENE-EXPRESSION | POLY(A) POLYMERASE | POLYMERASE-II TRANSCRIPTS | BIDIRECTIONAL PROMOTERS | RNA DEGRADATION | Saccharomyces cerevisiae - genetics | Multiprotein Complexes | Saccharomyces cerevisiae Proteins - biosynthesis | RNA, Messenger - metabolism | Promoter Regions, Genetic - genetics | RNA, Messenger - biosynthesis | RNA Helicases - physiology | Transcription, Genetic | RNA, Fungal - genetics | Gene Expression Regulation, Fungal | RNA-Binding Proteins - physiology | In Situ Hybridization, Fluorescence | Exosome Multienzyme Ribonuclease Complex - physiology | Saccharomyces cerevisiae Proteins - genetics | RNA, Fungal - metabolism | Polynucleotide Adenylyltransferase - physiology | Proton-Phosphate Symporters - genetics | RNA, Antisense - metabolism | Polyadenylation | Metalloendopeptidases - physiology | Models, Genetic | Nuclear Proteins - physiology | Saccharomyces cerevisiae Proteins - physiology | Histone Deacetylases - physiology | Proton-Phosphate Symporters - biosynthesis | Histone-Lysine N-Methyltransferase - physiology | DNA Helicases - physiology | RNA, Antisense - genetics | Cytogenetics | Research | Genetic transcription | DNA methylation | Gene expression | Molecular biology | Ribonucleic acid--RNA | Rrp6 | Nrd1-Nab3-Sen1 | transcription termination | PHO84 regulation | antisense RNA | yeast | single molecule FISH | antisense 3′ end processing
Journal Article
Nature (London), ISSN 1476-4687, 2015, Volume 527, Issue 7576, pp. 100 - 104
Journal Article
PLoS genetics, ISSN 1553-7404, 2019, Volume 15, Issue 2, p. e1007888
Journal Article
Molecular cell, ISSN 1097-2765, 2017, Volume 68, Issue 5, pp. 940 - 954.e3
Journal Article
Molecular cell, ISSN 1097-2765, 2016, Volume 64, Issue 3, pp. 520 - 533
The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its co-factor Mtr4p/hMTR4, which links to... 
RNA exosome | PAXT connection | nuclear RNA decay | poly(A) tail | NEXT complex | COMPLEX | MESSENGER-RNA | CRYPTIC UNSTABLE TRANSCRIPTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOLECULAR ARCHITECTURE | POLY(A)-BINDING PROTEIN | POLYMERASE | 3'-END MATURATION | QUALITY CONTROL | DEGRADATION | POLY(A) TAIL LENGTH | CELL BIOLOGY | RNA Helicases - metabolism | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | Humans | RNA, Messenger - metabolism | Cell Nucleus - metabolism | HEK293 Cells | Exosome Multienzyme Ribonuclease Complex - metabolism | RNA Helicases - genetics | Exosome Multienzyme Ribonuclease Complex - genetics | Nuclear Proteins - genetics | Poly(A)-Binding Protein I - genetics | Binding Sites | RNA-Binding Proteins - antagonists & inhibitors | RNA, Messenger - genetics | Carrier Proteins - antagonists & inhibitors | Poly(A)-Binding Protein I - metabolism | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Poly A - genetics | Transcription Factors - genetics | RNA Stability - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Poly A - metabolism | Carrier Proteins - metabolism | Cell Nucleus - genetics | Nuclear Proteins - antagonists & inhibitors | Poly(A)-Binding Protein I - antagonists & inhibitors | Protein Binding | HeLa Cells | RNA-Binding Proteins - metabolism | RNA, Small Interfering - metabolism | Zinc compounds | RNA | Molecular biology | Protein binding
Journal Article
Journal Article