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FEBS Journal, ISSN 1742-464X, 12/2011, Volume 278, Issue 23, pp. 4683 - 4700
Journal Article
Microbiology and Molecular Biology Reviews, ISSN 1092-2172, 2014, Volume 78, Issue 2, pp. 199 - 230
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 01/2011, Volume 17, Issue 1, pp. 100 - 110
Purpose: Designed ankyrin repeat proteins (DARPins) hold great promise as a new class of binding molecules to overcome the limitations of antibodies for... 
RECOMBINANT ANTIBODY | IMMUNOTOXIN | ONCOLOGY | EP-CAM | STABILITY | ANTICANCER AGENT | AERUGINOSA EXOTOXIN-A | PHASE-I | PSEUDOMONAS EXOTOXIN | CARCINOMA | CANCER STEM-CELLS | Cell Adhesion Molecules - chemistry | Injections, Intravenous | Cell Adhesion Molecules - administration & dosage | Recombinant Fusion Proteins - pharmacology | Humans | Antineoplastic Agents - administration & dosage | Recombinant Fusion Proteins - metabolism | Exotoxins - metabolism | Antineoplastic Agents - metabolism | ADP Ribose Transferases - administration & dosage | Exotoxins - administration & dosage | Protein Engineering | Cell Adhesion Molecules - pharmacology | Female | Antineoplastic Agents - pharmacology | Recombinant Fusion Proteins - administration & dosage | ADP Ribose Transferases - chemistry | ADP Ribose Transferases - metabolism | Cell Survival - drug effects | Exotoxins - chemistry | Ankyrin Repeat | Exotoxins - pharmacology | Virulence Factors - chemistry | Recombinant Fusion Proteins - chemistry | Antineoplastic Agents - chemistry | Cell Adhesion Molecules - metabolism | Bacterial Toxins - chemistry | Xenograft Model Antitumor Assays | Bacterial Toxins - metabolism | Animals | Pseudomonas aeruginosa - genetics | Bacterial Toxins - pharmacology | Mice, Nude | ADP Ribose Transferases - pharmacology | Cell Line, Tumor | Bacterial Toxins - administration & dosage | Virulence Factors - metabolism | Mice | Neoplasms, Experimental - drug therapy | Virulence Factors - administration & dosage | Virulence Factors - pharmacology
Journal Article
Immunological Reviews, ISSN 0105-2896, 03/2016, Volume 270, Issue 1, pp. 152 - 164
Recombinant immunotoxins ( RIT s) are chimeric proteins designed to treat cancer. They are made up of an Fv or Fab that targets an antigen on a cancer cell... 
neutralizing antibodies | mesothelioma | immunotherapy | anti‐drug antibodies | mesothelin | Mesothelin | Mesothelioma | Anti-drug antibodies | Neutralizing antibodies | Immunotherapy | anti-drug antibodies | ADVANCED SOLID TUMORS | IMMUNOLOGY | EXOTOXIN-A MUTANTS | SURFACE-EXPOSED RESIDUES | B-CELL | PHASE-I TRIAL | REDUCED IMMUNOGENICITY | SITE-SPECIFIC MANNER | T-CELL EPITOPE | PSEUDOMONAS EXOTOXIN | HEMATOLOGIC MALIGNANCIES | Epitope Mapping | Sequence Deletion | Virulence Factors - genetics | Humans | Immunosuppressive Agents - therapeutic use | Immunotoxins - adverse effects | Epitopes, B-Lymphocyte - immunology | Virulence Factors - immunology | Recombinant Fusion Proteins | Antibodies, Neutralizing - immunology | Neoplasms - therapy | Immunotoxins - administration & dosage | Immunoglobulin Fragments - therapeutic use | Bacterial Toxins - genetics | Immunotoxins - chemistry | Epitopes, T-Lymphocyte - immunology | Drug Therapy, Combination | Immunosuppressive Agents - administration & dosage | ADP Ribose Transferases - chemistry | ADP Ribose Transferases - immunology | Drug Administration Routes | Immunotoxins - immunology | Antibodies, Monoclonal, Humanized - therapeutic use | Exotoxins - chemistry | Polyethylene Glycols | Bacterial Toxins - immunology | Exotoxins - immunology | Clinical Trials as Topic | Virulence Factors - chemistry | Bacterial Toxins - chemistry | ADP Ribose Transferases - genetics | Immunotoxins - genetics | Animals | Genetic Engineering | Immunoglobulin Fragments - immunology | Immunotoxins - therapeutic use | Neoplasms - immunology | Exotoxins - genetics | Antibody Formation | Antigens - immunology | Mice | Antibodies, Monoclonal, Humanized - immunology | Biological products | Antibody-toxin conjugates | Health aspects | Index Medicus
Journal Article
The Journal of Immunology, ISSN 0022-1767, 10/2007, Volume 179, Issue 7, pp. 4919 - 4928
Journal Article
Blood, ISSN 0006-4971, 10/2017, Volume 130, Issue 14, pp. 1620 - 1627
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2014, Volume 111, Issue 23, pp. 8577 - 8582
Immune responses can make protein therapeutics ineffective or even dangerous. We describe a general computational protein design method for reducing... 
T lymphocytes | Immune response | Immunodominant epitopes | Exotoxins | Medical treatment | Alleles | T lymphocyte epitopes | Epitopes | Genetic mutation | Epics | Biotherapeutics | Immunotoxin | Deimmunization | Machine learning | Rosetta | biotherapeutics | MULTIDISCIPLINARY SCIENCES | ANTIBODY | deimmunization | ALGORITHMS | machine learning | IDENTIFICATION | GREEN FLUORESCENT PROTEIN | REDUCED IMMUNOGENICITY | THERAPEUTIC PROTEINS | immunotoxin | OPTIMIZATION | PHASE-I | Virulence Factors - genetics | Protein Engineering - methods | Humans | Molecular Sequence Data | Epitopes, T-Lymphocyte - genetics | Green Fluorescent Proteins - genetics | Virulence Factors - immunology | HLA Antigens - genetics | Support Vector Machine | Flow Cytometry | Bacterial Toxins - genetics | Immunotoxins - chemistry | Epitopes, T-Lymphocyte - immunology | Green Fluorescent Proteins - chemistry | ADP Ribose Transferases - chemistry | Protein Structure, Tertiary | ADP Ribose Transferases - immunology | Immunization | Immunotoxins - immunology | Exotoxins - chemistry | Bacterial Toxins - immunology | Exotoxins - immunology | Mice, Inbred C57BL | HLA Antigens - immunology | Models, Molecular | Spectrometry, Fluorescence | Virulence Factors - chemistry | Bacterial Toxins - chemistry | Proteins - immunology | Proteins - genetics | Sequence Homology, Amino Acid | ADP Ribose Transferases - genetics | Immunotoxins - genetics | Animals | Green Fluorescent Proteins - immunology | Exotoxins - genetics | Cell Line, Tumor | Mice | Computer-Aided Design | Proteins - chemistry | Microbiological research | Protein research | Peptides | Research | Pseudomonas | T cells | Health aspects | Index Medicus | Biological Sciences | Physical Sciences
Journal Article