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Science, ISSN 0036-8075, 11/2009, Volume 326, Issue 5957, pp. 1231 - 1235
Loss-of-function genetic screens in model organisms have elucidated numerous biological processes, but the diploid genome of mammalian cells has precluded... 
Haploidy | B lymphocytes | Genes | Cell lines | Medical genetics | Cell cycle | HeLa cells | Toxins | Genetic screening | Human genetics | Research Article | TARGET | PROTEIN | ADP-RIBOSYLATING TOXINS | DIPHTHAMIDE | BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | INFLUENZA | RECEPTOR | IDENTIFICATION | SACCHAROMYCES-CEREVISIAE | DIPHTHERIA-TOXIN | ADP Ribose Transferases - toxicity | Histidine - analogs & derivatives | Genetic Testing | Humans | N-Acylneuraminate Cytidylyltransferase - genetics | Adenosine Diphosphate Ribose - metabolism | Bacterial Toxins - toxicity | Molecular Sequence Data | Diphtheria Toxin - toxicity | N-Acylneuraminate Cytidylyltransferase - metabolism | Exotoxins - metabolism | Antigens, Bacterial - toxicity | Monosaccharide Transport Proteins - metabolism | ADP Ribose Transferases - metabolism | Monosaccharide Transport Proteins - genetics | Virulence Factors - toxicity | Amino Acid Sequence | Histidine - biosynthesis | Influenza A Virus, H1N1 Subtype - pathogenicity | Biosynthetic Pathways | Diphtheria Toxin - metabolism | Host-Pathogen Interactions | Proteins - genetics | Bacterial Toxins - metabolism | Proteins - metabolism | Cell Line, Tumor | Exotoxins - toxicity | Virulence Factors - metabolism | Mutagenesis, Insertional | Proteins - chemistry | Antigens, Bacterial - metabolism | Peptide Elongation Factor 2 - metabolism | Research | Mutagenesis | Methods | Testing | Models | Cellular biology | Medical screening | Genomics | Influenza | Index Medicus
Journal Article
Molecular Oral Microbiology, ISSN 2041-1006, 02/2016, Volume 31, Issue 1, pp. 94 - 105
The leukotoxin (LtxA) produced by Aggregatibacter actinomycetemcomitans kills host immune cells, allowing the bacterium to establish an ecological niche in the... 
Aggregatibacter actinomycetemcomitans | cholesterol‐binding | cholesterol recognition amino acid consensus motif | leukotoxin | Leukotoxin | Cholesterol-binding | Cholesterol recognition amino acid consensus motif | AGGREGATIBACTER-ACTINOMYCETEMCOMITANS LEUKOTOXIN | ADENYLATE-CYCLASE TOXIN | MICROBIOLOGY | CYTOLETHAL-DISTENDING TOXIN | ACTINOBACILLUS-ACTINOMYCETEMCOMITANS | SIGNAL-TRANSDUCTION | FATTY ACYLATION | ESCHERICHIA-COLI PROHAEMOLYSIN | cholesterol-binding | DENTISTRY, ORAL SURGERY & MEDICINE | LIPID RAFTS | BORDETELLA-PERTUSSIS | MEMBRANE ASSOCIATION | Jurkat Cells | Bacterial Toxins - immunology | Exotoxins - immunology | Humans | Carrier Proteins - antagonists & inhibitors | Aggregatibacter actinomycetemcomitans - metabolism | Lymphocyte Function-Associated Antigen-1 - metabolism | Pancreatic Elastase - metabolism | Pancreatic Elastase - antagonists & inhibitors | Cell Adhesion - drug effects | Cholesterol - metabolism | Exotoxins - metabolism | Bacterial Toxins - antagonists & inhibitors | Host-Pathogen Interactions | Bacterial Toxins - metabolism | Carrier Proteins - metabolism | Peptides - metabolism | Aggregatibacter actinomycetemcomitans - immunology | Exotoxins - antagonists & inhibitors | Exotoxins - toxicity | Cell Membrane - metabolism | Lipid Bilayers - metabolism | Mutation | Cell Membrane - drug effects | Proteins | Membrane lipids | Chemical properties | Niche (Ecology) | Cholesterol | Dentistry | leukotoxin (LtxA) | cholesterol recognition amino acid consensus (CRAC) motif
Journal Article
Blood, ISSN 0006-4971, 2009, Volume 113, Issue 16, pp. 3792 - 3800
Immunotoxins based on Pseudomonas exotoxin A (PE) are promising anticancer agents that combine a variable fragment (Fv) from an antibody to a tumor-associated... 
Immunoglobulin Variable Region - adverse effects | Virulence Factors - genetics | Exotoxins - pharmacokinetics | Humans | Antibodies, Monoclonal - adverse effects | Bacterial Toxins - pharmacokinetics | Immunotoxins - adverse effects | Immunotoxins - pharmacology | Endosomes - metabolism | Exotoxins - adverse effects | Lysosomes - metabolism | Virulence Factors - pharmacokinetics | ADP Ribose Transferases - pharmacokinetics | Bacterial Toxins - genetics | Female | Sialic Acid Binding Ig-like Lectin 2 | ADP Ribose Transferases - adverse effects | Antibodies, Monoclonal - pharmacology | Antibodies, Monoclonal - pharmacokinetics | Clinical Trials as Topic | Exotoxins - pharmacology | Bacterial Toxins - adverse effects | Xenograft Model Antitumor Assays | ADP Ribose Transferases - genetics | Antibodies, Monoclonal - genetics | Immunotoxins - genetics | Animals | Bacterial Toxins - pharmacology | Mice, Nude | ADP Ribose Transferases - pharmacology | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Exotoxins - genetics | Immunoglobulin Variable Region - pharmacology | Immunoglobulin Variable Region - genetics | Immunotoxins - pharmacokinetics | Mice | Mice, Inbred BALB C | Virulence Factors - adverse effects | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Mutation | Virulence Factors - pharmacology | Index Medicus | Abridged Index Medicus | Lymphoid Neoplasia
Journal Article
TOXICITY OF THURINGIENSIN ON IMMATURE AND ADULT STAGES OF Tetranychus urticae KOCH AND Panonychus ulmi (KOCH) (ACARINA: TETRANYCHIDAE). (Toxicidad de thuringiensin en estados inmaduros y adultos de Tetranychus urticae Koch and Panonychus ulmi (Koch) (Acarina: Tetranychidae).), 12/2001
The direct and residual toxicity of thuringiensin on different stages of Tetranychus urticae   Koch and Panonychus ulmi   (Koch), and the influence on T.... 
b -exotoxina, acaricida, toxicidad directa, toxicidad residual, bioensayos | b -exotoxin, miticide, direct toxicity, residual toxicity, bioassay
Journal
BLOOD, ISSN 0006-4971, 04/2009, Volume 113, Issue 16, pp. 3792 - 3800
Immunotoxins based on Pseudomonas exotoxin A (PE) are promising anticancer agents that combine a variable fragment (Fv) from an antibody to a tumor-associated... 
RECOMBINANT IMMUNOTOXIN | HAIRY-CELL LEUKEMIA | PSEUDOMONAS EXOTOXIN-A | PHASE-I TRIAL | GROWTH-FACTOR-ALPHA | DOMAIN-II | RFB4(DSFV)-PE38 BL22 | ANTIGEN PRESENTATION | ANTITUMOR-ACTIVITY | HEMATOLOGY | CATHEPSIN-S
Journal Article
Journal Article
Journal Article
Journal Article
Journal Article
The Journal of Immunology, ISSN 0022-1767, 08/2007, Volume 179, Issue 3, pp. 1996 - 2004
Expression of chemokine receptors by tumors, specifically CCR4 on cutaneous T cell lymphomas, is often associated with a poor disease outcome. To test the... 
BREAST-CANCER | IN-VITRO | LYMPH-NODE METASTASIS | DENDRITIC CELLS | PSEUDOMONAS-AERUGINOSA | CXCR4 EXPRESSION | CHRONIC LYMPHOCYTIC-LEUKEMIA | ANTITUMOR IMMUNITY | IMMUNOLOGY | OVARIAN-CARCINOMA | CLINICAL-SIGNIFICANCE | Immunotoxins - toxicity | ADP Ribose Transferases - toxicity | Virulence Factors - genetics | Humans | Cell Death - immunology | Bacterial Toxins - toxicity | Antineoplastic Agents - toxicity | Leukemia-Lymphoma, Adult T-Cell - immunology | Antineoplastic Agents - metabolism | Cell Death - genetics | Receptors, Chemokine - biosynthesis | Bacterial Toxins - genetics | Female | Leukemia-Lymphoma, Adult T-Cell - therapy | Virulence Factors - toxicity | Cell Line | Cytotoxicity, Immunologic - genetics | Chemokine CCL17 | Chemokines, CC - toxicity | Chemokines, CC - administration & dosage | Receptors, Chemokine - metabolism | Neoplasm Recurrence, Local | Viral Proteins - genetics | Leukemia-Lymphoma, Adult T-Cell - pathology | Mice, SCID | ADP Ribose Transferases - genetics | Immunotoxins - genetics | Animals | Leukemia-Lymphoma, Adult T-Cell - metabolism | Chemokines, CC - genetics | Exotoxins - genetics | Cell Line, Tumor | Eosinophil-Derived Neurotoxin - toxicity | Exotoxins - toxicity | Mice, Inbred NOD | Eosinophil-Derived Neurotoxin - genetics | Mice | Viral Proteins - toxicity | Receptors, CCR4 | Index Medicus | Abridged Index Medicus
Journal Article
Toxins, ISSN 2072-6651, 08/2016, Volume 8, Issue 8, pp. 217 - 217
Recombinant immunotoxins (RITs) are fusions of an Fv-based targeting moiety and a toxin. Pseudomonas exotoxin A (PE) has been used to make several immunotoxins... 
Mesothelin | Recombinant immunotoxin | Disulfide bond | Pseudomonas exotoxin A | Immunoglobulin Variable Region - blood | Immunotoxins - blood | Humans | Immunoglobulin Variable Region - chemistry | Half-Life | Tumor Microenvironment | Disulfides - blood | Structure-Activity Relationship | Immunotoxins - pharmacology | Dose-Response Relationship, Drug | Disulfides - chemistry | Drug Design | Inhibitory Concentration 50 | Protein Domains | Disulfides - pharmacology | Immunotoxins - chemistry | ADP Ribose Transferases - chemistry | Exotoxins - blood | Furin - metabolism | Bacterial Toxins - blood | Exotoxins - chemistry | Oxidation-Reduction | Drug Stability | Recombinant Proteins - chemistry | Exotoxins - pharmacology | Virulence Factors - chemistry | Recombinant Proteins - pharmacology | Bacterial Toxins - chemistry | Neoplasms - drug therapy | Recombinant Proteins - blood | Xenograft Model Antitumor Assays | Animals | ADP Ribose Transferases - blood | Bacterial Toxins - pharmacology | Mice, Nude | ADP Ribose Transferases - pharmacology | Immunoglobulin Variable Region - pharmacology | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Neoplasms - pathology | Virulence Factors - blood | Virulence Factors - pharmacology | Index Medicus | recombinant immunotoxin | disulfide bond | mesothelin
Journal Article
Journal Article